Reference on EC 4.1.1.65 - phosphatidylserine decarboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Volker, D.R.; Golden, E.B.
Phosphatidylserine decarboxylase from rat liver
Methods Enzymol.
209
360-365
1992
Rattus norvegicus
Bell, R.M.; Mavis, R.D.; Osborn, M.J.; Vagelos, P.R.
Enzymes of phospholipid metabolism: localization in the cytoplasmic and outer membrane of the cell envelope of Escherichia coli and Salmonella typhimurium
Biochim. Biophys. Acta
249
628-635
1971
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Cook, A.M.; Low, E.; Ishijimi, M.
Effect of phosphatidyl serine decarboxylase on neural excitation
Nature New Biol.
239
150-151
1972
Rattus norvegicus
Dowhan, W.; Wickner, W.T.; Kennedy, E.P.
Purification and properties of phosphatidylserine decarboxylase from Escherichia coli
J. Biol. Chem.
249
3079-3084
1974
Escherichia coli
Suda, T.; Matsuda, M.
Studies on decarboxylation of phosphatidylserine
Biochim. Biophys. Acta
369
331-337
1974
Mus musculus
-
Warner, T.G.; Dennis, E.A.
Phosphatidylserine decarboxylase: analysis of its action towards unsaturated and saturated phosphatidylserine and the effect of Triton X-100 on activity
Arch. Biochem. Biophys.
167
761-768
1975
Tetrahymena pyriformis
Warner, T.G.; Dennis, E.A.
Action of the highly purified, membrane-bound enzyme phosphatidylserine decarboxylase Escherichia coli toward phosphatidylserine in mixed micelles and erythrocyte ghosts in the presence of surfactant
J. Biol. Chem.
250
8004-8009
1975
Escherichia coli
Dutt, A.; Dowhan, W.
Intracellular distribution of enzymes of phospholipid metabolism in several gram-negative bacteria
J. Bacteriol.
132
159-165
1977
Klebsiella aerogenes, Micrococcus cerificans, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens
Satre, M.; Kennedy, E.P.
Identification of bound pyruvate essential for the activity of phosphatidylserine decarboxylase of Escherichia coli
J. Biol. Chem.
253
479-483
1978
Escherichia coli
Tyhach, R.J.; Hawrot, E.; Satre, M.; Kennedy, P.
Increased synthesis of phosphatidylserine decarboxylase in a strain of Escherichia coli bearing a hybrid plasmid
J. Biol. Chem.
254
627-633
1979
Escherichia coli
Hostetler, K.Y.; Zenner, B.D.; Morris, H.P.
Phosphatidylserine biosynthesis in mitochondria from the Morris 7777 hepatoma
J. Lipid Res.
20
607-613
1979
Rattus norvegicus
Igarashi, K.; Kaneda, M.; Yamaji, A.; Saido, T.C.; Kikkawa, U.; Ono, Y.; Inoue, K.; Umeda, M.
A novel phosphatidylserine-binding peptide motif defined by an anti-idiotypic monoclonal antibody
J. Biol. Chem.
270
29075-29078
1995
Cricetulus griseus
Rizzolo, L.J.
Kinetics and protein subunit interactions of Escherichia coli phosphatidylserine decarboxylase in detergent solution
Biochemistry
20
868-873
1981
Escherichia coli
Silber, P.; Borie, R.P.; Mikowski, E.J.; Goldfine, H.
Phospholipid biosynthesis in some anaerobic bacteria
J. Bacteriol.
147
57-61
1981
Clostridium butyricum, Desulfovibrio vulgaris, Escherichia coli, Megasphaera elsdenii, Veillonella parvula
Hawrot, E.
Phosphatidylserine decarboxylase from Escherichia coli
Methods Enzymol.
71
571-576
1981
Escherichia coli
Percy, A.K.; Moore, J.F.; Carson, M.A.; Waechter, C.J.
Characterization of brain phosphatidylserine decarboxylase: localization in the mitochondrial inner membrane
Arch. Biochem. Biophys.
223
484-494
1983
Bos taurus, Rattus norvegicus
Zborowski, J.; Dygas, A.; Wojtczak, L.
Phosphatidylserine decarboxylase is located on the external side of the inner mitochondrial membrane
FEBS Lett.
157
179-182
1983
Mus musculus, Rattus norvegicus
Cain, B.D.; Donohue, T.J.; Shepherd, W.D.; Kaplan, S.
