Reference on EC 4.4.1.5 - lactoylglutathione lyase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Regoli, F.; Saccucci, F.; Principato, G.
Mussel glyoxalase I as a possible marker for ecotoxicological studies: purification and preliminary characterization
Comp. Biochem. Physiol. C
113
313-317
1996
Mytilus galloprovincialis
-
vander Jagt, D.L.
The glyoxalase system
Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York
3
597-641
1989
Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus, Rhodospirillum rubrum, Sus scrofa
-
Inoue, Y.; Rhee, H.; Watanabe, K.; Murata, K.; Kimura, A.
Metabolism of 2-ketoaldehydes in mold: purification and characterization of glyoxalase I from Aspergillus niger
J. Biochem.
102
583-589
1987
Aspergillus niger
Baskaran, S.; Balasubramanian, K.A.
Purification and active site modification studies on glyoxalase I from monkey intestinal mucosa
Biochim. Biophys. Acta
913
377-385
1987
Macaca radiata
Rhee, H.; Murata, K.; Kimura, A.
Purification and characterization of glyoxalase I from Pseudomonas putida
Biochem. Biophys. Res. Commun.
141
993-999
1986
Pseudomonas putida
Murata, K.; Saikusa, T.; Watanabe, K.; Inoue, Y.; Fukuda, Y.; Shimosaka, M.; Kimura, A.
Complete purification of yeast glyoxalase I and its activation by ferrous ions and polyamines
Agric. Biol. Chem.
50
2381-2383
1986
Saccharomyces cerevisiae, Saccharomyces cerevisiae DKD-5D-H
-
Oray, B.; Norton, S.J.
Glyoxalase I from mouse liver
Methods Enzymol.
90
542-546
1982
Mus musculus
Mannervik, B.; Aronsson, A.C.; Tibbelin, G.
Glyoxalase I from human erythrocytes
Methods Enzymol.
90
535-541
1982
Homo sapiens
Mannervik, B.; Aronsson, A.C.; Marmstal, E.; Tibbelin, G.
Glyoxalase I (rat liver)
Methods Enzymol.
77
297-301
1981
Rattus norvegicus
Marmstal, E.; Aronsson, A.C.; Mannervik, B.
Comparison of glyoxalase I purified from yeast (Saccharomyces cerevisiae) with the enzyme from mammalian sources
Biochem. J.
183
23-30
1979
Saccharomyces cerevisiae, Homo sapiens, Rattus norvegicus, Sus scrofa
Marmstal, E.; Mannervik, B.
Purification, characterization and kinetic studies of glyoxalase I from rat liver
Biochim. Biophys. Acta
566
362-370
1979
Rattus norvegicus
Aronsson, A.C.; Tibbelin, G.; Mannervik, B.
Purification of glyoxalase I from human erythrocytes by the use of affinity chromatography and separation of the three isoenzymes
Anal. Biochem.
92
390-393
1979
Homo sapiens
Elango, N.; Janaki, S.; Rao, A.R.
Two affinity chromatography methods for the purification of glyoxalase I from rabbit liver
Biochem. Biophys. Res. Commun.
83
1388-1395
1978
Oryctolagus cuniculus
Aronsson, A.C.; Mannervik, B.
Characterization of glyoxalase I purified from pig erythrocytes by affinity chromatography
Biochem. J.
165
503-509
1977
Sus scrofa
Oray, B.; Norton, S.J.
A two-step purification of mouse liver glyoxalase I and evidence of its dimeric constitution
Biochim. Biophys. Acta
483
203-209
1977
Mus musculus
Han, L.P.B.; Davison, L.M.; vander Jagt, D.L.
Purification and kinetic study of glyoxalase-I from rat liver, erythrocytes, brain and kidney
Biochim. Biophys. Acta
445
486-499
1976
Rattus norvegicus
Kester, M.V.; Norton, S.J.
The isolation and characterization of mouse liver glyoxalase I
Biochim. Biophys. Acta
391
212-221
1975
Mus musculus
Uotila, L.; Koivusalo, M.
Purification and properties of glyoxalase I from sheep liver
Eur. J. Biochem.
52
493-503
1975
Ovis aries
Mannervik, B.; Lindstrm, L.; Bartfai, T.
Partial purification and characterization of glyoxalase I from porcine erythrocytes
Eur. J. Biochem.
29
276-281
1972
Sus scrofa
Douglas, K.T.; Sharif, J.G.
pH Dependence of the inhibition of yeast glyoxalase I by porphyrins
Biochim. Biophys. Acta
748
184-193
1983
Saccharomyces cerevisiae
Oray, B.; Norton, S.J.
Inhibitors of glyoxalase enzymes
Biochem. Biophys. Res. Commun.
95
624-629
1980
Mus musculus
Douglas, K.T.; Nadvi, I.N.
Inhibition of glyoxalase I: a possible transition-state analogue inhibitor approach to potential antineoplastic agents
FEBS Lett.
106
393-396
1979
Saccharomyces cerevisiae
Marmstal, E.; Mannervik, B.
Subunit structure of glyoxalase I from yeast
FEBS Lett.
85
275-278
1978
Saccharomyces cerevisiae
Han, L.P.B.; Schimandle, C.M.; Davison, L.M.; vander Jagt, D.L.
Comparative kinetics of Mg2+-, Mn2+-, Co2+-, and Ni2+-activated glyoxalase I. Evaluation of the role of the metal ion
Biochemistry
16
5478-5484
1977
Rattus norvegicus
Nakamura, H.; Itaka, Y.; Kurasawa, S.; Takeuchi, T.; Umezawa, H.
The crystal and molecular structure of a dibromo-derivative of MS-3: a glyoxalase I inhibitor produced by a mushroom Stereum hirsutum
Agric. Biol. Chem.
40
1781-1784
1976
Rattus norvegicus
-
Racker, E.
The mechanism of action of glyoxalase
J. Biol. Chem.
190
685-696
1951
Saccharomyces cerevisiae
Kurasawa, S.; Takeuchi, T.; Umezawa, H.
