Reference on EC 4.2.1.24 - porphobilinogen synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pilz, I.; Schwarz, E.; Vuga, M.; Beyersmann, D.
Small angle X-ray scattering study on bovine porphobilinogen synthase (5-aminolevulinate dehydratase)
Biol. Chem. Hoppe-Seyler
369
1099-1103
1988
Bos taurus
Wetmur, J.G.; Bishop, D.F.; Ostasiewicz, L.; Desnick, R.J.
Molecular cloning of cDNA for human delta-aminolevulinate dehydratase
Gene
43
123-130
1986
Homo sapiens
Jordan, P.M.; Seehra, J.S.
Purification of porphobilinogen synthase from bovine liver
Methods Enzymol.
123
427-434
1986
Bos taurus
Bishop, D.F.; Desnick, R.J.
Porphobilinogen synthase: a specific and sensitive coupled-enzyme assay
Methods Enzymol.
123
339-345
1986
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Gibbs, P.N.B.; Chaudhry, A.G.; Jordan, P.M.
Purification and properties of 5-aminolevulinate dehydratase from human erythrocytes
Biochem. J.
230
25-34
1985
Homo sapiens
Gibbs, P.N.B.; Gore, M.G.; Jordan, P.M.
Investigation of the effect of metal ions on the reactivity of thiol groups in human 5-aminolaevulinate dehydratase
Biochem. J.
225
573-580
1985
Homo sapiens
Hasnain, S.S.; Wardell, E.M.; Garner, C.D.; Schloesser, M.; Beyersmann, D.
Extended-X-ray-absorption-fine-structure investigations of zinc in 5-aminolevulinate dehydratase
Biochem. J.
230
625-633
1985
Bos taurus
Schaller, K.H.; Berlin, A.
delta-Aminolevulinate dehydratase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
4
363-368
1984
Homo sapiens
-
Liedgens, W.; Luetz, C.; Schneider, H.A.W.
Molecular properties of 5-aminolevulinic acid dehydratase from Spinacia oleracea
Eur. J. Biochem.
135
75-79
1983
Spinacia oleracea
Liedgens, W.; Gruetzmann, R.; Schneider, H.A.W.
Highly efficient purification of the labile plant enzyme 5-aminolevulinate dehydratase (EC 4.2.1.24) by means of monoclonal antibodies
Z. Naturforsch. C
35
958-962
1980
Spinacia oleracea
Gibbs, P.N.B.; Jordan, P.M.
5-Aminolaevulinate dehydratase: Zinc-65 binding and exchange with the enzyme from human erythrocytes
Biochem. Soc. Trans.
9
232-233
1981
Homo sapiens
-
Balange, A.P.; Lambert, C.
delta-Aminolevulinate dehydratase from Raphanus sativus cotyledons
Phytochemistry
19
2541-2545
1980
Raphanus sativus
-
Bevan, D.R.; Bodlaender, P.; Shemin, D.
Mechanism of porphobilinogen synthase. Requirement of Zn2+ for enzyme activity
J. Biol. Chem.
255
2030-2035
1980
Bos taurus
Chandrika, S.R.; Padmanaban, G.
Purification, properties and synthesis of delta-aminolaevulinate dehydratase from Neurospora crassa
Biochem. J.
191
29-36
1980
Neurospora crassa
Hueckel, D.; Beyersmann, D.
Rapid purification and direct spectrophotometric assay for 5-aminolevulinic acid dehydratase
Anal. Biochem.
97
277-281
1979
Homo sapiens
Anderson, P.M.; Desnick, R.J.
Purification and properties of delta-aminolevulinate dehydrase from human erythrocytes
J. Biol. Chem.
254
6924-6930
1979
Homo sapiens
Stella, A.M.; Del C.Batlle, A.M.
Porphyrin biosynthesis - immobilized enzymes and ligands VIII. Studies on the purification of delta-aminolaevulinate dehydratase from Euglena gracilis
Plant Sci. Lett.
11
87-92
1978
Euglena gracilis
-
Kreutzer, M.; Schmidt, M.; Stadler, E.; Zeitler, H.J.
Purification and characterization of animal porphobilinogen synthases. I. Bovine liver porphobilinogen synthase
Hoppe-Seyler's Z. Physiol. Chem.
358
1081-1091
1977
Bos taurus
Gurne, D.; Chen, J.; Shemin, D.
Dissociation and reassociation of immobilized porphobilinogen synthase: use of immobilized subunits for enzyme isolation
Proc. Natl. Acad. Sci. USA
74
1383-1387
1977
Bos taurus
Gurne, D.; Shemin, D.
The synthesis of porphobilinogen by immobilized delta-aminolevulinic acid dehydratase
Methods Enzymol.
44
844-849
1976
Bos taurus, Cereibacter sphaeroides
Finelli, V.N.; Klauder, D.S.; Karaffa, M.A.; Petering, H.G.
Interaction of zinc and lead on delta-aminolevulinate dehydratase
Biochem. Biophys. Res. Commun.
65
303-311
1975
Rattus norvegicus
Wu, W.H.; Shemin, D.; Richards, K.E.; Williams, R.C.
