Information on EC 5.1.3.18 - GDP-mannose 3,5-epimerase

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EC Tree
     5 Isomerases
         5.1 Racemases and epimerases
             5.1.3 Acting on carbohydrates and derivatives
                5.1.3.18 GDP-mannose 3,5-epimerase
IUBMB Comments
The enzyme catalyses the formation of the stable intermediate GDP-beta-L-gulose as well as GDP-beta-L-galactose. The reaction proceeds by C4' oxidation of GDP-alpha-D-mannose followed by epimerization of the C5' position to give GDP-beta-L-4-dehydro-gulose. This intermediate is either reduced to give GDP-beta-L-gulose or the C3' position is epimerized to give GDP-beta-L-4-dehydro-galactose, followed by C4' reduction to yield GDP-beta-L-galactose. Both products serve as intermediates in two different variants of plant L-ascorbate biosynthesis pathways.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
gdp-mannose-3',5'-epimerase, gdp-mannose 3,5-epimerase, gdp-d-mannose 3,5-epimerase, gdp-d-mannose-3',5'-epimerase, gdp-mannose 3',5'-epimerase, gdp-d-mannose 3'',5''-epimerase, gdp-d-mannose 3',5'-epimerase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-alpha-D-mannose = GDP-beta-L-galactose
show the reaction diagram
GDP-alpha-D-mannose = GDP-beta-L-gulose
show the reaction diagram
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