Localization of phospholipid biosynthetic enzyme activities in cell-free fractions derived from Rhodopseudomonas sphaeroides
J. Biol. Chem.
259
942-948
1984
Cereibacter sphaeroides
Kuchler, K.; Daum, G.; Paltauf, F.
Subcellular and submitochondrial localization of phospholipid-synthesizing enzymes in Saccharomyces cerevisiae
J. Bacteriol.
165
901-910
1986
Saccharomyces cerevisiae
No, Z.; Sanders, C.R.; Dowhan, W.; Tsai, M.D.
Steric course of the reaction catalyzed by phosphatidylserine decarboxylase from Escherichia coli
Bioorg. Chem.
16
184-188
1988
Escherichia coli
-
Verma, J.N.; Goldfine, H.
Phosphatidylserine decarboxylase from Clostridium butyricum
J. Lipid Res.
26
610-616
1985
Clostridium butyricum
Kuge, O.; Saito, K.; Kojima, M.; Akamatsu, Y.; Nishijima, M.
Post-translational processing of the phosphatidylserine decarboxylase gene product in Chinese hamster ovary cells
Biochem. J.
319
33-38
1996
Cricetulus griseus
Voelker, D.R.
Phosphatidylserine decarboxylase
Biochim. Biophys. Acta
1348
236-244
1997
Arabidopsis thaliana, Saccharomyces cerevisiae, Caenorhabditis elegans, Escherichia coli, Homo sapiens, Mammalia, Mus musculus
Overmeyer, J.H.; Waechter, C.J.
Regulation of phosphatidylserine decarboxylase in Saccharomyces cerevisiae by inositol and choline: kinetics of repression and derepression
Arch. Biochem. Biophys.
290
511-516
1991
Saccharomyces cerevisiae
Dowhan, W.
Phosphatidylserine decarboxylases: pyruvoyl-dependent enzymes from bacteria to mammals
Methods Enzymol.
280
81-88
1997
Cricetulus griseus, Escherichia coli, Homo sapiens, Saccharomyces cerevisiae
Dowhan, W.; Li, Q.X.
Phosphatidylserine decarboxylase from Escherichia coli
Methods Enzymol.
209
348-359
1992
Escherichia coli
Auchi, L.; Tsvetnitsky, V.; Yeboah, F.A.; Gibbons, W.A.
Purification of plasma membrane rat liver phosphatidylserine decarboxylase
Biochem. Soc. Trans.
21
488S
1993
Rattus norvegicus
Dygas, A.; Zborowski, J.
Effect of Triton X-100 on the activity and solubilization of rat liver mitochondrial phosphatidylserine decarboxylase
Acta Biochim. Pol.
36
131-141
1989
Rattus norvegicus
Li, Q.X.; Dowhan, W.
Studies on the mechanism of formation of the pyruvate prosthetic group of phosphatidylserine decarboxylase from Escherichia coli
J. Biol. Chem.
265
4111-4115
1990
Escherichia coli
Li, Q.X.; Dowhan, W.
Structural characterization of Escherichia coli phosphatidylserine decarboxylase
J. Biol. Chem.
263
11516-11522
1988
Escherichia coli
Hovius, R.; Faber, B.; Brigot, B.; Nicolay, K.; de Kruijff, B.
On the mechanism of the mitochondrial decarboxylation of phosphatidylserine
J. Biol. Chem.
267
16790-16795
1992
Rattus norvegicus
Kevala, J.H.; Kim, H.Y.
Determination of substrate preference in phosphatidylserine decarboxylation by liquid chromatography-electrospray ionization mass spectrometry
Anal. Biochem.
292
130-138
2001
Rattus norvegicus
Kitamura, H.; Wu, W.I.; Voelker, D.R.
The C2 domain of phosphatidylserine decarboxylase 2 is not required for catalysis but is essential for in vivo function
J. Biol. Chem.
277
33720-33726
2002
Saccharomyces cerevisiae
Wu, W.I.; Voelker, D.R.
Reconstitution of phosphatidylserine transport from chemically defined donor membranes to phosphatidylserine decarboxylase 2 implicates specific lipid domains in the process
J. Biol. Chem.
279
6635-6642
2004
Saccharomyces cerevisiae
Salvador, G.A.; Lopez, F.M.; Giusto, N.M.
Age-related changes in central nervous system phosphatidylserine decarboxylase activity
J. Neurosci. Res.
70
283-289
2002
Rattus norvegicus
Baunaure, F.; Eldin, P.; Cathiard, A.M.; Vial, H.
Characterization of a non-mitochondrial type I phosphatidylserine decarboxylase in Plasmodium falciparum
Mol. Microbiol.
