Disease on EC 4.2.1.3 - aconitate hydratase
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Acidosis, Lactic
Hereditary myopathy with lactic acidosis, succinate dehydrogenase and aconitase deficiency in northern Sweden: a genealogical study.
aconitate hydratase deficiency
Brain aconitase activity is not decreased in progressive supranuclear palsy.
aconitate hydratase deficiency
Functional cellular analyses reveal energy metabolism defect and mitochondrial DNA depletion in a case of mitochondrial aconitase deficiency.
aconitate hydratase deficiency
Hereditary myopathy with lactic acidosis, succinate dehydrogenase and aconitase deficiency in northern Sweden: a genealogical study.
aconitate hydratase deficiency
Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency.
aconitate hydratase deficiency
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
aconitate hydratase deficiency
Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain.
aconitate hydratase deficiency
Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency. Abnormalities of several iron-sulfur proteins.
aconitate hydratase deficiency
Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency.
aconitate hydratase deficiency
Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies.
Adenocarcinoma
Activated macrophage conditioned medium: identification of the soluble factors inducing cytotoxicity and the L-arginine dependent effector mechanism.
Adenocarcinoma
Cytokines induce an L-arginine-dependent effector system in nonmacrophage cells.
Adenocarcinoma
Inactivation of metabolic enzymes by photo-treatment with zinc meta N-methylpyridylporphyrin.
Adenocarcinoma
The role of transferrin receptor in the Helicobacter pylori pathogenesis; L-ferritin as a novel marker for intestinal metaplasia.
Adenocarcinoma of Lung
Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis.
Alzheimer Disease
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.
Alzheimer Disease
Lymphocytic mitochondrial aconitase activity is reduced in Alzheimer's disease and mild cognitive impairment.
Alzheimer Disease
Mitochondrial oxidative stress index, activity of redox-sensitive aconitase and effects of endogenous anti- and pro-oxidants on its activity in control, Alzheimer's disease and Swedish Familial Alzheimer's disease brain.
Amyotrophic Lateral Sclerosis
Superoxide dismutase 1 modulates expression of transferrin receptor.
Anemia
Role of hypolipidemic drug clofibrate in altering iron regulatory proteins IRP1 and IRP2 activities and hepatic iron metabolism in rats fed a low-iron diet.
Anemia
The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload.
Anemia
[Clinical and diagnostic significance of gepsidin level in the regulation of iron metabolism in patients with inflammatory bowel disease].
Anemia
[Expression of iron responsive element binding protein mRNA and analysis of aconitase activity in iron deficiency anemia rats]
Anemia, Hypochromic
Aconitase plays a role in regulating resistance to oxidative stress and cell death in Arabidopsis and Nicotiana benthamiana.
Anemia, Iron-Deficiency
[Expression of iron responsive element binding protein mRNA and analysis of aconitase activity in iron deficiency anemia rats]
Anemia, Sickle Cell
Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.
Ataxia
Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich's Ataxia Patients.
beta-Thalassemia
Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.
Brain Diseases
Aggravated effects of coexisting marginal thiamine deficits and zinc excess on SN56 neuronal cells.
Brain Diseases
Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice.
Brain Diseases
Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy.
Breast Neoplasms
Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels.
Breast Neoplasms
Racial disparities in breast cancer diagnosis in Central Georgia in the United States.
Breast Neoplasms
The African American Women and Mass Media campaign: a CDC breast cancer screening project.
Bronchopulmonary Dysplasia
Loss of lung mitochondrial aconitase activity due to hyperoxia in bronchopulmonary dysplasia in primates.
Candidiasis
The mitogen-activated protein kinase CgHog1 is required for iron homeostasis, adherence and virulence in Candida glabrata.
Carcinogenesis
p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells.
Carcinoma
Changes induced by Ehrlich ascites carcinoma in hepatic fumarase and aconitase activities.
Carcinoma
Cholesterol modulation of the expression of mitochondrial aconitase in human prostatic carcinoma cells.