The reaction mechanism of rat liver glyoxalase I and its inhibition by MS-3
Agric. Biol. Chem.
40
559-566
1976
Rattus norvegicus
-
Ekwall, K.; Mannervik, B.
The stereochemical configuration of the lactoyl group of S-lactoylglutathionine formed by the action of glyoxalase I from porcine erythrocytes and yeast
Biochim. Biophys. Acta
297
297-299
1973
Saccharomyces cerevisiae, Sus scrofa
Deswal, R.; Sopory, S.K.
Biochemical and immunochemical characterization of Brassica juncea glyoxalase I
Phytochemistry
49
2245-2253
1998
Arabidopsis sp., Brassica rapa subsp. oleifera, Brassica juncea, Brassica nigra, Brassica oleracea, Cajanus cajan, Candida albicans, Escherichia coli, Hordeum vulgare, Mus musculus, Sorghum bicolor, Triticum aestivum, Zea mays
Cameron, A.D.; Olin, B.; Ridderstrom, M.; Mannervik, B.; Jones, T.A.
Crystal structure of human glyoxalase I - evidence for gene duplication and 3D domain swapping
EMBO J.
16
3395-3395
1997
Homo sapiens
-
Hwang, S.J.; Chai, Y.G.
Purification and characterization of glyoxalase I from Chlamydomonas reinhardtii
J. Biochem. Mol. Biol.
29
294-299
1996
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii 5177D mt-
-
Espartero, J.; Sanchez-Aguayo, S.; Pardo, J.M.
Molecular characterization of glyoxalase-I from a higher plant; upregulation by stress
Plant Mol. Biol.
29
1223-1233
1995
Solanum lycopersicum
Clugston, S.L.; Barnard, J.F.J.; Kinach, R.; Miedema, D.; Ruman, R.; Daub, E.; Honek, J.F.
Overproduction and characterization of a dimeric non-zinc glyoxalase I from Escherichia coli: evidence for optimal activation by nickel ions
Biochemistry
37
8754-8763
1998
Escherichia coli (P0AC81), Escherichia coli, Escherichia coli MG1655/pGL10 (P0AC81)
Shih, M.J.; Edinger, J.W.; Creighton, D.J.
Diffusion-dependent kinetic properties of glyoxalase I and estimates of the steady-state concentrations of glyoxalase-pathway intermediates in glycolyzing erythrocytes
Eur. J. Biochem.
244
852-857
1997
Anser sp., Bos taurus, Saccharomyces cerevisiae, Canis lupus familiaris, Cavia porcellus, Gallus gallus, Oryctolagus cuniculus, Ovis aries, Macaca mulatta, Meleagris gallopavo, Mus musculus, Sus scrofa
Deswal, R.; Sopory, S.K.
Purification and partial characterization of glyoxalase I from a higher plant Brassica juncea
FEBS Lett.
282
277-280
1991
Brassica juncea
Ranganathan, S.; Walsh, E.S.; Godwin, A.K.; Tew, K.D.
Cloning and characterization of human colon glyoxalase-I
J. Biol. Chem.
268
5661-5667
1993
Homo sapiens
Kim, N.S.; Sekine, S.; Kiuchi, N.; Kato, S.
cDNA cloning and characterization of human glyoxalase I isoforms from HT-1080 cells
J. Biochem.
117
359-361
1995
Homo sapiens
Caccuri, A.M.; Risitano, A.; Marmocchi, F.; Venardi, G.; Aureli, G.; Petruzzelli, R.; Desideri, A.
Reinvestigation of the role of thiol groups of glyoxalase I purified from yeast (Saccharomyces cerevisiae)
Biochim. Biophys. Acta
1202
157-160
1993
Saccharomyces cerevisiae
Allen, R.E.; Lo, T.W.C.; Thornalley, P.J.
Inhibitors of glyoxalase I: design, synthesis, inhibitory characteristics and biological evaluation
Biochem. Soc. Trans.
21
535-540
1993
Saccharomyces cerevisiae, Homo sapiens
Kimura, A.; Inoue, Y.
Glyoxalase I in micro-organisms: molecular characteristics, genetics and biochemical regulation
Biochem. Soc. Trans.
21
518-522
1993
Saccharomyces cerevisiae, Pseudomonas putida
Allen, R.E.; Lo, T.W.C.; Thornalley, P.J.
A simplified method for the purification of human red blood cell glyoxalase. I. Characteristics, immunoblotting, and inhibitor studies
J. Protein Chem.
12
111-119
1993
Homo sapiens
Inoue, Y.; Tran, L.T.; Yoshikawa, K.; Murata, K.; Kimura, A.
Purification and characterization of glyoxalase I from Hansenula mrakii
J. Ferment. Bioeng.
71
131-133
1991
Cyberlindnera mrakii
-
Ito, M.; Sadakane, K.; Shiotsuki, T.; Eto, M.
Effects of substrate- (glutathione-) and inhibitor- (flavonoid-) analogues on glyoxalase I activity
Biosci. Biotechnol. Biochem.
56
1461-1462
1992
Saccharomyces cerevisiae
-
Paulus, C.; Kllner, B.; Jacobsen, H.J.
Physiological and biochemical characterization of glyoxalase I, a general marker for cell proliferation, from a soybean cell suspension
Planta
189
561-566
1993
Glycine max
Shinohara, M.; Thornalley, P.J.; Giardino, I.; Beisswenger, P.; Thorpe, S.R.; Onorato, J.; Brownlee, M.
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis
J. Clin. Invest.
101
1142-1147
1998
Homo sapiens
Norton, S.J.; Talesa, V.; Yuan, W.J.; Principato, G.B.
Glyoxalase I and glyoxalase II from Aloe vera: purification, characterization and comparison with animal glyoxalases
Biochem. Int.