51
33-46
2004
Plasmodium falciparum (Q9GPP8), Plasmodium falciparum
Burgermeister, M.; Birner, R.; Hrastnik, C.; Daum, G.
Phosphatidylserine decarboxylation and CDP-ethanolamine pathway contribute to the supply of phosphatidylethanolamine to mitochondria of the yeast
NATO Asi Ser. Ser. A
322
19-25
2000
Saccharomyces cerevisiae
-
Rontein, D.; Wu, W.I.; Voelker, D.R.; Hanson, A.D.
Mitochondrial phosphatidylserine decarboxylase from higher plants. Functional complementation in yeast, localization in plants, and overexpression in Arabidopsis
Plant Physiol.
132
1678-1687
2003
Arabidopsis thaliana, Solanum lycopersicum, Solanum tuberosum
Nishibori, A.; Kusaka, J.; Hara, H.; Umeda, M.; Matsumoto, K.
Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes
J. Bacteriol.
187
2163-2174
2005
Bacillus subtilis
Brgermeister, M.; Birner-Grunberger, R.; Heyn, M.; Daum, G.
Contribution of different biosynthetic pathways to species selectivity of aminoglycerophospholipids assembled into mitochondrial membranes of the yeast Saccharomyces cerevisiae
Biochim. Biophys. Acta
1686
148-160
2004
Saccharomyces cerevisiae
Brgermeister, M.; Birner-Grunberger, R.; Nebauer, R.; Daum, G.
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae
Biochim. Biophys. Acta
1686
161-168
2004
Saccharomyces cerevisiae
Steenbergen, R.; Nanowski, T.S.; Beigneux, A.; Kulinski, A.; Young, S.G.; Vance, J.E.
Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects
J. Biol. Chem.
280
40032-40040
2005
Mus musculus
Bleijerveld, O.B.; Brouwers, J.F.; Vaandrager, A.B.; Helms, J.B.; Houweling, M.
The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species
J. Biol. Chem.
282
28362-28372
2007
Cricetulus griseus, Rattus norvegicus
Forbes, C.D.; Toth, J.G.; Ozbal, C.C.; Lamarr, W.A.; Pendleton, J.A.; Rocks, S.; Gedrich, R.W.; Osterman, D.G.; Landro, J.A.; Lumb, K.J.
High-throughput mass spectrometry screening for inhibitors of phosphatidylserine decarboxylase
J. Biomol. Screen.
12
628-634
2007
Homo sapiens
Nerlich, A.; von Orlow, M.; Rontein, D.; Hanson, A.D.; Doermann, P.
Deficiency in phosphatidylserine decarboxylase activity in the psd1 psd2 psd3 triple mutant of Arabidopsis affects phosphatidylethanolamine accumulation in mitochondria
Plant Physiol.
144
904-914
2007
Arabidopsis thaliana (A4GNA8), Arabidopsis thaliana (F4KAK5), Arabidopsis thaliana (Q84V22)
Larsson, K.E.; Nystroem, B.; Liljenberg, C.
A phosphatidylserine decarboxylase activity in root cells of oat (Avena sativa) is involved in altering membrane phospholipid composition during drought stress acclimation
Plant Physiol. Biochem.
44
211-219
2006
Avena sativa
Vences-Guzman, M.A.; Geiger, O.; Sohlenkamp, C.
Sinorhizobium meliloti mutants deficient in phosphatidylserine decarboxylase accumulate phosphatidylserine and are strongly affected during symbiosis with alfalfa
J. Bacteriol.
190
6846-6856
2008
Sinorhizobium meliloti 1021 (Q9FDI9)
Vance, J.E.
Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids
J. Lipid Res.
49
1377-1387
2008
Saccharomyces cerevisiae, Mus musculus
Federovitch, C.M.; Jones, Y.Z.; Tong, A.H.; Boone, C.; Prinz, W.A.; Hampton, R.Y.
Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae
Mol. Biol. Cell
19
4506-4520
2008
Saccharomyces cerevisiae
Gulshan, K.; Schmidt, J.A.; Shahi, P.; Moye-Rowley, W.S.
Evidence for the bifunctional nature of mitochondrial phosphatidylserine decarboxylase: role in Pdr3-dependent retrograde regulation of PDR5 expression
Mol. Cell. Biol.
28
5851-5864
2008
Saccharomyces cerevisiae (P39006), Saccharomyces cerevisiae
Schuiki, I.; Schnabl, M.; Czabany, T.; Hrastnik, C.; Daum, G.
