Reference on EC 5.1.3.17 - heparosan-N-sulfate-glucuronate 5-epimerase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jacobsson, I.; Lindahl, U.; Jensen, J.W.; Roden, L.; Prihar, H.; Feingold, D.S.
Biosynthesis of heparin. Substrate specificity of heparosan N-sulfate D-glucuronosyl 5-epimerase
J. Biol. Chem.
259
1056-1063
1984
Mus musculus
Jensen, J.W.; Roden, L.; Jacobsson, I.; Lindahl, U.; Prihar, H.; Feingold, D.S.
Biosynthesis of heparin. A new substrate for heparosan-N-sulfate-D-glucopyranosyluronate 5-epimerase
Carbohydr. Res.
117
241-253
1983
Bos taurus
-
Campbell, P.; Feingold, D.S.; Jensen, J.W.; Malmström, A.; Roden, L.
New assay for uronosyl 5-epimerase
Anal. Biochem.
131
146-152
1983
Bos taurus
Malmström, A.; Roden, L.; Feingold, D.S.; Jacobsson, I.; Bäckström, G.; Lindahl, U.
Biosynthesis of heparin. Partial purification of the uronosyl C-5 epimerase
J. Biol. Chem.
255
3878-3883
1980
Mus musculus
Campbell, P.; Hannesson, H.H.; Sandbäck, D.; Roden, L.; Lindahl, U.; Li, J.
Biosynthesis of heparin/heparan sulfate. Purification of the D-glucuronyl C-5 epimerase from bovine liver
J. Biol. Chem.
269
26953-26958
1994
Bos taurus
Li, J.; Hagner-McWhirter, A.; Kjellen, L.; Palgi, J.; Jalkanen, M.; Lindahl, U.
Biosynthesis of heparin/heparan sulfate. cDNA cloning and expression of D-glucuronyl C5-epimerase from bovine lung
J. Biol. Chem.
272
28158-28163
1997
Bos taurus (O18756), Bos taurus
Tiedemann, K.; Larsson, T.; Heinegard, D.; Malmstrom, A.
The glucuronyl C5-epimerase activity is the limiting factor in the dermatan sulfate biosynthesis
Arch. Biochem. Biophys.
391
65-71
2001
Homo sapiens
Li, J.P.; Gong, F.; El Darwish, K.; Jalkanen, M.; Lindahl, U.
Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate
J. Biol. Chem.
276
20069-20077
2001
Mus musculus (Q9EPS3), Mus musculus
Ghiselli, G.; Agrawal, A.
The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway
Biochem. J.
390
493-499
2005
Homo sapiens (O94923), Homo sapiens
Ghiselli, G.; Farber, S.A.
D-Glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish
BMC Dev. Biol.
5
19
2005
Danio rerio
Hagner-McWhirter, A.; Li, J.P.; Oscarson, S.; Lindahl, U.
Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate
J. Biol. Chem.
279
14631-14638
2004
Homo sapiens
Lopes, C.C.; Toma, L.; Pinhal, M.A.; Porcionatto, M.A.; Sogayar, M.C.; Dietrich, C.P.; Nader, H.B.
EJ-ras oncogene transfection of endothelial cells upregulates the expression of syndecan-4 and downregulates heparan sulfate sulfotransferases and epimerase
Biochimie
88
1493-1504
2006
Oryctolagus cuniculus
Cadwallader, A.B.; Yost, H.J.
Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: III. 2-O-sulfotransferase and C5-epimerases
Dev. Dyn.
236
581-586
2007
Danio rerio (Q29RD8), Danio rerio (Q6TS32), Danio rerio
Feyerabend, T.B.; Li, J.; Lindahl, U.; Rodewald, H.
Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells
Nat. Chem. Biol.
2
195-196
2006
Mus musculus
Grigorieva, E.; Eshchenko, T.; Rykova, V.I.; Chernakov, A.; Zabarovsky, E.; Sidorov, S.V.
Decreased expression of human D-glucuronyl C5-epimerase in breast cancer
Int. J. Cancer
122
1172-1176
2008
Homo sapiens
Jia, J.; Maccarana, M.; Zhang, X.; Bespalov, M.; Lindahl, U.; Li, J.P.
Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling
J. Biol. Chem.
284
15942-15950
2009
Mus musculus
Li, K.; Bethea, H.N.; Liu, J.
Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutants
J. Biol. Chem.
285
11106-11113
2010
Homo sapiens
Reijmers, R.M.; Vondenhoff, M.F.; Roozendaal, R.; Kuil, A.; Li, J.P.; Spaargaren, M.; Pals, S.T.; Mebius, R.E.
Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase
J. Immunol.
184
3656-3664
2010
Mus musculus, Mus musculus C57BL/6
Grigorieva, E.; Prudnikova, T.; Domanitskaya, N.; Mostovich, L.; Pavlova, T.; Kashuba, V.; Zabarovsky, E.
D-Glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo
Br. J. Cancer
105
74-82
2011
Homo sapiens (O94923), Homo sapiens
Raedts, J.; Kengen, S.; Van Der Oost, J.
Occurrence of L-iduronic acid and putative D-glucuronyl C5-epimerases in prokaryotes
Glycoconj. J.
