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Reference on EC 5.1.2.2 - mandelate racemase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Neidhart, D.J.; Kenyon, G.L.; Gerlt, J.A.; Petsko, G.A.
Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous
Nature
347
692-694
1990
Pseudomonas putida
Manually annotated by BRENDA team
Tsou, A.Y.; Ransom, S.C.; Gerlt, J.A.; Buechter, D.D.; Babbitt, P.C.; Kenyon, G.L.
Mandelate pathway of Pseudomonas putida: sequence relationships involving mandelate racemase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase and expression of benzoylformate decarboxylase in Escherichia coli
Biochemistry
29
9856-9862
1990
Pseudomonas putida
Manually annotated by BRENDA team
Neidhart, D.J.; Powers, V.M.; Kenyon, G.L.; Tsou, A.Y.; Ransom, S.C.; Gerlt, J.A.; Petsko, G.A.
Preliminary X-ray data on crystals of mandelate racemase
J. Biol. Chem.
263
9268-9270
1988
Pseudomonas putida
Manually annotated by BRENDA team
Ransom, S.C.; Gerlt, J.A.; Powers, V.M.; Kenyon, G.L.
Cloning, DNA sequence analysis, and expression in Escherichia coli of the gene for mandelate racemase from Pseudomonas putida
Biochemistry
27
540-545
1988
Pseudomonas putida
Manually annotated by BRENDA team
Lin, D.T.; Powers, V.M.; Reynolds, L.J.; Whitman, C.P.; Kozarich, J.W.; Kenyon, G.L.
Evidence for the generation of alpha-carboxy-alpha-hydroxy-p-xylylene from p-(bromomethyl)mandelate by mandelate racemase
J. Am. Chem. Soc.
110
323-324
1988
Pseudomonas putida
-
Manually annotated by BRENDA team
Whitman, C.P.; Hegeman, G.D.; Cleland, W.W.; Kenyon, G.L.
Symmetry and asymmetry in mandelate racemase catalysis
Biochemistry
24
3936-3942
1985
Pseudomonas putida
Manually annotated by BRENDA team
Kenyon, G.L.; Hegeman, G.D.
Mandelate racemase
Adv. Enzymol. Relat. Areas Mol. Biol.
50
325-360
1979
Pseudomonas putida
Manually annotated by BRENDA team
Kenyon, G.L.; Hegeman, G.D.
Mandelate racemase
Methods Enzymol.
46
541-548
1977
Pseudomonas putida
Manually annotated by BRENDA team
Maggio, E.T.; Kenyon, G.L.; Mildvan, A.S.; Hegeman, G.D.
Mandelate racemase from Pseudomonas putida. Magnetic resonance and kinetic studies of the mechanism of catalysis
Biochemistry
14
1131-1139
1975
Pseudomonas putida
Manually annotated by BRENDA team
Fee, J.A.; Hegeman, G.D.; Kenyon, G.L.
Mandelate racemase from Pseudomonas putida. Affinity labeling of the enzyme by D,L-alpha-phenylglycidate in the presence of magnesium ion
Biochemistry
13
2533-2538
1974
Pseudomonas putida
Manually annotated by BRENDA team
Fee, J.A.; Hegeman, G.D.; Kenyon, G.L.
Mandelate racemase from pseudomonas putida. Subunit composition and absolute divalent metal ion requirement
Biochemistry
13
2528-2532
1974
Pseudomonas putida
Manually annotated by BRENDA team
Hegeman, G.D.
Mandelate racemase (Pseudomonas putida)
Methods Enzymol.
17
670-674
1970
Pseudomonas putida
-
Manually annotated by BRENDA team
Hegeman, G.D.; Rosenberg, E.Y.; Kenyon, G.L.
Mandelic acid racemase from Pseudomonas putida. Purification and properties of the enzyme
Biochemistry
9
4029-4036
1970
Pseudomonas putida, Pseudomonas putida A.3.12
Manually annotated by BRENDA team
Schafer, S.L.; Barrett, W.C.; Kallarakal, A.T.; Mitra, B.; Kozarich, J.W.; Gerlt, J.A.
Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the D270N mutant
Biochemistry
35
5662-5669
1996
Pseudomonas putida (P11444), Pseudomonas putida
Manually annotated by BRENDA team
Sharp, T.R.; Hegeman, G.D.; Kenyon, G.L.
A direct kinetic assay for mandelate racemase using circular dichroic measurements
Anal. Biochem.
94
329-334
1979
Pseudomonas putida
Manually annotated by BRENDA team
Sharp, T.R.; Hegeman, G.D.; Kenyon, G.L.
