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Information on EC - pyridoxal 5'-phosphate synthase (glutamine hydrolysing)

for references in articles please use BRENDA:EC4.3.3.6
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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.3 Amine-lyases
       pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
IUBMB Comments
The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel. The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate. The enzyme complex is found in aerobic bacteria, archaea, fungi and plants.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
plp synthase, rv2606c, pyridoxal biosynthesis lyase, ph1355, more
D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate
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overall reaction
D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate
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L-glutamine + H2O = L-glutamate + NH3
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