Information on EC 5.3.1.22 - Hydroxypyruvate isomerase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
5.3.1.22
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RECOMMENDED NAME
GeneOntology No.
Hydroxypyruvate isomerase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydroxypyruvate = 2-hydroxy-3-oxopropanoate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
intramolecular oxidoreduction
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-
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isomerization
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glyoxylate and dicarboxylate metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
hydroxypyruvate aldose-ketose-isomerase
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CAS REGISTRY NUMBER
COMMENTARY hide
74812-48-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain DSM 83
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Hydroxypyruvate
2-Hydroxy-3-oxopropanoate
show the reaction diagram
-
r
r
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tartronic semialdehyde
hydroxypyruvate
show the reaction diagram
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-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
tartronic semialdehyde
hydroxypyruvate
show the reaction diagram
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-
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?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cu2+
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0.1 mM, 57% inhibition
Fe2+
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0.1 mM, 18% inhibition
hydroxylamine
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20 mM, 60% inhibition
iodoacetate
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0.7 mM, 100% inhibition
NaCN
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2.5 mM, 21% inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
10
Hydroxypyruvate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.6 - 7.4
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.4 - 8.5
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50% of maximal activity at pH 5.4 and 8.5
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PDB
SCOP
CATH
UNIPROT
ORGANISM
Q2YLA2
Brucella abortus (strain 2308);
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45000
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6 * 45000, SDS-PAGE
265000
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gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexamer
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6 * 45000, SDS-PAGE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
67
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10 min stable
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
loss of activity by vacuum dialysis at 4°C or by freezing
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, stable for 1 month
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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