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Information on EC - tRNA 4-demethylwyosine synthase (AdoMet-dependent)

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
       tRNA 4-demethylwyosine synthase (AdoMet-dependent)
IUBMB Comments
This enzyme, which is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes, binds two [4Fe-4S] clusters [3,4]. Carbons C2 and C3 from pyruvate are incorporated into 4-demethylwyosine . The enzyme is found in eukaryotes where it is part of the pathway for wybutosine synthesis, and in archaea, where it is involved in the biosynthesis of archaeal wye bases, such as wyosine, isowyosine, and methylwyosine.
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The enzyme appears in viruses and cellular organisms
4-demethylwyosine synthase, Taw1, tRNA wyosine derivatives biosynthesis protein Taw1, TYW1, YPL207W, more
N1-methylguanine37 in tRNAPhe + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine37 in tRNAPhe + L-methionine + 5'-deoxyadenosine + CO2 + H2O
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