Reference on EC 4.3.3.7 - 4-hydroxy-tetrahydrodipicolinate synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bakhiet, N.; Forney, F.W.; Stahly, D.P.; Daniels, L.
Lysine biosynthesis in Methanobacterium thermoautotrophicum is by the diaminopimelic acid pathway
Curr. Microbiol.
10
195-198
1984
Methanothermobacter thermautotrophicus
-
Kumpaisal, R.; Hashimoto, T.; Yamada, Y.
Purification and characterization of dihydrodipicolinate synthase from wheat suspension cultures
Plant Physiol.
85
145-151
1987
Triticum aestivum
Wallsgrove, R.M.; Mazelis, M.
Spinach leaf dihydrodipicolinate synthase: partial purification and characterization
Phytochemistry
20
2651-2655
1981
Pisum sativum, Spinacia oleracea
-
Mazelis, M.; Watley, F.R.; Whatley, J.
The enzymology of lysine biosynthesis in higher plants. The occurrence, characterization and some regulatory properties of dihydrodipicolinate synthase
FEBS Lett.
84
236-240
1977
Brassica sp., Cucurbita sp., Phaseolus sp., Solanum tuberosum, Spinacia oleracea, Triticum aestivum, Zea mays
Halling, S.M.; Stahly, D.P.
Dihydrodipicolinic acid synthase of Bacillus licheniformis. Quaternary structure, kinetics, and stability in the presence of sodium chloride and substrates
Biochim. Biophys. Acta
452
580-596
1976
Bacillus licheniformis
Yamakura, F.; Ikeda, Y.; Kimura, K.; Sasakawa, T.
Partial purification and some properties of pyruvate-aspartic semialdehyde condensing enzyme from sporulating Bacillus subtilis
J. Biochem.
76
611-621
1974
Bacillus subtilis
Shedlarski, J.G.
Pyruvate-aspartic semialdehyde condensing enzyme (Escherichia coli)
Methods Enzymol.
17B
129-134
1971
Escherichia coli
-
Webster, F.H.; Lechowich, R.V.
Partial purification and characterization of dihydrodipicolinic acid synthetase from sporulating Bacillus megaterium
J. Bacteriol.
101
118-126
1970
Priestia megaterium
Shedlarski, J.G.; Gilvarg, C.
The pyruvate-aspartic semialdehyde condensing enzyme of Escherichia coli
J. Biol. Chem.
245
1362-1373
1970
Escherichia coli
Stahly, D.P.
Dihydrodipicolinic acid synthase of Bacillus licheniformis
Biochim. Biophys. Acta
191
439-451
1969
Bacillus licheniformis
Frisch, D.A.; Gengenbach, B.G.; Tommy, A.M.; Sellner, J.M.; Somers, D.A.; Myers, D.E.
Isolation and characterization of dihydrodipicolinate synthase from maize
Plant Physiol.
96
444-452
1991
Zea mays
Laber, B.; Gomis-Rueth, F.X.; Romao, M.J.; Huber, R.
Escherichia coli dihydrodipicolinate synthase. Identification of the active site and crystallization
Biochem. J.
268
691-695
1992
Escherichia coli
-
Mirwaldt, C.; Korndoerfer, I.; Huber, R.
The crystal structure of dihydrodipicolinate synthase from Escherichia coli at 2.5 A resolution
J. Mol. Biol.
246
227-239
1995
Escherichia coli
Selli, A.; Crociani, F.; DiGioia, D.; Fava, F.; Crisetig, G.; Matteuzzi, D.
Regulation of dihydrodipicolinate synthase and diaminopimelate decarboxylase activity in Bacillus stearothermophilus
Ital. J. Biochem.
43
29-35
1994
Geobacillus stearothermophilus
Dereppe, C.; Bold, G.; Ghisalba, O.; Ebert, E.; Schaer, H.P.
Purification and characterization of dihydrodipicolinate synthase from pea
Plant Physiol.
98
813-821
1991
Pisum sativum
Perl, A.; Shaul, O.; Galili, G.