22
411-418
1990
Aloe vera
Skipsey, M.; Andrews, C.J.; Townson, J.K.; Jepson, I.; Edwards, R.
Cloning and characterization of glyoxalase I from soybean
Arch. Biochem. Biophys.
374
261-268
2000
Glycine max (Q9ZS21), Glycine max
Creighton, D.J.; Hamilton, D.S.
Brief history of glyoxalase I and what we have learned about metal ion-dependent, enzyme-catalyzed isomerizations
Arch. Biochem. Biophys.
387
1-10
2001
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens
Mitsumoto, A.; Kim, K.R.; Oshima, G.; Kunimoto, M.; Okawa, K.; Iwamatsu, A.; Nakagawa, Y.
Glyoxalase I is a novel nitric-oxide-responsive protein
Biochem. J.
344
837-844
1999
Homo sapiens
Sommer, A.; Fischer, P.; Krause, K.; Boettcher, K.; Brophy, P.M.; Walter, R.D.; Liebau, E.
A stress-responsive glyoxalase I from the parasitic nematode Onchocerca volvulus
Biochem. J.
353
445-452
2001
Onchocerca volvulus
Clugston, S.L.; Yajima, R.; Honek, J.F.
Investigation of metal binding and activation of Escherichia coli glyoxalase I: kinetic, thermodynamic and mutagenesis studies
Biochem. J.
377
309-316
2004
Escherichia coli
Cameron, A.D.; Ridderstrom, M.; Olin, B.; Kavarana, M.J.; Creighton, D.J.; Mannervik, B.
Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue
Biochemistry
38
13480-13490
1999
Homo sapiens (Q04760), Homo sapiens
He, M.M.; Clugston, S.L.; Honek, J.F.; Matthews, B.W.
Determination of the Structure of Escherichia coli Glyoxalase I Suggests a Structural Basis for Differential Metal Activation
Biochemistry
39
8719-8727
2000
Escherichia coli
Deswal, R.; Sopory, S.K.
Glyoxalase I from Brassica juncea is a calmodulin stimulated protein
Biochim. Biophys. Acta
1450
460-467
1999
Brassica juncea
Sakamoto, H.; Mashima, T.; Kizaki, A.; Dan, S.; Hashimoto, Y.; Naito, M.; Tsuruo, T.
Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis
Blood
95
3214-3218
2000
Homo sapiens
Iozef, R.; Rahlfs, S.; Chang, T.; Schirmer, H.; Becker, K.
Glyoxalase I of the malarial parasite Plasmodium falciparum: evidence for subunit fusion
FEBS Lett.
554
284-288
2003
Plasmodium falciparum (Q71KM3), Plasmodium falciparum
Himo, F.; Siegbahn, P.E.
Catalytic mechanism of glyoxalase I: a theoretical study
J. Am. Chem. Soc.
123
10280-10289
2001
Homo sapiens
ichter, U.; Krauss, M.
Active site structure and mechanism of human glyoxalase I-an ab initio theoretical study
J. Am. Chem. Soc.
123
6973-6982
2001
Homo sapiens
Usui, Y.; Nakase, M.; Hotta, H.; Urisu, A.; Aoki, N.; Kitajima, K.; Matsuda, T.
A 33-kDa allergen from rice (Oryza sativa L. Japonica). cDNA cloning, expression, and identification as a novel glyoxalase I
J. Biol. Chem.
276
11376-11381
2001
Oryza sativa Japonica Group (Q948T6)
Frickel, E.M.; Jemth, P.; Widersten, M.; Mannervik, B.
Yeast glyoxalase I is a monomeric enzyme with two active sites
J. Biol. Chem.
276
1845-1849
2001
Saccharomyces cerevisiae
Jain, M.; Choudhary, D.; Kale, R.K.; Bhalla-Sarin, N.
Salt- and glyphosate-induced increase in glyoxalase I activity in cell lines of groundnut (Arachis hypogaea)
Physiol. Plant.
114
499-505
2002
Arachis hypogaea
Veena; Reddy, V.S.; Sopory, S.K.
Glyoxalase I from Brassica juncea: molecular cloning, regulation and its over-expression confer tolerance in transgenic tobacco under stress
Plant J.
17
385-395
1999
Brassica juncea (O04885), Brassica juncea
Johansen, K.S.; Svendsen, I.; Rasmussen, S.K.
Purification and cloning of the two domain glyoxalase I from wheat bran
Plant Sci.
155
11-20
2000
Triticum aestivum (Q9XGF2), Triticum aestivum
Lupidi, G.; Venardi, G.; Bollettini, M.; Marmocchi, F.; Rotilio, G.
Purification and partial characterization of glyoxalase I from bovine brain
Prep. Biochem. Biotechnol.
31
305-316
2001
Bos taurus, Saccharomyces cerevisiae
Lupidi, G.; Bollettini, M.; Venardi, G.; Marmocchi, F.; Rotilio, G.
Functional residues on the enzyme active site of glyoxalase I from bovine brain
Prep. Biochem. Biotechnol.
31
317-329
2001
Bos taurus, Saccharomyces cerevisiae, Homo sapiens
Singla-Pareek, S.L.; Reddy, M.K.; Sopory, S.K.
Genetic engineering of the glyoxalase pathway in tobacco leads to enhanced salinity tolerance
Proc. Natl. Acad. Sci. USA
100
14672-14677
2003
Brassica juncea (O04885)
Davidson, S.D.; Milanesa, D.M.; Mallouh, C.; Choudhury, M.S.; Tazaki, H.; Konno, S.
A possible regulatory role of glyoxalase I in cell viability of human prostate cancer
Urol. Res.
30
116-121
2002
Homo sapiens
Ariza, A.; Vickers, T.J.; Greig, N.; Fairlamb, A.H.; Bond, C.S.
Crystallization and preliminary x-ray analysis of Leishmania major glyoxalase I
Acta Crystallogr. Sect. F
F61
769-772
2005
Leishmania major
Takatsume, Y.; Izawa, S.; Inoue, Y.
