Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 4.6.1.19 - ribonuclease T2

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
1-acylglycerol-3-phosphate o-acyltransferase deficiency
ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield.
Acute Lung Injury
RNase L Is Involved in Liposaccharide-Induced Lung Inflammation.
Adenocarcinoma
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma.
Adenocarcinoma of Lung
Actinomycin D-Activated RNase L Promotes H2A.X/H2B-Mediated DNA Damage and Apoptosis in Lung Cancer Cells.
Ribonuclease L mediates the cell-lethal phenotype of the double-stranded RNA editing enzyme ADAR1 in a human cell line.
Adenomatous Polyposis Coli
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Adrenoleukodystrophy
ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis.
Alphavirus Infections
Alphavirus minus-strand synthesis and persistence in mouse embryo fibroblasts derived from mice lacking RNase L and protein kinase R.
Alzheimer Disease
Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.
Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke.
Polymorphisms in Glutathione S-Transferase Omega-1 Gene and Increased Risk of Sporadic Alzheimer Disease.
Aortic Coarctation
Prenatal diagnosis and molecular cytogenetic characterization of de novo partial trisomy 12q (12q24.21?qter) and partial monosomy 6q (6q27?qter) associated with coarctation of the aorta, ventriculomegaly and thickened nuchal fold.
Asthenozoospermia
RNASET2 impairs the sperm motility via PKA/PI3K/calcium signal pathways.
RNASET2 in human spermatozoa and seminal plasma: a novel relevant indicator for asthenozoospermia.
RNASET2 is required for ROS propagation during oxidative stress-mediated cell death.
Asymptomatic Infections
Effects of PKR/RNase L-dependent and alternative antiviral pathways on alphavirus replication and pathogenesis.
Atherosclerosis
Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression.
Avitaminosis
Hepatic peroxisome proliferation in vitamin A-deficient mice without a simultaneous increase in peroxisomal acyl-CoA oxidase activity.
Bacterial Infections
New insights into the role of RNase L in innate immunity.
Recombinant HvRNASET2 protein induces marked connective tissue remodelling in the invertebrate model Hirudo verbana.
Breast Neoplasms
Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer.
siRNA?induced ABCE1 silencing inhibits proliferation and invasion of breast cancer cells.
Carcinogenesis
ACTIBIND, an actin-binding fungal T2-RNase with antiangiogenic and anticarcinogenic characteristics.
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis.
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.
Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV from 22Rv1 Prostate Carcinoma Cells.
RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth.
RNASET2 as a tumor antagonizing gene in a melanoma cancer model.
Tumor and metastasis suppression by the human RNASET2 gene.
Carcinoid Tumor
New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1?.
Carcinoma
A Cell-Autonomous Oncosuppressive Role of Human RNASET2 Affecting ECM-Mediated Oncogenic Signaling.
Chromosome 6 Encoded RNaseT2 Protein is a Cell Growth Regulator.
Induction of the interferon-inducible RNA-degrading enzyme, RNase L, by stress-inducing agents in the human cervical carcinoma cells.
Lopinavir up-regulates expression of the antiviral protein ribonuclease L in human papillomavirus-positive cervical carcinoma cells.
Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection.
Rapid RNase L-Driven Arrest of Protein Synthesis in the dsRNA Response without Degradation of Translation Machinery.
[A comparism between lysosomal enzyme activity in normal ectocervical squamous epithelium and squamous carcinoma of the ectocervix]
Carcinoma, Hepatocellular
Acid ribonuclease activity of hepatoma cells.
Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L.
The ribonuclease L-dependent antiviral roles of human 2',5'-oligoadenylate synthetase family members against hepatitis C virus.
Carcinoma, Neuroendocrine
New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1?.
Carcinoma, Ovarian Epithelial
A Cell-Autonomous Oncosuppressive Role of Human RNASET2 Affecting ECM-Mediated Oncogenic Signaling.
Colonic Neoplasms
Human recombinant RNASET2: A potential anti-cancer drug.
Colorectal Neoplasms
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Coronavirus Infections
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.
COVID-19
Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export.
SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block.
Coxsackievirus Infections
RNase L and double-stranded RNA-dependent protein kinase exert complementary roles in islet cell defense during coxsackievirus infection.
