Reference on EC 4.2.1.10 - 3-dehydroquinate dehydratase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mitsuhashi, S.; Davis, B.D.
Aromatic biosynthesis. XII. Conversion of 5-dehydroquinic acid to 5-dehydroshikimic acid by 5-dehydroquinase
Biochim. Biophys. Acta
15
54-61
1954
Escherichia coli
Jacobson, J.W.; Hart, B.A.; Doy, C.H.; Giles, N.H.
Purification and stability of the multienzyme complex encoded in the arom gene cluster of Neurospora crassa
Biochim. Biophys. Acta
289
1-12
1972
Neurospora crassa
Hautala, J.A.; Jacobson, J.W.; Case, M.E.; Giles, N.H.
Purification and characterization of catabolic dehydroquinase, an enzyme in the inducible quinic acid catabolic pathway of Neurospora crassa
J. Biol. Chem.
250
6008-6014
1975
Neurospora crassa
Polley, L.D.
Purification and characterization of 3-dehydroquinate hydrolase and shikmate oxidoreductase. Evidence for a bifunctional enzyme
Biochim. Biophys. Acta
526
259-266
1978
Physcomitrium patens
Saijo, R.; Takeo, T.
Some properties of the initial four enzymes involved in shikimic acid biosynthesis in tea plant
Agric. Biol. Chem.
43
1427-1432
1979
Camellia sinensis
-
Bode, R.; Birnbaum, D.
Aggregation und Trennbarkeit der Enzyme des Shikimat-Pathway bei Hefen
Z. Allg. Mikrobiol.
21
417-422
1981
Saccharomyces cerevisiae, Meyerozyma guilliermondii, Wickerhamomyces anomalus, Cyberlindnera jadinii, Cyberlindnera fabianii, Ogataea henricii, Lodderomyces elongisporus, Neurospora crassa, Rhodotorula sphaerocarpa, Rhodotorula toruloides, Rhodotorula mucilaginosa, Saccharomycopsis lipolytica
Kinghorn, J.R.; Hawkins, A.R.
Cloning and expression in Escherichia coli K-12 of the biosynthetic dehydroquinase function of the arom cluster gene from the eucaryote, Aspergillus nidulans
Mol. Gen. Genet.
186
145-152
1982
Aspergillus nidulans
Catchside, D.E.A.; Storer, P.J.; Klein, B.
Cloning of the ARO cluster gene of Neurospora crassa and its expression in Escherichia coli
Mol. Gen. Genet.
199
446-451
1985
Neurospora crassa
Warburg, R.J.; Mahler, I.; Tipper, D.J.; Halvorson, H.O.
Cloning the Bacillus 168 aroC gene encoding dehydroquinase
Gene
32
57-66
1984
Bacillus subtilis, Bacillus subtilis 168
Hawkins, A.R.; Reinert, W.R.; Giles, N.H.
Characterization of Neurospora crassa catabolic dehydroquinase purified from N. crassa and Escherichia coli
Biochem. J.
203
769-773
1982
Neurospora crassa
Chaudhuri, S.; Lambert, J.M.; McColl, L.A.; Coggins, J.R.
Purification and characterization of 3-dehydroquinase from Escherichia coli
Biochem. J.
239
699-704
1986
Escherichia coli
Chaudhuri, S.; Duncan, K.; Coggins, J.R.
3-Dehydroquinate dehydratase from Escherichia coli
Methods Enzymol.
142
320-324
1987
Escherichia coli, Escherichia coli AB2848/pKD201
Mousdale, D.M.; Coggins, J.R.
Subcellular localization of the common shikimate-pathway enzymes in Pisum sativum L.
Planta
163
241-249
1985
Pisum sativum
da Silva, A.J.F.; Whittington, H.; Clements, J.; Roberts, C.; Hawkins, A.R
Sequence analysis and transformation by the catabolic 3-dehydroquinase (QUTE) gene from Aspergillus nidulans
Biochem. J.
240
481-488
1986
Aspergillus nidulans, Aspergillus nidulans WA53
Bottomley, J.R.; Clayton, C.L.; Chalk, P.A.; Kleanthous, C.
Cloning, sequencing, expression, purification and preliminary characterization of a type II dehydroquinase from Helicobacter pylori
Biochem. J.
