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Information on EC 5.1.3.17 - heparosan-N-sulfate-glucuronate 5-epimerase

for references in articles please use BRENDA:EC5.1.3.17
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IUBMB Comments
The enzyme acts on D-glucosyluronate residues in N-sulfated heparosan polymers, converting them to L-iduronate, thus modifying the polymer to heparan-N-sulfate. The enzyme requires that at least the N-acetylglucosamine residue linked to C-4 of the substrate has been deacetylated and N-sulfated, and activity is highest with fully N-sulfated substrate. It does not act on glucuronate residues that are O-sulfated or are adjacent to N-acetylglucosamine residues that are O-sulfated at the 6 position. Thus the epimerization from D-glucuronate to L-iduronate occurs after N-sulfation of glucosamine residues but before O-sulfation. Not identical with EC 5.1.3.19 chondroitin-glucuronate 5-epimerase or with EC 5.1.3.36, heparosan-glucuronate 5-epimerase.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
c5-epimerase, d-glucuronyl c5-epimerase, glucuronyl c5-epimerase, hsepi, hs c5-epimerase, c5-epi, d-glucuronyl c-5 epimerase, heparosan n-sulfate d-glucuronosyl 5-epimerase, hs glucuronyl c5-epimerase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Epimerization of D-glucuronate in heparosan-N-sulfate to L-iduronate
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