Cystic Fibrosis
Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
Cysts
Clinical, radiological and possible pathological overlap of cystic leukoencephalopathy without megalencephaly and Aicardi-Goutières syndrome.
RMND1-Related Leukoencephalopathy With Temporal Lobe Cysts and Hearing Loss-Another Mendelian Mimicker of Congenital Cytomegalovirus Infection.
rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA.
Structure and activity of the only human RNase T2.
Cytomegalovirus Infections
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.
Dementia, Vascular
Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke.
Demyelinating Diseases
New insights into the role of RNase L in innate immunity.
RNase L mediated protection from virus induced demyelination.
Dengue
Identification and comparative analysis of hepatitis C virus-host cell protein interactions.
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Zika Virus Production Is Resistant to RNase L Antiviral Activity.
Dermatitis, Contact
Skin allograft rejection is suppressed in mice lacking the antiviral enzyme, 2',5'-oligoadenylate-dependent RNase L.
Diabetes Mellitus, Type 1
RNase L contributes to experimentally induced type 1 diabetes onset in mice.
double-stranded rna adenine deaminase deficiency
A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency.
Encephalomyelitis
RNase L mediated protection from virus induced demyelination.
Epilepsy
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
Fatigue Syndrome, Chronic
2',5'-Oligoadenylate size is critical to protect RNase L against proteolytic cleavage in chronic fatigue syndrome.
37-Kilodalton/83-kilodalton RNase L isoform ratio in peripheral blood mononuclear cells: analytical performance and relevance for chronic fatigue syndrome.
A 37 kDa 2-5A binding protein as a potential biochemical marker for chronic fatigue syndrome.
Biochemical evidence for a novel low molecular weight 2-5A-dependent RNase L in chronic fatigue syndrome.
Changes in the 2-5A synthetase/RNase L antiviral pathway in a controlled clinical trial with poly(I)-poly(C12U) in chronic fatigue syndrome.
Exercise capacity and immune function in male and female patients with chronic fatigue syndrome (CFS).
Physical performance and prediction of 2-5A synthetase/RNase L antiviral pathway activity in patients with chronic fatigue syndrome.
Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients.
RNase L levels in peripheral blood mononuclear cells: 37-kilodalton/83-kilodalton isoform ratio is a potential test for chronic fatigue syndrome.
Structural and functional features of the 37-kDa 2-5A-dependent RNase L in chronic fatigue syndrome.
Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance.
Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome.
Variability of the RNase L isoform ratio (37 kiloDaltons/83 kiloDaltons) in diagnosis of chronic fatigue syndrome.
Fibrosarcoma
Tumour suppressor function of RNase L in a mouse model.
Flavivirus Infections
RNase L antiviral activity is not a critical component of the Oas1b-mediated flavivirus resistance phenotype.
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Foot-and-Mouth Disease
Inhibition of Antiviral Innate Immunity by Foot-and-Mouth Disease Virus Lpro through Interaction with the N-Terminal Domain of Swine RNase L.
Glioma
Monitoring activation of ribonuclease L by 2',5'-oligoadenylates using purified recombinant enzyme and intact malignant glioma cells.
Granuloma
Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function.
Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo.
Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response.
Graves Disease
RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
[Association of RNASET2 gene polymorphisms and haplotypes with Graves disease in Han Chinese population from coastal regions of Shandong].
Hematologic Neoplasms
Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax.
Hepatitis
A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.
Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
Antagonism of RNase L is required for murine coronavirus replication in Kupffer cells and liver sinusoidal endothelial cells but not in hepatocytes.
Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.
Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation.
RNase L mediated protection from virus induced demyelination.
[Clinical significance of interleukin-28B and RNAse L gene polymorphism determination in patients with chronic viral hepatitis C].
Hepatitis B
Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L.
Hepatitis C
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Clinical relevance of the 2'-5'-oligoadenylate synthetase/RNase L system for treatment response in chronic hepatitis C.
Effect of ribavirin on the frequency of RNase L cleavage sites within the hepatitis C viral genome.
Hepatitis C virus RNA: dinucleotide frequencies and cleavage by RNase L.
Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a vaccinia virus recombinant.
JNJ-4178 (AL-335, Odalasvir, and Simeprevir) for 6 or 8 Weeks in Hepatitis C Virus-infected Patients without Cirrhosis: OMEGA-1.
Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs.
RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.
Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites.
