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Information on EC 4.2.3.12 - 6-pyruvoyltetrahydropterin synthase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.12 6-pyruvoyltetrahydropterin synthase
IUBMB Comments
Catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. It has been identified in human liver. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 3.5.4.16 (GTP cyclohydrolase I) .
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
ptps, 6-pyruvoyl-tetrahydropterin synthase, ptp synthase, eptps, ptps-iii, pyruvoyltetrahydropterin synthase, sco 6650, 6-pyruvoyl tetrahydrobiopterin synthase, ph0634, ptps homologue, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
show the reaction diagram
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