The quarternary structure of delta-aminolevulinic acid dehydratase from bovine liver
Proc. Natl. Acad. Sci. USA
71
1767-1770
1974
Bos taurus
Nandi, D.L.; Shemin, D.
delta-Aminolevulinic acid dehydratase of Rhodopseudomonas capsulata
Arch. Biochem. Biophys.
158
305-311
1973
Rhodobacter capsulatus
Shemin, D.
delta-Aminolevulinic acid dehydratase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
7
323-337
1972
Bos taurus, Saccharomyces cerevisiae, Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Nicotiana tabacum, Rattus norvegicus, Rhodobacter capsulatus, Cereibacter sphaeroides, Triticum aestivum
-
Wilson, E.L.; Burger, P.E.; Dowdle, E.B.
Beef-liver 5-aminolevulinic acid dehydratase
Eur. J. Biochem.
29
563-671
1972
Bos taurus
Yamada, M.
delta-Aminolevulinic acid dehydratase from shell gland and liver of Japanese quail, Coturnix coturnix japonica. I. Purification, properties and hormonal induction
Biochim. Biophys. Acta
279
535-543
1972
Coturnix japonica
Van Heyningen, S.; Shemin, D.
Inhibition of delta-aminolaevulate dehydratase by pyridoxal derivatives and by cyanide
Biochem. J.
124
68P
1971
Cereibacter sphaeroides
Van Heyningen, S.; Shemin, D.
Quarternary structure of delta-aminolevulinate dehydratase from Rhodopseudomonas spheroides
Biochemistry
10
4676-4682
1971
Cereibacter sphaeroides
Yamasaki, H.; Moriyama, T.
delta-Aminolevulinic acid dehydratase of Mycobacterium phlei
Biochim. Biophys. Acta
227
698-705
1971
Mycolicibacterium phlei
Komai, H.; Neilands, J.B.
The metalloprotein nature of Ustilago delta-aminolevulinate dehydratase
Biochim. Biophys. Acta
171
311-320
1969
Ustilago sphaerogena
Bhosale, S.; Kshirsagar, D.; Pawar, P.; Yeole, T.; Ranade, D.
Purification and characterization of 5-aminolevulinic acid dehydratase from Methanosarcina barkeri
FEMS Microbiol. Lett.
127
151-155
1995
Methanosarcina barkeri
-
Schroeder, T.M.; Caspers, M.L.
Kinetics of aluminium-induced inhibition of delta-aminolevulinic acid dehydratase in vitro
Biochem. Pharmacol.
52
927-931
1996
Rattus norvegicus
Frankenberg, N.; Kittel, T.; Hungerer, C.; Rrnemann, D.
Cloning, mapping and functional characterization of the hemB gene of Pseudomonas aeruginosa, which encodes a magnesium-dependent 5-aminolevulinic acid dehydratase
Mol. Gen. Genet.
257
485-489
1998
Pseudomonas aeruginosa
Schaumburg, A.; Schneider-Poetsch, H.A.W.; Eckerskorn, C.
Characterization of plastid 5-aminolevulinate dehydratase (ALAD; EC 4.2.1.24) from spinach (Spinacia oleracea L.) by sequencing and comparison with non-plant ALAD enzymes
Z. Naturforsch. C
47
77-84
1992
Spinacia oleracea
Luond, R.M.; Walker, J.; Neier, R.W.
Assessment of the active-site requirements of 5-aminolevulinic acid dehydratase: evaluation of substrate and product analogues as competitive inhibitors
J. Org. Chem.
57
5005-5013
1992
Cereibacter sphaeroides
-
Stolz, M.; Drnemann, D.
Purification, metal cofactor, N-terminal sequence and subunit composition of a 5-aminolevulinic acid dehydratase from the unicellular green alga Scenedesmus obliquus, mutant C-2A'
Eur. J. Biochem.
236
600-608
1996
Tetradesmus obliquus
Erskine, P.T.; Norton, E.; Cooper, J.B.; Lambert, R.; Coker, A.; Lewis, G.; Spencer, P.; Sarwar, M.; Wood, S.P.; Warren, M.J.; Shoolingin-Jordan, P.M.
X-ray structure of 5-aminolevulinic acid dehydratase from Escherichia coli complexed with the inhibitor levulinic acid at 2.0 A resolution
Biochemistry
38
4266-4276
1999
Escherichia coli (P0ACB2), Escherichia coli
Spencer, P.; Jordan, P.M.
Purification and characterization of 5-aminolevulinic acid dehydratase from Escherichia coli and a study of the reactive thiols at the metal-binding domain
Biochem. J.
290
279-287
1993
Escherichia coli
Gross, M.; Hessefort, S.; Olin, A.
Purification of a 38-kDa protein from rabbit reticulocyte lysate which promotes protein renaturation by heat shock protein 70 and its identification as delta-aminolevulinic acid dehydratase and as a putative DnaJ protein
J. Biol. Chem.
274
3125-3134
1999
Oryctolagus cuniculus
Guo, G.G.; Gu, M.; Etlinger, J.D.
240-kDa proteasome inhibitor (CF-2) is identical to delta-aminolevulinic acid dehydratase
J. Biol. Chem.
269
12399-12402
1994
Homo sapiens
Borralho, L.M.; Ortiz, C.H.D.; Panek, A.D.; Mattoon, J.R.
