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Information on EC 4.3.2.8 - gamma-glutamylamine cyclotransferase

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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.2 Amidine-lyases
                4.3.2.8 gamma-glutamylamine cyclotransferase
IUBMB Comments
The enzyme, found in vertebrates, has no activity toward alpha-(gamma-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9, gamma-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
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The enzyme appears in viruses and cellular organisms
Synonyms
GGACT, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline
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