Reference on EC 4.1.1.33 - diphosphomevalonate decarboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Alvear, M.; Jabalquinto, A.M.; Eyzaguirre, J.; Cardemil, E.
Purification and characterization of avian liver mevalonate-5-pyrophosphate decarboxylase
Biochemistry
21
4646-4650
1982
Gallus gallus
Cardemil, E.; Jabalquinto, A.M.
The mechanism of action of mevalonate-5-pyrophosphate decarboxylase
Trends Biochem. Sci.
8
7
1983
Saccharomyces cerevisiae
-
Jabalquinto, A.M.; Eyzaguirre, J.; Cardemil, E.
Evidence of essential arginyl residues in chicken liver mevalonate-5-pyrophosphate decarboxylase
Arch. Biochem. Biophys.
225
338-343
1983
Gallus gallus
Gonzalez-Pacanowska, D.; Marco, C.; Garcia-Martinez, J.; Garcia-Peregrin, E.
Role of mevalonate-5-pyrophosphate decarboxylase in the regulation of chick intestinal cholesterogenesis
Biochim. Biophys. Acta
833
449-455
1985
Gallus gallus
Cardemil, E.; Jabalquinto, A.M.
Mevalonate 5-pyrophosphate decarboxylase from chicken liver
Methods Enzymol.
110
86-92
1985
Gallus gallus
Jabalquinto, A.M.; Cardemil, E.
The effect of diabetes, nutritional factors, and sex on rat liver and kidney mevalonate kinase, mevalonate-5-phosphate kinase, and mevalonate-5-pyrophosphate decarboxylase
Arch. Biochem. Biophys.
210
132-139
1981
Rattus norvegicus
Lalitha, R.; George, R.; Ramasarma, T.
Mevalonate decarboxylation in lemon grass leaves
Phytochemistry
24
2569-2571
1985
Arachis hypogaea, Cymbopogon citratus, Oryza sativa, Vigna radiata, Pisum sativum
-
Chiew, Y.E.; O'Sullivan, W.J.; Lee, Ch.S.
Studies on pig liver mevalonate-5-diphosphate decarboxylase
Biochim. Biophys. Acta
916
271-278
1987
Sus scrofa
Jabalquinto, A.M.; Cardemil, E.
Kinetic effect of ATP, divalent metal ions and pH on chicken liver mevalonate 5-diphosphate decarboxylase
Biochim. Biophys. Acta
916
172-178
1987
Gallus gallus
Iyengar, R.; Cardemil, E.; Frey, P.A.
Mevalonate-5-diphosphate decarboxylase: stereochemical course of ATP-dependent phosphorylation of mevalonate 5-diphosphate
Biochemistry
25
4693-4698
1986
Gallus gallus
Gonzalez-Pacanowska, D.; Marco, C.; Garcia-Martinez, J.; Garcia-Peregrin, E.
Effects of different nutritional conditions on chick liver mevalonate-activating enzymes
Biochim. Biophys. Acta
875
605-609
1986
Gallus gallus
Nunez, A.; Castillo, M.; Iglesias, J.; Martinez-Cayuela, M.; Gonzales-Pacanowska, D.; Garcia-Peregrin, E.
Regulation of mevalonate 5-pyrophosphate decarboxylase in HeLa cells. Inhibition of enzymatic protein synthesis by serum lipoproteins
Int. J. Biochem. Cell Biol.
29
1037-1041
1997
Homo sapiens
Toth, M.J.; Huwyler, L.; Park, J.
Purification of rat liver mevalonate pyrophosphate decarboxylase
Prep. Biochem. Biotechnol.
26
47-51
1996
Rattus norvegicus
Michihara, A.; Sawamura, M.; Nara, Y.; Ikeda, K.; Yamori, Y.
Purification and characterization of two mevalonate pyrophosphate decarboxylases from rat liver: a novel molecular species of 37 kDa
J. Biochem.
122
647-654
1997
Rattus norvegicus
Alvear, M.; Jabalquinto, A.M.; Cardemil, E.