Regulation of lysine synthesis in transgenic potato plants expressing a bacterial dihydrodipicolinate synthase in their chloroplasts
Plant Mol. Biol.
19
815-823
1992
Escherichia coli, Solanum tuberosum
Shaul, O.; Galili, G.
Concerted regulation of lysine and threonine synthesis in tobacco plants expressing bacterial feedback-insensitive aspartate kinase and dihydrodipicolinate synthase
Plant Mol. Biol.
23
759-768
1993
Escherichia coli, Nicotiana tabacum
Couper, L.; McKendrick, J.E.; Robins, D.J.
Pyridine and piperidine derivatives as inhibitors of dihydrdipicolinic acid synthase, a key enzyme in the diaminopimelate pathway to L-lysine
Bioorg. Med. Chem. Lett.
4
2267-2272
1994
Escherichia coli
-
Brinch-Pedersen, H.; Galili, G.; Knudsen, S.; Holm, P.B.
Engineering of the aspartate family biosynthetic pathway in barley (Hordeum vulgare L.) by transformation with heterologous genes encoding feed-back-insensitive aspartate kinase and dihydrodipicolinate synthase
Plant Mol. Biol.
32
611-620
1996
Hordeum vulgare
Karsten, W.E.
Dihydrodipicolinate synthase from Escherichia coli: pH dependent changes in the kinetic mechanism and kinetic mechanism of allosteric inhibition by L-lysine
Biochemistry
36
1730-1739
1997
Escherichia coli
Blickling, S.; Beisel, H.G.; Bozic, D.; Knaeblein, J.; Laber, B.; Huber, R.
Structure of dihydrodipicolinate synthase of Nicotiana sylvestris reveals novel quaternary structure
J. Mol. Biol.
274
608-621
1997
Nicotiana sylvestris
Blickling, S.; Knaeblein, J.
Feedback inhibition of dihydrodipicolinate synthase enzymes by L-lysine
Biol. Chem.
378
207-210
1997
Escherichia coli
Vauterin, M.; Frankhard, V.; Jacobs, M.
The Arabidopsis thaliana dhdps gene encoding dihydrodipicolinate synthase, key enzyme of lysine biosynthesis, is expressed in a cell-specific manner
Plant Mol. Biol.
39
695-708
1990
Arabidopsis thaliana
Bonnassie, S.; Oreglia, J.; Sicard, A.M.
Nucleotide sequence of the dapA gene from Corynebacterium glutamicum
Nucleic Acids Res.
18
6421
1990
Corynebacterium glutamicum
Dobson, R.C.; Gerrard, J.A.; Pearce, F.G.
Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate beta-semialdehyde
Biochem. J.
377
757-762
2004
Escherichia coli, Escherichia coli XL1-Blue
Dobson, R.C.; Valegard, K.; Gerrard, J.A.
The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad
J. Mol. Biol.
338
329-339
2004
Escherichia coli (P0A6L2), Escherichia coli
Dobson, R.C.; Griffin, M.D.; Jameson, G.B.; Gerrard, J.A.
The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance
Acta Crystallogr. Sect. D
61
1116-1124
2005
Escherichia coli (P0A6L2), Escherichia coli
Dobson, R.C.; Devenish, S.R.; Turner, L.A.; Clifford, V.R.; Pearce, F.G.; Jameson, G.B.; Gerrard, J.A.
Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase
Biochemistry
44
13007-13013
2005
Escherichia coli (P0A6L2), Escherichia coli
Dobson, R.C.; Griffin, M.D.; Roberts, S.J.; Gerrard, J.A.
Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate
Biochimie
86
311-315
2004
Escherichia coli
Turner, J.J.; Gerrard, J.A.; Hutton, C.A.
Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive
Bioorg. Med. Chem.
13
2133-2140
2005
Escherichia coli
Blagova, E.; Levdikov, V.; Milioti, N.; Fogg, M.J.; Kalliomaa, A.K.; Brannigan, J.A.; Wilson, K.S.; Wilkinson, A.J.