Mandelate racemase from Pseudomonas putida. Absence of detectable intermolecular proton transfer accompanying racemization
Biochemistry
16
1123-1128
1977
Pseudomonas putida, Pseudomonas putida A.3.12
Manually annotated by BRENDA team
Kenyon, G.L.; Hegeman, G.D.
Mandelic acid racemase from Pseudomonas putida. Evidence favoring a carbanion intermediate in the mechanism of action
Biochemistry
9
4036-4043
1970
Pseudomonas putida
Manually annotated by BRENDA team
Tsou, A.Y.; Ransom, S.C.; Gerlt, J.A.; Powers, V.M.; Kenyon, G.L.
Selection and characterization of a mutant of the cloned gene for mandelate racemase that confers resistance to an affinity label by greatly enhanced production of enzyme
Biochemistry
28
969-975
1989
Pseudomonas putida
Manually annotated by BRENDA team
Neidhart, D.C.; Howell, P.L.; Petsko, G.A.; Gerlt, J.A.; Kozarich, J.W.; Powers, V.M.; Kenyon, G.L.
Restructuring catalysis in the mandelate pathway
Biochem. Soc. Symp.
57
135-141
1990
Pseudomonas putida
Manually annotated by BRENDA team
Landro, J.A.; Kallarakal, A.T.; Ransom, S.C.; Gerlt, J.A.; Kozarich, J.W.; Neidhart, D.J.; Kenyon, G.L.
Mechanism of the reaction catalyzed by mandelate racemase. 3. Asymmetry in reactions catalyzed by the H297N mutant
Biochemistry
30
9274-9281
1991
Pseudomonas putida
Manually annotated by BRENDA team
Neidhart, D.J.; Howell, P.L.; Petsko, G.A.; Powers, V.M.; Li, R.; Kenyon, G.L.; Gerlt, J.A.
Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-A resolution: identification of the active site and possible catalytic residues
Biochemistry
30
9264-9273
1991
Pseudomonas putida
Manually annotated by BRENDA team
Powers, V.M.; Koo, C.W.; Kenyon, G.L.; Gerlt, J.A.; Kozarich, J.W.
Mechanism of the reaction catalyzed by mandelate racemase. 1. Chemical and kinetic evidence for a two-base mechanism
Biochemistry
30
9255-9263
1991
Pseudomonas putida
Manually annotated by BRENDA team
Gerlt, J.A.; Kenyon, G.L.; Kozarich, J.W.; Neidhart, D.J.; Petsko, G.A.; Powers, V.M.
Mandelate racemase and class-related enzymes
Curr. Opin. Struct. Biol.
2
736-742
1992
Pseudomonas putida
-
Manually annotated by BRENDA team
Landro, J.A.; Gerlt, J.A.; Kozarich, J.W.; Koo, C.W.; Shah, V.J.; Kenyon, G.L.; Neidhart, D.J.; Fujita, S.; Petsko, G.A.
The role of lysine 166 in the mechanism of mandelate racemase from Pseudomonas putida: mechanistic and crystallographic evidence for stereospecific alkylation by (R)-alpha-phenylglycidate
Biochemistry
33
635-643
1994
Pseudomonas putida
Manually annotated by BRENDA team
Li, R.; Powers, V.M.; Kozarich, J.W.; Kenyon, G.L.
Racemization of vinylglycolate catalyzed by mandelate racemase
J. Org. Chem.
60
3347-3351
1995
Pseudomonas putida
-
Manually annotated by BRENDA team
Kallarakal, A.T.; Mitra, B.; Kozarich, J.W.; Gerlt, J.A.; Clifton, J.G.; Petsko, G.A.; Kenyon, G.L.
Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the K166R mutant
Biochemistry
34
2788-2797
1995
Pseudomonas putida
Manually annotated by BRENDA team
Stecher, H.; Felfer, U.; Faber, K.
Large-scale production of mandelate racemase by Pseudomonas putida ATCC 12633: optimization of enzyme induction and development of a stable crude enzyme preparation
J. Biotechnol.
56
33-40
1997
Pseudomonas putida
-
Manually annotated by BRENDA team
Mitra, B.; Kallarakal, A.T.; Kozarich, J.W.; Gerlt, J.A.; Clifton, J.G.; Petsko, G.A.; Kenyon, G.L.
Mechanism of the reaction catalyzed by mandelate racemase: importance of electrophilic catalysis by glutamic acid 317
Biochemistry
34
2777-2787
1995
Pseudomonas putida
Manually annotated by BRENDA team
ST.Maurice, M.; Bearne, S.L.