Identification of thermostable glyoxalase I in the fission yeast Schizosaccharomyces pombe
Arch. Microbiol.
181
371-377
2004
Schizosaccharomyces pombe, Schizosaccharomyces pombe PR 109
Takatsume, Y.; Izawa, S.; Inoue, Y.
Unique regulation of glyoxalase I activity during osmotic stress response in the fission yeast Schizosaccharomyces pombe: neither the mRNA nor the protein level of glyoxalase I increase under conditions that enhance its activity
Arch. Microbiol.
183
224-227
2005
Schizosaccharomyces pombe
Padmanabhan, P.K.; Mukherjee, A.; Singh, S.; Chattopadhyaya, S.; Gowri, V.S.; Myler, P.J.; Srinivasan, N.; Madhubala, R.
Glyoxalase I from Leishmania donovani: a potential target for anti-parasite drug
Biochem. Biophys. Res. Commun.
337
1237-1248
2005
Leishmania donovani (Q5XQR1), Leishmania donovani
Sukdeo, N.; Clugston, S.L.; Daub, E.; Honek, J.F.
Distinct classes of glyoxalase I: metal specificity of the Yersinia pestis, Pseudomonas aeruginosa and Neisseria meningitidis enzymes
Biochem. J.
384
111-117
2004
Neisseria meningitidis, Yersinia pestis, Pseudomonas aeruginosa
Akoachere, M.; Iozef, R.; Rahlfs, S.; Deponte, M.; Mannervik, B.; Creighton, D.J.; Schirmer, H.; Becker, K.
Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts
Biol. Chem.
386
41-52
2005
Homo sapiens, Plasmodium falciparum
Solomon, P.S.; Oliver, R.P.
Functional characterisation of glyoxalase I from the fungal wheat pathogen Stagonospora nodorum
Curr. Genet.
46
115-121
2004
Parastagonospora nodorum (Q696X2), Parastagonospora nodorum, Parastagonospora nodorum SN15 (Q696X2)
Vickers, T.J.; Greig, N.; Fairlamb, A.H.
A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major
Proc. Natl. Acad. Sci. USA
101
13186-13191
2004
Leishmania major (Q68RJ8), Leishmania major
Greig, N.; Wyllie, S.; Vickers, T.J.; Fairlamb, A.H.
Trypanothione-dependent glyoxalase I in Trypanosoma cruzi
Biochem. J.
400
217-223
2006
Trypanosoma cruzi
Sukdeo, N.; Honek, J.F.
Pseudomonas aeruginosa contains multiple glyoxalase I-encoding genes from both metal activation classes
Biochim. Biophys. Acta
1774
756-763
2007
Pseudomonas aeruginosa PAO1 (Q9HU72), Pseudomonas aeruginosa PAO1
More, S.S.; Vince, R.
A metabolically stable tight-binding transition-state inhibitor of glyoxalase-I
Bioorg. Med. Chem. Lett.
16
6039-6042
2006
Saccharomyces cerevisiae
More, S.S.; Vince, R.
Design, synthesis, and binding studies of bidentate Zn-chelating peptidic inhibitors of glyoxalase-I
Bioorg. Med. Chem. Lett.
17
3793-3797
2007
Saccharomyces cerevisiae
Antognelli, C.; Baldracchini, F.; Talesa, V.N.; Costantini, E.; Zucchi, A.; Mearini, E.
Overexpression of glyoxalase system enzymes in human kidney tumor
Cancer J.
12
222-228
2006
Homo sapiens, Homo sapiens (Q04760)
Korithoski, B.; Levesque, C.M.; Cvitkovitch, D.G.
Involvement of the detoxifying enzyme lactoylglutathione lyase in Streptococcus mutans aciduricity
J. Bacteriol.
189
7586-7592
2007
Streptococcus mutans, Streptococcus mutans UA159
Miller, A.G.; Smith, D.G.; Bhat, M.; Nagaraj, R.H.
Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions
J. Biol. Chem.
281
11864-11871
2006
Homo sapiens
Deponte, M.; Sturm, N.; Mittler, S.; Harner, M.; Mack, H.; Becker, K.
Allosteric coupling of two different functional active sites in monomeric Plasmodium falciparum glyoxalase I
J. Biol. Chem.
282
28419-28430
2007
Plasmodium falciparum
Staniszewska, M.M.; Nagaraj, R.H.
Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses
Mol. Cell. Biochem.
288
29-36
2006
Mus musculus
Ariza, A.; Vickers, T.J.; Greig, N.; Armour, K.A.; Dixon, M.J.; Eggleston, I.M.; Fairlamb, A.H.; Bond, C.S.
Specificity of the trypanothione-dependent Leishmania major glyoxalase I: structure and biochemical comparison with the human enzyme
Mol. Microbiol.
59
1239-1248
2006
Homo sapiens (Q04760), Homo sapiens, Leishmania major (Q68RJ8), Leishmania major
Kuhla, B.; Boeck, K.; Schmidt, A.; Ogunlade, V.; Arendt, T.; Muench, G.; Lueth, H.J.
Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimers disease brains
Neurobiol. Aging
28
29-41
2007
Homo sapiens
Korybalska, K.; Wisniewska-Elnur, J.; Trominska, J.; Joerres, A.; Breborowicz, A.; Witowski, J.
The role of the glyoxalase pathway in reducing mesothelial toxicity of glucose degradation products
Perit. Dial. Int.
26
259-265
2006
Homo sapiens
Kitamura, Y.; Kawase, M.; Ohmori, S.
Formate excretion in urine of rats fed dimethylaminoazobenzene-rich diets: the possibility of formate formation from D-lactate
Acta Med. Okayama
62
193-203
2008
Rattus norvegicus
Morcos, M.; Du, X.; Pfisterer, F.; Hutter, H.; Sayed, A.A.; Thornalley, P.; Ahmed, N.; Baynes, J.; Thorpe, S.; Kukudov, G.; Schlotterer, A.; Bozorgmehr, F.; El Baki, R.A.; Stern, D.; Moehrlen, F.; Ibrahim, Y.; Oikonomou, D.; Hamann, A.; Becker, C.; Zeier, M.; Schwenger, V.; Miftari, N.; Humpert, P.; H, H.a.
Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans
Aging Cell
7
260-269
2008
Caenorhabditis elegans
Kumagai, T.; Nangaku, M.; Kojima, I.; Nagai, R.; Ingelfinger, J.R.; Miyata, T.; Fujita, T.; Inagi, R.
Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats
Am. J. Physiol. Renal Physiol.
296
F912-21
2009
Rattus norvegicus
Ahmed, U.; Dobler, D.; Larkin, S.J.; Rabbani, N.; Thornalley, P.J.
Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitro
Ann. N. Y. Acad. Sci.
1126
262-264
2008
Homo sapiens
Kumagai, T.; Nangaku, M.; Inagi, R.
Pathophysiological role of the glyoxalase system in renal hypoxic injury
Ann. N. Y. Acad. Sci.
1126
265-267
2008
Rattus norvegicus
Kalousova, M.; Germanova, A.; Jachymova, M.; Mestek, O.; Tesar, V.; Zima, T.
A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients
Ann. N. Y. Acad. Sci.
1126
268-271
2008
Homo sapiens
Nakadate, Y.; Uchida, K.; Shikata, K.; Yoshimura, S.; Azuma, M.; Hirata, T.; Konishi, H.; Kiyama, H.; Tachibana, T.
The formation of argpyrimidine, a methylglyoxal-arginine adduct, in the nucleus of neural cells
Biochem. Biophys. Res. Commun.
378
209-212
2009
Mus musculus (Q9CPU0)
Miranda, H.V.; Ferreira, A.E.; Quintas, A.; Cordeiro, C.; Freire, A.P.
Measuring intracellular enzyme concentrations. Assessing the effect of oxidative stress on the amount of glyoxalase I
Biochem. Mol. Biol. Educ.
36
135-138
2008
Saccharomyces cerevisiae
Saint-Jean, A.P.; Phillips, K.R.; Creighton, D.J.; Stone, M.J.
Active monomeric and dimeric forms of Pseudomonas putida glyoxalase I: evidence for 3D domain swapping.
Biochemistry
37
10345-10353
1998
Pseudomonas putida
Su, Z.; Sukdeo, N.; Honek, J.F.
15N-1H HSQC NMR evidence for distinct specificity of two active sites in Escherichia coli glyoxalase I
Biochemistry
47
13232-13241
2008
Escherichia coli (P0AC81), Escherichia coli
Takasawa, R.; Takahashi, S.; Saeki, K.; Sunaga, S.; Yoshimori, A.; Tanuma, S.
Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects
Bioorg. Med. Chem.
16
3969-3975
2008
Homo sapiens (Q04760), Homo sapiens
Elia, A.C.; Fanetti, A.; Doerr, A.J.; Taticchi, M.I.
Effects of concentrated drinking water injection on glutathione and glutathione-dependent enzymes in liver of Cyprinus carpio L
Chemosphere
72
791-796
2008
Cyprinus carpio
Doerr, A.J.; Pacini, N.; Abete, M.C.; Prearo, M.; Elia, A.C.
Effects of a selenium-enriched diet on antioxidant response in adult crayfish (Procambarus clarkii)
Chemosphere
73
1090-1095
2008
Procambarus clarkii
Mannervik, B.
Molecular enzymology of the glyoxalase system
Drug Metabol. Drug Interact.
23
13-27
2008
Mus musculus
Sukdeo, N.; Honek, J.F.
Microbial glyoxalase enzymes: metalloenzymes controlling cellular levels of methylglyoxal
Drug Metabol. Drug Interact.
23
29-50
2008
Escherichia coli, Escherichia coli (P0AC81), Homo sapiens, Homo sapiens (Q04760), Leishmania braziliensis, Leishmania donovani, Leishmania major, Leishmania sp., Neisseria meningitidis, Neisseria meningitidis (P0A0T3), Yersinia pestis, Plasmodium falciparum, Pseudomonas aeruginosa, Pseudomonas aeruginosa (Q9HU72), Pseudomonas aeruginosa (Q9HY85), Pseudomonas aeruginosa (Q9I5L8), Pseudomonas putida, Pseudomonas putida (Q88GF8), Trypanosoma cruzi
Yadav, S.K.; Singla-Pareek, S.L.; Sopory, S.K.
An overview on the role of methylglyoxal and glyoxalases in plants
Drug Metabol. Drug Interact.
23
51-68
2008
Aloe vera, Amaranthus sp., Brassica juncea, Brassica oleracea, Brassica sp., Glycine max, Solanum lycopersicum, Nicotiana sp., Oryza sativa, Pisum sativum, Solanum tuberosum, Triticum aestivum
Devi, S.L.; Viswanathan, P.; Anuradha, C.V.
Taurine enhances the metabolism and detoxification of ethanol and prevents hepatic fibrosis in rats treated with iron and alcohol
Environ. Toxicol. Pharmacol.
27
120-126
2009
Rattus norvegicus
Greig, N.; Wyllie, S.; Patterson, S.; Fairlamb, A.H.
A comparative study of methylglyoxal metabolism in trypanosomatids
FEBS J.
276
376-386
2009
Leishmania major, Trypanosoma cruzi, no activity in Trypanosoma brucei
Ispolnov, K.; Gomes, R.A.; Silva, M.S.; Freire, A.P.
Extracellular methylglyoxal toxicity in Saccharomyces cerevisiae: role of glucose and phosphate ions
J. Appl. Microbiol.
104
1092-1102
2008
Saccharomyces cerevisiae
Magnani, D.; Barre, O.; Gerber, S.D.; Solioz, M.