Phosphatidylethanolamine synthesized by four different pathways is supplied to the plasma membrane of the yeast Saccharomyces cerevisiae
Biochim. Biophys. Acta
1801
480-486
2010
Saccharomyces cerevisiae, Saccharomyces cerevisiae FY1679
Luo, J.; Matsuo, Y.; Gulis, G.; Hinz, H.; Patton-Vogt, J.; Marcus, S.
Phosphatidylethanolamine is required for normal cell morphology and cytokinesis in the fission yeast Schizosaccharomyces pombe
Eukaryot. Cell
8
790-799
2009
Schizosaccharomyces pombe, Schizosaccharomyces pombe SP870
Wriessnegger, T.; Sunga, A.J.; Cregg, J.M.; Daum, G.
Identification of phosphatidylserine decarboxylases 1 and 2 from Pichia pastoris
FEMS Yeast Res.
9
911-922
2009
Komagataella pastoris, Komagataella pastoris GS115
Gulshan, K.; Shahi, P.; Moye-Rowley, W.S.
Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance
Mol. Biol. Cell
21
443-455
2010
Saccharomyces cerevisiae
Chen, Y.L.; Montedonico, A.E.; Kauffman, S.; Dunlap, J.R.; Menn, F.M.; Reynolds, T.B.
Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicans
Mol. Microbiol.
75
1112-1132
2010
Candida albicans
Thanawastien, A.; Montor, W.R.; Labaer, J.; Mekalanos, J.J.; Yoon, S.S.
Vibrio cholerae proteome-wide screen for immunostimulatory proteins identifies phosphatidylserine decarboxylase as a novel Toll-like receptor 4 agonist
PLoS Pathog.
5
e1000556
2009
Vibrio cholerae serotype O1
Hoerl, G.; Wagner, A.; Cole, L.K.; Malli, R.; Reicher, H.; Kotzbeck, P.; Koefeler, H.; Hoefler, G.; Frank, S.; Bogner-Strauss, J.G.; Sattler, W.; Vance, D.E.; Steyrer, E.
Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo
J. Biol. Chem.
286
17338-17350
2011
Mus musculus
Muthukumar, K.; Nachiappan, V.
Phosphatidylethanolamine from phosphatidylserine decarboxylase2 is essential for autophagy under cadmium stress in Saccharomyces cerevisiae
Cell Biochem. Biophys.
67
1353-1363
2013
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Choi, J.Y.; Augagneur, Y.; Ben Mamoun, C.; Voelker, D.R.
Identification of gene encoding Plasmodium knowlesi phosphatidylserine decarboxylase by genetic complementation in yeast and characterization of in vitro maturation of encoded enzyme
J. Biol. Chem.
287
222-232
2012
Plasmodium knowlesi
Gupta, N.; Hartmann, A.; Lucius, R.; Voelker, D.R.
The obligate intracellular parasite Toxoplasma gondii secretes a soluble phosphatidylserine decarboxylase
J. Biol. Chem.
287
22938-22947
2012
Toxoplasma gondii, Toxoplasma gondii TaTi
Horvath, S.E.; Boettinger, L.; Voegtle, F.N.; Wiedemann, N.; Meisinger, C.; Becker, T.; Daum, G.
Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1
J. Biol. Chem.
287
36744-36755
2012
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Chan, E.Y.; McQuibban, G.A.
Phosphatidylserine decarboxylase 1 (Psd1) promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of mitochondrial genome maintenance protein 1 (Mgm1)
J. Biol. Chem.
287
40131-40139
2012
Saccharomyces cerevisiae
Riekhof, W.R.; Wu, W.I.; Jones, J.L.; Nikrad, M.; Chan, M.M.; Loewen, C.J.; Voelker, D.R.
An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiae
J. Biol. Chem.
289
5809-5819
2014
Saccharomyces cerevisiae
Hartmann, A.; Hellmund, M.; Lucius, R.; Voelker, D.R.; Gupta, N.
Phosphatidylethanolamine synthesis in the parasite mitochondrion is required for efficient growth but dispensable for survival of Toxoplasma gondii
J. Biol. Chem.
289
6809-6824
2014
Toxoplasma gondii
Gsell, M.; Mascher, G.; Schuiki, I.; Ploier, B.; Hrastnik, C.; Daum, G.
Transcriptional response to deletion of the phosphatidylserine decarboxylase Psd1p in the yeast Saccharomyces cerevisiae
PLoS ONE
8
e77380
2013
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4742
Soupene, E.; Kuypers, F.A.
