Information on EC - heparosan-N-sulfate-glucuronate 5-epimerase

for references in articles please use BRENDA:EC5.1.3.17
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IUBMB Comments
The enzyme acts on D-glucosyluronate residues in N-sulfated heparosan polymers, converting them to L-iduronate, thus modifying the polymer to heparan-N-sulfate. The enzyme requires that at least the N-acetylglucosamine residue linked to C-4 of the substrate has been deacetylated and N-sulfated, and activity is highest with fully N-sulfated substrate. It does not act on glucuronate residues that are O-sulfated or are adjacent to N-acetylglucosamine residues that are O-sulfated at the 6 position. Thus the epimerization from D-glucuronate to L-iduronate occurs after N-sulfation of glucosamine residues but before O-sulfation. Not identical with EC chondroitin-glucuronate 5-epimerase or with EC, heparosan-glucuronate 5-epimerase.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
c5-epimerase, hsepi, d-glucuronyl c5-epimerase, glucuronyl c5-epimerase, c5-epi, hg-5epi, hs c5-epimerase, d-glucuronyl c-5 epimerase, heparosan n-sulfate d-glucuronosyl 5-epimerase, hnsg-5epi, more
heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate
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