We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments The enzyme employs a two-base mechanism, with a thiolate-thiol pair in the active site. It participates in the biosynthetic pathway of D -cycloserine, an antibiotic substance produced by several Streptomyces species.
Synonyms
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DcsC
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
O-ureido-L-serine = O-ureido-D-serine
O-ureido-L-serine = O-ureido-D-serine
-
-
-
-
O-ureido-L-serine = O-ureido-D-serine
the enzyme employs a two-base mechanism, with a thiolatethiol pair in the active site
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MetaCyc
D-cycloserine biosynthesis
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2S)-2-amino-3-[(carbamoylamino)oxy]propanoate 2-epimerase
The enzyme employs a two-base mechanism, with a thiolate-thiol pair in the active site. It participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
O-ureido-D-serine
O-ureido-L-serine
Substrates: two-base mechanism, with a thiolate-thiol pair in the active site
r
O-ureido-L-serine
O-ureido-D-serine
O-ureido-L-serine
O-ureido-D-serine
Substrates: two-base mechanism, with a thiolate-thiol pair in the active site
r
O-ureido-L-serine
O-ureido-D-serine
Substrates: the enzyme is involved in the biosynthesis of the antibiotic D-cycloserine
r
O-ureido-L-serine
O-ureido-D-serine
Substrates: O-ureido-L-serine i.e. (2S)-2-amino-3-[(carbamoylamino)oxy]propanoate
?
O-ureido-L-serine
O-ureido-D-serine
Substrates: -
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
O-ureido-L-serine
O-ureido-D-serine
Substrates: the enzyme is involved in the biosynthesis of the antibiotic D-cycloserine
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1-carboxy-1-O-ureido-methoxy oxirane
-
-
3-[[(carbamoylamino)oxy]methyl]oxiran-2-carboxylic acid
irreversible inhibition
Hg2+
0.01 mM, activity is completely abolished
Hg2+
0.01 mM, complete inhibition
iodoacetamide
-
iodoacetamide
complete inhibition
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
17
O-ureido-D-serine
pH 7.9, 30°C
110
O-ureido-L-serine
pH 7.9, 30°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
29
O-ureido-D-serine
pH 7.9, 30°C
158
O-ureido-L-serine
pH 7.9, 30°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1.71
O-ureido-D-serine
pH 7.9, 30°C
1.44
O-ureido-L-serine
pH 7.9, 30°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7.8
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
SwissProt
brenda
-
UniProt
brenda
Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DCSC_STRLA
287
0
30382
Swiss-Prot
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
31205
x * 31205, ESI-TOF mass spectrometry
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
?
x * 31205, ESI-TOF mass spectrometry
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ni2+-affinity chromatography
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in Escherichia coli
expression in Escherichia coli M15
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Kumagai, T.; Koyama, Y.; Oda, K.; Noda, M.; Matoba, Y.; Sugiyama, M.
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae
Antimicrob. Agents Chemother.
54
1132-1139
2010
Streptomyces lavendulae subsp. lavendulae (D2Z026)
brenda
Dietrich, D.; van Belkum, M.J.; Vederas, J.C.
Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine
Org. Biomol. Chem.
10
2248-2254
2012
Streptomyces lavendulae subsp. lavendulae (D2Z026)
brenda
Ahn, Y.; Fischer, C.; Van Belkum, M.; Vederas, J.
PLP-independent racemization Mechanistic and mutational studies of O -ureidoserine racemase (DcsC)
Org. Biomol. Chem.
16
1126-1133
2018
Streptomyces lavendulae (D2Z026)
brenda
html completed
show
top