Inactivation of chicken liver mevalonate 5-diphosphate decarboxylase by sulfhydryl-directed reagents: evidence of a functional dithiol
Biochim. Biophys. Acta
994
7-11
1989
Gallus gallus
Jabalquinto, A.M.; Cardemil, E.
Substrate binding order in mevalonate 5-diphosphate decarboxylase from chicken liver
Biochim. Biophys. Acta
996
257-259
1989
Gallus gallus
Hulcher, F.H.
Modification of the radiochemical assay of rat liver mevalonate-5-diphosphate decarboxylase and induction and stabilization of the activity
Biochem. Biophys. Res. Commun.
181
1449-1455
1991
Rattus norvegicus
Sawamura, M.; Nara, Y.; Yamori, Y.
Liver mevalonate 5-pyrophosphate decarboxylase is responsible for reduced serum cholesterol in stroke-prone spontaneously hypertensive rat
J. Biol. Chem.
267
6051-6055
1992
Rattus norvegicus
Iglesias, J.; Gonzalez-Pacanowska, D.; Marco, C.; Garcia-Peregrin, E.
Regulation of mevalonate 5-pyrophosphate decarboxylase in isolated cells from chick intestinal epithelium
Biochem. J.
260
333-337
1989
Gallus gallus
Michihara, A.; Akasaki, K.; Yamori, Y.; Tsuji, H.
Tissue distribution of a major mevalonate pyrophosphate decarboxylase in rats
Biol. Pharm. Bull.
24
1231-1234
2001
Rattus norvegicus
Michihara, A.; Sawamura, M.; Yamori, Y.; Akasaki, K.; Tsuji, H.
Mevalonate pyrophosphate decarboxylase is predominantly located in the cytosol of rat hepatocytes
Biol. Pharm. Bull.
24
1235-1240
2001
Rattus norvegicus
Michihara, A.; Sawamura, M.; Yamori, Y.; Akasaki, K.; Tsuji, H.
Difference in subcellular distribution between 45- and 37-kDa mevalonate pyrophosphate decarboxylase in rat liver
Biol. Pharm. Bull.
24
1347-1350
2001
Rattus norvegicus
Michihara, A.; Akasaki, K.; Yamori, Y.; Tsuji, H.
Purification and characterization of mouse mevalonate pyrophosphate decarboxylase
Biol. Pharm. Bull.
25
302-306
2002
Mus musculus
Michihara, A.; Akasaki, K.; Yamori, Y.; Tsuji, H.
Change in the protein level of mevalonate pyrophosphate decarboxylase in tissues of mouse by pravastatin
Biol. Pharm. Bull.
26
1082-1085
2003
Mus musculus
Michihara, A.; Sawamura, M.; Yamori, Y.; Akasaki, K.; Tsuji, H.
Probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver
Biol. Pharm. Bull.
26
1484-1486
2003
Rattus norvegicus
Michihara, A.; Akasaki, K.; Yamori, Y.; Tsuji, H.
Subcellular distribution of mouse mevalonate pyrophosphate decarboxylase
Biol. Pharm. Bull.
26
579-584
2003
Mus musculus
Cordier, H.; Lacombe, C.; Karst, F.; Berges, T.
The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase (erg19p) forms homodimers in vivo, and a single substitution in a structurally conserved region impairs dimerization
Curr. Microbiol.
38
290-294
1999
Saccharomyces cerevisiae
Hogenboom, S.; Tuyp, J.J.M.; Espeel, M.; Koster, J.; Wanders, R.J.A.; Waterham, H.R.
Human mevalonate pyrophosphate decarboxylase is localized in the cytosol
Mol. Genet. Metab.
81
216-224
2004
Homo sapiens
Cordier, H.; Karst, F.; Berges, T.
Heterologous expression in Saccharomyces cerevisiae of an Arabidopsis thaliana cDNA encoding mevalonate diphosphate decarboxylase
Plant Mol. Biol.