Purification of delta-aminolevulinate dehydratase from genetically engineered yeast
Yeast
6
319-330
1990
Saccharomyces cerevisiae
Conner, E.A.; Fowler, B.A.
Biochemical and immunological properties of hepatic delta-aminolevulinic acid dehydratase in channel catfish (Ictalurus punctatus)
Aquat. Toxicol.
28
37-52
1994
Ictalurus punctatus
-
Tomokuni, K.; Ichiba, M.; Hirai, Y.
Elevated urinary excretion of beta-aminoisobutyric acid and delta-aminolevulinic acid (ALA) and the inhibition of ALA-synthase and ALA-dehydratase activities in both liver and kidney in mice exposed to lead
Toxicol. Lett.
59
169-173
1991
Mus musculus
Jaffe, E.K.; Ali, S.; Mitchell, L.W.; Taylor, K.M.; Volin, M.; Markham, G.D.
Characterization of the role of the stimulatory magnesium of Escherichia coli porphobilinogen synthase
Biochemistry
34
244-251
1995
Escherichia coli
Cheung, K.M.; Spencer, P.; Timko, M.P.; Shoolingin-Jordan, P.M.
Characterization of a recombinant pea 5-aminolevulinic acid dehydratase and comparative inhibition studies with the Escherichia coli dehydratase
Biochemistry
36
1148-1156
1997
Pisum sativum
Petrovich, R.M.; Litwin, S.; Jaffe, E.K.
Bradyrhizobium japonicum porphobilinogen synthase uses two Mg(II) and monovalent cations
J. Biol. Chem.
271
8692-8699
1996
Bradyrhizobium japonicum
Frankenberg, N.; Jahn, D.; Jaffe, E.K.
Pseudomonas aeruginosa contains a novel type V porphobilinogen synthase with no required catalytic metal ions
Biochemistry
38
13976-13982
1999
Pseudomonas aeruginosa
Kervinen, J.; Dunbrack, R.L.; Litwin, S.; Martins, J.; Scarrow, R.C.; Volin, M.; Yeung, A.T.; Yoon, E.; Jaffe, E.K.
Porphobilinogen synthase from pea: expression from an artificial gene, kinetic characterization, and novel implications for subunit interactions
Biochemistry
39
9018-9029
2000
Pisum sativum
Jaffe, E.K.
The porphobilinogen synthase family of metalloenzymes
Acta Crystallogr. Sect. D
56
115-128
2000
Actinobacillus sp., Synechocystis sp., Aquifex sp., Archaeoglobus sp., Bordetella sp., Bradyrhizobium sp., Campylobacter sp., Candida sp. (in: Saccharomycetales), Caulobacter sp., Streptomyces sp., Chlamydia sp., Chlamydomonas sp., Clostridium sp., Deinococcus sp., Escherichia coli, Helicobacter sp., Homo sapiens, Methanobacterium sp., Methanococcus sp., Methanothermus sp., Mycobacterium sp., Neisseria sp., Physcomitrella sp., Pisum sativum, Propionibacterium sp., Rattus norvegicus, Rhodobacter sp., Rickettsia sp., Salmonella sp., Schizosaccharomyces sp., Shewanella sp., Vibrio sp., Yersinia sp., Saccharomyces cerevisiae (P05373), Pseudomonas aeruginosa (Q59643)
Mitchell, L.W.; Jaffe, E.K.
Porphobilinogen synthase from Escherichia coli is a Zn(II) metalloenzyme stimulated by Mg(II)
Arch. Biochem. Biophys.
300
169-177
1993
Escherichia coli
Hoffman, M.; Gora, M.; Rytka, J.
Identification of rate-limiting steps in yeast heme biosynthesis
Biochem. Biophys. Res. Commun.
310
1247-1253
2003
Saccharomyces cerevisiae
Erskine, P.T.; Coates, L.; Butler, D.; Youell, J.H.; Brindley, A.A.; Wood, S.P.; Warren, M.J.; Shoolingin-Jordan, P.M.; Cooper, J.B.
X-ray structure of a putative reaction intermediate of 5-aminolevulinic acid dehydratase
Biochem. J.
373
733-738
2003
Saccharomyces cerevisiae (P05373), Saccharomyces cerevisiae
Shoolingin-Jordan, P.M.; Spencer, P.; Sarwar, M.; Erskine, P.E.; Cheung, K.M.; Cooper, J.B.; Norton, E.B.
5-Aminolaevulinic acid dehydratase: metals, mutants and mechanism
Biochem. Soc. Trans.
30
584-590
2002
Escherichia coli
Nogueira, C.W.; Santos, F.W.; Soares, F.A.; Rocha, J.B.
2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid, and meso-2,3-dimercaptosuccinic acid inhibit delta-aminolevulinate dehydratase from human erythrocytes in vitro
Environ. Res.
94
254-261
2004
Homo sapiens
Jaffe, E.K.; Kervinen, J.; Martins, J.; Stauffer, F.; Neier, R.; Wlodawer, A.; Zdanov, A.
Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid
J. Biol. Chem.
277
19792-19799
2002
Escherichia coli (P0ACB2), Escherichia coli
Kundrat, L.; Martins, J.; Stith, L.; Dunbrack, R.L., Jr.; Jaffe, E.K.