Carcinoma
Cyclic adenosine 3',5'-monosphosphate mediate prolactin regulation of mitochondrial aconitase in human prostate carcinoma cells.
Carcinoma
Decreased intracellular superoxide levels activate Sindbis virus-induced apoptosis.
Carcinoma
Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes.
Carcinoma
Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells.
Carcinoma
Manganese antagonizes iron blocking mitochondrial aconitase expression in human prostate carcinoma cells.
Carcinoma
Modulation of iron on mitochondrial aconitase expression in human prostatic carcinoma cells.
Carcinoma
Modulation of mitochondrial aconitase on the bioenergy of human prostate carcinoma cells.
Carcinoma
Nitroprusside stimulates mitochondrial aconitase gene expression through the cyclic adenosine 3',5'-monosphosphate signal transduction pathway in human prostate carcinoma cells.
Carcinoma
p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells.
Carcinoma
Testosterone modulates mitochondrial aconitase in the full-length human androgen receptor-transfected PC-3 prostatic carcinoma cells.
Carcinoma
Zinc blocks gene expression of mitochondrial aconitase in human prostatic carcinoma cells.
Carcinoma, Ehrlich Tumor
Characterization of aconitate hydratase from mitochondria and cytoplasm of ascites tumor cells.
Carcinoma, Hepatocellular
Cholesterol modulation of the expression of mitochondrial aconitase in human prostatic carcinoma cells.
Carcinoma, Hepatocellular
Influence of parenteral iron preparations on non-transferrin bound iron uptake, the iron regulatory protein and the expression of ferritin and the divalent metal transporter DMT-1 in HepG2 human hepatoma cells.
Carcinoma, Hepatocellular
Transferrin receptor regulates malignancies and the stemness of hepatocellular carcinoma-derived cancer stem-like cells by affecting iron accumulation.
Cardiomegaly
Renal and cardiac Na+-K +-ATPase and aconitase in a rat model of fetal programming.
Cardiomyopathy, Dilated
The use of transgenic and mutant mice to study oxygen free radical metabolism.
Cardiotoxicity
Chronic cardiotoxicity of anticancer anthracyclines in the rat: role of secondary metabolites and reduced toxicity by a novel anthracycline with impaired metabolite formation and reactivity.
Cardiotoxicity
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management.
Cardiotoxicity
Doxorubicin-induced cardiotoxicity: direct correlation of cardiac fibroblast and H9c2 cell survival and aconitase activity with heat shock protein 27.
Cardiotoxicity
The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein-1 in cytosolic fractions from human myocardium.
Cataract
Extension of murine life span by overexpression of catalase targeted to mitochondria.
Chemical and Drug Induced Liver Injury
Effect of N-[Imino(4-morpholyl)methyl]guanidine on the oxidative status in rats with toxic hepatitis.
Chemical and Drug Induced Liver Injury
Free radical oxidation and catalytic activity of aconitate hydratase in rat liver under normal conditions and during toxic hepatitis.
Chemical and Drug Induced Liver Injury
[Citrate influence on oxidative status of rats tissues under experimental toxic hepatitis].
Chemical and Drug Induced Liver Injury
[The oxidative effects of melatonin, the content of citrate and the activity of aconitate hydratase in the rat liver in toxic hepatitis].
Colorectal Neoplasms
Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling.
Craniocerebral Trauma
Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.
Cysts
Sarcocystis fusiformis: some Krebs cycle enzymes in various fractions of sarcocysts of buffalo (Bubalus bubalis).
Dehydration
AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates.
Dehydration
Bacterial L-serine dehydratases: a new family of enzymes containing iron-sulfur clusters.
Dehydration
CO2 adducts as reactive analogues of carboxylate substrates for aconitase and other enzymes of carbohydrate metabolism.
Dehydration
Crystal structures of aconitase X enzymes from bacteria and archaea provide insights into the molecular evolution of the aconitase superfamily.
Dehydration
Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate.
Dehydration
The Crystal Structure of Fe4S4 Quinolinate Synthase Unravels an Enzymatic Dehydration Mechanism That Uses Tyrosine and a Hydrolase-Type Triad.
