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Information on EC 4.3.99.3 - 7-carboxy-7-deazaguanine synthase

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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.99 Other carbon-nitrogen lyases
                4.3.99.3 7-carboxy-7-deazaguanine synthase
IUBMB Comments
Requires Mg2+. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. The reaction is part of the biosynthesis pathway of queuosine.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
cdg synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH3
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PATHWAY SOURCE
PATHWAYS
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