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Information on EC 4.1.2.43 - 3-hexulose-6-phosphate synthase

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.43 3-hexulose-6-phosphate synthase
IUBMB Comments
Requires Mg2+ or Mn2+ for maximal activity . The enzyme is specific for D-ribulose 5-phosphate as substrate as ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. In addition to formaldehyde, the enzyme can also use glycolaldehyde and methylglyoxal . This enzyme, along with EC 5.3.1.27, 6-phospho-3-hexuloisomerase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds . The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of this enzyme and EC 5.3.1.27, 6-phospho-3-hexuloisomerase . This enzyme is a member of the orotidine 5'-monophosphate decarboxylase (OMPDC) suprafamily .
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
3-hexulosephosphate synthase, hexulose-6-phosphate synthase, hps-phi, hps/phi, 3-hexulose phosphate synthase, hexose phosphate synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde
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