Reference on EC 4.1.1.90 - peptidyl-glutamate 4-carboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hubbard, B.R.; Ulrich, M.M.W.; Jacobs, M.; Vermeer, C.; Walsh, C.; Furie, B.; Furie, B.C.
Vitamin K-dependent carboxylase: affinity purification from bovine liver by using a synthetic propeptide containing the gamma-carboxylation recognition site
Proc. Natl. Acad. Sci. USA
86
6893-6897
1989
Bos taurus (Q07175), Bos taurus
Sugiura, I.; Furie, B.; Walsh, C.T.; Furie, B.C.
Profactor IX propeptide and glutamate substrate binding sites on the vitamin K-dependent carboxylase identified by site-directed mutagenesis
J. Biol. Chem.
271
17837-17844
1996
Bos taurus (Q07175), Bos taurus
Rishavy, M.A.; Hallgren, K.W.; Yakubenko, A.V.; Shtofman, R.L.; Runge, K.W.; Berkner, K.L.
Bronsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation
Biochemistry
45
13239-13248
2006
Homo sapiens
Suttie, J.W.
Vitamin K-dependent carboxylase
Annu. Rev. Biochem.
54
459-477
1985
Rattus norvegicus
Berkner, K.L.
The vitamin K-dependent carboxylase
Annu. Rev. Nutr.
25
127-149
2005
Homo sapiens
Canfield, L.M.
Vitamin K-dependent oxygenase/carboxylase; differential inactivation by sulfhydryl reagents
Biochem. Biophys. Res. Commun.
148
184-191
1987
Rattus norvegicus (O88496)
Romero, E.E.; Deo, R.; Velazquez-Estades, L.J.; Roth, D.A.
Cloning, structural organization, and transcriptional activity of the rat vitamin K-dependent gamma-glutamyl carboxylase gene
Biochem. Biophys. Res. Commun.
248
783-788
1998
Rattus norvegicus (O88496)
Yamada, M.; Kuliopulos, A.; Nelson, N.P.; Roth, D.A.; Furie, B.; Furie, B.C.; Walsh, C.T.
Localization of the factor IX propeptide binding site on recombinant vitamin K dependent carboxylase using benzoylphenylalanine photoaffinity peptide inactivators: carboxylase using benzoylphenylalanine photoaffinity peptide inactivators
Biochemistry
34
481-489
1995
Bos taurus (Q07175)
Tie, J.K.; Zheng, M.Y.; Hsiao, K.L.; Perera, L.; Stafford, D.W.; Straight, D.L.
Transmembrane domain interactions and residue proline 378 are essential for proper structure, especially disulfide bond formation, in the human vitamin K-dependent gamma-glutamyl carboxylase
Biochemistry
47
6301-6310
2008
Homo sapiens
Helgeland, L.
The submicrosomal site for the conversion of prothrombin precursor to biologically active prothrombin in rat liver
Biochim. Biophys. Acta
499
181-193
1977
Rattus norvegicus (O88496)
Zhu, A.; Sun, H.; Raymond, R.M. Jr.; Furie, B.C.; Furie, B.; Bronstein, M.; Kaufman, R.J.; Westrick, R.; Ginsburg, D.
Fatal hemorrhage in mice lacking (gamma)-glutamyl carboxylase
Blood
109
5270-5275
2007
Mus musculus
Tie, J.; Wu, S.; Jin, D.; Nicchitta, C.V.; Stafford, D.W.
A topological study of the human gamma-glutamyl carboxylase
Blood
96
973-978
2000
Homo sapiens (P38435), Homo sapiens
Czerwiec, E.; Begley, G.S.; Bronstein, M.; Stenflo, J.; Taylor, K.; Furie, B.C.; Furie, B.
Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile
Eur. J. Biochem.
269
6162-6172
2002
Conus textile (Q8IA33), Conus textile
Romero, E.E.; Velazquez-Estades, L.J.; Deo, R.; Schapiro, B.; Roth, D.A.
Cloning of rat vitamin K-dependent gamma-glutamyl carboxylase and developmentally regulated gene expression in postimplantation embryos
Exp. Cell Res.
243
334-346
1998
Rattus norvegicus (O88496)
Maillet, M.; Morris, D.; Gaudry, M.; Marquet, A.
The active site region of the vitamin K-dependent carboxylase includes both the amino-terminal hydrophobic and carboxy-terminal hydrophilic domains of the protein
FEBS Lett.
