Reference on EC 4.1.1.48 - indole-3-glycerol-phosphate synthase
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Turgeon, B.G.; MacRae, W.D.; Garber, R.C.; Fink, G.R.; Yoder, O.C.
A cloned tryptophan-synthesis gene from the ascomycete Cochliobolus heterostrophus functions in Escherichia coli, yeast and Aspergillus nidulans
Gene
42
79-88
1986
Bipolaris maydis
Hoch, S.O.
Isolation and characterization of two tryptophan biosynthetic enzymes, indoleglycerol phosphate synthase and phosphoribosyl anthranilate isomerase, from Bacillus subtilis
J. Bacteriol.
139
362-368
1979
Bacillus subtilis
Miozzari, G.; Niederberger, P.; Hutter, R.
Tryptophan biosynthesis in Saccharomyces cerevisiae: control of the flux through the pathway
J. Bacteriol.
134
48-59
1978
Saccharomyces cerevisiae
Sugimoto, S.i.; Shiio, I.
Enzymes of the tryptophan synthetic pathway in Brevibacterium flavum
J. Biochem.
81
823-833
1977
[Brevibacterium] flavum
Reyers, G.R.; Rocha, V.
Immunochemical comparison of phosphoribosylanthranilate isomerase-indoleglycerol phosphate synthetase among the enterobacteriaceae
J. Bacteriol.
129
1448-1456
1977
Klebsiella aerogenes, Escherichia coli, Pectobacterium carotovorum, Proteus vulgaris, Salmonella enterica subsp. enterica serovar Typhimurium, Serratia marcescens
Fantes, P.A.; Roberts, L.M.; Huetter, R.
Free tryptophan pool and tryptophan biosynthetic enzymes in Saccharomyces cerevisiae
Arch. Microbiol.
107
207-214
1976
Saccharomyces cerevisiae
Hankins, C.N.; Largen, M.; Mills, S.E.
A rapid spectrophotofluorometric assay for indoleglycerol phosphate synthase
Anal. Biochem.
69
510-517
1975
Escherichia coli, Escherichia coli W3110 / ATCC 27325
Largen, M.; Belser, W.L.
Tryptophan biosynthetic pathway in the Enterobacteriaceae: some physical properties of the enzymes
J. Bacteriol.
121
239-249
1975
Enterobacter cloacae, Aeromonas caviae, Citrobacter freundii, Hafnia alvei, Enterobacter liquefaciens, Pectobacterium carotovorum, Enterobacter cloacae subsp. dissolvens, Morganella morganii, Proteus vulgaris, Serratia marcescens, Serratia rubidaea
Proctor, A.R.; Kloos, W.E.
Tryptophan biosynthetic enzymes of Staphylococcus aureus
J. Bacteriol.
114
169-177
1973
Staphylococcus aureus
Potts, J.M.; Drapeau, G.R.
Partial characterization of phosphoribosyl transferase, phosphoribosyl anthranilate isomerase, and indole glycerol phosphate synthase from Serratia marcescens
J. Bacteriol.
111
334-339
1972
Serratia marcescens
Creighton, T.E.; Yanofsky, C.
Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon
J. Biol. Chem.
241
4616-4624
1966
Escherichia coli
Hankins, C.N.; Mills, S.E.
A dimer of a single polypeptide chain catalyzes the terminal four reactions of the L-tryptophan pathway in Euglena gracilis
J. Biol. Chem.
252
235-239
1977
Euglena gracilis
Hulett, F.M.; DeMoss, J.A.
Subunit structure of anthranilate synthetase from Neurospora crassa
J. Biol. Chem.
250
6648-6652
1975
Neurospora crassa
Twarog, R.; Liggins, G.L.
Enzymes of the tryptophan pathway in Acinetobacter calco-aceticus
J. Bacteriol.
104
254-263
1970
Acinetobacter calcoaceticus
McQuade III, J.F.; Creighton, T.E.
Purification and comparison of the N-(5'-phosphoribosyl)anthranilic acid isomerase/indole-3-glycerol phosphate synthetase of tryptophan biosynthesis from three species of Enterobacteriaceae
Eur. J. Biochem.
16
199-207
1970
Escherichia coli, Klebsiella aerogenes, Salmonella enterica subsp. enterica serovar Typhimurium
Wegman, J.; Crawford, I.P.
Tryptophan synthetic pathway and its regulation in Chromobacterium violaceum
J. Bacteriol.
95
2325-2335
1968
Chromobacterium violaceum
Enatsu, T.; Crawford, I.P.
Enzymes of the tryptophan synthetic pathway in Pseudomonas putida
J. Bacteriol.
95
107-112
1968
Pseudomonas putida
Stehlin, C.; Dahm, A.; Kirschner, K.
Deletion mutagenesis as a test of evolutionary relatedness of indoleglycerol phosphate synthase with other TIM barrel enzymes
FEBS Lett.
403
268-272
1997
Escherichia coli, Saccharolobus solfataricus
Andreotti, G.; Cubellis, M.V.; di Palo, M.; Fessas, D.; Sannia, G.; Marino, G.