A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase
J. Biol. Chem.
278
31325-31330
2003
Drosophila melanogaster
Dhanasekaran, S.; Chandra, N.R.; Chandrasekhar Sagar, B.K.; Rangarajan, P.N.; Padmanaban, G.
delta-Aminolevulinic acid dehydratase from Plasmodium falciparum: indigenous versus imported
J. Biol. Chem.
279
6934-6942
2004
Mus musculus, Plasmodium falciparum
Jaffe, E.K.
Investigations on the metal switch region of human porphobilinogen synthase
J. Biol. Inorg. Chem.
8
176-184
2003
Homo sapiens (P13716), Homo sapiens
Frere, F.; Schubert, W.D.; Stauffer, F.; Frankenberg, N.; Neier, R.; Jahn, D.; Heinz, D.W.
Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism
J. Mol. Biol.
320
237-247
2002
Pseudomonas aeruginosa (Q59643), Pseudomonas aeruginosa
Breinig, S.; Kervinen, J.; Stith, L.; Wasson, A.S.; Fairman, R.; Wlodawer, A.; Zdanov, A.; Jaffe, E.K.
Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase
Nat. Struct. Biol.
10
757-763
2003
Homo sapiens (P13716), Homo sapiens
Goodwin, C.E.; Leeper, F.J.
Stereochemistry and mechanism of the conversion of 5-aminolaevulinic acid into porphobilinogen catalysed by porphobilinogen synthase
Org. Biomol. Chem.
1
1443-1446
2003
Bacillus subtilis, Bos taurus
Bolzan, R.C.; Folmer, V.; Farina, M.; Zeni, G.; Nogueira, C.W.; Rocha, J.B.; Emanuelli, T.
delta-Aminolevulinate dehydratase inhibition by phenyl selenoacetylene: effect of reaction with hydrogen peroxide
Pharmacol. Toxicol.
90
214-219
2002
Cucumis sativus, Rattus norvegicus
Berthe, T.; Klein-Eude, D.; Balange, A.P.
Study of 5-aminolevulinate dehydratase in radish seedlings: are there housekeeping and light-induced enzymes?
Plant Sci.
164
395-405
2003
Raphanus sativus
-
Farina, M.; Brandao, R.; de Lara, F.S.; Pagliosa, L.B.; Soares, F.A.; Souza, D.O.; Rocha, J.B.
Profile of nonprotein thiols, lipid peroxidation and delta-aminolevulinate dehydratase activity in mouse kidney and liver in response to acute exposure to mercuric chloride and sodium selenite
Toxicology
184
179-187
2003
Mus musculus
Nogueira, C.W.; Soares, F.A.; Nascimento, P.C.; Muller, D.; Rocha, J.B.
2,3-Dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase mercury- and cadmium-induced inhibition of delta-aminolevulinate dehydratase
Toxicology
184
85-95
2003
Homo sapiens
Nogueira, C.W.; Borges, V.C.; Zeni, G.; Rocha, J.B.T.
Organochalcogens effects on D-aminolevulinate dehydratase activity from human erythrocytic cells in vitro
Toxicology
191
169-178
2003
Homo sapiens
Erskine, P.T.; Coates, L.; Newbold, R.; Brindley, A.A.; Stauffer, F.; Beaven, G.D.; Gill, R.; Coker, A.; Wood, S.P.; Warren, M.J.; Shoolingin-Jordan, P.M.; Neier, R.; Cooper, J.B.
Structure of yeast 5-aminolaevulinic acid dehydratase complexed with the inhibitor 5-hydroxylaevulinic acid
Acta Crystallogr. Sect. D
61
1222-1226
2005
Saccharomyces cerevisiae (P05373), Saccharomyces cerevisiae
Coates, L.; Beaven, G.; Erskine, P.T.; Beale, S.I.; Wood, S.P.; Shoolingin-Jordan, P.M.; Cooper, J.B.
Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor
Acta Crystallogr. Sect. D
61
1594-1598
2005
Prosthecochloris vibrioformis
Frankenberg, N.; Heinz, D.W.; Jahn, D.
Production, purification, and characterization of a Mg2+-responsive porphobilinogen synthase from pseudomonas aeruginosa
Biochemistry
38
13968-13975
1999
Pseudomonas aeruginosa
Bollivar, D.W.; Clauson, C.; Lighthall, R.; Forbes, S.; Kokona, B.; Fairman, R.; Kundrat, L.; Jaffe, E.K.
Rhodobacter capsulatus porphobilinogen synthase, a high activity metal ion independent hexamer
BMC Biochem.
5
17
2004
Rhodobacter capsulatus (Q6IVV3), Rhodobacter capsulatus
Gabriel, D.; Pivetta, L.; Folmer, V.; Soares, J.C.; Augusti, G.R.; Nogueira, C.W.; Zeni, G.; Rocha, J.B.
Human erythrocyte delta-aminolevulinate dehydratase inhibition by monosaccharides is not mediated by oxidation of enzyme sulfhydryl groups
Cell Biol. Int.
29
669-674
2005
Homo sapiens
Perottoni, J.; Lobato, L.P.; Silveira, A.; Rocha, J.B.; Emanuelli, T.