Delirium
CA1-03: Cognitive Impairment in Patients Hospitalized for Acute Coronary Syndromes: Preliminary Findings from TRACE-CORE.
Delirium
PS1-34: Clinical Factors Associated with Cognitive Function in Patients Hospitalized for Acute Coronary Syndromes: Preliminary Findings from TRACE-CORE.
Dementia
CA1-03: Cognitive Impairment in Patients Hospitalized for Acute Coronary Syndromes: Preliminary Findings from TRACE-CORE.
Dementia
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.
Dementia
PS1-34: Clinical Factors Associated with Cognitive Function in Patients Hospitalized for Acute Coronary Syndromes: Preliminary Findings from TRACE-CORE.
Diabetes Mellitus
Effects of N-[Imino(1-Piperidinyl)Methyl] Guanidine on the Intensity of Free Radical Processes, Aconitase Activity, and Citrate Level in the Tissues of Rats with Experimental Type 2 Diabetes Mellitus.
Diabetes Mellitus
Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin.
Diabetes Mellitus
[EFFECTS OF MELATONIN ON THE ACONITATE HYDRATASE ACTIVITY, CONTENT OF LIPID PEROXIDATION PRODUCTS AND SOME NON-ENZYMATIC ANTIOXIDANTS IN THE BLOOD OF PATIENTS WITH TYPE 2 DIABETES MELLITUS COMPLICATED BY STEATOHEPATITIS].
Diabetes Mellitus
[Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy].
Diabetes Mellitus, Experimental
Alterations in mitochondrial aconitase activity and respiration, and in concentration of citrate in some organs of mice with experimental or genetic diabetes.
Diabetes Mellitus, Type 2
Effects of N-[Imino(1-Piperidinyl)Methyl] Guanidine on the Intensity of Free Radical Processes, Aconitase Activity, and Citrate Level in the Tissues of Rats with Experimental Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin.
Diabetes Mellitus, Type 2
Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress.
Diabetes Mellitus, Type 2
[EFFECTS OF MELATONIN ON THE ACONITATE HYDRATASE ACTIVITY, CONTENT OF LIPID PEROXIDATION PRODUCTS AND SOME NON-ENZYMATIC ANTIOXIDANTS IN THE BLOOD OF PATIENTS WITH TYPE 2 DIABETES MELLITUS COMPLICATED BY STEATOHEPATITIS].
Diabetes Mellitus, Type 2
[Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy].
dihydrolipoyl dehydrogenase deficiency
The expanding clinical spectrum of mitochondrial diseases.
Encephalomyelitis
The habenula and iron metabolism in cerebral mouse models of multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
The habenula and iron metabolism in cerebral mouse models of multiple sclerosis.
Eosinophilia
Increased glutathione levels contribute to the beneficial effects of hydrogen sulfide and inducible nitric oxide inhibition in allergic lung inflammation.
Epilepsy
The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction.
Fatty Liver
Identification of novel molecular candidates for fatty liver in the hyperlipidemic mouse model, HcB19.
Fatty Liver
[EFFECTS OF MELATONIN ON THE ACONITATE HYDRATASE ACTIVITY, CONTENT OF LIPID PEROXIDATION PRODUCTS AND SOME NON-ENZYMATIC ANTIOXIDANTS IN THE BLOOD OF PATIENTS WITH TYPE 2 DIABETES MELLITUS COMPLICATED BY STEATOHEPATITIS].
Fatty Liver
[Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy].
Friedreich Ataxia
Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia.
Friedreich Ataxia
Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome.
Friedreich Ataxia
Deferiprone targets aconitase: implication for Friedreich's ataxia treatment.
Friedreich Ataxia
Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia.
Friedreich Ataxia
Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells.
Friedreich Ataxia
Novel antibody-based strategies for the rapid diagnosis of mitochondrial disease and dysfunction.
fumarate hydratase deficiency
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
Gait Ataxia
Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome.
Gastritis
The role of transferrin receptor in the Helicobacter pylori pathogenesis; L-ferritin as a novel marker for intestinal metaplasia.