The ribonuclease L-dependent antiviral roles of human 2',5'-oligoadenylate synthetase family members against hepatitis C virus.
Hepatitis C, Chronic
Clinical relevance of the 2'-5'-oligoadenylate synthetase/RNase L system for treatment response in chronic hepatitis C.
Intrahepatic mRNA expression of interferon-inducible antiviral genes in liver diseases: dsRNA-dependent protein kinase overexpression and RNase L inhibitor suppression in chronic hepatitis C.
JNJ-4178 (AL-335, Odalasvir, and Simeprevir) for 6 or 8 Weeks in Hepatitis C Virus-infected Patients without Cirrhosis: OMEGA-1.
[Clinical significance of interleukin-28B and RNAse L gene polymorphism determination in patients with chronic viral hepatitis C].
Herpes Simplex
Delivery of Interferon-gamma by an adenovirus vector blocks herpes simplex virus Type 1 reactivation in vitro and in vivo independent of RNase L and double-stranded RNA-dependent protein kinase pathways.
Herpes simplex virus type 2-mediated disease is reduced in mice lacking RNase L.
RNase L activity does not contribute to host RNA degradation induced by herpes simplex virus infection.
The murine double-stranded RNA-dependent protein kinase PKR and the murine 2',5'-oligoadenylate synthetase-dependent RNase L are required for IFN-beta-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture.
HIV Infections
RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells.
Hypertension
Cytochrome P-450 metabolites of arachidonic acid: implications for blood pressure regulation.
Hyperthyroidism
RNASET2, GPR174, and PTPN22 gene polymorphisms are related to the risk of liver damage associated with the hyperthyroidism in patients with Graves' disease.
Ileus
[Changes in the activity of lysosomal enzymes in experimental ileus]
Infections
A 2',5'-oligoadenylate analogue inhibits murine hepatitis virus strain 3 (MHV-3) replication in vitro but does not reduce MHV-3-related mortality or induction of procoagulant activity in susceptible mice.
A mammalian 2-5A system functions as an antiviral pathway in transgenic plants.
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Activation and evasion of the antiviral 2'-5' oligoadenylate synthetase/ribonuclease L pathway by hepatitis C virus mRNA.
Activation of PKR by Bunyamwera virus is independent of the viral interferon antagonist NSs.
Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells.
AIF-1 and RNASET2 Play Complementary Roles in the Innate Immune Response of Medicinal Leech.
Alphavirus minus-strand synthesis and persistence in mouse embryo fibroblasts derived from mice lacking RNase L and protein kinase R.
An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes.
Antagonism of RNase L is required for murine coronavirus replication in Kupffer cells and liver sinusoidal endothelial cells but not in hepatocytes.
Apoptosis induced by a cytopathic hepatitis A virus is dependent on caspase activation following ribosomal RNA degradation but occurs in the absence of 2'-5' oligoadenylate synthetase.
Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus.
Cellular and biochemical differences between two attenuated poxvirus vaccine candidates (MVA and NYVAC) and role of the C7L gene.
Changes in Two Ribonuclease Isozymes During Rust Infection of Flax Cotyledons.
Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function.
Correction for Li et al., Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Dengue virus replication in infected human keratinocytes leads to activation of antiviral innate immune responses.
Effect of sodium stibogluconate on hepatic mixed function oxidase system and marker enzymes of golden hamsters during Leishmania donovani infection.
Enteropathogenic Escherichia coli inhibits type I interferon- and RNase L-mediated host defense to disrupt intestinal epithelial cell barrier function.
Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1.
Herpes simplex virus type 2-mediated disease is reduced in mice lacking RNase L.
ICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cells.
Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant.
Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling.
Inducible expression of the 2-5A synthetase/RNase L system results in inhibition of vaccinia virus replication.
Influenza A induced cellular signal transduction pathways.
Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L.
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.
Reverse genetics reveals a role of the rotavirus VP3 phosphodiesterase activity in inhibiting RNase L signaling and contributing to intestinal viral replication in vivo.
Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation.
Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.
RMND1-Related Leukoencephalopathy With Temporal Lobe Cysts and Hearing Loss-Another Mendelian Mimicker of Congenital Cytomegalovirus Infection.
RNase activity prevents the growth of a fungal pathogen in tobacco leaves and increases upon induction of systemic acquired resistance with elicitin.
RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells.
RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells.
RNase L levels in peripheral blood mononuclear cells: 37-kilodalton/83-kilodalton isoform ratio is a potential test for chronic fatigue syndrome.
RNase L mediated protection from virus induced demyelination.
RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection.
RNase L Plays a Role in the Antiviral Response to West Nile Virus.
RNase L Triggers Autophagy in Response to Viral Infections.
Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection.
Rotavirus Controls Activation of the 2'-5'-Oligoadenylate Synthetase/RNase L Pathway Using at Least Two Distinct Mechanisms.
Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro.
Suppression of NYVAC Infection in HeLa Cells Requires RNase L but Is Independent of Protein Kinase R Activity.
The 2-5A system and HIV infection.
The cytopathic 18f strain of Hepatitis A virus induces RNA degradation in FrhK4 cells.
The RNase L inhibitor (RLI) is induced by double-stranded RNA.
The vaccinia virus A18R DNA helicase is a postreplicative negative transcription elongation factor.
Varicella-zoster virus does not significantly induce cell defence mechanism mediated by the 2-5A/RNase L pathway during its replication cycle.
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Zika Virus Production Is Resistant to RNase L Antiviral Activity.
Inflammatory Breast Neoplasms
In Vitro Assessment of the Inflammatory Breast Cancer Cell Line SUM 149: Discovery of 2 Single Nucleotide Polymorphisms in the RNase L Gene.
Influenza, Human
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Influenza A induced cellular signal transduction pathways.
Novel inhibitor of influenza NS1 blocks multi-cycle replication in an RNase L dependent manner.
RNase L activates the NLRP3 inflammasome during viral infections.
RNase L limits host and viral protein synthesis via inhibition of mRNA export.
RNase L Targets Distinct Sites in Influenza A Virus RNAs.
Solid-phase synthesis of 5'-triphosphate 2'-5'-oligoadenylates analogs with 3'-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.
Insulin Resistance
Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people.
RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation.
Intracranial Aneurysm
Polymorphisms of homocysteine metabolism are associated with intracranial aneurysms.
Intracranial Arteriosclerosis
Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression.
Ischemic Stroke
Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population.
Keratitis
Increased severity of HSV-1 keratitis and mortality in mice lacking the 2-5A-dependent RNase L gene.
Leukemia
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.
Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.
Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.
Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV from 22Rv1 Prostate Carcinoma Cells.
Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer.
Xenotropic murine leukemia virus-related virus is susceptible to AZT.
XMRV Discovery and Prostate Cancer-Related Research.
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
[RNase L, a crucial mediator of innate immunity and other cell functions]
Leukemia, Erythroblastic, Acute
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
2',5'-Oligoadenylate-antisense chimeras cause RNase L to selectively degrade bcr/abl mRNA in chronic myelogenous leukemia cells.
RNase L and increased endoribonuclease activities in the mononuclear cells of patients with chronic myelogenous leukemia.
The properties of ribonucleases isolated from urine of patients with chronic granulocytic leukemia (CGL). II. Urinary acid ribonuclease.
[The properties of ribonucleases isolated from urine of patients with chronic granulocytic leukemia (CGL). II. Urinary acid ribonuclease (RNase)]
Leukemia, Myeloid
Activities of serum acid ribonuclease in patients with malignant neoplasms or with renal failure.
Serum acid ribonuclease in myelogenous leukemia.
Leukemia, Myeloid, Acute
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
Leukemia, Promyelocytic, Acute
[Clinical significance of serum ribonuclease (RNase) assay in acute leukemia]
Leukoencephalopathies
Clinical, radiological and possible pathological overlap of cystic leukoencephalopathy without megalencephaly and Aicardi-Goutières syndrome.
Heterogeneity of PNPT1 neuroimaging: mitochondriopathy, interferonopathy or both?
Novel RNASET2 Pathogenic Variants in an East Asian Child with Delayed Psychomotor Development.
RMND1-Related Leukoencephalopathy With Temporal Lobe Cysts and Hearing Loss-Another Mendelian Mimicker of Congenital Cytomegalovirus Infection.
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA.
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.
RNASET2-deficient leukoencephalopathy mimicking congenital CMV infection and Aicardi-Goutieres syndrome: a case report with a novel pathogenic variant.
Structure and activity of the only human RNase T2.