39
953-967
1999
Arabidopsis thaliana (O23722), Arabidopsis thaliana
Byres, E.; Martin, D.M.A.; Hunter, W.N.
A preliminary crystallographic analysis of the putative mevalonate diphosphate decarboxylase from Trypanosoma brucei
Acta Crystallogr. Sect. F
F61
581-584
2005
Trypanosoma brucei
Krepkiy, D.V.; Miziorko, H.M.
Investigation of the functional contributions of invariant serine residues in yeast mevalonate diphosphate decarboxylase
Biochemistry
44
2671-2677
2005
Saccharomyces cerevisiae (P32377), Saccharomyces cerevisiae
Krepkiy, D.; Miziorko, H.M.
Identification of active site residues in mevalonate diphosphate decarboxylase: implications for a family of phosphotransferases
Protein Sci.
13
1875-1881
2004
Saccharomyces cerevisiae (P32377)
Qiu, Y.; Li, D.
Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase
Org. Lett.
8
1013-1016
2006
Rattus norvegicus
Qiu, Y.; Li, D.
Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs
Biochim. Biophys. Acta
1760
1080-1087
2006
Rattus norvegicus
Qiu, Y.; Gao, J.; Guo, F.; Qiao, Y.; Li, D.
Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase
Bioorg. Med. Chem. Lett.
17
6164-6168
2007
Rattus norvegicus
Byres, E.; Alphey, M.S.; Smith, T.K.; Hunter, W.N.
Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity
J. Mol. Biol.
371
540-553
2007
Staphylococcus aureus (A0A0H2XIV6), Staphylococcus aureus, Saccharomyces cerevisiae (P32377), Saccharomyces cerevisiae, Trypanosoma brucei (Q388P2), Trypanosoma brucei
Pang, Y.; Shen, G.; Berges, T.; Cardier, H.; Wu, W.; Sun, X.; Tang, K.
Molecular cloning, characterization and heterologous expression in Saccharomyces cerevisiae of a mevalonate diphosphate decarboxylase cDNA from Ginkgo biloba
Physiol. Plant.
127
19-27
2006
Ginkgo biloba (Q5UCT8)
Wang, Y.; Muneton, S.; Sjoevall, J.; Jovanovic, J.N.; Griffiths, W.J.
The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome
J. Proteome Res.
7
1606-1614
2008
Rattus norvegicus
Voynova, N.E.; Fu, Z.; Battaile, K.P.; Herdendorf, T.J.; Kim, J.J.; Miziorko, H.M.
Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure
Arch. Biochem. Biophys.
480
58-67
2008
Homo sapiens (P53602), Homo sapiens
Michihara, A.; Morita, S.; Toda, K.; Akasaki, K.; Tsuji, H.
Mevalonate pyrophosphate decarboxylase is predominantly located in the cytosol of both B16 and B16F10 cells in mouse melanoma treated with lovastatin
J. Health Sci.
54
216-223
2008
Mus musculus
-
Shimatani, M.; Michihara, A.; Akasaki, K.
Tissue distribution of mevalonate pyrophosphate decarboxylase in guinea pig
Biol. Pharm. Bull.
32
1476-1479
2009
Cavia porcellus
Ren, A.; Qin, L.; Shi, L.; Dong, X.; Mu, D.S.; Li, Y.X.; Zhao, M.W.
Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lucidum
Biores. Technol.
101
6785-6790
2010
Ganoderma lucidum, Ganoderma lucidum HG
Lefurgy, S.T.; Rodriguez, S.B.; Park, C.S.; Cahill, S.; Silverman, R.B.; Leyh, T.S.
Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae
J. Biol. Chem.
285
20654-20663
2010
Streptococcus pneumoniae
Weerasinghe, S.; Samantha Dassanayake, R.
Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (MVD)
J. Mol. Model.
16
489-498
2010
Saccharomyces cerevisiae (P32377), Saccharomyces cerevisiae
Rothwell, C.; Lebreton, A.; Young Ng, C.; Lim, J.Y.; Liu, W.; Vasudevan, S.; Labow, M.; Gu, F.; Gaither, L.A.