Crystal structure of dihydrodipicolinate synthase (BA3935) from Bacillus anthracis at 1.94 A resolution
Proteins
62
297-301
2005
Bacillus anthracis (Q81WN7), Bacillus anthracis
Kefala, G.; Weiss, M.S.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of DapA (Rv2753c) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
62
1116-1119
2006
Mycobacterium tuberculosis
Leduc, Y.A.; Phenix, C.P.; Puttick, J.; Nienaber, K.; Palmer, D.R.; Delbaere, L.T.
Crystallization, preliminary X-ray diffraction and structure solution of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti L5-30
Acta Crystallogr. Sect. F
62
49-51
2006
Sinorhizobium meliloti, Sinorhizobium meliloti L5-30
Pearce, F.G.; Perugini, M.A.; McKerchar, H.J.; Gerrard, J.A.
Dihydrodipicolinate synthase from Thermotoga maritima
Biochem. J.
400
359-366
2006
Thermotoga maritima (Q9X1K9), Thermotoga maritima
Kefala, G.; Evans, G.; Griffin, M.D.; Devenish, S.R.; Perugini, M.A.; Gerrard, J.A.; Weiss, M.S.; Dobson, R.C.
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis
Biochem. J.
411
351-360
2008
Mycobacterium tuberculosis (P9WP25), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WP25)
Mitsakos, V.; Dobson, R.C.; Pearce, F.G.; Devenish, S.R.; Evans, G.L.; Burgess, B.R.; Perugini, M.A.; Gerrard, J.A.; Hutton, C.A.
Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens?
Bioorg. Med. Chem. Lett.
18
842-844
2007
Escherichia coli, Staphylococcus aureus, Mycobacterium tuberculosis
Varisi, V.A.; Medici, L.O.; van der Meer, I.; Lea, P.J.; Azevedo, R.A.
Dihydrodipicolinate synthase in opaque and floury maize mutants
Plant Sci.
173
458-467
2007
Zea mays
Devenish, S.R.; Gerrard, J.A.; Jameson, G.B.; Dobson, R.C.
The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate
Acta Crystallogr. Sect. F
64
1092-1095
2008
Escherichia coli (P0A6L2), Escherichia coli
Dobson, R.C.; Atkinson, S.C.; Gorman, M.A.; Newman, J.M.; Parker, M.W.; Perugini, M.A.
The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum
Acta Crystallogr. Sect. F
64
206-208
2008
Clostridium botulinum
Burgess, B.R.; Dobson, R.C.; Dogovski, C.; Jameson, G.B.; Parker, M.W.; Perugini, M.A.
Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus
Acta Crystallogr. Sect. F
64
659-661
2008
Staphylococcus aureus (Q6GH13), Staphylococcus aureus, Staphylococcus aureus MRSA252 (Q6GH13)
Rice, E.A.; Bannon, G.A.; Glenn, K.C.; Jeong, S.S.; Sturman, E.J.; Rydel, T.J.
Characterization and crystal structure of lysine insensitive Corynebacterium glutamicum dihydrodipicolinate synthase (cDHDPS) protein
Arch. Biochem. Biophys.
480
111-121
2008
Corynebacterium glutamicum (P19808), Corynebacterium glutamicum
Pearce, F.G.; Dobson, R.C.; Weber, A.; Lane, L.A.; McCammon, M.G.; Squire, M.A.; Perugini, M.A.; Jameson, G.B.; Robinson, C.V.; Gerrard, J.A.
Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme
Biochemistry
47
12108-12117
2008
Escherichia coli (P0A6L2)
Phenix, C.P.; Palmer, D.R.
Isothermal titration microcalorimetry reveals the cooperative and noncompetitive nature of inhibition of Sinorhizobium meliloti L5-30 dihydrodipicolinate synthase by (S)-lysine
Biochemistry
47
7779-7781
2008
Sinorhizobium meliloti (Q07607), Sinorhizobium meliloti L5-30 (Q07607), Sinorhizobium meliloti L5-30
Boughton, B.A.; Griffin, M.D.; ODonnell, P.A.; Dobson, R.C.; Perugini, M.A.; Gerrard, J.A.; Hutton, C.A.
Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues
Bioorg. Med. Chem.
16
9975-9983
2008
Escherichia coli (P0A6L2)
Boughton, B.A.; Dobson, R.C.; Gerrard, J.A.; Hutton, C.A.
Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase
Bioorg. Med. Chem. Lett.
18
460-463
2008
Escherichia coli (P0A6L2)
Phenix, C.P.; Nienaber, K.; Tam, P.H.; Delbaere, L.T.; Palmer, D.R.
Structural, functional and calorimetric investigation of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti l5-30, does not support involvement in rhizopine biosynthesis
ChemBioChem
9
1591-1602
2008
Sinorhizobium meliloti (Q07607), Sinorhizobium meliloti L5-30 (Q07607), Sinorhizobium meliloti L5-30
Wolterink-van Loo, S.; Levisson, M.; Cabrieres, M.C.; Franssen, M.C.; van der Oost, J.
Characterization of a thermostable dihydrodipicolinate synthase from Thermoanaerobacter tengcongensis
Extremophiles
12
461-469
2008
Caldanaerobacter subterraneus subsp. tengcongensis (Q8RBI5), Caldanaerobacter subterraneus subsp. tengcongensis
Girish, T.S.; Sharma, E.; Gopal, B.
Structural and functional characterization of Staphylococcus aureus dihydrodipicolinate synthase
FEBS Lett.
582
2923-2930
2008
Staphylococcus aureus (Q5HG25), Staphylococcus aureus, Staphylococcus aureus COL (Q5HG25)
Burgess, B.R.; Dobson, R.C.; Bailey, M.F.; Atkinson, S.C.; Griffin, M.D.; Jameson, G.B.; Parker, M.W.; Gerrard, J.A.; Perugini, M.A.
Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen
J. Biol. Chem.
283
27598-27603
2008
Staphylococcus aureus (Q6GH13), Staphylococcus aureus, Staphylococcus aureus MRSA252 (Q6GH13)
Dobson, R.C.; Griffin, M.D.; Devenish, S.R.; Pearce, F.G.; Hutton, C.A.; Gerrard, J.A.; Jameson, G.B.; Perugini, M.A.
Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase
Protein Sci.
17
2080-2090
2008
Escherichia coli (P0A6L2), Escherichia coli
Padmanabhan, B.; Strange, R.W.; Antonyuk, S.V.; Ellis, M.J.; Hasnain, S.S.; Iino, H.; Agari, Y.; Bessho, Y.; Yokoyama, S.
Structure of dihydrodipicolinate synthase from Methanocaldococcus jannaschii
Acta Crystallogr. Sect. F
65
1222-1226
2009
Methanocaldococcus jannaschii (Q57695), Methanocaldococcus jannaschii
Voss, J.E.; Scally, S.W.; Taylor, N.L.; Dogovski, C.; Alderton, M.R.; Hutton, C.A.; Gerrard, J.A.; Parker, M.W.; Dobson, R.C.; Perugini, M.A.
Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate
Acta Crystallogr. Sect. F
65
188-191
2009
Bacillus anthracis (Q81WN7), Bacillus anthracis, Bacillus anthracis Sterne (Q81WN7)
Atkinson, S.C.; Dobson, R.C.; Newman, J.M.; Gorman, M.A.; Dogovski, C.; Parker, M.W.; Perugini, M.A.
Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate
Acta Crystallogr. Sect. F
65
253-255
2009
Clostridium botulinum
Sibarani, N.E.; Gorman, M.A.; Dogovski, C.; Parker, M.W.; Perugini, M.A.
Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae
Acta Crystallogr. Sect. F
66
32-36
2010
Streptococcus pneumoniae, Streptococcus pneumoniae OXC141
Griffin, M.D.; Dobson, R.C.; Gerrard, J.A.; Perugini, M.A.
Exploring the dihydrodipicolinate synthase tetramer: how resilient is the dimer-dimer interface?
Arch. Biochem. Biophys.
494
58-63
2010
Escherichia coli (P0A6L2)
Guo, B.B.; Devenish, S.R.; Dobson, R.C.; Muscroft-Taylor, A.C.; Gerrard, J.A.
The C-terminal domain of Escherichia coli dihydrodipicolinate synthase (DHDPS) is essential for maintenance of quaternary structure and efficient catalysis
Biochem. Biophys. Res. Commun.
380
802-806
2009
Escherichia coli (P0A6L2), Escherichia coli
Devenish, S.R.; Huisman, F.H.; Parker, E.J.; Hadfield, A.T.; Gerrard, J.A.
Cloning and characterisation of dihydrodipicolinate synthase from the pathogen Neisseria meningitidis
Biochim. Biophys. Acta
1794
1168-1174
2009
Escherichia coli, Neisseria meningitidis (Q9JZR4), Neisseria meningitidis, Neisseria meningitidis MC58 (Q9JZR4)
Domigan, L.J.; Scally, S.W.; Fogg, M.J.; Hutton, C.A.; Perugini, M.A.; Dobson, R.C.; Muscroft-Taylor, A.C.; Gerrard, J.A.; Devenish, S.R.
Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis
Biochim. Biophys. Acta
1794
1510-1516
2009
Escherichia coli, Bacillus anthracis (Q81WN7), Bacillus anthracis
Dobson, R.C.; Perugini, M.A.; Jameson, G.B.; Gerrard, J.A.
Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis
Biochimie
91
1036-1044
2009
Escherichia coli (P0A6L2), Escherichia coli
Muscroft-Taylor, A.C.; Soares da Costa, T.P.; Gerrard, J.A.
New insights into the mechanism of dihydrodipicolinate synthase using isothermal titration calorimetry
Biochimie
92
254-262
2010
Thermotoga maritima, Escherichia coli (P0A6L2), Escherichia coli
Soares da Costa, T.P.; Muscroft-Taylor, A.C.; Dobson, R.C.; Devenish, S.R.; Jameson, G.B.; Gerrard, J.A.
How essential is the essential active-site lysine in dihydrodipicolinate synthase?
Biochimie
92
837-845
2010
Escherichia coli (P0A6L2), Escherichia coli
Kang, B.S.; Kim, Y.G.; Ahn, J.W.; Kim, K.J.
Crystal structure of dihydrodipicolinate synthase from Hahella chejuensis at 1.5 A resolution
Int. J. Biol. Macromol.
46
512-516
2010
Hahella chejuensis (Q2S9K4), Hahella chejuensis
Voss, J.E.; Scally, S.W.; Taylor, N.L.; Atkinson, S.C.; Griffin, M.D.; Hutton, C.A.; Parker, M.W.; Alderton, M.R.; Gerrard, J.A.; Dobson, R.C.; Dogovski, C.; Perugini, M.A.
Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax
J. Biol. Chem.
285
5188-5195
2010
Bacillus anthracis (Q81WN7), Bacillus anthracis, Bacillus anthracis Sterne (Q81WN7)
Orsburn, B.C.; Melville, S.B.; Popham, D.L.
EtfA catalyses the formation of dipicolinic acid in Clostridium perfringens
Mol. Microbiol.
75
178-186
2010
Clostridium botulinum
Kong, F.; Jiang, S.; Meng, X.; Song, C.; Shi, J.; Jin, D.; Jiang, S.; Wang, B.
Cloning and characterization of the DHDPS gene encoding the lysine biosynthetic enzyme dihydrodipocolinate synthase from Zizania latifolia (Griseb)
Plant Mol. Biol. Rep.
27
199-208
2009
Zizania latifolia (Q1PDD5)
-
Devenish, S.R.; Blunt, J.W.; Gerrard, J.A.
NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase
J. Med. Chem.
53
4808-4812
2010
Escherichia coli
Wubben, J.M.; Dogovski, C.; Dobson, R.C.; Codd, R.; Gerrard, J.A.; Parker, M.W.; Perugini, M.A.
Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica
Acta Crystallogr. Sect. F
66
1511-1516
2010
Shewanella benthica, Shewanella benthica ATCC 3392
Muscroft-Taylor, A.C.; Catchpole, R.J.; Dobson, R.C.; Pearce, F.G.; Perugini, M.A.; Gerrard, J.A.
Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine
Arch. Biochem. Biophys.
503
202-206
2010
Escherichia coli
Evans, G.; Schuldt, L.; Griffin, M.D.; Devenish, S.R.; Grant Pearce, F.; Perugini, M.A.; Dobson, R.C.; Jameson, G.B.; Weiss, M.S.; Gerrard, J.A.
A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis
Arch. Biochem. Biophys.
512
154-159
2011
Mycobacterium tuberculosis
Pearce, F.G.; Dobson, R.C.; Jameson, G.B.; Perugini, M.A.; Gerrard, J.A.
Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization
Biochim. Biophys. Acta
1814
1900-1909
2011
Thermotoga maritima
Kaur, N.; Gautam, A.; Kumar, S.; Singh, A.; Singh, N.; Sharma, S.; Sharma, R.; Tewari, R.; Singh, T.P.
Biochemical studies and crystal structure determination of dihydrodipicolinate synthase from Pseudomonas aeruginosa
Int. J. Biol. Macromol.
48
779-787
2011
no activity in Homo sapiens, Pseudomonas aeruginosa (Q9I4W3), Pseudomonas aeruginosa
Blickling, S.; Renner, C.; Laber, B.; Pohlenz, H.; Holak, T.; Huber, R.
Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy
Biochemistry
36
24-33
1997
Escherichia coli (P0A6L2), Escherichia coli
Schnell, R.; Oehlmann, W.; Sandalova, T.; Braun, Y.; Huck, C.; Maringer, M.; Singh, M.; Schneider, G.
Tetrahydrodipicolinate N-succinyltransferase and dihydrodipicolinate synthase from Pseudomonas aeruginosa: structure analysis and gene deletion
PLoS ONE
7
e31133
2012
Pseudomonas aeruginosa (Q9I4W3), Pseudomonas aeruginosa
Griffin, M.D.; Billakanti, J.M.; Gerrard, J.A.; Dobson, R.C.; Pearce, F.G.
Crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase 2 from Arabidopsis thaliana
Acta Crystallogr. Sect. F
67
1386-1390
2011
Arabidopsis thaliana (Q9FVC8), Arabidopsis thaliana
Atkinson, S.C.; Dogovski, C.; Newman, J.; Dobson, R.C.; Perugini, M.A.
Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the grapevine Vitis vinifera
Acta Crystallogr. Sect. F
67
1537-1541
2011
Vitis vinifera
Atkinson, S.C.; Dogovski, C.; Dobson, R.C.; Perugini, M.A.
Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from Agrobacterium tumefaciens
Acta Crystallogr. Sect. F
68
1040-1047
2012
Agrobacterium tumefaciens (Q8UGL3), Agrobacterium tumefaciens, Agrobacterium tumefaciens C58 / ATCC 33970 (Q8UGL3)
Siddiqui, T.; Paxman, J.J.; Dogovski, C.; Panjikar, S.; Perugini, M.A.
Cloning to crystallization of dihydrodipicolinate synthase from the intracellular pathogen Legionella pneumophila
Acta Crystallogr. Sect. F
69
1177-1181
2013
Legionella pneumophila
Geng, F.; Chen, Z.; Zheng, P.; Sun, J.; Zeng, A.
Exploring the allosteric mechanism of dihydrodipicolinate synthase by reverse engineering of the allosteric inhibitor binding sites and its application for lysine production
Appl. Microbiol. Biotechnol.
97
1963-1971
2012
Corynebacterium glutamicum, Escherichia coli, Corynebacterium glutamicum ATCC 13032, Escherichia coli MG1655
Skovpen, Y.V.; Palmer, D.R.