Effects of mercury and selenite on delta-aminolevulinate dehydratase activity and on selected oxidative stress parameters in rats
Environ. Res.
95
166-173
2004
Rattus norvegicus
Antunes Soares, F.; Farina, M.; Boettcher, A.C.; Braga, A.L.; Batista, T.R.J.
Organic and inorganic forms of selenium inhibited differently fish (Rhamdia quelen) and rat (Rattus norvergicus albinus) delta-aminolevulinate dehydratase
Environ. Res.
98
46-54
2005
Rattus norvegicus, Rhamdia quelen
Coates, L.; Beaven, G.; Erskine, P.T.; Beale, S.I.; Avissar, Y.J.; Gill, R.; Mohammed, F.; Wood, S.P.; Shoolingin-Jordan, P.; Cooper, J.B.
The X-ray structure of the plant like 5-aminolaevulinic acid dehydratase from Chlorobium vibrioforme complexed with the inhibitor laevulinic acid at 2.6 A resolution
J. Mol. Biol.
342
563-570
2004
Prosthecochloris vibrioformis
Jain, M.; Gadre, R.
Inhibition of 5-aminolevulinic acid dehydratase activity by arsenic in excised etiolated maize leaf segments during greening
J. Plant Physiol.
161
251-255
2004
Zea mays
Rocha, J.B.; Tuerlinckx, S.M.; Schetinger, M.R.; Folmer, V.
Effect of Group 13 metals on porphobilinogen synthase in vitro
Toxicol. Appl. Pharmacol.
200
169-176
2004
Bos taurus
Trevisan, A.; Borella-Venturini, M.; Di Marco, L.; Fabrello, A.; Giraldo, M.; Zanetti, E.; Marzano, C.; Fregona, D.
Erythrocyte aminolevulinic acid dehydratase inhibition by cis-platin
Toxicol. Lett.
152
105-110
2004
Rattus norvegicus
Folmer, V.; Bolzan, R.C.; Farina, M.; Zeni, G.; Nogueira, C.W.; Emanuelli, T.; Rocha, J.B.
Mechanism of delta-aminolevulinate dehydratase inhibition by phenyl selenoacetylene involves its conversion to diphenyl diselenide
Toxicology
206
403-411
2005
Rattus norvegicus
Baranauskiene, D.; Naginiene, R.; Kregzdyte, R.; Ryselis, S.; Abdrakhmanovas, O.
Application of D-aminolevulinic acid dehydratase test for the assessment of occupational long-term lead exposure
Trace Elem. Electrolytes
21
232-235
2004
Homo sapiens
-
Soares, J.C.; Gabriel, D.; Folmer, V.; Augusti, G.R.; Rocha, J.B.
High concentrations of glucose can activate or inhibit human erythrocyte aminolevulinate dehydratase in vitro depending exposure time
Am. J. Biochem. Biotechnol.
2
180-185
2006
Homo sapiens
-
Tahara, T.; Tanaka, M.; Nozaki, S.; Jin, G.; Onoe, H.; Watanabe, Y.
Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue
Biochem. Biophys. Res. Commun.
353
1068-1073
2007
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Frere, F.; Nentwich, M.; Gacond, S.; Heinz, D.W.; Neier, R.; Frankenberg-Dinkel, N.
Probing the active site of Pseudomonas aeruginosa porphobilinogen synthase using newly developed inhibitors
Biochemistry
45
8243-8253
2006
Pseudomonas aeruginosa (Q59643), Pseudomonas aeruginosa
da Silva, A.C.; Rocha, J.B.; Morsch, A.L.; Zanin, R.F.; Kaizer, R.; Maldonado, P.A.; Arantes, L.C.; Silva, L.A.; Morsch, V.M.; Schetinger, M.R.
Oxidative stress and delta-ALA-D activity in chronic renal failure patients
Biomed. Pharmacother.
61
180-185
2007
Homo sapiens
Peixoto, N.C.; Kratz, C.P.; Roza, T.; Morsch, V.M.; Pereira, M.E.
Effects of HgCl2 on porphobilinogen-synthase (E.C. 4.2.1.24) activity and on mercury levels in rats exposed during different precocious periods of postnatal life
Cell Biol. Int.
31
1057-1062
2007
Rattus norvegicus
Gacond, S.; Frere, F.; Nentwich, M.; Faurite, J.P.; Frankenberg-Dinkel, N.; Neier, R.
Synthesis of bisubstrate inhibitors of porphobilinogen synthase from Pseudomonas aeruginosa
Chem. Biodivers.
4
189-202
2007
Pseudomonas aeruginosa
Luchese, C.; Zeni, G.; Rocha, J.B.; Nogueira, C.W.; Santos, F.W.
Cadmium inhibits delta-aminolevulinate dehydratase from rat lung in vitro: interaction with chelating and antioxidant agents
Chem. Biol. Interact.
165
127-137
2007
Rattus norvegicus
Souza, J.B.; Rocha, J.B.; Nogueira, C.W.; Borges, V.C.; Kaizer, R.R.; Morsch, V.M.; Dressler, V.L.; Martins, A.F.; Flores, E.M.; Schetinger, M.R.
delta-Aminolevulinate dehydratase (delta-ALA-D) activity in diabetes and hypothyroidism
Clin. Biochem.