319
559-565
1996
Helicobacter pylori
Gourley, D.G.; Coggins, J.R.; Isaacs, N.W.; Moore, J.D.; Charles, I.G.; Hwakins, A.R.
Crystallization of a type II dehydroquinase from Mycobacterium tuberculosis
J. Mol. Biol.
241
488-491
1994
Mycobacterium tuberculosis
Moore, J.D.; Hawkins, A.R.; Charles, I.G.; Deka, R.; Coggins, J.R.; Cooper, A.; Kelly, S.M.; Price, N.C.
Characterization of the type I dehydroquinase from Salmonella typhi
Biochem. J.
295
277-285
1993
Salmonella enterica subsp. enterica serovar Typhi
White, P.J.; Young, J.; Hunter, I.S.; Nimmo, H.G.; Coggins, J.R.
The purification and characterization of 3-dehydroquinase from Streptomyces coelicolor
Biochem. J.
265
735-738
1990
Streptomyces coelicolor
Moore, J.D.; Lamb, H.K.; Garbe, T.; Servos, S.; Dougan, G.; Charles, I.G.; Hawkins, A.R.
Inducible overproduction of the Aspergillus nidulans pentafunctional AROM protein and the type-I and -II 3-dehydroquinase from Salmonella typhi and Mycobacterium tuberculosis
Biochem. J.
287
173-181
1992
Aspergillus nidulans, Mycobacterium tuberculosis, Salmonella enterica subsp. enterica serovar Typhi
Deka, R.K.; Anton, I.A.; Dunbar, B.; Coggins, J.R.
The characterisation of the shikimate pathway enzyme dehydroquinase from Pisum sativum
FEBS Lett.
349
397-402
1994
Pisum sativum
Kleanthous, C.; Deka, R.; Davis, K.; Kelly, S.M.; Cooper, A.; Harding, S.E.; Price, N.C.; Hawkins, A.R.; Coggins, J.R.
A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes
Biochem. J.
282
687-695
1992
Aspergillus nidulans, Escherichia coli
Frederickson, M.; Parker, E.J.; Hawkins, A.R.; Coggins, J.R.; Abell, C.
Selective inhibition of type II dehydroquinases
J. Org. Chem.
64
2612-2613
1999
Aspergillus nidulans, Mycobacterium tuberculosis, Salmonella enterica subsp. enterica serovar Typhi, Streptomyces coelicolor
Gourley, D.G.; Shrive, A.K.; Polikarpov, I.; Krell, T.; Coggins, J.R.; Hawkins, A.R.; Isaacs, N.W.; Sawyer, L.
The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction
Nat. Struct. Biol.
6
521-525
1999
Helicobacter pylori, Salmonella enterica subsp. enterica serovar Typhi, Streptomyces coelicolor, Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis H37Rv (P9WPX7)
Euverink, G.J.W.; Hessels, G.I.; Vrijbloed, J.W.; Coggins, J.R.; Dijkhuizen, L.
Purification and characterization of a dual function 3-dehydroquinate dehydratase from Amycolatopsis methanolica
J. Gen. Microbiol.
138
2449-2457
1992
Amycolatopsis methanolica
Hawkins, A.R.; Moore, J.D.; Adeokun, A.M.
Characterization of the 3-dehydroquinase domain of the pentafunctional AROM protein, and the quinate dehydrogenase from Aspergillus nidulans, and the overproduction of the type II 3-dehydroquinase from Neurospora crassa
Biochem. J.
296
451-457
1993
Aspergillus nidulans, Neurospora crassa
Schmidt, C.L.; Grundemann, D.; Groth, G.; Muler, B.; Hennig, H.; Schultz, G.
Shikimate pathway in non-photosynthetic tissues. Identification of common enzymes and partial purification of dehydroquinate hydrolase-shikimate oxidoreductase and chorismate mutase from roots
J. Plant Physiol.
138
51-56
1991
Brassica rapa, Spinacia oleracea
-
Kwak, J.E.; Lee, J.Y.; Han, B.W.; Moon, J.J.; Sohn, S.H.; Suh, S.W.
Crystallization and preliminary X-ray crystallographic analysis of type II dehydroquinase from Helicobacter pylori
Acta Crystallogr. Sect. D
57
279-280
2001
Helicobacter pylori
Lee, W.H.; Perles, L.A.; Nagem, R.A.; Shrive, A.K.; Hawkins, A.; Sawyer, L.; Polikarpov, I.