Dihydrodipicolinate synthase from Campylobacter jejuni: kinetic mechanism of cooperative allosteric inhibition and inhibitor-induced substrate cooperativity
Biochemistry
52
5454-5462
2013
Campylobacter jejuni
Boughton, B.A.; Hor, L.; Gerrard, J.A.; Hutton, C.A.
1,3-Phenylene bis(ketoacid) derivatives as inhibitors of Escherichia coli dihydrodipicolinate synthase
Bioorg. Med. Chem.
20
2419-2426
2012
Escherichia coli
Sridharan, U.; Ebihara, A.; Kuramitsu, S.; Yokoyama, S.; Kumarevel, T.; Ponnuraj, K.
Crystal structure and in silico studies of dihydrodipicolinate synthase (DHDPS) from Aquifex aeolicus
Extremophiles
18
973-985
2014
Aquifex aeolicus (O67216), Aquifex aeolicus
Erzeel, E.; Van Bochaute, P.; Thu, T.T.; Angenon, G.
Medicago truncatula dihydrodipicolinate synthase (DHDPS) enzymes display novel regulatory properties
Plant Mol. Biol.
81
401-415
2013
Medicago truncatula, Medicago truncatula Jemalong 2HA
Atkinson, S.C.; Dogovski, C.; Downton, M.T.; Czabotar, P.E.; Dobson, R.C.; Gerrard, J.A.; Wagner, J.; Perugini, M.A.
Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition
Plant Mol. Biol.
81
431-446
2013
Vitis vinifera (D7U7T8), Vitis vinifera
Reboul, C.F.; Porebski, B.T.; Griffin, M.D.; Dobson, R.C.; Perugini, M.A.; Gerrard, J.A.; Buckle, A.M.
Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase
PLoS Comput. Biol.
8
e1002537
2012
Escherichia coli, Staphylococcus aureus
Boughton, B.; Dobson, R.; Hutton, C.
The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: unambiguous resolution of the stereochemistry of the condensation product
Proteins
80
2117-2122
2012
Escherichia coli (P0A6L2), Escherichia coli
Atkinson, S.; Hor, L.; Dogovski, C.; Dobson, R.; Perugini, M.
Identification of the bona fide DHDPS from a common plant pathogen
Proteins
82
1869-1883
2014
Agrobacterium tumefaciens (A9CFV4), Agrobacterium tumefaciens (A9CGZ4), Agrobacterium tumefaciens (A9CHR2), Agrobacterium tumefaciens (A9CL94), Agrobacterium tumefaciens (A9CL97), Agrobacterium tumefaciens (Q7CU96), Agrobacterium tumefaciens (Q7D0E8), Agrobacterium tumefaciens (Q7D313), Agrobacterium tumefaciens (Q7D3Z9), Agrobacterium tumefaciens (Q8UGL3), Agrobacterium tumefaciens, Agrobacterium tumefaciens C58 / ATCC 33970 (A9CFV4), Agrobacterium tumefaciens C58 / ATCC 33970 (A9CGZ4), Agrobacterium tumefaciens C58 / ATCC 33970 (A9CHR2), Agrobacterium tumefaciens C58 / ATCC 33970 (A9CL94), Agrobacterium tumefaciens C58 / ATCC 33970 (A9CL97), Agrobacterium tumefaciens C58 / ATCC 33970 (Q7CU96), Agrobacterium tumefaciens C58 / ATCC 33970 (Q7D0E8), Agrobacterium tumefaciens C58 / ATCC 33970 (Q7D313), Agrobacterium tumefaciens C58 / ATCC 33970 (Q7D3Z9), Agrobacterium tumefaciens C58 / ATCC 33970 (Q8UGL3)
Shrivastava, P.; Navratna, V.; Silla, Y.; Dewangan, R.P.; Pramanik, A.; Chaudhary, S.; Rayasam, G.; Kumar, A.; Gopal, B.; Ramachandran, S.
