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Information on EC 4.1.99.12 - 3,4-dihydroxy-2-butanone-4-phosphate synthase

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.99 Other carbon-carbon lyases
                4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase
IUBMB Comments
Requires a divalent cation, preferably Mg2+, for activity . The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5 . The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin .
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Word Map
  • 4.1.99.12
  • disinfection
  • trihalomethanes
  • haloacetic
  • brominate
  • chloramination
  • halogen
  • bromide
  • haloacetonitriles
  • chloroform
  • ozone
  • swimming
  • dichloroacetic
  • humic
  • genotoxic
  • wastewater
  • monochloramine
  • dichloroacetonitrile
  • carbonaceous
  • bromoform
  • river
  • halide
  • bromodichloromethane
  • iodinated
  • indoor
  • n-nitrosodimethylamine
  • diastolic
  • speciation
  • chloral
  • non-regulated
  • potable
  • excitation-emission
  • synthesis
  • shower
  • swimmers
  • influent
  • biofiltration
  • full-scale
  • drinking-water
  • bromoacetic
  • iodate
  • nanofiltration
  • ballast
  • municipal
  • hypochlorite
  • chcl3
  • chlorite
  • toilet
  • clo2
  • n-nitrosamines
  • drug development
  • fulvic
  • acid-like
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
dbps, dhbps, mtb-dhbps, mtb-riba2, atriba1, dhbp synthase, atriba2, dihydroxybutanone phosphate synthase, dhbps/gchii, l-3,4-dihydroxy-2-butanone-4-phosphate synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate
show the reaction diagram
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