Reference on EC 4.4.1.17 - Holocytochrome-c synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Enosawa, S.; Ohashi, A.
Localization of enzyme for heme attachment to apocytochrome c in yeast mitochindria
Biochem. Biophys. Res. Commun.
141
1145-1150
1986
Saccharomyces cerevisiae
Dumont, M.; Ernst, J.F.; Hampsey, D.M.; Sherman, F.
Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Sacchomyces cerevisiae
EMBO J.
6
235-241
1987
Saccharomyces cerevisiae
Nicholson, D.W.; Khler, H.; Neupert, W.
Import of cytochrome c into mitochondria. Cytochrome c heme lyase
Eur. J. Biochem.
164
147-157
1987
Neurospora crassa
Lill, R.; Stuart, R.A.; Drygas, M.E.; Nargang, F.E.; Neupert, W.
Import of cytochrome c heme lyase into mitochondria: a novel pathway into the intermembarne space
EMBO J.
11
449-456
1992
Neurospora crassa
Zollner, A.; Rdel, G.; Haid, A.
Molecular cloning and characterization of the Saccharomyces cerevisiae CYT2 gene encoding cytochrome-c1-heme lyase
Eur. J. Biochem.
207
1093-1100
1992
Saccharomyces cerevisiae, Neurospora crassa
Drygas, M.E.; Lambowitz, A.M.; Nargang, F.E.
Cloning and analysis of the Neurospora crassa gene for cytochrome c heme lyase
J. Biol. Chem.
264
17897-17906
1989
Neurospora crassa
Schaefer, L.; Ballabio, A.; Zoghbi, H.Y.
Cloning and characterization of a putative human holocytochrome c-type synthetase gene (HCCS) isolated from the critical region for microphthalmia with linear skin defects (MLS)
Genomics
34
166-172
1996
Homo sapiens (P53701), Mus musculus (P53702)
Steiner, H.; Zollner, A.; Haid, A.; Neupert, W.; Lill, R.
Biogenesis of mitochondrial heme lyases in yeast. Import and folding in the intermembrane space
J. Biol. Chem.
270
22842-22849
1995
Saccharomyces cerevisiae
Tong, J.; Margoliash, E.
Cytochrome c heme lyase activity of yeast mitochondria
J. Biol. Chem.
273
25695-25702
1998
Saccharomyces cerevisiae
Ren, Q.; Ahuja, U.; Thony-Meyer, L.
A bacterial cytochrome c heme lyase. CcmF forms a complex with the heme chaperone CcmE and CcmH but not with apocytochrome c
J. Biol. Chem.
277
7657-7663
2002
Escherichia coli
Bernard, D.G.; Gabilly, S.T.; Dujardin, G.; Merchant, S.; Hamel, P.P.
Overlapping specificities of the mitochondrial cytochrome c and c1 heme lyases
J. Biol. Chem.
278
49732-49742
2003
Homo sapiens (P53701), Homo sapiens, Mus musculus (P53702), Saccharomyces cerevisiae
Cervera, A.M.; Gozalbo, D.; McCreath, K.J.; Gow, N.A.R.; Martinez, J.P.; Casanova, M.
Molecular cloning and characterization of a Candida albicans gene coding for cytochrome c heme lyase and a cell wall-related protein
Mol. Microbiol.
30
67-81
1998
Candida albicans (P53700)
Bernard, D.G.; Quevillon-Cheruel, S.; Merchant, S.; Guiard, B.; Hamel, P.P.
Cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromes
J. Biol. Chem.
280
39852-39859
2005
Saccharomyces cerevisiae
Wimplinger, I.; Morleo, M.; Rosenberger, G.; Iaconis, D.; Orth, U.; Meinecke, P.; Lerer, I.; Ballabio, A.; Gal, A.; Franco, B.; Kutsche, K.
Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome
Am. J. Hum. Genet.
79
878-889
2006
Homo sapiens
Kiryu-Seo, S.; Gamo, K.; Tachibana, T.; Tanaka, K.; Kiyama, H.
Unique anti-apoptotic activity of EAAC1 in injured motor neurons
EMBO J.
25
3411-3421
2006
Mus musculus
Hartshorne, R.S.; Kern, M.; Meyer, B.; Clarke, T.A.; Karas, M.; Richardson, D.J.; Simon, J.