Characterization of the CopR regulon of Lactococcus lactis IL1403
J. Bacteriol.
190
536-545
2008
Lactococcus lactis (Q9CJC0), Lactococcus lactis, Lactococcus lactis IL1404 (Q9CJC0)
Zhu, M.M.; Skraly, F.A.; Cameron, D.C.
Accumulation of methylglyoxal in anaerobically grown Escherichia coli and its detoxification by expression of the Pseudomonas putida glyoxalase I gene.
Metab. Eng.
3
218-225
2001
Pseudomonas putida (P16635), Pseudomonas putida
Bhomkar, P.; Upadhyay, C.P.; Saxena, M.; Muthusamy, A.; Shiva Prakash, N.; Pooggin, M.; Hohn, T.; Sarin, N.B.
Salt stress alleviation in transgenic Vigna mungo L. Hepper (blackgram) by overexpression of the glyoxalase I gene using a novel Cestrum yellow leaf curling virus (CmYLCV) promoter
Mol. Breed.
22
169-181
2008
Brassica juncea
de Hemptinne, V.; Rondas, D.; Toepoel, M.; Vancompernolle, K.
Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB
Mol. Cell. Biochem.
325
169-178
2009
Homo sapiens
Lin, C.C.; Yin, M.C.
Antiglycative and anti-VEGF effects of s-ethyl cysteine and s-propyl cysteine in kidney of diabetic mice
Mol. Nutr. Food Res.
52
1358-1364
2008
Mus musculus
Santel, T.; Pflug, G.; Hemdan, N.Y.; Schaefer, A.; Hollenbach, M.; Buchold, M.; Hintersdorf, A.; Lindner, I.; Otto, A.; Bigl, M.; Oerlecke, I.; Hutschenreuter, A.; Sack, U.; Huse, K.; Groth, M.; Birkemeyer, C.; Schellenberger, W.; Gebhardt, R.; Platzer, M.; Weiss, T.; Vijayalakshmi, M.A.; Krueger, M.
Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity
PLoS ONE
3
e3508
2008
Homo sapiens
Kawatani, M.; Okumura, H.; Honda, K.; Kanoh, N.; Muroi, M.; Dohmae, N.; Takami, M.; Kitagawa, M.; Futamura, Y.; Imoto, M.; Osada, H.
he identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I
Proc. Natl. Acad. Sci. USA
105
11691-11696
2008
Mus musculus (Q9CPU0)
Barata, L.; Sousa Silva, M.; Schuldt, L.; da Costa, G.; Tomas, A.M.; Ferreira, A.E.; Weiss, M.S.; Ponces Freire, A.; Cordeiro, C.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of glyoxalase I from Leishmania infantum
Acta Crystallogr. Sect. F
66
571-574
2010
Leishmania infantum (Q2PYM9), Leishmania infantum
Inagi, R.; Kumagai, T.; Fujita, T.; Nangaku, M.
The role of glyoxalase system in renal hypoxia
Adv. Exp. Med. Biol.
662
49-55
2010
Homo sapiens
Takatsume, Y.; Ohdate, T.; Maeta, K.; Nomura, W.; Izawa, S.; Inoue, Y.
Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca2+ in Saccharomyces cerevisiae
Biochem. J.
427
275-287
2010
Saccharomyces cerevisiae, Saccharomyces cerevisiae YPH250
Mailankot, M.; Padmanabha, S.; Pasupuleti, N.; Major, D.; Howell, S.; Nagaraj, R.H.
Glyoxalase I activity and immunoreactivity in the aging human lens
Biogerontology
10
711-720
2009
Homo sapiens
Liu, M.; Yuan, M.; Luo, M.; Bu, X.; Luo, H.B.; Hu, X.
Binding of curcumin with glyoxalase I: Molecular docking, molecular dynamics simulations, and kinetics analysis
Biophys. Chem.
147
28-34
2010
Homo sapiens (Q04760)
Hossain, M.A.; Fujita, M.
Purification of glyoxalase I from onion bulbs and molecular cloning of its cDNA
Biosci. Biotechnol. Biochem.
73
2007-2013
2009
Allium cepa
Louie, B.; Rajamahanty, S.; Pyo, P.; Choudhury, M.; Konno, S.
Mode of cytotoxic action of nephrotoxic agents: oxidative stress and glutathione-dependent enzyme
BJU Int.
105
264-268
2010
Homo sapiens
Antognelli, C.; Del Buono, C.; Ludovini, V.; Gori, S.; Talesa, V.N.; Crino, L.; Barberini, F.; Rulli, A.
CYP17, GSTP1, PON1 and GLO1 gene polymorphisms as risk factors for breast cancer: an Italian case-control study
BMC Cancer
9
115
2009
Homo sapiens
Germanova, A.; Germanova, A.; Tesarova, P.; Jachymova, M.; Zvara, K.; Zima, T.; Kalousova, M.
Glyoxalase I Glu111Ala polymorphism in patients with breast cancer
Cancer Invest.
27
655-660
2009
Homo sapiens
Takeuchi, M.; Kimura, S.; Kuroda, J.; Ashihara, E.; Kawatani, M.; Osada, H.; Umezawa, K.; Yasui, E.; Imoto, M.; Tsuruo, T.; Yokota, A.; Tanaka, R.; Nagao, R.; Nakahata, T.; Fujiyama, Y.; Maekawa, T.
Glyoxalase-I is a novel target against Bcr-Abl+ leukemic cells acquiring stem-like characteristics in a hypoxic environment
Cell Death Differ.
17
1211-1220
2010
Homo sapiens
Queisser, M.A.; Yao, D.; Geisler, S.; Hammes, H.P.; Lochnit, G.; Schleicher, E.D.; Brownlee, M.; Preissner, K.T.
Hyperglycemia impairs proteasome function by methylglyoxal
Diabetes
59
670-678
2010
Mus musculus
Davies, G.F.; Juurlink, B.H.; Harkness, T.A.