28
57-66
2011
Bacillus cereus, Bacteroides sp., Clostridium kluyveri, Escherichia coli, Methanothermobacter thermautotrophicus, Methanocaldococcus jannaschii, Methanococcus voltae, Ruminococcus sp., Shigella boydii, Vibrio cholerae, Caldanaerobacter subterraneus subsp. tengcongensis, Methanothermobacter marburgensis, Thermococcus onnurineus, Photorhabdus laumondii subsp. laumondii, Candidatus Korarchaeum cryptofilum, Campylobacter hominis, Nautilia profundicola, Bermanella marisrubri, Photorhabdus asymbiotica, Methanocaldococcus fervens, Methanocaldococcus infernus, Methanocaldococcus vulcanius, Thermococcus sibiricus, Thermococcus barophilus, Candidatus Koribacter versatilis, Candidatus koribacter, Sanguibacter keddieii, Conexibacter woesei, Clostridium ljungdahlii, Vibrio cholerae serotype O1, Escherichia coli O112ab, Vibrio cholerae serotype O1 CO845, Clostridium ljungdahlii ATCC 49587, Bacteroides sp. 1_1_6, Vibrio cholerae VL426, Ruminococcus sp. 18P13, Candidatus Korarchaeum cryptofilum OPF8, Methanothermobacter thermautotrophicus DELTAH, Sanguibacter keddieii DSM 10542, Photorhabdus laumondii subsp. laumondii TTO1, Methanocaldococcus fervens AG86, Methanocaldococcus jannaschii DSM 2661, Bacillus cereus R309803, Thermococcus sibiricus MM 739, Methanococcus voltae A3, Conexibacter woesei DSM 14684, Campylobacter hominis ATCC BAA-381, Clostridium kluyveri NBRC 12016, Methanocaldococcus infernus ME, Nautilia profundicola AmH, Methanocaldococcus vulcanius M7, Bermanella marisrubri RED65, Thermococcus barophilus MP, Clostridium kluyveri DSM 555
Prudnikova, T.Y.; Soulitzis, N.; Kutsenko, O.S.; Mostovich, L.A.; Haraldson, K.; Ernberg, I.; Kashuba, V.I.; Spandidos, D.A.; Zabarovsky, E.R.; Grigorieva, E.V.
Heterogeneity of D-glucuronyl C5-epimerase expression and epigenetic regulation in prostate cancer
Cancer Med.
2
654-661
2013
Homo sapiens
Sheng, J.; Xu, Y.; Dulaney, S.B.; Huang, X.; Liu, J.
Uncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis
J. Biol. Chem.
287
20996-21002
2012
Homo sapiens
Raedts, J.; Lundgren, M.; Kengen, S.W.; Li, J.P.; van der Oost, J.
A novel bacterial enzyme with D-glucuronyl C5-epimerase activity
J. Biol. Chem.
288
24332-24339
2013
Bermanella marisrubri (Q1N097), Bermanella marisrubri
Dejima, K.; Takemura, M.; Nakato, E.; Peterson, J.; Hayashi, Y.; Kinoshita-Toyoda, A.; Toyoda, H.; Nakato, H.
Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid
J. Biol. Chem.
288
34384-34393
2013
Drosophila melanogaster
Zhang, J.; Suflita, M.; Li, G.; Zhong, W.; Li, L.; Dordick, J.S.; Linhardt, R.J.; Zhang, F.
High cell density cultivation of recombinant Escherichia coli strains expressing 2-O-sulfotransferase and C5-epimerase for the production of bioengineered heparin
Appl. Biochem. Biotechnol.
175
2986-2995
2015
Homo sapiens (O94923)
Mochizuki, H.; Yamagishi, K.; Suzuki, K.; Kim, Y.S.; Kimata, K.
Heparosan-glucuronate 5-epimerase molecular cloning and characterization of a novel enzyme
Glycobiology
25
735-744
2015
Lissachatina fulica (O94923), Lissachatina fulica
Qin, Y.; Ke, J.; Gu, X.; Fang, J.; Wang, W.; Cong, Q.; Li, J.; Tan, J.; Brunzelle, J.S.; Zhang, C.; Jiang, Y.; Melcher, K.; Li, J.P.; Xu, H.E.; Ding, K.
Structural and functional study of D-glucuronyl C5-epimerase
J. Biol. Chem.
290
4620-4630
2015
Danio rerio (F1QR43)
Babu, P.; Victor, X.V.; Raman, K.; Kuberan, B.
A rapid, nonradioactive assay for measuring heparan sulfate C-5 epimerase activity using hydrogen/deuterium exchange-mass spectrometry
Methods Mol. Biol.
1229
209-219
2015
Homo sapiens (O94923), Homo sapiens
Rosenberg, E.; Prudnikova, T.; Zabarovsky, E.; Kashuba, V.; Grigorieva, E.
D-Glucuronyl C5-epimerase cell type specifically affects angiogenesis pathway in different prostate cancer cells
Tumor Biol.
35
3237-3245
2014
Homo sapiens (O94923)
Ushakov, V.; Tsidulko, A.; De La Bourdonnaye, G.; Kazanskaya, G.; Volkov, A.; Kiselev, R.; Kobozev, V.; Kostromskaya, D.; Gaytan, A.; Krivoshapkin, A.; Aidagulova, S.; Grigorieva, E.
Heparan sulfate biosynthetic system is inhibited in human glioma due to EXT1/2 and HS6ST1/2 down-regulation
Int. J. Mol. Sci.
18
2301
2017
Homo sapiens (O94923)
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