40
321-325
2007
Homo sapiens
Valentini, J.; Schmitt, G.C.; Grotto, D.; Santa Maria, L.D.; Boeira, S.P.; Piva, S.J.; Brucker, N.; Bohrer, D.; Pomblum, V.J.; Emanuelli, T.; Garcia, S.C.
Human erythrocyte delta-aminolevulinate dehydratase activity and oxidative stress in hemodialysis patients
Clin. Biochem.
40
591-594
2007
Homo sapiens
Golombieski, R.M.; Graichen, D.A.; Pivetta, L.A.; Nogueira, C.W.; Loreto, E.L.; Rocha, J.B.
Diphenyl diselenide [(PhSe)(2)] inhibits Drosophila melanogaster delta-aminolevulinate dehydratase (delta-ALA-D) gene transcription and enzyme activity
Comp. Biochem. Physiol. C Toxicol. Pharmacol.
147
198-204
2008
Mus musculus
Pereira, L.B.; Tabaldi, L.A.; Goncalves, J.F.; Jucoski, G.O.; Pauletto, M.M.; Weis, S.N.; Nicoloso, F.T.; Borher, D.; Rocha, J.B.; Schetinger, M.R.
Effect of aluminum on delta -aminolevulinic acid dehydratase (ALA-D) and the development of cucumber (Cucumis sativus)
Environ. Exp. Bot.
57
106-115
2006
Cucumis sativus
-
Kutlu, M.; Suemer, S.
Some biochemical properties of delta-aminolevulinic acid dehydratase in Gammarus pulex
Food Chem. Toxicol.
46
115-118
2008
Gammarus pulex
Tang, L.; Breinig, S.; Stith, L.; Mischel, A.; Tannir, J.; Kokona, B.; Fairman, R.; Jaffe, E.K.
Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins)
J. Biol. Chem.
281
6682-6690
2006
Homo sapiens (P13716), Homo sapiens
Kumar, P.; Bhatt, K.; Pant, S.C.; Satish, H.T.; Flora, S.J.
Effect of antioxidants on essential trace metals, glutathione, and delta-aminolevulinic acid dehydratase levels in rats
J. Cell Tissue Res.
7
1101-1105
2007
Rattus norvegicus
-
Kade, I.J.; Paixao, M.W.; Rodrigues, O.E.; Barbosa, N.B.; Braga, A.L.; Avila, D.S.; Nogueira, C.W.; Rocha, J.B.
Comparative studies on dicholesteroyl diselenide and diphenyl diselenide as antioxidant agents and their effect on the activities of Na(+)/K (+) ATPase and delta-aminolevulinic acid dehydratase in the rat brain
Neurochem. Res.
33
167-178
2008
Rattus norvegicus
Borges, V.C.; Dadalt, G.; Savegnago, L.; Moro, A.V.; Rocha, J.B.; Nogueira, C.W.
1,1,2-Tris-organoselenide alkene derivatives, but not 1,2-bis-organoselenide alkene derivatives, inhibited delta-aminolevulinate dehydratase activity from human erythrocytic cells in vitro
Toxicol. In Vitro
21
387-391
2007
Homo sapiens
Kokona, B.; Rigotti, D.J.; Wasson, A.S.; Lawrence, S.H.; Jaffe, E.K.; Fairman, R.
Probing the oligomeric assemblies of pea porphobilinogen synthase by analytical ultracentrifugation
Biochemistry
47
10649-10656
2008
Pisum sativum
Selwood, T.; Tang, L.; Lawrence, S.H.; Anokhina, Y.; Jaffe, E.K.
Kinetics and thermodynamics of the interchange of the morpheein forms of human porphobilinogen synthase
Biochemistry
47
3245-3257
2008
Homo sapiens (P13716), Homo sapiens
Barbosa, N.B.; Oliveira, C.; Araldi, D.; Folmer, V.; Rocha, J.B.; Nogueira, C.W.
Acute diphenyl diselenide treatment reduces hyperglycemia but does not change delta-aminolevulinate dehydratase activity in alloxan-induced diabetes in rats
Biol. Pharm. Bull.
31
2200-2204
2008
Rattus norvegicus
Li, N.; Chu, X.; Liu, X.; Li, D.
Probing the active site of rat porphobilinogen synthase using newly developed inhibitors
Bioorg. Chem.
37
33-40
2009
Rattus sp.
Lin, J.; Fu, W.; Cen, P.
Characterization of 5-aminolevulinate synthase from Agrobacterium radiobacter, screening new inhibitors for 5-aminolevulinate dehydratase from Escherichia coli and their potential use for high 5-aminolevulinate production
Biores. Technol.
100
2293-2297
2009
Escherichia coli, Escherichia coli Rosetta(DE3)
Kade, I.J.; Borges, V.C.; Savegnago, L.; Ibukun, E.O.; Zeni, G.; Nogueira, C.W.; Rocha, J.B.
Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats
Cell Biol. Toxicol.
25
415-424
2008
Rattus norvegicus
Inoue, R.; Akagi, R.