Troglitazone reverses the multiple drug resistance phenotype in cancer cells
Drug Des. Devel. Ther.
3
79-88
2009
Homo sapiens
Wang, Z.H.; Hsu, C.C.; Huang, C.N.; Yin, M.C.
Anti-glycative effects of oleanolic acid and ursolic acid in kidney of diabetic mice
Eur. J. Pharmacol.
628
255-260
2010
Mus musculus
Nakadate, Y.; Mizuguchi, C.; Azuma, M.; Tachibana, T.
Generation of a rat monoclonal antibody specific for glyoxalase I
Hybridoma
28
447-450
2009
Mus musculus
Tatone, C.; Carbone, M.C.; Campanella, G.; Festuccia, C.; Artini, P.G.; Talesa, V.; Focarelli, R.; Amicarelli, F.
Female reproductive dysfunction during ageing: role of methylglyoxal in the formation of advanced glycation endproducts in ovaries of reproductively-aged mice
J. Biol. Regul. Homeost. Agents
24
63-72
2010
Mus musculus
Engelen, L.; Ferreira, I.; Brouwers, O.; Henry, R.M.; Dekker, J.M.; Nijpels, G.; Heine, R.J.; van Greevenbroek, M.M.; van der Kallen, C.J.; Blaak, E.E.; Feskens, E.J.; ten Cate, H.; Stehouwer, C.D.; Schalkwijk, C.G.
Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies
J. Hypertens.
27
1399-1403
2009
Homo sapiens
More, S.S.; Vince, R.
Inhibition of glyoxalase I: the first low-nanomolar tight-binding inhibitors
J. Med. Chem.
52
4650-4656
2009
Homo sapiens
Hambsch, B.; Chen, B.G.; Brenndoerfer, J.; Meyer, M.; Avrabos, C.; Maccarrone, G.; Liu, R.H.; Eder, M.; Turck, C.W.; Landgraf, R.
Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain
J. Neurochem.
113
1240-1251
2010
Mus musculus
Helgager, J.; Li, J.; Lubensky, I.A.; Lonser, R.; Zhuang, Z.
Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents
J. Oncol.
2010
373491
2010
Homo sapiens
Sobhanian, H.; Motamed, N.; Jazii, F.R.; Nakamura, T.; Komatsu, S.
Salt stress induced differential proteome and metabolome response in the shoots of Aeluropus lagopoides (Poaceae), a halophyte C4 plant
J. Proteome Res.
9
2882-2897
2010
Aeluropus lagopoides
Bair, W.B.; Cabello, C.M.; Uchida, K.; Bause, A.S.; Wondrak, G.T.
GLO1 overexpression in human malignant melanoma
Melanoma Res.
20
85-96
2010
Homo sapiens
Karg, E.; Papp, F.; Tassi, N.; Janaky, T.; Wittmann, G.; Turi, S.
Enhanced methylglyoxal formation in the erythrocytes of hemodialyzed patients
Metab. Clin. Exp.
58
976-982
2009
Homo sapiens
Lin, F.; Xu, J.; Shi, J.; Li, H.; Li, B.
Molecular cloning and characterization of a novel glyoxalase I gene TaGly I in wheat (Triticum aestivum L.)
Mol. Biol. Rep.
37
729-735
2010
Triticum aestivum
Urscher, M.; Przyborski, J.M.; Imoto, M.; Deponte, M.
Distinct subcellular localization in the cytosol and apicoplast, unexpected dimerization and inhibition of Plasmodium falciparum glyoxalases
Mol. Microbiol.
76
92-103
2010
Plasmodium falciparum
Thornalley, P.J.; Waris, S.; Fleming, T.; Santarius, T.; Larkin, S.J.; Winklhofer-Roob, B.M.; Stratton, M.R.; Rabbani, N.
Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance
Nucleic Acids Res.
38
5432-5442
2010
Homo sapiens
Williams, R.; Lim, J.E.; Harr, B.; Wing, C.; Walters, R.; Distler, M.G.; Teschke, M.; Wu, C.; Wiltshire, T.; Su, A.I.; Sokoloff, G.; Tarantino, L.M.; Borevitz, J.O.; Palmer, A.A.
A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior
PLoS ONE
4
e4649
2009
Mus musculus
Chauhan, S.C.; Madhubala, R.
Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification
PLoS ONE
4
e6805
2009
Leishmania donovani
Frank, E.; Kessler, M.S.; Filiou, M.D.; Zhang, Y.; Maccarrone, G.; Reckow, S.; Bunck, M.; Heumann, H.; Turck, C.W.; Landgraf, R.; Hambsch, B.
Stable isotope metabolic labeling with a novel N-enriched bacteria diet for improved proteomic analyses of mouse models for psychopathologies
PLoS ONE
4
e7821
2009
Mus musculus
Birkenmeier, G.; Stegemann, C.; Hoffmann, R.; Guenther, R.; Huse, K.; Birkemeyer, C.
Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation
PLoS ONE
5
e10399
2010
Homo sapiens (Q04760), Homo sapiens
El-Shabrawi, H.; Kumar, B.; Kaul, T.; Reddy, M.K.; Singla-Pareek, S.L.; Sopory, S.K.
Redox homeostasis, antioxidant defense, and methylglyoxal detoxification as markers for salt tolerance in Pokkali rice
Protoplasma
245
85-96
2010
Oryza sativa
Thornalley, P.J.; Rabbani, N.
Highlights and hotspots of protein glycation in end-stage renal disease
Semin. Dial.
22
400-404
2009
Homo sapiens
Liu, M.; Yuan, M.; Li, Z.; Cheng, Y.K.; Luo, H.B.; Hu, X.
Structural investigation into the inhibitory mechanisms of indomethacin and its analogues towards human glyoxalase I
Bioorg. Med. Chem. Lett.
21
4243-4247
2011
Homo sapiens
Takasawa, R.; Tao, A.; Saeki, K.; Shionozaki, N.; Tanaka, R.; Uchiro, H.; Takahashi, S.; Yoshimori, A.; Tanuma, S.