Phosphatidylserine decarboxylase CT699, lysophospholipid acyltransferase CT775, and acyl-ACP synthase CT776 provide membrane lipid diversity to Chlamydia trachomatis
Sci. Rep.
7
15767
2017
Chlamydia trachomatis (P0CD79), Chlamydia trachomatis, Chlamydia trachomatis serovar D (P0CD79)
Khandelwal, N.; Sarkar, P.; Gaur, N.; Chattopadhyay, A.; Prasad, R.
Phosphatidylserine decarboxylase governs plasma membrane fluidity and impacts drug susceptibilities of Candida albicans cells
Biochim. Biophys. Acta
1860
2308-2319
2018
Candida albicans (Q5ABC5), Candida albicans (Q5AK66), Candida albicans, Candida albicans ATCC MYA-2876 (Q5ABC5), Candida albicans ATCC MYA-2876 (Q5AK66)
Di Bartolomeo, F.; Doan, K.N.; Athenstaedt, K.; Becker, T.; Daum, G.
Involvement of a putative substrate binding site in the biogenesis and assembly of phosphatidylserine decarboxylase 1 from Saccharomyces cerevisiae
Biochim. Biophys. Acta
1862
716-725
2017
Saccharomyces cerevisiae (P39006), Saccharomyces cerevisiae
Wagner, A.; Di Bartolomeo, F.; Klein, I.; Hrastnik, C.; Doan, K.N.; Becker, T.; Daum, G.
Identification and characterization of the mitochondrial membrane sorting signals in phosphatidylserine decarboxylase 1 from Saccharomyces cerevisiae
Biochim. Biophys. Acta
1863
117-125
2018
Saccharomyces cerevisiae (P39006), Saccharomyces cerevisiae
Choi, J.Y.; Duraisingh, M.T.; Marti, M.; Ben Mamoun, C.; Voelker, D.R.
From protease to decarboxylase the molecular metamorphosis of phosphatidylserine decarboxylase
J. Biol. Chem.
290
10972-10980
2015
Plasmodium knowlesi (B3L2V1), Plasmodium knowlesi, Plasmodium knowlesi H (B3L2V1)
Onguka, O.; Calzada, E.; Ogunbona, O.B.; Claypool, S.M.
Phosphatidylserine decarboxylase 1 autocatalysis and function does not require a mitochondrial-specific factor
J. Biol. Chem.
290
12744-12752
2015
Saccharomyces cerevisiae (P39006), Saccharomyces cerevisiae
Choi, J.Y.; Surovtseva, Y.V.; Van Sickle, S.M.; Kumpf, J.; Bunz, U.H.F.; Ben Mamoun, C.; Voelker, D.R.
A novel fluorescence assay for measuring phosphatidylserine decarboxylase catalysis
J. Biol. Chem.
293
1493-1503
2018
Plasmodium knowlesi (B3L2V1), Plasmodium knowlesi H (B3L2V1)
Ogunbona, O.; Onguka, O.; Calzada, E.; Claypool, S.
Multitiered and cooperative surveillance of mitochondrial phosphatidylserine decarboxylase 1
Mol. Cell. Biol.
37
e00049
2017
Saccharomyces cerevisiae (P39006)
Farine, L.; Jelk, J.; Choi, J.Y.; Voelker, D.R.; Nunes, J.; Smith, T.K.; Buetikofer, P.
Phosphatidylserine synthase 2 and phosphatidylserine decarboxylase are essential for aminophospholipid synthesis in Trypanosoma brucei
Mol. Microbiol.
104
412-427
2017
Trypanosoma brucei (Q38DZ5), Trypanosoma brucei, Trypanosoma brucei 927/4 GUTat10.1 (Q38DZ5)
Choi, J.Y.; Kumar, V.; Pachikara, N.; Garg, A.; Lawres, L.; Toh, J.Y.; Voelker, D.R.; Ben Mamoun, C.
Characterization of Plasmodium phosphatidylserine decarboxylase expressed in yeast and application for inhibitor screening
Mol. Microbiol.
99
999-1014
2016
Plasmodium falciparum (Q9GPP8)
Chen, Y.; Humphries, B.; Brien, R.; Gibbons, A.; Chen, Y.; Qyli, T.; Haley, H.; Pirone, M.; Chiang, B.; Xiao, A.; Cheng, Y.; Luan, Y.; Zhang, Z.; Cong, J.; Luker, K.; Luker, G.; Yoon, E.
Functional isolation of tumor-initiating cells using microfluidic-based migration identifies phosphatidylserine decarboxylase as a key regulator
Sci. Rep.
8
244
2018
Homo sapiens
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