Reaction intermediate analogues for mandelate racemase: interaction between Asn 197 and the alpha-hydroxyl of the substrate promotes catalysis
Biochemistry
39
13324-13335
2000
Pseudomonas putida
Manually annotated by BRENDA team
St Maurice, M.; Bearne, S.L.
Kinetics and thermodynamics of mandelate racemase catalysis
Biochemistry
41
4048-4058
2002
Pseudomonas putida
Manually annotated by BRENDA team
St Maurice, M.; Bearne, S.L.
Hydrophobic nature of the active site of mandelate racemase
Biochemistry
43
2524-2532
2004
Pseudomonas putida (P11444), Pseudomonas putida
Manually annotated by BRENDA team
Strauss, U.T.; Kandelbauer, A.; Faber, K.
Stabilization and activity-enhancement of mandelate racemase from Pseudomonas putida ATCC 12336 by immobilization
Biotechnol. Lett.
22
515-520
2000
Pseudomonas putida, Pseudomonas putida ATCC 12336
-
Manually annotated by BRENDA team
Garcia-Viloca, M.; Gonzalez-Lafont, A.; Lluch, J.M.
A QM/MM study of the racemization of vinylglycolate catalyzed by mandelate racemase enzyme
J. Am. Chem. Soc.
123
709-721
2001
Pseudomonas putida (P11444)
Manually annotated by BRENDA team
Goriup, M.; Strauss, U.T.; Felfer, U.; Kroutil, W.; Faber, K.
Substrate spectrum of mandelate racemase. Part 1: Variation of the a-hydroxy acid moiety
J. Mol. Catal. B
15
207-211
2001
Pseudomonas putida
-
Manually annotated by BRENDA team
Felfer, U.; Strauss, U.T.; Kroutil, W.; Fabian, W.M.F.; Faber, K.
Substrate spectrum of mandelate racemase. Part 2. (Hetero)-aryl-substituted mandelate derivatives and modulation of activity
J. Mol. Catal. B
15
213-222
2001
Pseudomonas putida
-
Manually annotated by BRENDA team
Bauer, C.; Boy, M.; Faber, K.; Felfer, U.; Voss, H.
Activation of mandelate racemase via immobilization in lyotropic liquid crystals for biocatalysis in organic solvents: application and modeling
J. Mol. Catal. B
16
91-100
2001
Pseudomonas putida
-
Manually annotated by BRENDA team
Felfer, U.; Goriup, M.; Koegl, M.F.; Wagner, U.; Larissegger-Schnell, B.; Faber, K.; Kroutil, W.
The substrate spectrum of mandelate racemase: Minimum structural requirements for substrates and substrate model
Adv. Synth. Catal.
347
951-961
2005
Pseudomonas putida
-
Manually annotated by BRENDA team
Siddiqi, F.; Bourque, J.R.; Jiang, H.; Gardner, M.; St Maurice, M.; Blouin, C.; Bearne, S.L.
Perturbing the hydrophobic pocket of mandelate racemase to probe phenyl motion during catalysis
Biochemistry
44
9013-9021
2005
Pseudomonas putida (P11444), Pseudomonas putida
Manually annotated by BRENDA team
Burley, R.K.; Bearne, S.L.
Inhibition of mandelate racemase by the substrate-intermediate-product analogue 1,1-diphenyl-1-hydroxymethylphosphonate
Bioorg. Med. Chem. Lett.
15
4342-4344
2005
Pseudomonas putida
Manually annotated by BRENDA team
Brosseau, C.L.; St.Maurice, M.; Bearne, S.L.; Roscoe, S.G.
Electrochemical quartz crystal nanobalance (EQCN) studies of the adsorption behaviour of an enzyme, mandelate racemase, and its substrate, mandelic acid, on Pt
Electrochim. Acta
50
1289-1297
2005
Pseudomonas putida
-
Manually annotated by BRENDA team
Prat-Resina, X.; Gonzalez-Lafont, A.; Lluch, J.M.
Reaction mechanism of the mandelate anion racemization catalyzed by mandelate racemase enzyme: A QM/MM Molecular Dynamics Free Energy Study
J. Phys. Chem. B
109
21089-21101
2005
Pseudomonas putida (P11444)
Manually annotated by BRENDA team
Bourque, J.R.; Burley, R.K.; Bearne, S.L.
Intermediate analogue inhibitors of mandelate racemase: N-Hydroxyformanilide and cupferron
Bioorg. Med. Chem. Lett.