Discovery of a new type inhibitor of human glyoxalase I by myricetin-based 4-point pharmacophore
Bioorg. Med. Chem. Lett.
21
4337-4342
2011
Homo sapiens
Yuan, M.; Luo, M.; Song, Y.; Xu, Q.; Wang, X.; Cao, Y.; Bu, X.; Ren, Y.; Hu, X.
Identification of curcumin derivatives as human glyoxalase I inhibitors: A combination of biological evaluation, molecular docking, 3D-QSAR and molecular dynamics simulation studies
Bioorg. Med. Chem.
19
1189-1196
2011
Homo sapiens
Skapare, E.; Riekstina, U.; Liepinsh, E.; Konrade, I.; Makrecka, M.; Maurina, B.; Dambrova, M.
Flow cytometric analysis of glyoxalase-1 expression in human leukocytes
Cell Biochem. Funct.
29
171-174
2011
Homo sapiens
Park, E.H.; Lee, D.H.; Seo, J.H.; Kim, M.D.
Cloning and characterization of a glyoxalase I gene from the osmotolerant yeast Candida magnoliae
J. Microbiol. Biotechnol.
21
277-283
2011
Starmerella magnoliae (D6QLX5), Starmerella magnoliae
Hanssen, N.M.; Stehouwer, C.D.; Schalkwijk, C.G.
Methylglyoxal and glyoxalase I in atherosclerosis
Biochem. Soc. Trans.
42
443-449
2014
Homo sapiens
Deponte, M.
Glyoxalase diversity in parasitic protists
Biochem. Soc. Trans.
42
473-478
2014
Homo sapiens, Leishmania braziliensis, Leishmania donovani, Leishmania infantum, Leishmania major, no activity in Entamoeba histolytica, Plasmodium falciparum, Trypanosoma cruzi, no activity in Trypanosoma brucei, no activity in Giardia lamblia
Honek, J.F.
Bacterial glyoxalase I enzymes: structural and biochemical investigations
Biochem. Soc. Trans.
42
479-484
2014
Saccharomyces cerevisiae, Clostridium acetobutylicum, Escherichia coli, Homo sapiens, Leishmania donovani, Leishmania infantum, Leishmania major, Neisseria meningitidis, Yersinia pestis, Plasmodium falciparum, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas syringae, Trypanosoma cruzi
Arai, M.; Nihonmatsu-Kikuchi, N.; Itokawa, M.; Rabbani, N.; Thornalley, P.J.
Measurement of glyoxalase activities
Biochem. Soc. Trans.
42
491-494
2014
Mammalia
Wortmann, M.; Peters, A.S.; Hakimi, M.; Boeckler, D.; Dihlmann, S.
Glyoxalase I (Glo1) and its metabolites in vascular disease
Biochem. Soc. Trans.
42
528-533
2014
Homo sapiens, Mus musculus
Chiba, T.; Ohwada, J.; Sakamoto, H.; Kobayashi, T.; Fukami, T.A.; Irie, M.; Miura, T.; Ohara, K.; Koyano, H.
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors
Bioorg. Med. Chem. Lett.
22
7486-7489
2012
Homo sapiens
Holewinski, R.J.; Creighton, D.J.
Inhibition by active site directed covalent modification of human glyoxalase I
Bioorg. Med. Chem.
22
3301-3308
2014
Homo sapiens
Suttisansanee, U.; Lau, K.; Lagishetty, S.; Rao, K.N.; Swaminathan, S.; Sauder, J.M.; Burley, S.K.; Honek, J.F.
Structural variation in bacterial glyoxalase I enzymes: investigation of the metalloenzyme glyoxalase I from Clostridium acetobutylicum
J. Biol. Chem.
286
38367-38374
2011
Clostridium acetobutylicum (Q97H22), Clostridium acetobutylicum
Mustafiz, A.; Ghosh, A.; Tripathi, A.K.; Kaur, C.; Ganguly, A.K.; Bhavesh, N.S.; Tripathi, J.K.; Pareek, A.; Sopory, S.K.; Singla-Pareek, S.L.
A unique Ni2+ -dependent and methylglyoxal-inducible rice glyoxalase I possesses a single active site and functions in abiotic stress response
Plant J.
78
951-963
2014
Oryza sativa Japonica Group (Q948T6)
Bhomkar, P.; Upadhyay, C.P.; Saxena, M.; Muthusamy, A.; Shiva Prakash, N.; Pooggin, M.; Hohn, T.; Sarin, N.B.
Salt stress alleviation in transgenic Vigna mungo L. Hepper (blackgram) by overexpression of the glyoxalase I gene using a novel Cestrum yellow leaf curling virus (CmYLCV) promoter
Mol. Breed.
22
169-181
2018
Brassica juncea (O04885)
-
Hikita, K.; Yamada, S.; Shibata, R.; Katoh, M.; Murata, T.; Kato, K.; Tanaka, H.; Kaneda, N.
Inhibitory effect of isoflavones from Erythrina poeppigiana on the growth of HL-60 human leukemia cells through inhibition of glyoxalase I
Nat. Prod. Commun.
10
1581-1584
2015
Homo sapiens (Q04760), Homo sapiens
Zhang, M.M.; Ong, C.L.; Walker, M.J.; McEwan, A.G.
Defence against methylglyoxal in Group A Streptococcus a role for Glyoxylase I in bacterial virulence and survival in neutrophils?
Pathog. Dis.
74
ftv122
2016
Streptococcus pyogenes, Streptococcus pyogenes M1T1
Chakraborty, S.; Gogoi, M.; Chakravortty, D.
Lactoylglutathione lyase, a critical enzyme in methylglyoxal detoxification, contributes to survival of Salmonella in the nutrient rich environment
Virulence
6
50-65
2015
Salmonella enterica subsp. enterica serovar Typhimurium (Q8ZM36), Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (Q8ZM36)
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