Liver Diseases
Intrahepatic mRNA expression of interferon-inducible antiviral genes in liver diseases: dsRNA-dependent protein kinase overexpression and RNase L inhibitor suppression in chronic hepatitis C.
Lung Neoplasms
Actinomycin D-Activated RNase L Promotes H2A.X/H2B-Mediated DNA Damage and Apoptosis in Lung Cancer Cells.
IFN-? restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization.
Lymphoma
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
Lymphoma, Large-Cell, Anaplastic
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
Lymphoma, Non-Hodgkin
Effect of in vitro glucocorticoid treatment on acid ribonuclease activity in P1798 lymphosarcoma cells.
Studies on an acid ribonuclease from corticoid-sensitive 9alpha-fluoroprednisolone-treated lymphosarcoma P1798: changes in heat inactivation kinetics of the enzyme due to steroid treatment.
Megalencephaly
Clinical, radiological and possible pathological overlap of cystic leukoencephalopathy without megalencephaly and Aicardi-Goutières syndrome.
Novel RNASET2 Pathogenic Variants in an East Asian Child with Delayed Psychomotor Development.
Melanoma
ACTIBIND, a T2 RNase, competes with angiogenin and inhibits human melanoma growth, angiogenesis, and metastasis.
Human recombinant RNASET2: A potential anti-cancer drug.
Intracellular trafficking of RNASET2, a novel component of P-bodies.
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.
RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules.
RNASET2 as a tumor antagonizing gene in a melanoma cancer model.
Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer.
Memory Disorders
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
Mitochondrial Diseases
Heterogeneity of PNPT1 neuroimaging: mitochondriopathy, interferonopathy or both?
Muscle Weakness
Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase and RNase L) in patients with chronic fatigue immune dysfunction syndrome.
Myalgia
Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase and RNase L) in patients with chronic fatigue immune dysfunction syndrome.
Myocardial Infarction
The function of RNase L and its degradation mechanism in cardiac acute ischemic injury.
Neoplasm Metastasis
ACTIBIND, a T2 RNase, competes with angiogenin and inhibits human melanoma growth, angiogenesis, and metastasis.
Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma.
RNase L is a negative regulator of cell migration.
Tumor and metastasis suppression by the human RNASET2 gene.
Neoplasms
A Cell-Autonomous Oncosuppressive Role of Human RNASET2 Affecting ECM-Mediated Oncogenic Signaling.
A clinical evaluation of serological diagnosis for pancreatic cancer.
A novel apoptotic pathway of 3'-Ethynylcytidine(ECyd) involving the inhibition of RNA synthesis--the possibility of RNase L activated pathway as a target of ECyd.
A recombinant human RNASET2 glycoprotein with antitumorigenic and antiangiogenic characteristics: expression, purification, and characterization.
ACTIBIND, a T2 RNase, competes with angiogenin and inhibits human melanoma growth, angiogenesis, and metastasis.
ACTIBIND, an actin-binding fungal T2-RNase with antiangiogenic and anticarcinogenic characteristics.
Actinomycin D-Activated RNase L Promotes H2A.X/H2B-Mediated DNA Damage and Apoptosis in Lung Cancer Cells.
Activities of serum acid ribonuclease in patients with malignant neoplasms or with renal failure.
Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.
An apoptotic pathway of 3'-Ethynylcytidine(ECyd) involving the inhibition of RNA synthesis mediated by RNase L.
Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins.
Comparison of the baculovirus-insect cell and Pichia pastoris heterologous systems for the expression of the human tumor suppressor protein RNASET2.
Development and Clinical Validation of a Seven-Gene Prognostic Signature Based on Multiple Machine Learning Algorithms in Kidney Cancer.
Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax.
Diverse functions of RNase L and implications in pathology.
Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer.
Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect.
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Expression and purification of the human tumor suppressor protein RNASET2 in CHO-S cells.
Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma.
FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome.
Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL.
Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer.
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.
Human recombinant RNASET2: A potential anti-cancer drug.
Human recombinant truncated RNASET2, devoid of RNase activity; A potential cancer therapeutic agent.
Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway.
IFN-? restores the impaired function of RNase L and induces mitochondria-mediated apoptosis in lung cancer.
Induction of the interferon-inducible RNA-degrading enzyme, RNase L, by stress-inducing agents in the human cervical carcinoma cells.
