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Disease on EC 5.1.1.18 - serine racemase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide.
Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease.
Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog.
Amyotrophic Lateral Sclerosis
Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.
Ataxia Telangiectasia
Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.
Brain Diseases
The Role of Serine Racemase in the Pathophysiology of Brain Disorders.
Brain Ischemia
Serine racemase deletion protects against cerebral ischemia and excitotoxicity.
Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia.
Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia.
Choroidal Neovascularization
Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells.
Colorectal Neoplasms
Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine.
Dehydration
Catalytic mechanism of serine racemase from Dictyostelium discoideum.
Crystal structure of a pyridoxal 5'-phosphate-dependent aspartate racemase derived from the bivalve mollusc Scapharca broughtonii.
Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP.
Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine.
The Energy Landscape of Human Serine Racemase.
Dermatitis, Atopic
Inflammatory cytokine-mediated induction of serine racemase in atopic dermatitis.
Diabetes Mellitus
Serine racemase rs391300 G/A polymorphism influences the therapeutic efficacy of metformin in Chinese patients with diabetes mellitus type 2.
Diabetes Mellitus, Type 2
Association of serine racemase gene variants with type 2 diabetes in the Chinese Han population.
Faster progression from MCI to probable AD for carriers of a single-nucleotide polymorphism associated with type 2 diabetes.
Diabetic Retinopathy
Loss-of-function mutation of serine racemase attenuates excitotoxicity by intravitreal injection of N-methyl-D-aspartate.
Loss-of-function mutation of serine racemase attenuates retinal ganglion cell loss in diabetic mice.
Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats.
Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy.
Serine racemase deletion attenuates neurodegeneration and microvascular damage in diabetic retinopathy.
Epilepsy
Potential roles of D-serine and serine racemase in experimental temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Potential roles of D-serine and serine racemase in experimental temporal lobe epilepsy.
Glioblastoma
Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells.
Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells.
Glioma
D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).
Hyperalgesia
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
Hypertension
Neuroprotective effects of DAAO are mediated via the ERK1/2 signaling pathway in a glaucomatous animal model.
Infarction, Middle Cerebral Artery
Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.
Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia.
Memory Disorders
Reduced serine racemase expression contributes to age-related deficits in hippocampal cognitive function.
Serine racemase as a prime target for age-related memory deficits.
Neoplasms
Moderate-Intensity Exercise Induces Neurogenesis and Improves Cognition in Old Mice by Upregulating Hippocampal Hippocalcin, Otub1, and Spectrin-?.
Total Flavones of Abelmoschus manihot Remodels Gut Microbiota and Inhibits Microinflammation in Chronic Renal Failure Progression by Targeting Autophagy-Mediated Macrophage Polarization.
Neuralgia
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Neurobehavioral Manifestations
D-amino Acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy.
Neurodegenerative Diseases
Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase.
Neurobiology through the looking-glass: D-serine as a new glial-derived transmitter.
Seizures
D-Serine Contributes to Seizure Development via ERK Signaling.
Decreased susceptibility to seizures induced by pentylenetetrazole in serine racemase knockout mice.
serine racemase deficiency
Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells.
Stroke
Neurobiology through the looking-glass: D-serine as a new glial-derived transmitter.
Peripheral Biomarker for Vascular Disorders.
Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog.