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The expected taxonomic range for this enzyme is: Fusarium fujikuroi species complex
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(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
the original STC5 from Fusarium fujikuroi is inactive because of a critically naturally occuring mutation at position 288 in STC5 that leads to an asparagine to lysine exchange in the NSE triad. Sequence correction by site-directed mutagenesis (K288N) restores activity. No activity with geranyl diphosphate and geranylgeranyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene = (1R)-1-methyl-4-methylidene-7-(propan-2-yl)-1,2,3,3a,4,5,6,8a-octahydroazulene i.e. (1R)-7-isopropyl-1-methyl-4-methylene-1,2,3,3a,4,5,6,8a-octahydroazulene
-
?
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
the original STC5 from Fusarium fujikuroi is inactive because of a critically naturally occuring mutation at position 288 in STC5 that leads to an asparagine to lysine exchange in the NSE triad. Sequence correction by site-directed mutagenesis (K288N) restores activity. No activity with geranyl diphosphate and geranylgeranyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene = (1R)-1-methyl-4-methylidene-7-(propan-2-yl)-1,2,3,3a,4,5,6,8a-octahydroazulene i.e. (1R)-7-isopropyl-1-methyl-4-methylene-1,2,3,3a,4,5,6,8a-octahydroazulene
-
?
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
-
no activity with geranyl diphosphate and geranylgeranyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene i.e. (1R)-1-methyl-4-methylidene-7-(propan-2-yl)-1,2,3,3a,4,5,6,8a-octahydroazulene i.e. (1R)-7-isopropyl-1-methyl-4-methylene-1,2,3,3a,4,5,6,8a-octahydroazulene
-
?
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
-
no activity with geranyl diphosphate and geranylgeranyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene i.e. (1R)-1-methyl-4-methylidene-7-(propan-2-yl)-1,2,3,3a,4,5,6,8a-octahydroazulene i.e. (1R)-7-isopropyl-1-methyl-4-methylene-1,2,3,3a,4,5,6,8a-octahydroazulene
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
-
-
-
?
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
-
-
-
-
?
(2E,6E)-farnesyl diphosphate
(1R,4R,5S)-(-)-guaia-6,10(14)-diene + diphosphate
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Enzyme Nomenclature
4.2.3.165 (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase
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