Stability of a thermophilic TIM-barrel enzyme: indole-3-glycerol phosphate synthase from the thermophilic archaeon Sulfolobus solfataricus
Biochem. J.
323
259-264
1997
Saccharolobus solfataricus
Eberhard, M.; Tsai-Pflugfelder, M.; Bolewska, K.; Hommel, U.; Kirschner, K.
Indoleglycerol phosphate synthase - phosphoribosyl anthranilate isomerase: comparison of the bifunctional enzyme from Escherichia coli with engineered monofunctional domains
Biochemistry
34
5419-5428
1995
Escherichia coli
Andreotti, G.; Tutino, M.L.; Sannia, G.; Marino, G.; Cubellis, M.V.
Indole-3-glycerol-phosphate synthase from Sulfolobus solfataricus as a model for studying thermostable TIM-barrel enzymes
Biochim. Biophys. Acta
1208
310-315
1994
Escherichia coli, Saccharolobus solfataricus
Knchel, T.R.; Hennig, M.; Merz, A.; Darimont, B.; Kirschner, K.; Jansonius, J.N.
The crystal structure of indole-3-glycerol phosphate synthase from hyperthermophilic archaeon Sulfolobus solfataricus in three different crystal forms: effects of ionic strength
J. Mol. Biol.
262
502-515
1996
Saccharolobus solfataricus
Eberhard, M.; Kirschner, K.
Modification of a catalytically important residues of indoleglycerol-phosphate synthase from Escherichia coli
FEBS Lett.
245
219-222
1989
Escherichia coli
Hennig, M.; Darimont, B.; Sterner, R.; Kirschner, K.; Jansonius, J.N.
2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability
Structure
3
1295-1306
1995
Escherichia coli, Saccharolobus solfataricus, Saccharolobus solfataricus (Q06121)
Bieger, C.D.; Crawford, I.P.
Tryptophan biosynthesis in the marine luminous bacterium Vibrio harveyi
J. Bacteriol.
153
884-894
1983
Vibrio harveyi
Sterner, R.; Merz, A.; Thoma, R.; Kirschner, K.
Phosphoribosylanthranilate isomerase and indoleglycerol-phosphate synthase: tryptophan biosynthetic enzymes from Thermotoga maritima
Methods Enzymol.
331
270-280
2001
Thermotoga maritima
Knochel, T.; Pappenberger, A.; Jansonius, J.N.; Kirschner, K.
The crystal structure of indoleglycerol-phosphate synthase from Thermotoga maritima. Kinetic stabilization by salt bridges
J. Biol. Chem.
277
8626-8634
2002
Thermotoga maritima
Merz, A.; Knochel, T.; Jansonius, J.N.; Kirschner, K.
The hyperthermostable indoleglycerol phosphate synthase from Thermotoga maritima is destabilized by mutational disruption of two solvent-exposed salt bridges
J. Mol. Biol.
288
753-763
1999
Thermotoga maritima
Hennig, M.; Darimont, B.D.; Jansonius, J.N.; Kirschner, K.
The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product
J. Mol. Biol.
319
757-766
2002
Saccharolobus solfataricus (Q06121), Saccharolobus solfataricus
Forsyth, W.R.; Matthews, C.R.
Folding mechanism of indole-3-glycerol phosphate synthase from Sulfolobus solfataricus: a test of the conservation of folding mechanisms hypothesis in (beta(alpha))(8) barrels
J. Mol. Biol.
320
1119-1133
2002
Saccharolobus solfataricus
Schneider, B.; Knochel, T.; Darimont, B.; Hennig, M.; Dietrich, S.; Babinger, K.; Kirschner, K.; Sterner, R.
Role of the N-terminal extension of the (betaalpha)(8)-barrel enzyme indole-3-glycerol phosphate synthase for its fold, stability, and catalytic activity
Biochemistry
44
16405-16412
2005
Saccharolobus solfataricus (Q06121), Saccharolobus solfataricus, Thermotoga maritima (Q56319), Thermotoga maritima
Mazumder-Shivakumar, D.; Kahn, K.; Bruice, T.C.
Computational study of the ground state of thermophilic indole glycerol phosphate synthase: structural alterations at the active site with temperature
J. Am. Chem. Soc.
126
5936-5937
2004
Saccharolobus solfataricus (Q06121)
Mazumder-Shivakumar, D.; Bruice, T.C.
Molecular dynamics studies of ground state and intermediate of the hyperthermophilic indole-3-glycerol phosphate synthase
Proc. Natl. Acad. Sci. USA
101
14379-14384
2004
Saccharolobus solfataricus (Q06121)
Yang, Y.; Zhang, M.; Zhang, H.; Lei, J.; Jin, R.; Xu, S.; Bao, J.; Zhang, L.; Wang, H.
Purification and characterization of Mycobacterium tuberculosis indole-3-glycerol phosphate synthase
Biochemistry
71
S38-S43
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
-
Gu, Z.; Zitzewitz, J.A.; Matthews, C.R.