Innate Immune Response Regulation by the Human RNASET2 Tumor Suppressor Gene.
Interaction between the androgen receptor and RNase L mediates a cross-talk between the interferon and androgen signaling pathways.
Intracellular trafficking of RNASET2, a novel component of P-bodies.
Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer.
Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis.
Mammary tumor regression. V. Role of acid ribonuclease and cathepsin.
Mammary tumor regression. VI. Synthesis and degradation of acid ribonuclease.
Mapping of the human RNASEL promoter and expression in cancer and normal cells.
Metabolic fate of omega-1 and omega-2 oxidized N-nitrosodibutylamines in the rat.
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.
Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells.
Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer.
New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1?.
New insights into the role of RNase L in innate immunity.
New Strategies for Expression and Purification of Recombinant Human RNASET2 Protein in Pichia pastoris.
Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection.
Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase.
Promyelocytic leukemia zinc finger triggers ATP-binding cassette subfamily E member 1-mediated growth inhibition in breast cancer cells.
Ribonuclease L and metal-ion-independent endoribonuclease cleavage sites in host and viral RNAs.
RNase L and increased endoribonuclease activities in the mononuclear cells of patients with chronic myelogenous leukemia.
RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1.
RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth.
RNase L is a negative regulator of cell migration.
RNase T2 in Inflammation and Cancer: Immunological and Biological Views.
RNASET2 - An autoantigen in anaplastic large cell lymphoma identified by protein array analysis.
RNASET2 as a tumor antagonizing gene in a melanoma cancer model.
RNASET2 silencing affects miRNAs and target gene expression pattern in a human ovarian cancer cell model.
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.
Stress-induced RNASET2 overexpression mediates melanocyte apoptosis via the TRAF2 pathway in vitro.
Structure and activity of the only human RNase T2.
T2 Family ribonucleases: ancient enzymes with diverse roles.
The 1.8 Å crystal structure of ACTIBIND suggests a mode of action for T2 ribonucleases as antitumorigenic agents.
The association of elevated 2',5'-oligoadenylate-dependent RNase L with lung cancer correlated with deficient enzymatic activity and decreased capacity of RNase L dimerization.
The biological regulation of ABCE1.
The human RNASET2 protein affects the polarization pattern of human macrophages in vitro.
The role of IFN regulatory factor-3 in the cytotoxic activity of NS-9, a polyinosinic-polycytidylic acid/cationic liposome complex, against tumor cells.
The synergistic cytocidal effect produced by immune interferon and tumor necrosis factor in HT-29 cells is associated with inhibition of rRNA processing and (2',5') oligo (A) activation of RNase L.
Tumor and metastasis suppression by the human RNASET2 gene.
Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response.
Tumour suppressor function of RNase L in a mouse model.
[Host factors in cancer chemotherapy]
Neuroinflammatory Diseases
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
Ovarian Neoplasms
Caspase-dependent apoptosis by 2',5'-oligoadenylate activation of RNase L is enhanced by IFN-beta.
Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer.
FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer.
Human recombinant RNASET2-induced inflammatory response and connective tissue remodeling in the medicinal leech.
Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells.
Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase.
RNase L restricts the mobility of engineered retrotransposons in cultured human cells.
RNASET2 as a tumor antagonizing gene in a melanoma cancer model.
RNASET2 silencing affects miRNAs and target gene expression pattern in a human ovarian cancer cell model.
Tumor and metastasis suppression by the human RNASET2 gene.
Pancreatic Neoplasms
A clinical evaluation of serological diagnosis for pancreatic cancer.
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Pancreatitis
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Serum ribonuclease elevations and pancreatic necrosis in acute pancreatitis.
Pancreatitis, Chronic
Sensitivity and specificity of serum ribonuclease in the diagnosis of pancreatic cancer.
Serum ribonuclease elevations and pancreatic necrosis in acute pancreatitis.
Papillomavirus Infections
Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer.
Paramyxoviridae Infections
Impact of RNase L overexpression on viral and cellular growth and death.
Small-molecule activators of RNase L with broad-spectrum antiviral activity.
Parasitic Diseases
T2 Family ribonucleases: ancient enzymes with diverse roles.
Parkinson Disease
Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications.
Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.
Persistent Infection
Functionally conserved architecture of hepatitis C virus RNA genomes.