Co-synthesis of human delta-aminolevulinate dehydratase (ALAD) mutants with the wild-type enzyme in cell-free system-critical importance of conformation on enzyme activity-
J. Clin. Biochem. Nutr.
43
143-153
2008
Homo sapiens
Kalman, J.; Riba, I.; Blasco, J.; DelValls, T.A.
Is delta-aminolevulinic acid dehydratase activity in bivalves from south-west Iberian Peninsula a good biomarker of lead exposure?
Mar. Environ. Res.
66
38-40
2008
Chamelea gallina
Goncalves, T.L.; Benvegnu, D.M.; Bonfanti, G.; Frediani, A.V.; Rocha, J.B.
delta-Aminolevulinate dehydratase activity and oxidative stress during melphalan and cyclophosphamide-BCNU-etoposide (CBV) conditioning regimens in autologous bone marrow transplantation patients
Pharmacol. Res.
59
279-284
2008
Homo sapiens
Konuk, M.; Cigerci, I.H.; Aksan, S.; Korcan, S.E.
Isolation and biochemical characterization of delta-aminolevulinic acid dehydratase from Streptomyces yokosukanensis ATCC 25520
Prikl. Biokhim. Mikrobiol.
44
394-398
2008
Streptomyces yokosukanensis
Vanparys, C.; Dauwe, T.; Van Campenhout, K.; Bervoets, L.; De Coen, W.; Blust, R.; Eens, M.
Metallothioneins (MTs) and delta-aminolevulinic acid dehydratase (ALAd) as biomarkers of metal pollution in great tits (Parus major) along a pollution gradient
Sci. Total Environ.
401
184-193
2008
Parus major
Kade, I.J.; Paixao, M.W.; Rodrigues, O.E.; Ibukun, E.O.; Braga, A.L.; Zeni, G.; Nogueira, C.W.; Rocha, J.B.
Studies on the antioxidant effect and interaction of diphenyl diselenide and dicholesteroyl diselenide with hepatic delta-aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase
Toxicol. In Vitro
23
14-20
2009
Rattus norvegicus
Lobo, S.A.; Brindley, A.; Warren, M.J.; Saraiva, L.M.
Functional characterization of the early steps of tetrapyrrole biosynthesis and modification in Desulfovibrio vulgaris Hildenborough
Biochem. J.
420
317-325
2009
Desulfovibrio vulgaris (Q72DS3)
Heinemann, I.U.; Schulz, C.; Schubert, W.D.; Heinz, D.W.; Wang, Y.G.; Kobayashi, Y.; Awa, Y.; Wachi, M.; Jahn, D.; Jahn, M.
Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin
Antimicrob. Agents Chemother.
54
267-272
2010
Pseudomonas aeruginosa (Q59643), Pseudomonas aeruginosa
Fu, W.; Lin, J.; Cen, P.
Expression of a hemA gene from Agrobacterium radiobacter in a rare codon optimizing Escherichia coli for improving 5-aminolevulinate production
Appl. Biochem. Biotechnol.
160
456-466
2010
Agrobacterium tumefaciens
Goncalves, T.L.; Benvegnu, D.M.; Bonfanti, G.; Frediani, A.V.; Rocha, J.B.
Delta-ALA-D activity is a reliable marker for oxidative stress in bone marrow transplant patients
BMC Cancer
9
138
2009
Homo sapiens
Jia, H.; Ren, H.; Endo, H.; Hayashi, T.
Effect of cadmium binding form on rabbit aminolevulinate dehydratase in high molecular weight fraction of rainbow trout liver
Fish. Sci.
76
495-501
2010
Oncorhynchus mykiss
-
Lawrence, S.H.; Ramirez, U.D.; Selwood, T.; Stith, L.; Jaffe, E.K.
Allosteric inhibition of human porphobilinogen synthase
J. Biol. Chem.
284
35807-35817
2009
Homo sapiens (P13716), Homo sapiens
Shanmugam, D.; Wu, B.; Ramirez, U.; Jaffe, E.K.; Roos, D.S.
Plastid associated porphobilinogen synthase from toxoplasma gondii: kinetic and structural properties validate therapeutic potential
J. Biol. Chem.
285
22122-22131
2010
Toxoplasma gondii
Choiniere, J.R.; Scott, C.R.; Gelb, M.H.; Turecek, F.
Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry
Anal. Chem.
82
6730-6736
2010
Homo sapiens
Bonfanti, G.; Ceolin, R.B.; Valcorte, T.; De Bona, K.S.; de Lucca, L.; Goncalves, T.L.; Moretto, M.B.
delta-Aminolevulinate dehydratase activity in type 2 diabetic patients and its association with lipid profile and oxidative stress
Clin. Biochem.
44
1105-1109
2011
Homo sapiens
Bardag-Gorce, F.; French, S.W.
delta-Aminolevulinic dehydratase is a proteasome interacting protein
Exp. Mol. Pathol.
91
485-489
2011
Rattus norvegicus
Erdtman, E.; Bushnell, E.A.; Gauld, J.W.; Eriksson, L.A.