Gastrointestinal Stromal Tumors
FAM96A Protects Mice From Dextran Sulfate Sodium (DSS)-Induced Colitis by Preventing Microbial Dysbiosis.
Glioblastoma
Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms.
Glucose Intolerance
Trehalose Protects against Insulin Resistance-Induced Tissue Injury and Excessive Autophagy in Skeletal Muscles and Kidney.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Effects of Glucose 6-Phosphate Dehydrogenase Deficiency on the Metabolic and Cardiac Responses to Obesogenic or High Fructose Diets.
Glucosephosphate Dehydrogenase Deficiency
Effects of Glucose 6-Phosphate Dehydrogenase Deficiency on the Metabolic and Cardiac Responses to Obesogenic or High Fructose Diets.
Heart Arrest
Oxidative stress reversibly inactivates myocardial enzymes during cardiac arrest.
Hemochromatosis
Genetic modification of iron metabolism in mice affects the gut microbiota.
Hemochromatosis
Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis.
Hemochromatosis
Iron regulatory protein 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.
Hemochromatosis
Iron-responsive element-binding protein in hemochromatosis liver and intestine.
Hemochromatosis
Response of monocyte iron regulatory protein activity to inflammation: abnormal behavior in genetic hemochromatosis.
Hepatitis
Mitochondrial aconitase binds to the 3' untranslated region of the mouse hepatitis virus genome.
Huntington Disease
Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
Huntington Disease
Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.
Huntington Disease
Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.
Hyperglycemia
Effects of two oral antidiabetics, pioglitazone and repaglinide, on aconitase inactivation, inflammation and oxidative/nitrosative stress in tissues under alloxan-induced hyperglycemia.
Hyperglycemia
Potential Role of Endoplasmic Reticulum Stress in Pathogenesis of Diabetic Retinopathy.
Hypersensitivity
Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone.
Hypersensitivity
Transsulfuration Pathway Seleno-amino Acids are Mediators of Selenomethionine Toxicity in Saccharomyces cerevisiae.
Hypertension
Genetic Variant Coding for Iron Regulatory Protein HFE Contributes to Hypertension, the TAMRISK Study.
Hypertension
Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study.
Hypertension, Pulmonary
Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2?.
Hypertension, Pulmonary
Therapeutic inhibition of HIF2? reverses polycythemia and pulmonary hypertension in murine models of two human diseases.
Hyperthyroidism
Oxidative status and citrate concentration in rat tissues during experimental hyperthyroidism and melatonin treatment.
Hyperthyroidism
[Effect of melaxen and valdoxan on free radical processes intensity, aconitate hydratase activity and citrate content in rats tissues under hyperthyroidism].
Infections
An Unusual Occurrence of Southern Rust, Caused by Rpp9-virulent Puccinia polysora, on Corn in Southwestern Georgia.
Infections
Cytosolic Fe-superoxide dismutase safeguards Trypanosoma cruzi from macrophage-derived superoxide radical.
Infections
Decreased intracellular superoxide levels activate Sindbis virus-induced apoptosis.
Infections
Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.
Infections
Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1.
Infections
Heparin inhibits intracellular Mycobacterium tuberculosis bacterial replication by reducing iron levels in human macrophages.
Infections
Identification of Genes Expressed Differentially in Grapefruit Infected with Candidatus Liberibacter asiaticus in the Late Stage of Disease
Infections
Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis.
Infections
Mitochondrial aconitase binds to the 3' untranslated region of the mouse hepatitis virus genome.
Infections
Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice.
Influenza, Human
Recognition of a sequestered self peptide by influenza virus-specific CD8+ cytolytic T lymphocytes.
Insulin Resistance
Iron regulatory protein 2 deficiency may correlate with insulin resistance.
Insulin Resistance
Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1?.
Insulinoma
Heat shock inhibits cytokine-induced nitric oxide synthase expression by rat and human islets.
Iron Deficiencies
Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats.
Iron Deficiencies
Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome.