413
1-6
1997
Bos taurus (Q07175)
Morris, D.P.; Soute, B.A.; Vermeer, C.; Stafford, D.W.
Characterization of the purified vitamin K-dependent gamma-glutamyl carboxylase
J. Biol. Chem.
268
8735-8742
1993
Bos taurus (Q07175), Bos taurus
Kuliopulos, A.; Nelson, N.P.; Yamada, M.; Walsh, C.T.; Furie, B.; Furie, B.C.; Roth, D.A.
Localization of the affinity peptide-substrate inactivator site on recombinant vitamin K-dependent carboxylase
J. Biol. Chem.
269
21364-21370
1994
Bos taurus (Q07175), Bos taurus
Wu, S.M.; Mutucumarana. V.P.; Geromanos, S.; Stafford, D.W.
The propeptide binding site of the bovine gamma-glutamyl carboxylase
J. Biol. Chem.
272
11718-11722
1997
Bos taurus (Q07175), Bos taurus
Walker, C.S.; Shetty, R.P.; Clark, K.; Kazuko, S.G.; Letsou, A.; Olivera, B.M.; Bandyopadhyay, P.K.
On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila
J. Biol. Chem.
276
7769-7774
2001
Drosophila melanogaster (Q9W0C4), Drosophila melanogaster
Mutucumarana, V.P.; Acher, F.; Straight, D.L.; Jin, D.Y.; Stafford, D.W.
A conserved region of human vitamin K-dependent carboxylase between residues 393 and 404 is important for its interaction with the glutamate substrate
J. Biol. Chem.
278
46488-46493
2003
Homo sapiens (P38435), Homo sapiens
Vanakker, O.M.; Martin, L.; Gheduzzi, D.; Leroy, B.P.; Loeys, B.L.; Guerci, V.I.; Matthys, D; Terry, S.F.; Coucke, P.J.; Pasquali-Ronchetti, I.; De Paepe, A.
Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity
J. Invest. Dermatol.
127
581-587
2007
Homo sapiens (P38435)
Crosier, M.D.; Peter, I.; Booth, S.L.; Bennett, G.; Dawson-Hughes, B.; Ordovas, J.M.
Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status
J. Nutr. Sci. Vitaminol.
55
112-119
2009
Homo sapiens
Stafford, D.W.
The vitamin K cycle
J. Thromb. Haemost.
3
1873-1878
2005
Homo sapiens
Kulman, J.D.; Harris, J.E.; Nakazawa, N.; Ogasawara, M.; Satake, M.; Davie, E.W.
Vitamin K-dependent proteins in Ciona intestinalis, a basal chordate lacking a blood coagulation cascade
Proc. Natl. Acad. Sci. USA
103
15794-15799
2006
Ciona intestinalis (Q008V9), Ciona intestinalis
Wu, S.M.; Morris, D.P.; Stafford, D.W.
Identification and purification to near homogeneity of the vitamin K-dependent carboxylase
Proc. Natl. Acad. Sci. USA
88
2236-2240
1991
Bos taurus (Q07175), Bos taurus
Price, P.A.; Williamson, M.K.
Substrate recognition by the vitamin K-dependent gamma-glutamyl carboxylase: Identification of a sequence homology between the carboxylase and the carboxylase recognition site in the substrate
Protein Sci.
2
1987-1988
1993
Homo sapiens (P38435), Bos taurus (Q07175)
Wu, S.M.; Cheung, W.F.; Frazier, D.; Stafford, D.W.
Cloning and expression of the cDNA for human gamma-glutamyl carboxylase
Science
13
1634-1636
1991
Homo sapiens (P38435), Homo sapiens
Harbeck, M.C.; Cheung, A.Y.; Suttie, J.W.
Vitamin K-dependent carboxylase: partial purification of the enzyme by antibody affinity techniques
Thromb. Res.
56
317-323
1989
Bos taurus (Q07175), Bos taurus
Li, Q.; Schurgers, L.J.; Smith, A.C.; Tsokos, M.; Uitto, J.; Cowen, E.W.
Co-existent pseudoxanthoma elasticum and vitamin K-dependent coagulation factor deficiency: compound heterozygosity for mutations in the GGCX gene
Am. J. Pathol.
174
534-540
2009
Homo sapiens
Rai, A.J.; Udar, N.; Saad, R.; Fleisher, M.
