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Information on EC 4.3.2.6 - gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

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EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.2 Amidine-lyases
                4.3.2.6 gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase
IUBMB Comments
The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the terminal gamma-L-glutamate of the side chain, releasing it as the cyclic 5-oxoproline.
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The expected taxonomic range for this enzyme is: Bacillus circulans
Synonyms
btrG, gamma-glutamyl cyclotransferase, GGC, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
gamma-L-glutamyl-butirosin B = butirosin B + 5-oxo-L-proline
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