Pneumonia
RNase L Is Involved in Liposaccharide-Induced Lung Inflammation.
Prostatic Hyperplasia
Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer.
Prostatic Neoplasms
A convenient and sensitive fluorescence resonance energy transfer assay for RNase L and 2',5' oligoadenylates.
A scientific journey through the 2-5A/RNase L system.
A Single Nucleotide Polymorphism in Inflammatory Gene RNASEL Predicts Outcome after Radiation Therapy for Localized Prostate Cancer.
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.
An update analysis of two polymorphisms in encoding ribonuclease L gene and prostate cancer risk: involving 13,372 cases and 11,953 controls.
Arg462Gln and Asp541Glu polymorphisms in ribonuclease L and prostate cancer risk: a meta-analysis.
Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study.
Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.
Diverse functions of RNase L and implications in pathology.
Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates.
Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL.
Genetic analysis of the principal genes related to prostate cancer: A review.
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1.
HPC1/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand.
Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant.
Implications for RNase L in prostate cancer biology.
Induction of the interferon-inducible RNA-degrading enzyme, RNase L, by stress-inducing agents in the human cervical carcinoma cells.
Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.
Involvement of the RNAse L gene in prostate cancer.
Mapping of the human RNASEL promoter and expression in cancer and normal cells.
Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV from 22Rv1 Prostate Carcinoma Cells.
Mutation analysis suggests role for ribonuclease L gene in prostate cancer.
Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer.
New advances in our understanding of the "unique" RNase L in host pathogen interaction and immune signaling.
New insights into the role of RNase L in innate immunity.
No association of xenotropic murine leukemia virus-related viruses with prostate cancer.
Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.
RNase L is a negative regulator of cell migration.
RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.
RNASEL 1623A>C variant is associated with the risk of prostate cancer in African descendants.
RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans.
Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells.
Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.
Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer.
Xenotropic murine leukemia virus-related virus in chronic fatigue syndrome and prostate cancer.
Xenotropic murine leukemia virus-related virus is susceptible to AZT.
XMRV Discovery and Prostate Cancer-Related Research.
[RNase L, a crucial mediator of innate immunity and other cell functions]
Protein Deficiency
Downregulation of RNase L inhibitor correlates with upregulation of interferon-induced proteins (2-5A synthetase and RNase L) in patients with chronic fatigue immune dysfunction syndrome.
Protein-Energy Malnutrition
Nutritionally triggered alterations in the regiospecificity of arachidonic acid oxygenation by rat liver microsomal cytochrome P450.
Psychomotor Disorders
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
Pulmonary Disease, Chronic Obstructive
Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling.
Renal Insufficiency
Activities of serum acid ribonuclease in patients with malignant neoplasms or with renal failure.
Retroviridae Infections
Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.
ribonuclease t2 deficiency
Heterogeneity of PNPT1 neuroimaging: mitochondriopathy, interferonopathy or both?
RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response.
RNase L mediated protection from virus induced demyelination.
RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory.
RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.
Structure and activity of the only human RNase T2.
Schistosomiasis
Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens.
Seizures
Picrotoxin-induced convulsions and lysosomal function in the rat brain.
Starvation
Induction of an Extracellular Ribonuclease in Cultured Tomato Cells upon Phosphate Starvation.
Isolation and characterization of a wound-inducible ribonuclease from Nicotiana glutinosa leaves.
Molecular characterisation of an S-like RNase of Nicotiana alata that is induced by phosphate starvation.
Tissue-specific expression of tomato Ribonuclease LX during phosphate starvation-induced root growth.
Stroke
Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke.
Thyroid Diseases
RNASET2 tag SNP but not CCR6 polymorphisms is associated with autoimmune thyroid diseases in the Chinese Han population.
Urinary Bladder Neoplasms
Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case-control study.
Metabolic fate of omega-1 and omega-2 oxidized N-nitrosodibutylamines in the rat.
Uterine Cervical Neoplasms
Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect.
Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer.
Vaccinia
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells.
Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.
Impact of RNase L overexpression on viral and cellular growth and death.
Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a vaccinia virus recombinant.
Vesicular Stomatitis
Impact of RNase L overexpression on viral and cellular growth and death.
Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways.
Phosphorothioate analogues of (2'-5')(A)4: agonist and antagonist activities in intact cells.
RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection.
RNase L Triggers Autophagy in Response to Viral Infections.
Virus Diseases
A novel apoptotic pathway of 3'-Ethynylcytidine(ECyd) involving the inhibition of RNA synthesis--the possibility of RNase L activated pathway as a target of ECyd.
A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand.
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.
ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections.
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Activation of the antiviral factor RNase L triggers translation of non-coding mRNA sequences.
Age-dependent changes are observed in the levels of an enzyme mediator of interferon action: a (2'-5')A(n)-dependent endoribonuclease.
An alternative spliced RNASEL variant in peripheral blood leukocytes.
Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.
Cell-type-specific effects of RNase L on viral induction of beta interferon.
Circular RNAs and RNase L in PKR activation and virus infection.
Cloning and characterization of a ribonuclease L inhibitor from the silkworm, Bombyx mori.
Correction to: Circular RNAs and RNase L in PKR activation and virus infection.
CRISPR-Cas9 Mediated RNase L Knockout Regulates Cellular Function of PK-15 Cells and Increases PRV Replication.
Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3.
Curcumin, a natural antioxidant, acts as a noncompetitive inhibitor of human RNase L in presence of its cofactor 2-5A in vitro.
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection.
Genetic variation in RNASEL associated with prostate cancer risk and progression.
High yield synthesis, purification and characterisation of the RNase L activators 5'-triphosphate 2'-5'-oligoadenylates.
ICP0 prevents RNase L-independent rRNA cleavage in herpes simplex virus type 1-infected cells.
IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.
Induction of the interferon-inducible RNA-degrading enzyme, RNase L, by stress-inducing agents in the human cervical carcinoma cells.
Mechanistic insights into RNase L through use of an MDMX-derived multi-functional protein domain.
New insights into the role of RNase L in innate immunity.
Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L.
OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses.
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases.
PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons.
RNase L activates the NLRP3 inflammasome during viral infections.
RNase L activity does not contribute to host RNA degradation induced by herpes simplex virus infection.
RNase L Amplifies Interferon Signaling by Inducing Protein Kinase R-Mediated Antiviral Stress Granules.
RNase L and the NLRP3-inflammasome: An old merchant in a new trade.
RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1.
RNase L contributes to experimentally induced type 1 diabetes onset in mice.
RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways.
RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entry.
RNase L Is Involved in Liposaccharide-Induced Lung Inflammation.
RNase L mediates the antiviral effect of interferon through a selective reduction in viral RNA during encephalomyocarditis virus infection.
RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.
RNase L Triggers Autophagy in Response to Viral Infections.
Rotavirus Controls Activation of the 2'-5'-Oligoadenylate Synthetase/RNase L Pathway Using at Least Two Distinct Mechanisms.
Schistosoma mansoni soluble egg antigen (SEA) and recombinant Omega-1 modulate induced CD4+ T-lymphocyte responses and HIV-1 infection in vitro.
Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.
Small self-RNA generated by RNase L amplifies antiviral innate immunity.
Small-molecule activators of RNase L with broad-spectrum antiviral activity.
Specificity and Mechanism of Coronavirus, Rotavirus, and Mammalian Two-Histidine Phosphoesterases That Antagonize Antiviral Innate Immunity.
Structural architecture of an RNA that competitively inhibits RNase L.
Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity.
The 2-5A system in viral infection and apoptosis.
The biological regulation of ABCE1.
The Endogenous RIG-I Ligand Is Generated in Influenza A-Virus Infected Cells.
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
[Investigation of the role of ribonuclease L gene in the response of tonsil tissues against viral infections]
Vitiligo
Rnaset2 inhibits melanocyte outgrowth possibly through interacting with shootin1.
RNASET2 is required for ROS propagation during oxidative stress-mediated cell death.
Role and Mechanism of RNASET2 in the Pathogenesis of Vitiligo.
Stress-induced RNASET2 overexpression mediates melanocyte apoptosis via the TRAF2 pathway in vitro.
West Nile Fever
PKR and RNase L contribute to protection against lethal West Nile Virus infection by controlling early viral spread in the periphery and replication in neurons.
RNase L Plays a Role in the Antiviral Response to West Nile Virus.
Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.
Zika Virus Infection
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Zika Virus Production Is Resistant to RNase L Antiviral Activity.