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Information on EC 4.2.1.33 - 3-isopropylmalate dehydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.33 3-isopropylmalate dehydratase
IUBMB Comments
Forms part of the leucine biosynthesis pathway. The enzyme brings about the interconversion of the two isomers of isopropylmalate. It contains an iron-sulfur cluster.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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Synonyms
isopropylmalate isomerase, leucd, alpha-isopropylmalate isomerase, isopropylmalate dehydratase, ipm isomerase, mj0499, alpha-ipm isomerase, leu1s, ipmi ssu1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
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overall reaction
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(2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O
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2-isopropylmaleate + H2O = (2S)-2-isopropylmalate
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(1b)
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