Disease on EC 5.1.1.18 - serine racemase
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Alzheimer Disease
Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide.
Alzheimer Disease
Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease.
Alzheimer Disease
Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog.
Amyotrophic Lateral Sclerosis
Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.
Ataxia Telangiectasia
Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data.
Brain Ischemia
Serine racemase deletion protects against cerebral ischemia and excitotoxicity.
Brain Ischemia
Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia.
Brain Ischemia
Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia.
Choroidal Neovascularization
Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells.
Colorectal Neoplasms
Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine.
Dehydration
Crystal structure of a pyridoxal 5'-phosphate-dependent aspartate racemase derived from the bivalve mollusc Scapharca broughtonii.
Dehydration
Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP.
Dehydration
Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine.
Dermatitis, Atopic
Inflammatory cytokine-mediated induction of serine racemase in atopic dermatitis.
Diabetes Mellitus
Serine racemase rs391300 G/A polymorphism influences the therapeutic efficacy of metformin in Chinese patients with diabetes mellitus type 2.
Diabetes Mellitus, Type 2
Association of serine racemase gene variants with type 2 diabetes in the Chinese Han population.
Diabetes Mellitus, Type 2
Faster progression from MCI to probable AD for carriers of a single-nucleotide polymorphism associated with type 2 diabetes.
Diabetic Retinopathy
Loss-of-function mutation of serine racemase attenuates excitotoxicity by intravitreal injection of N-methyl-D-aspartate.
Diabetic Retinopathy
Loss-of-function mutation of serine racemase attenuates retinal ganglion cell loss in diabetic mice.
Diabetic Retinopathy
Overexpression of D-amino acid oxidase prevents retinal neurovascular pathologies in diabetic rats.
Diabetic Retinopathy
Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy.
Diabetic Retinopathy
Serine racemase deletion attenuates neurodegeneration and microvascular damage in diabetic retinopathy.
Epilepsy
Potential roles of D-serine and serine racemase in experimental temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Potential roles of D-serine and serine racemase in experimental temporal lobe epilepsy.
Glioblastoma
Mutual regulation between serine and nitric oxide metabolism in human glioblastoma cells.
Glioblastoma
Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells.
Glioma
D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).
Hyperalgesia
Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.
Hypertension
Neuroprotective effects of DAAO are mediated via the ERK1/2 signaling pathway in a glaucomatous animal model.
Infarction, Middle Cerebral Artery
Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.
Infarction, Middle Cerebral Artery
Serine racemase expression in mouse cerebral cortex after permanent focal cerebral ischemia.
Memory Disorders
Reduced serine racemase expression contributes to age-related deficits in hippocampal cognitive function.
Neoplasms
Moderate-Intensity Exercise Induces Neurogenesis and Improves Cognition in Old Mice by Upregulating Hippocampal Hippocalcin, Otub1, and Spectrin-?.
Neoplasms
Total Flavones of Abelmoschus manihot Remodels Gut Microbiota and Inhibits Microinflammation in Chronic Renal Failure Progression by Targeting Autophagy-Mediated Macrophage Polarization.
Neuralgia
Inhibition of Cytochrome P450 Side-Chain Cleavage Attenuates the Development of Mechanical Allodynia by Reducing Spinal D-Serine Production in a Murine Model of Neuropathic Pain.
Neurobehavioral Manifestations
D-amino Acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy.
Neurodegenerative Diseases
Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase.
Neurodegenerative Diseases
Neurobiology through the looking-glass: D-serine as a new glial-derived transmitter.
Seizures
Decreased susceptibility to seizures induced by pentylenetetrazole in serine racemase knockout mice.
serine racemase deficiency
Serine racemase deficiency attenuates choroidal neovascularization and reduces nitric oxide and VEGF levels by retinal pigment epithelial cells.
Stroke
Neurobiology through the looking-glass: D-serine as a new glial-derived transmitter.
Stroke
Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog.
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