Iron Deficiencies
Dietary iron intake rapidly influences iron regulatory proteins, ferritin subunits and mitochondrial aconitase in rat liver.
Iron Deficiencies
Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress.
Iron Deficiencies
Differential translational control of 5' IRE-containing mRNA in response to dietary iron deficiency and acute iron overload.
Iron Deficiencies
Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease.
Iron Deficiencies
Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain.
Iron Deficiencies
Iron deficiency decreases mitochondrial aconitase abundance and citrate concentration without affecting tricarboxylic acid cycle capacity in rat liver.
Iron Deficiencies
Iron enzymes in iron deficiency. VI. Aconitase activity and citrate metabolism.
Iron Deficiencies
Iron regulatory protein 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.
Iron Deficiencies
Mitochondrial cysteine desulfurase iron-sulfur cluster S and aconitase are post-transcriptionally regulated by dietary iron in skeletal muscle of rats.
Iron Deficiencies
Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways.
Iron Deficiencies
Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation.
Iron Deficiencies
Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2.
Iron Deficiencies
The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage.
Iron Deficiencies
[Clinical and diagnostic significance of gepsidin level in the regulation of iron metabolism in patients with inflammatory bowel disease].
Iron Deficiencies
[Expression of iron regulatory protein-2 and ferritins in intestinal mucosa of rats with iron deficiency]
Iron Deficiencies
[Expression of iron responsive element binding protein mRNA and analysis of aconitase activity in iron deficiency anemia rats]
Iron Overload
Compartmentalization and regulation of iron metabolism proteins protect male germ cells from iron overload.
Iron Overload
Differential translational control of 5' IRE-containing mRNA in response to dietary iron deficiency and acute iron overload.
Iron Overload
Effects of hepatocellular iron imbalance on nitric oxide and reactive oxygen intermediates production in a model of sepsis.
Iron Overload
Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts.
Iron Overload
Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.
Iron Overload
Iron-responsive element-binding protein in hemochromatosis liver and intestine.
Iron Overload
SAXS and stability studies of iron-induced oligomers of bacterial frataxin CyaY.
Iron Overload
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
Leishmaniasis, Visceral
Association of pro-inflammatory cytokines and iron regulatory protein 2 (IRP2) with Leishmania burden in canine visceral leishmaniasis.
Leukemia, Erythroblastic, Acute
Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.
Leukemia, Erythroblastic, Acute
Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells.
Leukemia, Myeloid
Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells.
Liver Diseases
Falsely normal value in fluorometric transferase screening of galactosemic blood. A cautionary note.
Lung Neoplasms
Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts.
Lymphoma
Induction of iron regulatory protein 1 RNA-binding activity by nitric oxide is associated with a concomitant increase in the labile iron pool: implications for DNA damage.
Malaria
The antimalarial drug primaquine targets Fe-S cluster proteins and yeast respiratory growth.
Melanoma
Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma.
MERRF Syndrome
Mitochondrial DNA Mutation-Elicited Oxidative Stress, Oxidative Damage, and Altered Gene Expression in Cultured Cells of Patients with MERRF Syndrome.
Mitochondrial Diseases
Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia.
Mitochondrial Diseases
Identification of novel compound heterozygous mutations in ACO2 in a patient with progressive cerebral and cerebellar atrophy.
Mitochondrial Myopathies
Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency. Abnormalities of several iron-sulfur proteins.
Movement Disorders
Analysis of nucleotide variations in genes of iron management in patients of Parkinson's disease and other movement disorders.
Multiple Sclerosis
Mitochondrial Complex Enzyme Activities and Cytochrome c Expression Changes in Multiple Sclerosis.
Muscular Diseases
Clinical manifestation and a new ISCU mutation in iron-sulphur cluster deficiency myopathy.
Muscular Diseases
Hereditary myopathy with lactic acidosis, succinate dehydrogenase and aconitase deficiency in northern Sweden: a genealogical study.
Muscular Diseases
Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.
Muscular Diseases
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
Muscular Diseases
Structure and dynamics of the iron-sulfur cluster assembly scaffold protein IscU and its interaction with the cochaperone HscB.