Mapping the structure of folding cores in TIM barrel proteins by hydrogen exchange mass spectrometry: the roles of motif and sequence for the indole-3-glycerol phosphate synthase from Sulfolobus solfataricus
J. Mol. Biol.
368
582-594
2007
Saccharolobus solfataricus
Gu, Z.; Rao, M.K.; Forsyth, W.R.; Finke, J.M.; Matthews, C.R.
Structural analysis of kinetic folding intermediates for a TIM barrel protein, indole-3-glycerol phosphate synthase, by hydrogen exchange mass spectrometry and Go model simulation
J. Mol. Biol.
374
528-546
2007
Saccharolobus solfataricus, Saccharolobus solfataricus (Q06121)
Shen, H.; Wang, F.; Zhang, Y.; Huang, Q.; Xu, S.; Hu, H.; Yue, J.; Wang, H.
A novel inhibitor of indole-3-glycerol phosphate synthase with activity against multidrug-resistant Mycobacterium tuberculosis
FEBS J.
276
144-154
2009
Mycobacterium tuberculosis (P9WFX7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Ra (A5U2W7), Mycobacterium tuberculosis H37Rv (P9WFX7), Mycobacterium tuberculosis variant bovis BCG (A1KJ27)
Czekster, C.M.; Neto, B.A.; Lapis, A.A.; Dupont, J.; Santos, D.S.; Basso, L.A.
Steady-state kinetics of indole-3-glycerol phosphate synthase from Mycobacterium tuberculosis
Arch. Biochem. Biophys.
486
19-26
2009
Mycobacterium tuberculosis
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
Shen, H.; Yang, E.; Wang, F.; Jin, R.; Xu, S.; Huang, Q.; Wang, H.
Altered protein expression patterns of Mycobacterium tuberculosis induced by ATB107
J. Microbiol.
48
337-346
2010
Mycobacterium tuberculosis, Mycobacterium tuberculosis Rv3246c
Schlee, S.; Dietrich, S.; Kurcon, T.; Delaney, P.; Goodey, N.M.; Sterner, R.
Kinetic mechanism of indole-3-glycerol phosphate synthase
Biochemistry
52
132-142
2012
Saccharolobus solfataricus (Q06121), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q06121)
Tang, X.; Ezaki, S.; Fujiwara, S.; Takagi, M.; Atomi, H.; Imanaka, T.
The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA
Mol. Gen. Genet.
262
815-821
1999
Thermococcus kodakarensis (Q9YGB5), Thermococcus kodakarensis
Merz, A.; Yee, M.C.; Szadkowski, H.; Pappenberger, G.; Crameri, A.; Stemmer, W.P.; Yanofsky, C.; Kirschner, K.
Improving the catalytic activity of a thermophilic enzyme at low temperatures
Biochemistry
39
880-889
2000
Saccharolobus solfataricus
Zaccardi, M.J.; Yezdimer, E.M.; Boehr, D.D.
Functional identification of the general acid and base in the dehydration step of indole-3-glycerol phosphate synthase catalysis
J. Biol. Chem.
288
26350-26356
2013
Saccharolobus solfataricus (Q06121), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q06121)
Zaccardi, M.J., O'Rourke, K.F.; Yezdimer, E.M.; Loggia, L.J.; Woldt, S.; Boehr, D.D.
Loop-loop interactions govern multiple steps in indole-3-glycerol phosphate synthase catalysis
Protein Sci.
23
302-311
2014
Saccharolobus solfataricus
Bagautdinov, B.; Yutani, K.
Structure of indole-3-glycerol phosphate synthase from Thermus thermophilus HB8: implications for thermal stability
Acta Crystallogr. Sect. D
67
1054-1064
2011
Thermus thermophilus (P84126), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (P84126)
Zaccardi, M.J.; Mannweiler, O.; Boehr, D.D.
Differences in the catalytic mechanisms of mesophilic and thermophilic indole-3-glycerol phosphate synthase enzymes at their adaptive temperatures
Biochem. Biophys. Res. Commun.
418
324-329
2012
Escherichia coli
Gerth, M.L.; Nigon, L.V.; Patrick, W.M.
Characterization of the indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa PAO1
Protein J.
31
359-365
2012
Pseudomonas aeruginosa
Schlee, S.; Klein, T.; Schumacher, M.; Nazet, J.; Merkl, R.; Steinhoff, H.J.; Sterner, R.
Relationship of Catalysis and Active Site Loop Dynamics in the (betaalpha)8 barrel enzyme indole-3-glycerol phosphate synthase
Biochemistry
57
3265-3277
2018
Saccharolobus solfataricus (Q06121), Saccharolobus solfataricus
O'Rourke, K.; Jelowicki, A.; Boehr, D.
Controlling active site loop dynamics in the (beta/alpha)8 barrel enzyme indole-3-glycerol phosphate synthase
Catalysts
6
129
2016
Saccharolobus solfataricus (Q06121), Saccharolobus solfataricus DSM 1617 (Q06121)
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