Comparison of different crystal forms of 3-dehydroquinase from Salmonella typhi and its implication for the enzyme activity
Acta Crystallogr. Sect. D
58
798-804
2002
Salmonella enterica subsp. enterica serovar Typhi
Maes, D.; Gonzalez-Ramirez, L.A.; Lopez-Jaramillo, J.; Yu, B.; De Bondt, H.; Zegers, I.; Afonina, E.; Garcia-Ruiz, J.M.; Gulnik, S.
Structural study of the type II 3-dehydroquinate dehydratase from Actinobacillus pleuropneumoniae
Acta Crystallogr. Sect. D
60
463-471
2004
Actinobacillus pleuropneumoniae
Price, N.C.; Boam, D.J.; Kelly, S.M.; Duncan, D.; Krell, T.; Gourley, D.G.; Coggins, J.R.; Virden, R.; Hawkins, A.R.
The folding and assembly of the dodecameric type II dehydroquinases
Biochem. J.
338
195-202
1999
Mycobacterium tuberculosis, Streptomyces coelicolor
-
Evans, L.D.B.; Roszak, A.W.; Noble, L.J.; Robinson, D.A.; Chalk, P.A.; Matthews, J.L.; Coggins, J.R.; Price, N.C.; Lapthorn, A.J.
Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions
FEBS Lett.
530
24-30
2002
Streptomyces coelicolor, Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis H37Rv (P9WPX7)
Toscano, M.D.; Frederickson, M.; Evans, D.P.; Coggins, J.R.; Abell, C.; Gonzalez-Bello, C.
Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase
Org. Biomol. Chem.
1
2075-2083
2003
Streptomyces coelicolor
Lee, B.I.; Kwak, J.E.; Suh, S.W.
Crystal structure of the type II 3-dehydroquinase from Helicobacter pylori
Proteins Struct. Funct. Genet.
51
616-617
2003
Helicobacter pylori
Roszak, A.W.; Robinson, D.A.; Krell, T.; Hunter, I.S.; Fredrickson, M.; Abell, C.; Coggins, J.R.; Lapthorn, A.J.
The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor
Structure
10
493-503
2002
Streptomyces coelicolor (P15474), Streptomyces coelicolor
Sanchez-Sixto, C.; Prazeres, V.F.; Castedo, L.; Lamb, H.; Hawkins, A.R.; Gonzalez-Bello, C.
Structure-based design, synthesis, and biological evaluation of inhibitors of Mycobacterium tuberculosis type II dehydroquinase
J. Med. Chem.
48
4871-4881
2005
Mycobacterium tuberculosis
Robinson, D.A.; Stewart, K.A.; Price, N.C.; Chalk, P.A.; Coggins, J.R.; Lapthorn, A.J.
Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: New Directions for Inhibitor Design
J. Med. Chem.
49
1282-1290
2006
Helicobacter pylori (Q48255), Helicobacter pylori
Le Sann, C.; Gower, M.A.; Abell, A.D.
Inhibitors of types I and II dehydroquinase
Mini Rev. Med. Chem.
4
747-756
2004
Aspergillus nidulans, Mycobacterium tuberculosis, Salmonella enterica subsp. enterica serovar Typhimurium, Streptomyces coelicolor
Frederickson, M.; Roszak, A.W.; Coggins, J.R.; Lapthorn, A.J.; Abell, C.
(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases
Org. Biomol. Chem.
2
1592-1596
2004
Salmonella enterica subsp. enterica serovar Typhi, Streptomyces coelicolor (P15474), Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis H37Rv (P9WPX7)
Nichols, C.E.; Lockyer, M.; Hawkins, A.R.; Stammers, D.K.
Crystal structures of Staphylococcus aureus type I dehydroquinase from enzyme turnover experiments
Proteins
56
625-628
2004
Staphylococcus aureus
Stewart, K.A.; Robinson, D.A.; Lapthorn, A.J.
Type II dehydroquinase: molecular replacement with many copies
Acta Crystallogr. Sect. D
64
108-118
2008
Helicobacter pylori, Streptomyces coelicolor (P15474)
Singh, S.A.; Christendat, D.
Structure of Arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase and implications for metabolic channeling in the shikimate pathway
Biochemistry
45
7787-7796
2006
Arabidopsis thaliana (Q9SQT8)
Toscano, M.D.; Payne, R.J.; Chiba, A.; Kerbarh, O.; Abell, C.
Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism
ChemMedChem
2
101-112
2007
Mycobacterium tuberculosis, Salmonella enterica subsp. enterica serovar Typhi, Streptomyces coelicolor
Payne, R.J.; Peyrot, F.; Kerbarh, O.; Abell, A.D.; Abell, C.
Rational design, synthesis, and evaluation of nanomolar type II dehydroquinase inhibitors
ChemMedChem
2
1015-1029
2007
Mycobacterium tuberculosis, Streptomyces coelicolor
Prazeres, V.F.; Sanchez-Sixto, C.; Castedo, L.; Lamb, H.; Hawkins, A.R.; Riboldi-Tunnicliffe, A.; Coggins, J.R.; Lapthorn, A.J.; Gonzalez-Bello, C.
Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase
ChemMedChem
2
194-207
2007
Mycobacterium tuberculosis, Streptomyces coelicolor
Ding, L.; Hofius, D.; Hajirezaei, M.R.; Fernie, A.R.; Boernke, F.; Sonnewald, U.
Functional analysis of the essential bifunctional tobacco enzyme 3-dehydroquinate dehydratase/shikimate dehydrogenase in transgenic tobacco plants
J. Exp. Bot.
58
2053-2067
2007
Nicotiana tabacum (Q6PUF9), Nicotiana tabacum (Q6PUG0), Nicotiana tabacum
Smith, N.N.; Gallagher, D.T.
Structure and lability of archaeal dehydroquinase
Acta Crystallogr. Sect. F
64
886-892
2008
Archaeoglobus fulgidus (O30011), Archaeoglobus fulgidus
Liu, J.S.; Cheng, W.C.; Wang, H.J.; Chen, Y.C.; Wang, W.C.
Structure-based inhibitor discovery of Helicobacter pylori dehydroquinate synthase
Biochem. Biophys. Res. Commun.
373
1-7
2008
Helicobacter pylori
Adachi, O.; Ano, Y.; Toyama, H.; Matsushita, K.
A novel 3-dehydroquinate dehydratase catalyzing extracellular formation of 3-dehydroshikimate by oxidative fermentation of Gluconobacter oxydans IFO 3244
Biosci. Biotechnol. Biochem.
72
1475-1482
2008
Gluconobacter oxydans, Gluconobacter oxydans IFO 3244
Sanchez-Sixto, C.; Prazeres, V.F.; Castedo, L.; Suh, S.W.; Lamb, H.; Hawkins, A.R.; Canada, F.J.; Jimenez-Barbero, J.; Gonzalez-Bello, C.
Competitive inhibitors of Helicobacter pylori type II dehydroquinase: synthesis, biological evaluation, and NMR studies
ChemMedChem
3
756-770
2008
Helicobacter pylori (Q48255), Helicobacter pylori
Han, J.; Lee, K.; Yoon, M.; Kang, S.; Kim, G.
Cold stress regulation of a bi-functional 3-dehydroquinate dehydratase/shikimate dehydrogenase (DHQ/SDH)-like gene in the freshwater green alga Spirogyra varians
Botanica Marina
52
178-185
2009
Spirogyra varians
-
Prazeres, V.; Castedo, L.; Lamb, H.; Hawkins, A.; Gonzlez-Bello, C.
2-Substituted-3-dehydroquinic acids as potent competitive inhibitors of type II dehydroquinase
ChemMedChem
4
1980-1984
2009
Mycobacterium tuberculosis (P9WPX7), Helicobacter pylori (Q48255), Mycobacterium tuberculosis H37Rv (P9WPX7)
Blomberg, L.; Mangold, M.; Mitchell, J.; Blumberger, J.
Theoretical study of the reaction mechanism of Streptomyces coelicolor type II dehydroquinase
J. Chem. Theory Comput.
5
1284-1294
2009
Streptomyces coelicolor (P15474), Streptomyces coelicolor
Prazeres, V.F.; Tizon, L.; Otero, J.M.; Guardado-Calvo, P.; Llamas-Saiz, A.L.; van Raaij, M.J.; Castedo, L.; Lamb, H.; Hawkins, A.R.; Gonzalez-Bello, C.
Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues
J. Med. Chem.
53
191-200
2010
Helicobacter pylori (Q48255), Helicobacter pylori
Dias, M.V.; Snee, W.C.; Bromfield, K.M.; Payne, R.J.; Palaninathan, S.K.; Ciulli, A.; Howard, N.I.; Abell, C.; Sacchettini, J.C.; Blundell, T.L.
Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis
Biochem. J.
436
729-739
2011
Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPX7)
Light, S.H.; Minasov, G.; Shuvalova, L.; Peterson, S.N.; Caffrey, M.; Anderson, W.F.; Lavie, A.
A conserved surface loop in type I dehydroquinate dehydratases positions an active site arginine and functions in substrate binding
Biochemistry
50
2357-2363
2011
no activity in Homo sapiens, Salmonella enterica (P58687), Salmonella enterica
Shinagawa, E.; Adachi, O.; Ano, Y.; Yakushi, T.; Matsushita, K.
Purification and characterization of membrane-bound 3-dehydroshikimate dehydratase from Gluconobacter oxydans IFO 3244, a new enzyme catalyzing extracellular protocatechuate formation
Biosci. Biotechnol. Biochem.
74
1084-1088
2010
Gluconobacter oxydans, Gluconobacter oxydans IFO 3244
Peon, A.; Otero, J.M.; Tizon, L.; Prazeres, V.F.; Llamas-Saiz, A.L.; Fox, G.C.; van Raaij, M.J.; Lamb, H.; Hawkins, A.R.; Gago, F.; Castedo, L.; Gonzalez-Bello, C.
Understanding the key factors that control the inhibition of type II dehydroquinase by (2R)-2-benzyl-3-dehydroquinic acids
ChemMedChem
5
1726-1733
2010
Mycobacterium tuberculosis, Helicobacter pylori (Q48255), Helicobacter pylori
Tran, A.; Cergol, K.; West, N.; Randall, E.; Britton, W.; Bokhari, S.; Ibrahim, M.; Lapthorn, A.; Payne, R.
Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads
ChemMedChem
6
262-265
2011
Mycobacterium tuberculosis, Streptomyces coelicolor (P15474), Helicobacter pylori (Q48255)
Paz, S.; Tizon, L.; Otero, J.; Llamas-Saiz, A.; Fox, G.; Van Raaij, M.; Lamb, H.; Hawkins, A.; Lapthorn, A.; Castedo, L.; Gonzalez-Bello, C.
Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase
ChemMedChem
6
266-272
2011
Helicobacter pylori, Mycobacterium tuberculosis, Streptomyces coelicolor
Light, S.H.; Minasov, G.; Shuvalova, L.; Duban, M.E.; Caffrey, M.; Anderson, W.F.; Lavie, A.
Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates
J. Biol. Chem.
286
3531-3539
2011
Clostridioides difficile, Salmonella enterica (P58687), Salmonella enterica, Clostridioides difficile 630, Salmonella enterica LT2 (P58687)
Tran, A.; Cergol, K.; Britton, W.; Imran Bokhari, S.; Ibrahim, M.; Lapthorn, A.; Payne, R.
Rapid assembly of potent type II dehydroquinase inhibitors via 'click' chemistry
MedChemComm
1
271-275
2010
Helicobacter pylori, Mycobacterium tuberculosis, Streptomyces coelicolor
-
Nishikura-Imamura, S.; Matsutani, M.; Insomphun, C.; Vangnai, A.S.; Toyama, H.; Yakushi, T.; Abe, T.; Adachi, O.; Matsushita, K.
Overexpression of a type II 3-dehydroquinate dehydratase enhances the biotransformation of quinate to 3-dehydroshikimate in Gluconobacter oxydans
Appl. Microbiol. Biotechnol.
98
2955-2963
2014
Gluconobacter oxydans (W6JLW3), Gluconobacter oxydans, Gluconobacter oxydans NBRC3244 (W6JLW3)
Devi, A.S.; Ebihara, A.; Kuramitsu, S.; Yokoyama, S.; Kumarevel, T.; Ponnuraj, K.
Crystal structure of type I 3-dehydroquinate dehydratase of Aquifex aeolicus suggests closing of active site flap is not essential for enzyme action
Biochem. Biophys. Res. Commun.
432
350-354
2013
Aquifex aeolicus
Coderch, C.; Lence, E.; Peon, A.; Lamb, H.; Hawkins, A.R.; Gago, F.; Gonzalez-Bello, C.
Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases
Biochem. J.
458
547-557
2014
Helicobacter pylori, Mycobacterium tuberculosis
Light, S.H.; Antanasijevic, A.; Krishna, S.N.; Caffrey, M.; Anderson, W.F.; Lavie, A.
Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation
Biochemistry
53
872-880
2014
Salmonella enterica (P58687), Salmonella enterica
Blanco, B.; Sedes, A.; Peon, A.; Otero, J.M.; van Raaij, M.J.; Thompson, P.; Hawkins, A.R.; Gonzalez-Bello, C.
Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors
J. Med. Chem.
57
3494-3510
2014
Helicobacter pylori, Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis
Yao, Y.; Li, Z.S.
New insights into the mechanism of the Schiff base hydrolysis catalyzed by type I dehydroquinate dehydratase from S. enterica: a theoretical study
Org. Biomol. Chem.
10
7037-7044
2012
Salmonella enterica
Ratia, K.; Light, S.H.; Antanasijevic, A.; Anderson, W.F.; Caffrey, M.; Lavie, A.
Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase
PLoS ONE
9
e89356
2014
Clostridioides difficile
Light, S.H.; Anderson, W.F.; Lavie, A.
Reassessing the type I dehydroquinate dehydratase catalytic triad: kinetic and structural studies of Glu86 mutants
Protein Sci.
22
418-424
2013
Salmonella enterica (P58687), Salmonella enterica
Reiling, S.; Kelleher, A.; Matsumoto, M.; Robinson, G.; Asojo, O.
Structure of type II dehydroquinase from Pseudomonas aeruginosa
Acta Crystallogr. Sect. F
70
1485-1491
2014
Pseudomonas aeruginosa (O30557), Pseudomonas aeruginosa, Pseudomonas aeruginosa DSM (O30557)
Liu, C.; Liu, Y.; Sun, Q.; Jiang, C.; Liu, S.
Unraveling the kinetic diversity of microbial 3-dehydroquinate dehydratases of shikimate pathway
AMB Express
5
007
2015
Acetivibrio clariflavus (G8M0G7), Acetivibrio clariflavus DSM 19732 (G8M0G7), Alcanivorax borkumensis (Q0VMZ2), Alcanivorax borkumensis SK-2 (Q0VMZ2), Alicyclobacillus acidocaldarius (B7DR33), Alicyclobacillus acidocaldarius LAA1 (B7DR33), Arthrobacter crystallopoietes (N1V364), Arthrobacter crystallopoietes BAB-32 (N1V364), Bacillus subtilis (P54517), Bacillus subtilis 168 (P54517), Butyrivibrio crossotus (D4S0D1), Butyrivibrio crossotus DSM 2876 (D4S0D1), Citrobacter koseri (A8AQF2), Citrobacter koseri ATCC BAA-895 (A8AQF2), Corynebacterium glutamicum (O52377), Corynebacterium glutamicum, Corynebacterium glutamicum DSM 20300 (O52377), Escherichia coli (P05194), Escherichia coli, Geobacillus sp. Y4.1MC1, Gluconobacter oxydans (WP_011252021), Gluconobacter oxydans 621-H (WP_011252021), Halanaerobium hydrogeniformans (E4RLB7), Klebsiella aerogenes (A0A0H3FM50), Klebsiella aerogenes DSM 30053 (A0A0H3FM50), Klebsiella pneumoniae (EMH96211.1), Klebsiella pneumoniae RYC492 (EMH96211.1), Lancefieldella rimae (B9CK59), Lancefieldella rimae ATCC 49626 (B9CK59), Micromonospora lupini (I0L192), Micromonospora lupini Lupac 08 (I0L192), Mycobacterium tuberculosis (WP_003413001), Mycobacterium tuberculosis KZN 1435 (WP_003413001), Natranaerobius thermophilus (B2A551), Natranaerobius thermophilus DSM 18059 (B2A551), Pseudomonas putida (Q88IJ6), Pseudomonas putida DSM 6125 (Q88IJ6), Psychrobacter sp. PRwf-1 (A5WDH9), Psychromonas ingrahamii (A1SZA3), Psychromonas ingrahamii 37 (A1SZA3), Ruminococcus champanellensis (D4LCT8), Ruminococcus champanellensis DSM 18848 (D4LCT8), Streptomyces acidiscabies (A0A124C1Y7), Thermodesulfobium narugense (M1E6S9), Thermodesulfobium narugense DSM 14796 (M1E6S9), Thermomonospora curvata (D1A7X0), Thermomonospora curvata DSM 43183 (D1A7X0), Xylella fastidiosa (Q9PH97), Xylella fastidiosa 9a5c (Q9PH97)
Maneiro, M.; Peon, A.; Lence, E.; Otero, J.M.; Van Raaij, M.J.; Thompson, P.; Hawkins, A.R.; Gonzalez-Bello, C.