Computational insights into the mechanism of porphobilinogen synthase
J. Phys. Chem. B
114
16860-16870
2010
Saccharomyces cerevisiae
Franca, R.T.; DA Silva, A.S.; Wolkmer, P.; Oliveira, V.A.; Pereira, M.E.; Leal, M.L.; Silva, C.B.; Nunes, M.A.; Dressler, V.L.; Mazzanti, C.M.; Monteiro, S.G.; Lopes, S.T.
delta-Aminolevulinate dehydratase activity in red blood cells of rats infected with Trypanosoma evansi
Parasitology
138
1272-1277
2011
Rattus norvegicus, Rattus norvegicus Wistar
Sarangthem, J.; Jain, M.; Gadre, R.
Inhibition of delta-aminolevulinic acid dehydratase activity by cadmium in excised etiolated maize leaf segments during greening
Plant Soil Environ.
57
332-337
2011
Zea mays
-
Korcan, S.E.; Mutlu, M.B.; Cigerci, I.H.; Gven, K.; Konuk, M.; Kutlu, H.M.
delta-Aminolevulinic acid dehydratase of Haloarcula argentinensis isolated from Tuz Lake in Turkey
Environ. Monit. Assess.
169
229-236
2010
Haloarcula argentinensis
Brito, V.B.; Folmer, V.; Guerra, I.I.; Rocha, J.B.
Kinetics of alloxan-induced inhibition on delta-aminolevulinate dehydratase activity in mouse liver homogenates
Appl. Biochem. Biotechnol.
166
1047-1056
2012
Mus musculus
Schmatz, R.; Perreira, L.B.; Stefanello, N.; Mazzanti, C.; Spanevello, R.; Gutierres, J.; Bagatini, M.; Martins, C.C.; Abdalla, F.H.; Daci da Silva Serres, J.; Zanini, D.; Vieira, J.M.; Cardoso, A.M.; Schetinger, M.R.; Morsch, V.M.
Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats
Biochimie
94
374-383
2012
Rattus norvegicus
Vargas, L.M.; Soares, M.B.; Izaguirry, A.P.; Luedtke, D.S.; Braga, H.C.; Savegnago, L.; Wollenhaupt, S.; Brum, D.d.o.s..S.; Leivas, F.G.; Santos, F.W.
Cadmium inhibits the ovary delta-aminolevulinate dehydratase activity in vitro and ex vivo: protective role of seleno-furanoside
J. Appl. Toxicol.
33
679-684
2013
Mus musculus
Saraiva, R.A.; Bueno, D.C.; Nogara, P.A.; Rocha, J.B.
Molecular docking studies of disubstituted diaryl diselenides as mammalian delta-aminolevulinic acid dehydratase enzyme inhibitors
J. Toxicol. Environ. Health A
75
1012-1022
2012
Homo sapiens
Gupta, P.; Jain, M.; Sarangthem, J.; Gadre, R.
Inhibition of 5-aminolevulinic acid dehydratase by mercury in excised greening maize leaf segments
Plant Physiol. Biochem.
62
63-69
2013
Zea mays
Mills-Davies, N.; Butler, D.; Norton, E.; Thompson, D.; Sarwar, M.; Guo, J.; Gill, R.; Azim, N.; Coker, A.; Wood, S.; Erskine, P.; Coates, L.; Cooper, J.; Rashid, N.; Akhtar, M.; Shoolingin-Jordan, P.
Structural studies of substrate and product complexes of 5-aminolaevulinic acid dehydratase from humans, Escherichia coli and the hyperthermophile Pyrobaculum calidifontis
Acta Crystallogr. Sect. D
73
9-21
2017
Pyrobaculum calidifontis (A3MWV9), Pyrobaculum calidifontis, Escherichia coli (P0ACB2), Escherichia coli, Homo sapiens (P13716), Homo sapiens, Pyrobaculum calidifontis JCM 11548 (A3MWV9)
Jain, M.; Tiwary, S.; Gadre, R.
Modulation of delta-aminolevulinic acid dehydratase activity by the sorbitol-induced osmotic stress in maize leaf segments
Biochemistry (Moscow)
83
32-36
2018
Zea mays
Zanini, D.; Pelinson, L.; Schmatz, R.; Belmonte Pereira, L.; Curry Martins, C.; Baldissareli, J.; Pires Amaral, G.; Antunes Soares, F.; Brenner Reetz, L.; Araujo, M.; Chiesa, J.; Morsch, V.; Bitencourt Rosa Leal, D.; Schetinger, M.
delta-Aminolevulinate dehydratase activity in lung cancer patients and its relationship with oxidative stress
Biomed. Pharmacother.
68
603-609
2014
Homo sapiens
Espin, S.; Martinez-Lopez, E.; Jimenez, P.; Maria-Mojica, P.; Garcia-Fernandez, A.J.
Delta-aminolevulinic acid dehydratase (deltaALAD) activity in four free-living bird species exposed to different levels of lead under natural conditions
Environ. Res.
137
185-198
2015
Bubo bubo, Chroicocephalus genei, Gyps fulvus, Ichthyaetus audouinii
Chai, Q.; Shang, X.; Wu, S.; Zhu, G.; Cheng, C.; Cai, C.; Wang, X.; Guo, W.
5-aminolevulinic acid dehydratase gene dosage affects programmed cell death and immunity
Plant Physiol.
175
511-528
2017
Gossypium hirsutum
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