Myocardial Ischemia
Effects of lipoic acid on citrate content, aconitate hydratase activity, and oxidative status during myocardial ischemia in rats.
Myocarditis
Effect of 3,5-dicarbomethoxyphenylbiguanide on free radical homeostasis in rats with experimental myocarditis.
Myoglobinuria
Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency. Abnormalities of several iron-sulfur proteins.
Myoglobinuria
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
Neoplasm Metastasis
Modulation of mitochondrial aconitase on the bioenergy of human prostate carcinoma cells.
Neoplasms
Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response.
Neoplasms
Aconitase 2 sensitizes MCF-7 cells to cisplatin eliciting p53-mediated apoptosis in a ROS-dependent manner.
Neoplasms
Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective.
Neoplasms
Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia.
Neoplasms
Characterization of aconitate hydratase from mitochondria and cytoplasm of ascites tumor cells.
Neoplasms
Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.
Neoplasms
Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase.
Neoplasms
Exploiting the passenger ACO1-deficiency arising from 9p21 deletions to kill T-cell lymphoblastic neoplasia cells.
Neoplasms
FAM96A Protects Mice From Dextran Sulfate Sodium (DSS)-Induced Colitis by Preventing Microbial Dysbiosis.
Neoplasms
Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2.
Neoplasms
Hepatocytes Determine the Hypoxic Microenvironment and Radiosensitivity of Colorectal Cancer Cells Through Production of Nitric Oxide That Targets Mitochondrial Respiration.
Neoplasms
In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin.
Neoplasms
Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses.
Neoplasms
Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages.
Neoplasms
Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression.
Neoplasms
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.
Neoplasms
Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms.
Neoplasms
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
Neoplasms
Modulation of mitochondrial aconitase on the bioenergy of human prostate carcinoma cells.
Neoplasms
Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.
Neoplasms
NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells.
Neoplasms
Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts.
Neoplasms
Racial disparities in breast cancer diagnosis in Central Georgia in the United States.
Neoplasms
Removing the cells from adult bone marrow derived stem cell therapy does not eliminate cardioprotection.
Neoplasms
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
Neoplasms
Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis.
Neoplasms
The L-arginine dependent effector mechanism is induced in murine adenocarcinoma cells by culture supernatant from cytotoxic activated macrophages.
Neoplasms
The return of the Scarlet Pimpernel: cobalamin in inflammation II - cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS.
Neoplasms
The return of the Scarlet Pimpernel: cobalamin in inflammation II -- cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS
Neoplasms
The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells.
Neuroblastoma
Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 1.
Neuroblastoma
Effects of sodium metavanadate on in vitro neuroblastoma and red blood cells.
Neuroblastoma
Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines.
Neurodegenerative Diseases
Brain aconitase activity is not decreased in progressive supranuclear palsy.
Neurodegenerative Diseases
Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency.
Neurodegenerative Diseases
Infantile Cerebellar-Retinal Degeneration Associated with a Mutation in Mitochondrial Aconitase, ACO2.
Neurodegenerative Diseases
Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases.
Neurodegenerative Diseases
Mitochondrial aconitase in Neurodegenerative disorders: role of a metabolism-related molecule in neurodegeneration.
Neurodegenerative Diseases
MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice.
Neurodegenerative Diseases
Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency.
Neurodegenerative Diseases
Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice.
Neuroinflammatory Diseases
Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich's Ataxia Patients.
Obesity
A mitochondria-targeted vitamin E derivative decreases hepatic oxidative stress and inhibits fat deposition in mice.
Obesity
Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry.
Oligodendroglioma
Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells.
Optic Nerve Diseases
Dominant ACO2 mutations are a frequent cause of isolated optic atrophy.
Optic Nerve Diseases
Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy.
oxoglutarate dehydrogenase (succinyl-transferring) deficiency
The expanding clinical spectrum of mitochondrial diseases.
Paralysis
Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.
Parkinson Disease
A novel treatment strategy to prevent Parkinson's disease: focus on iron regulatory protein 1 (IRP1).