Insights into substrate binding and catalysis in bacterial type I dehydroquinase
Biochem. J.
462
415-424
2014
Mycobacterium tuberculosis, Salmonella enterica subsp. enterica serovar Typhi (P24670), Salmonella enterica subsp. enterica serovar Typhi
de Avila, M.B.; de Azevedo, W.F.
Development of machine learning models to predict inhibition of 3-dehydroquinate dehydratase
Chem. Biol. Drug Des.
92
1468-1474
2018
Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis H37Rv (P9WPX7)
Howard, N.I.; Dias, M.V.; Peyrot, F.; Chen, L.; Schmidt, M.F.; Blundell, T.L.; Abell, C.
Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis
ChemMedChem
10
116-133
2015
Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WPX7)
Peon, A.; Robles, A.; Blanco, B.; Convertino, M.; Thompson, P.; Hawkins, A.R.; Caflisch, A.; Gonzalez-Bello, C.
Reducing the flexibility of type II dehydroquinase for inhibition a fragment-based approach and molecular dynamics study
ChemMedChem
12
1512-1524
2017
Helicobacter pylori (Q48255), Helicobacter pylori, Helicobacter pylori 26695 (Q48255)
Iqbal, N.; Kumar, M.; Sharma, P.; Yadav, S.P.; Kaur, P.; Sharma, S.; Singh, T.P.
Binding studies and structure determination of the recombinantly produced type-II 3-dehydroquinate dehydratase from Acinetobacter baumannii
Int. J. Biol. Macromol.
94
459-465
2017
Acinetobacter baumannii (A3M692), Acinetobacter baumannii, Acinetobacter baumannii ATCC 17978 (A3M692)
Petersen, G.O.; Saxena, S.; Renuka, J.; Soni, V.; Yogeeswari, P.; Santos, D.S.; Bizarro, C.V.; Sriram, D.
Structure-based virtual screening as a tool for the identification of novel inhibitors against Mycobacterium tuberculosis 3-dehydroquinate dehydratase
J. Mol. Graph. Model.
60
124-131
2015
Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPX7)
Tizon, L.; Maneiro, M.; Peon, A.; Otero, J.M.; Lence, E.; Poza, S.; van Raaij, M.J.; Thompson, P.; Hawkins, A.R.; Gonzalez-Bello, C.
Irreversible covalent modification of type I dehydroquinase with a stable Schiff base
Org. Biomol. Chem.
13
706-716
2015
Salmonella enterica subsp. enterica serovar Typhi (P24670), Salmonella enterica subsp. enterica serovar Typhi
Lence, E.; van der Kamp, M.W.; Gonzalez-Bello, C.; Mulholland, A.J.
QM/MM simulations identify the determinants of catalytic activity differences between type II dehydroquinase enzymes
Org. Biomol. Chem.
16
4443-4455
2018
Mycobacterium tuberculosis (P9WPX7), Mycobacterium tuberculosis, Helicobacter pylori (Q48255), Helicobacter pylori, Helicobacter pylori ATCC 700392 (Q48255), Mycobacterium tuberculosis H37Rv (P9WPX7)
Cheung, V.W.; Xue, B.; Hernandez-Valladares, M.; Go, M.K.; Tung, A.; Aguda, A.H.; Robinson, R.C.; Yew, W.S.
Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis
PLoS ONE
9
e103598
2014
Enterococcus faecalis (P36923), Enterococcus faecalis, Enterococcus faecalis ATCC 700802 (P36923)
Tahara, K.; Nishiguchi, M.; Funke, E.; Miyazawa, S.I.; Miyama, T.; Milkowski, C.
Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis
Planta
253
3
2020
Eucalyptus camaldulensis (A0A5H2WZU5), Eucalyptus camaldulensis (A0A5H2X4C4), Eucalyptus camaldulensis
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