A dedicated haem lyase is required for the maturation of a novel bacterial cytochrome c with unconventional covalent haem binding
Mol. Microbiol.
64
1049-1060
2007
Wolinella succinogenes
Kemmer, D.; McHardy, L.M.; Hoon, S.; Reberioux, D.; Giaever, G.; Nislow, C.; Roskelley, C.D.; Roberge, M.
Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis
BMC Microbiol.
9
9-9
2009
Saccharomyces cerevisiae
Drenckhahn, J.D.; Schwarz, Q.P.; Gray, S.; Laskowski, A.; Kiriazis, H.; Ming, Z.; Harvey, R.P.; Du, X.J.; Thorburn, D.R.; Cox, T.C.
Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development
Dev. Cell
15
521-533
2008
Mus musculus
Qidwai, K.; Pearson, D.; Patel, G.; Pober, B.; Immken, L.; Cheung, S.; Scott, D.
Deletions of Xp provide evidence for the role of holocytochrome c-type synthase (HCCS) in congenital diaphragmatic hernia
Am. J. Med. Genet. A
152
1588-1590
2010
Homo sapiens (P53701)
Stevens, J.M.; Zhang, Y.; Muthuvel, G.; Sam, K.A.; Allen, J.W.; Ferguson, S.J.
The mitochondrial cytochrome c N-terminal region is critical for maturation by holocytochrome c synthase
FEBS Lett.
585
1891-1896
2011
Saccharomyces cerevisiae
Corvest, V.; Murrey, D.A.; Bernard, D.G.; Knaff, D.B.; Guiard, B.; Hamel, P.P.
c-type cytochrome assembly in Saccharomyces cerevisiae: a key residue for apocytochrome c1/lyase interaction
Genetics
186
561-571
2010
Saccharomyces cerevisiae
Babbitt, S.E.; San Francisco, B.; Bretsnyder, E.C.; Kranz, R.G.
Conserved residues of the human mitochondrial holocytochrome C synthase mediate interactions with heme
Biochemistry
53
5261-5271
2014
Homo sapiens (P53701), Homo sapiens
Moore, R.L.; Stevens, J.M.; Ferguson, S.J.
Mitochondrial cytochrome c synthase: CP motifs are not necessary for heme attachment to apocytochrome c
FEBS Lett.
585
3415-3419
2011
Saccharomyces cerevisiae
Zhang, Y.; Stevens, J.M.; Ferguson, S.J.
Substrate recognition of holocytochrome c synthase: N-terminal region and CXXCH motif of mitochondrial cytochrome c
FEBS Lett.
588
3367-3374
2014
Saccharomyces cerevisiae
Babbitt, S.E.; San Francisco, B.; Mendez, D.L.; Lukat-Rodgers, G.S.; Rodgers, K.R.; Bretsnyder, E.C.; Kranz, R.G.
Mechanisms of mitochondrial holocytochrome c synthase and the key roles played by cysteines and histidine of the heme attachment site, CysXXCysHis
J. Biol. Chem.
289
28795-18807
2014
Homo sapiens (P53701), Homo sapiens
Kleingardner, J.G.; Bren, K.L.
Comparing substrate specificity between cytochrome c maturation and cytochrome c heme lyase systems for cytochrome c biogenesis
Metallomics
3
396-403
2011
Saccharomyces cerevisiae (P06182)
San Francisco, B.; Bretsnyder, E.C.; Kranz, R.G.
Human mitochondrial holocytochrome c synthases heme binding, maturation determinants, and complex formation with cytochrome c
Proc. Natl. Acad. Sci. USA
110
E788-E797
2013
Homo sapiens (P53701), Homo sapiens
Babbitt, S.E.; Hsu, J.; Mendez, D.L.; Kranz, R.G.
Biosynthesis of single thioether c-type cytochromes provides insight into mechanisms intrinsic to holocytochrome c synthase (HCCS)
Biochemistry
56
3337-3346
2017
Homo sapiens (P53701)
Babbitt, S.E.; Hsu, J.; Kranz, R.G.
Molecular basis behind inability of mitochondrial holocytochrome c synthase to mature bacterial cytochromes Defining a critical role for cytochrome c alpha helix-1
J. Biol. Chem.
291
17523-17534
2016
Homo sapiens (P53701), Homo sapiens
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