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Information on EC 4.1.3.27 - anthranilate synthase

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.3 Oxo-acid-lyases
                4.1.3.27 anthranilate synthase
IUBMB Comments
In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase ), EC 4.1.1.48 (indole-3-glycerol-phosphate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)]. The native enzyme in the complex uses either glutamine or, less efficiently, NH3. The enzyme separated from the complex uses NH3 only.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
anthranilate synthase, anthranilate synthetase, oasa1d, oasa1, oasa2, phnab, anthranilate synthase component i, trped, anthranilate synthase-phosphoribosyltransferase, caasa1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate
show the reaction diagram