Parkinson Disease
Analysis of nucleotide variations in genes of iron management in patients of Parkinson's disease and other movement disorders.
Parkinson Disease
Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease.
Parkinson Disease
Iron-sulfur enzyme mediated mitochondrial superoxide toxicity in experimental Parkinson's disease.
Parkinson Disease
Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity.
Parkinson Disease
Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease.
Parkinson Disease
[Mechanism of ?-lipoic acid promoting iron efflux in substantia nigra cells of Parkinson's disease rats].
Polycythemia
Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2?.
Polycythemia
Therapeutic inhibition of HIF2? reverses polycythemia and pulmonary hypertension in murine models of two human diseases.
Porphyrias, Hepatic
Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism.
Prostatic Neoplasms
Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase.
Prostatic Neoplasms
p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells.
Prostatic Neoplasms
Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone.
Prostatic Neoplasms
Zinc cooperates with p53 to inhibit the activity of mitochondrial aconitase through reactive oxygen species accumulation.
Protein Deficiency
Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia.
Protein Deficiency
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
Protein Deficiency
Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies.
Proteinuria
Effect of month-long treatment with oral N-acetylcysteine on the oxidative stress and proteinuria in patients with diabetic nephropathy: a pilot study.
protoporphyrin ferrochelatase deficiency
Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice.
protoporphyrin ferrochelatase deficiency
Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia.
protoporphyrin ferrochelatase deficiency
Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.
protoporphyrin ferrochelatase deficiency
The mitochondrial protein frataxin is essential for heme biosynthesis in plants.
protoporphyrin ferrochelatase deficiency
Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia.
Pulmonary Disease, Chronic Obstructive
Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population.
Pulmonary Fibrosis
The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis.
Renal Insufficiency, Chronic
Hepcidin and risk of anemia in CKD: a cross-sectional and longitudinal analysis in the CKiD cohort.
Restless Legs Syndrome
Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome.
Restless Legs Syndrome
Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome.
Restless Legs Syndrome
Profile of altered brain iron acquisition in restless legs syndrome.
Retinal Degeneration
Dominant ACO2 mutations are a frequent cause of isolated optic atrophy.
Sarcoma
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
Scurvy
Gene expression of iron-related proteins during iron deficiency caused by scurvy in guinea pigs.
Seizures
Depletion of reduced glutathione precedes inactivation of mitochondrial enzymes following limbic status epilepticus in the rat hippocampus.
Seizures
Inhibition of aconitase in astrocytes increases the sensitivity to chemical convulsants.
Seizures
Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice.
Sepsis
SS31, a mitochondrially targeted antioxidant, prevents sepsis-induced reductions in diaphragm strength and endurance.
Shock, Septic
In vitro serial passage of Staphylococcus aureus: changes in physiology, virulence factor production, and agr nucleotide sequence.
Silicosis
[Study of lipid metabolism in the lungs in experimental silicosis i rats. Activity of lung lupases and aconitase]
Starvation
Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.
Starvation
Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.
Stomach Neoplasms
Decreased expression of the mitochondrial metabolic enzyme aconitase (ACO2) is associated with poor prognosis in gastric cancer.
Supranuclear Palsy, Progressive
Brain aconitase activity is not decreased in progressive supranuclear palsy.
Syphilis
The Tuskegee Syphilis Study and the Scientific Concept of Racial Nervous Resistance.
Syphilis
Tuskegee University experience challenges conventional wisdom: is integrative bioethics practice the new ethics for the public's health?
Thalassemia
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.
Tics
Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.
Tuberculosis
Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry.
Tuberculosis
Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner.
Tuberculosis
Superoxide production by the mycobacterial and pseudomonad quinoid pigments phthiocol and pyocyanine in human lung cells.
Uterine Cervical Neoplasms
The African American Women and Mass Media campaign: a CDC breast cancer screening project.
Whooping Cough
A Functional Tricarboxylic Acid Cycle Operates during Growth of Bordetella pertussis on Amino Acid Mixtures as Sole Carbon Substrates.
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