Cholesterol biosynthesis modulation regulates dengue viral replication
Virology
389
8-19
2009
Homo sapiens
Gogerty, D.S.; Bobik, T.A.
Formation of isobutene from 3-hydroxy-3-methylbutyrate by diphosphomevalonate decarboxylase
Appl. Environ. Microbiol.
76
85004-8010
2010
Saccharomyces cerevisiae (P32377), Saccharomyces cerevisiae
Reuther, G.; Harris, R.; Girvin, M.; Leyh, T.S.
Backbone 1H, 13C, 15N NMR assignments of the unliganded and substrate ternary complex forms of mevalonate diphosphate decarboxylase from Streptococcus pneumoniae
Biomol. NMR Assign.
5
11-14
2011
Streptococcus pneumoniae
Barta, M.L.; Skaff, D.A.; McWhorter, W.J.; Herdendorf, T.J.; Miziorko, H.M.; Geisbrecht, B.V.
Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis
J. Biol. Chem.
286
23900-23910
2011
Staphylococcus epidermidis (Q9FD73), Staphylococcus epidermidis
Michihara, A.; Shimatani, M.; Akasaki, K.
Comparison of the gene expression levels of mevalonate pyrophosphate decarboxylase between stroke-prone spontaneously hypertensive and Wistar Kyoto rats
J. Health Sci.
56
733-737
2010
Rattus norvegicus (Q62967)
-
Nishimura, H.; Azami, Y.; Miyagawa, M.; Hashimoto, C.; Yoshimura, T.; Hemmi, H.
Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus
J. Biochem.
153
415-420
2013
Saccharolobus solfataricus (Q97UL5), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97UL5), Saccharolobus solfataricus DSM 1617 (Q97UL5)
Barta, M.L.; McWhorter, W.J.; Miziorko, H.M.; Geisbrecht, B.V.
Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase
Biochemistry
51
5611-5621
2012
Staphylococcus epidermidis (Q9FD73), Staphylococcus epidermidis
Vannice, J.C.; Skaff, D.A.; Keightley, A.; Addo, J.K.; Wyckoff, G.J.; Miziorko, H.M.
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway
J. Bacteriol.
196
1055-1063
2014
Haloferax volcanii
Shi, L.; Qin, L.; Xu, Y.; Ren, A.; Fang, X.; Mu, D.; Tan, Q.; Zhao, M.
Molecular cloning, characterization, and function analysis of a mevalonate pyrophosphate decarboxylase gene from Ganoderma lucidum
Mol. Biol. Rep.
39
6149-6159
2012
Ganoderma lucidum (G9BIY1), Ganoderma lucidum, Ganoderma lucidum HG (G9BIY1)
Simkin, A.J.; Guirimand, G.; Papon, N.; Courdavault, V.; Thabet, I.; Ginis, O.; Bouzid, S.; Giglioli-Guivarch, N.; Clastre, M.
Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta
Planta
234
903-914
2011
Catharanthus roseus (F6K7K1), Catharanthus roseus
Hattori, A.; Unno, H.; Goda, S.; Motoyama, K.; Yoshimura, T.; Hemmi, H.
In vivo formation of the protein disulfide bond that enhances the thermostability of diphosphomevalonate decarboxylase, an intracellular enzyme from the hyperthermophilic archaeon Sulfolobus solfataricus
J. Bacteriol.
197
3463-3471
2015
Saccharolobus solfataricus (Q97UL5), Saccharolobus solfataricus, Saccharolobus solfataricus DSM 1617 (Q97UL5)
Kim, Y.K.; Kim, Y.B.; Uddin, M.R.; Lee, S.; Kim, S.U.; Park, S.U.
Enhanced triterpene accumulation in Panax ginseng hairy roots overexpressing mevalonate-5-pyrophosphate decarboxylase and farnesyl pyrophosphate synthase
ACS Synth. Biol.