17
105-108
2007
Pseudomonas putida
Manually annotated by BRENDA team
Choi, W.J.; Lee, K.Y.; Kang, S.H.; Lee, S.B.
Biocatalytic enantioconvergent separation of racemic mandelic acid
Sep. Purif. Technol.
53
178-182
2007
Pseudomonas putida
-
Manually annotated by BRENDA team
Bourque, J.R.; Bearne, S.L.
Mutational analysis of the active site flap (20s loop) of mandelate racemase
Biochemistry
47
566-578
2008
Pseudomonas putida (P11444), Pseudomonas putida
Manually annotated by BRENDA team
Narmandakh, A.; Bearne, S.L.
Purification of recombinant mandelate racemase: improved catalytic activity
Protein Expr. Purif.
69
39-46
2010
Pseudomonas putida (P11444), Pseudomonas putida
Manually annotated by BRENDA team
Nagar, M.; Narmandakh, A.; Khalak, Y.; Bearne, S.L.
Redefining the minimal substrate tolerance of mandelate racemase. Racemization of trifluorolactate
Biochemistry
50
8846-8852
2011
Pseudomonas putida (P11444), Pseudomonas putida
Manually annotated by BRENDA team
Lietzan, A.D.; Nagar, M.; Pellmann, E.A.; Bourque, J.R.; Bearne, S.L.; St Maurice, M.
Structure of mandelate racemase with bound intermediate analogues benzohydroxamate and cupferron
Biochemistry
51
1160-1170
2012
Pseudomonas putida (P11444), Pseudomonas putida
Manually annotated by BRENDA team
Nagar, M.; Lietzan, A.D.; St Maurice, M.; Bearne, S.L.
Potent inhibition of mandelate racemase by a fluorinated substrate-product analogue with a novel binding mode
Biochemistry
53
1169-1178
2014
Pseudomonas putida (P11444), Pseudomonas putida
Manually annotated by BRENDA team
Li, D.; Zeng, Z.; Yang, J.; Wang, P.; Jiang, L.; Feng, J.; Yang, C.
Mandelate racemase and mandelate dehydrogenase coexpressed recombinant Escherichia coli in the synthesis of benzoylformate
Biosci. Biotechnol. Biochem.
77
1236-1239
2013
Pseudomonas aeruginosa (R9RJF1), Pseudomonas aeruginosa, Pseudomonas aeruginosa NUST (R9RJF1)
Manually annotated by BRENDA team
Gu, J.; Liu, M.; Guo, F.; Xie, W.; Lu, W.; Ye, L.; Chen, Z.; Yuan, S.; Yu, H.
Virtual screening of mandelate racemase mutants with enhanced activity based on binding energy in the transition state
Enzyme Microb. Technol.
55
121-127
2014
Pseudomonas putida (P11444)
Manually annotated by BRENDA team
Gu, J.; Yu, H.
The role of residue S139 of mandelate racemase: synergistic effect of S139 and E317 on transition state stabilization
J. Biomol. Struct. Dyn.
30
585-593
2012
Pseudomonas putida (P11444), Pseudomonas putida
Manually annotated by BRENDA team
Meshach Paul, D.; Chadah, T.; Senthilkumar, B.; Sethumadhavan, R.; Rajasekaran, R.
Structural distortions due to missense mutations in human formylglycine-generating enzyme leading to multiple sulfatase deficiency
J. Biomol. Struct. Dyn.
36
3575-3585
2017
Pseudomonas putida (P11444)
Manually annotated by BRENDA team
Yang, C.; Ye, L.; Gu, J.; Yang, X.; Li, A.; Yu, H.
Directed evolution of mandelate racemase by a novel high-throughput screening method
Appl. Microbiol. Biotechnol.
101
1063-1072
2017
Pseudomonas putida (P11444), Pseudomonas putida ATCC 12633 (P11444)
Manually annotated by BRENDA team
Nagar, M.; Wyatt, B.N.; St Maurice, M.; Bearne, S.L.
Inactivation of mandelate racemase by 3-hydroxypyruvate reveals a potential mechanistic link between enzyme superfamilies
Biochemistry
54
2747-2757
2015
Pseudomonas putida (P11444)
Manually annotated by BRENDA team
Nagar, M.; Bearne, S.L.
An additional role for the Broensted acid-base catalysts of mandelate racemase in transition state stabilization
Biochemistry
54
6743-6752
2015
Pseudomonas putida (P11444)
Manually annotated by BRENDA team