Inhibition of Mycobacterium tuberculosis dihydrodipicolinate synthase by alpha-ketopimelic acid and its other structural analogues
Sci. Rep.
6
30827
2016
Mycobacterium tuberculosis (P9WP25), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WP25)
Christensen, J.B.; Soares da Costa, T.P.; Faou, P.; Pearce, F.G.; Panjikar, S.; Perugini, M.A.
Structure and function of cyanobacterial DHDPS and DHDPR
Sci. Rep.
6
37111
2016
Trichormus variabilis (Q3MFY8), Trichormus variabilis
Mank, N.; Arnette, A.; Klapper, V.; Offermann, L.; Chruszcz, M.
Structure of dihydrodipicolinate synthase from the commensal bacterium Bacteroides thetaiotaomicron at 2.1 A resolution
Acta Crystallogr. Sect. F
71
449-454
2015
Bacteroides thetaiotaomicron (Q8A3Z0), Bacteroides thetaiotaomicron, Bacteroides thetaiotaomicron ATCC 29148 (Q8A3Z0)
Naqvi, K.F.; Staker, B.L.; Dobson, R.C.; Serbzhinskiy, D.; Sankaran, B.; Myler, P.J.; Hudson, A.O.
Cloning, expression, purification, crystallization and X-ray diffraction analysis of dihydrodipicolinate synthase from the human pathogenic bacterium Bartonella henselae strain Houston-1 at 2.1 A resolution
Acta Crystallogr. Sect. F
72
2-9
2016
Bartonella henselae (Q6G468), Bartonella henselae, Bartonella henselae ATCC 49882 (Q6G468), Bartonella henselae Houston 1 (Q6G468)
Karsten, W.E.; Nimmo, S.A.; Liu, J.; Chooback, L.
Identification of 2, 3-dihydrodipicolinate as the product of the dihydrodipicolinate synthase reaction from Escherichia coli
Arch. Biochem. Biophys.
653
50-62
2018
Escherichia coli, Escherichia coli JM109
Xu, J.; Han, M.; Ren, X.; Zhang, W.
Modification of aspartokinase III and dihydrodipicolinate synthetase increases the production of L-lysine in Escherichia coli
Biochem. Eng. J.
114
79-86
2016
Escherichia coli (P0A6L2), Escherichia coli LATR11 (P0A6L2)
-
Sowole, M.A.; Simpson, S.; Skovpen, Y.V.; Palmer, D.R.; Konermann, L.
Evidence of allosteric enzyme regulation via changes in conformational dynamics A hydrogen/deuterium exchange investigation of dihydrodipicolinate synthase
Biochemistry
55
5413-5422
2016
Campylobacter jejuni
Ren, W.; Tao, J.; Shi, D.; Chen, W.; Chen, C.
Involvement of a dihydrodipicolinate synthase gene (FaDHDPS1) in fungal development, pathogenesis and stress responses in Fusarium asiaticum
BMC Microbiol.
18
128
2018
Fusarium asiaticum
Skovpen, Y.V.; Conly, C.J.; Sanders, D.A.; Palmer, D.R.
Biomimetic design results in a potent allosteric inhibitor of dihydrodipicolinate synthase from Campylobacter jejuni
J. Am. Chem. Soc.
138
2014-2020
2016
Campylobacter jejuni
Gupta, R.; Hogan, C.J.; Perugini, M.A.; Soares da Costa, T.P.
Characterization of recombinant dihydrodipicolinate synthase from the bread wheat Triticum aestivum
Planta
248
381-391
2018
Triticum aestivum (P24846), Triticum aestivum
Gupta, R.; Soares da Costa, T.P.; Faou, P.; Dogovski, C.; Perugini, M.A.
Comparison of untagged and his-tagged dihydrodipicolinate synthase from the enteric pathogen Vibrio cholerae
Protein Expr. Purif.
145
85-93
2018
Vibrio cholerae (A5F699), Vibrio cholerae, Vibrio cholerae O395 (A5F699)
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