3
773-779
2014
Panax ginseng (F8QQQ7), Panax ginseng
Skaff, D.A.; McWhorter, W.J.; Geisbrecht, B.V.; Wyckoff, G.J.; Miziorko, H.M.
Inhibition of bacterial (R)-5-diphosphomevalonate decarboxylase by eriochrome compounds
Arch. Biochem. Biophys.
566
1-6
2015
Staphylococcus epidermidis (Q9FD73), Staphylococcus epidermidis
Hayakawa, H.; Sobue, F.; Motoyama, K.; Yoshimura, T.; Hemmi, H.
Identification of enzymes involved in the mevalonate pathway of Flavobacterium johnsoniae
Biochem. Biophys. Res. Commun.
487
702-708
2017
Flavobacterium johnsoniae
Michihara, A.; Ide, N.; Mizutani, Y.; Okamoto, M.; Uchida, M.; Matsuoka, H.; Akasaki, K.
Involvement of microRNA214 and transcriptional regulation in reductions in mevalonate pyrophosphate decarboxylase mRNA levels in stroke-prone spontaneously hypertensive rat livers
Biosci. Biotechnol. Biochem.
79
1759-1770
2015
Rattus norvegicus (Q62967)
Chai, J.; Wang, D.; Peng, Y.; Zhao, X.; Zhang, Q.; Li, P.; Fang, X.; Wang, M.; Cai, X.
Molecular cloning, expression and immunolocalization analysis of diphosphomevalonate decarboxylase involved in terpenoid biosynthesis from Euphorbia helioscopia L.
Biotechnol. Biotechnol. Equip.
31
1106-1115
2017
Euphorbia helioscopia (A0A0M4FQ19)
-
Abbassi, S.J.; Vishwakarma, R.K.; Patel, P.; Kumari, U.; Khan, B.M.
Bacopa monniera recombinant mevalonate diphosphate decarboxylase Biochemical characterization
Int. J. Biol. Macromol.
79
661-668
2015
Bacopa monnieri (A0A0F6WBJ2), Bacopa monnieri
Abbassi, S.; Patel, K.; Khan, B.; Bhosale, S.; Gaikwad, S.
Functional and conformational transitions of mevalonate diphosphate decarboxylase from Bacopa monniera
Int. J. Biol. Macromol.
83
160-170
2016
Bacopa monnieri (A0A0F6WBJ2), Bacopa monnieri
Addo, J.; Skaff, D.; Miziorko, H.
Active site binding modes of inhibitors of Staphylococcus aureus mevalonate diphosphate decarboxylase from docking and molecular dynamics simulations
J. Mol. Model.
22
1-18
2016
Staphylococcus aureus
-
Wu, C.; Li, Y.; Nie, Z.; Dai, L.; Kang, G.; Zeng, R.
Molecular cloning and expression analysis of the mevalonate diphosphate decarboxylase gene from the latex of Hevea brasiliensis
Tree Genet. Genomes
13
22
2017
Hevea brasiliensis (A0A0H3WJ12)
-
Wu, C.; Lan, L.; Li, Y.; Nie, Z.; Zeng, R.
The relationship between latex metabolism gene expression with rubber yield and related traits in Hevea brasiliensis
BMC Genomics
19
897
2018
Hevea brasiliensis (A9ZN03), Hevea brasiliensis
Motoyama, K.; Unno, H.; Hattori, A.; Takaoka, T.; Ishikita, H.; Kawaide, H.; Yoshimura, T.; Hemmi, H.
A single amino acid mutation converts (R)-5-diphosphomevalonate decarboxylase into a kinase
J. Biol. Chem.
292
2457-2469
2017
Saccharolobus solfataricus (Q97UL5), Saccharolobus solfataricus, Saccharolobus solfataricus ATCC 35092 (Q97UL5), Saccharolobus solfataricus DSM 1617 (Q97UL5), Saccharolobus solfataricus JCM 11322 (Q97UL5), Saccharolobus solfataricus P2 (Q97UL5)
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