A multiplex assay for detecting genetic variations in CYP2C9, VKORC1, and GGCX involved in warfarin metabolism
Clin. Chem.
55
823-826
2009
Homo sapiens
Qiao, J.; Wang, T.; Yang, J.; Liu, J.; Gong, X.; Guo, X.; Wang, S.; Ye, Z.
Genetic mutation of vitamin K-dependent gamma-glutamyl carboxylase domain in patients with calcium oxalate urolithiasis
J. Huazhong Univ. Sci. Technol. Med. Sci.
29
604-608
2009
Homo sapiens
Li, Q.; Uitto, J.
The mineralization phenotype in Abcc6 (-/-) mice is affected by Ggcx gene deficiency and genetic background--a model for pseudoxanthoma elasticum
J. Mol. Med.
88
173-181
2010
Mus musculus
Titapiwatanakun, R.; Rodriguez, V.; Middha, S.; Dukek, B.A.; Pruthi, R.K.
Novel splice site mutations in the gamma glutamyl carboxylase gene in a child with congenital combined deficiency of the vitamin K-dependent coagulation factors (VKCFD)
Pediatr. Blood Cancer
53
92-95
2009
Homo sapiens
Wang, T.; Yang, J.; Qiao, J.; Liu, J.; Guo, X.; Ye, Z.
Activity and expression of vitamin K-dependent gamma-glutamyl carboxylase in patients with calcium oxalate urolithiasis
Urol. Int.
85
94-99
2010
Homo sapiens
Krossy, C.; Lock, E.; rnsrud, R.
Vitamin K-dependent gamma-glutamylcarboxylase in Atlantic salmon (Salmo salar L.)
Fish Physiol. Biochem.
36
627-635
2010
Salmo salar
Rishavy, M.A.; Usubalieva, A.; Hallgren, K.W.; Berkner, K.L.
Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation
J. Biol. Chem.
286
7267-7278
2011
Homo sapiens
Wu, S.; Liu, S.; Davis, C.H.; Stafford, D.W.; Kulman, J.D.; Pedersen, L.G.
A hetero-dimer model for concerted action of vitamin K carboxylase and vitamin K reductase in vitamin K cycle
J. Theor. Biol.
279
143-149
2011
Homo sapiens (A7YA96)
King, C.R.; Deych, E.; Milligan, P.; Eby, C.; Lenzini, P.; Grice, G.; Porche-Sorbet, R.M.; Ridker, P.M.; Gage, B.F.
Gamma-glutamyl carboxylase and its influence on warfarin dose
Thromb. Haemost.
104
750-754
2010
Homo sapiens
Kaesler, N.; Schettgen, T.; Mutucumarana, V.P.; Brandenburg, V.; Jahnen-Dechent, W.; Schurgers, L.J.; Krueger, T.
A fluorescent method to determine vitamin K-dependent gamma-glutamyl carboxylase activity
Anal. Biochem.
421
411-416
2012
Rattus norvegicus
Haraikawa, M.; Tsugawa, N.; Sogabe, N.; Tanabe, R.; Kawamura, Y.; Okano, T.; Hosoi, T.; Goseki-Sone, M.
Effects of gamma-glutamyl carboxylase gene polymorphism (R325Q) on the association between dietary vitamin K intake and gamma-carboxylation of osteocalcin in young adults
Asia Pac. J. Clin. Nutr.
22
646-654
2013
Homo sapiens
Shiba, S.; Ikeda, K.; Azuma, K.; Hasegawa, T.; Amizuka, N.; Horie-Inoue, K.; Inoue, S.
gamma-Glutamyl carboxylase in osteoblasts regulates glucose metabolism in mice
Biochem. Biophys. Res. Commun.
453
350-355
2014
Mus musculus (Q3TME3)
Parker, C.H.; Morgan, C.R.; Rand, K.D.; Engen, J.R.; Jorgenson, J.W.; Stafford, D.W.
A conformational investigation of propeptide binding to the integral membrane protein gamma-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry
Biochemistry
53
1511-1520
2014
Homo sapiens
Vermeer, C.; van t Hoofd, C.; Knapen, M.H.J.; Xanthoulea, S.
Synthesis of 2-methyl-1,4-naphthoquinones with higher gamma-glutamyl carboxylase activity than MK-4 both in vitro and in vivo
Bioorg. Med. Chem. Lett.
27
208-211
2017
Homo sapiens, Rattus norvegicus
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