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Disease on EC 4.1.1.32 - phosphoenolpyruvate carboxykinase (GTP)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
The regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat kidney cortex. The role of acid-base balance and glucocorticoids.
The transcriptional regulation of phosphoenolpyruvate carboxykinase gene in the kidney requires the HNF-1 binding site of the gene.
Acidosis, Lactic
Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Cause of Hypoglycemia-Induced Seizure and Death.
Adenoviridae Infections
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Autoimmune Diseases
Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope.
Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation for primary biliary cirrhosis.
Blister
Apotopes and the biliary specificity of primary biliary cirrhosis.
Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis.
Pathophysiology of primary biliary cholangitis.
Carcinoma
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability.
Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells.
Carcinoma, Hepatocellular
3-Aminobenzamide inhibits poly(ADP ribose) synthetase activity and induces phosphoenolpyruvate carboxykinase (GTP) in H4IIE hepatoma cells.
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Effects of amino acid analogues on protein synthesis and degradation in isolated cells.
Epidermal growth factor inhibits phosphoenolpyruvate carboxykinase gene expression in rat hepatocytes in primary culture.
Expression of the genes for the mitochondrial and cytosolic forms of phosphoenolpyruvate carboxykinase in avian liver during development.
Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit.
Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells.
Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin.
Properties of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesized in hepatoma cells in the presence of amino acid analogues.
Regulated production of mature insulin by non-beta-cells.
Regulation of gene expression in rat hepatocytes and hepatoma cells by insulin: quantitation of messenger ribonucleic acid's coding for tyrosine aminotransferase, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase.
Regulation of phosphoenolpyruvate carboxykinase gene transcription by insulin and cAMP: reciprocal actions on initiation and elongation.
The effect of phorbol esters and diacylglycerol on expression of the phosphoenolpyruvate carboxykinase (GTP) gene in rat hepatoma H4IIE cells.
The promoter regulatory regions of the genes for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from the chicken and the rat have different species-specific roles in gluconeogenesis.
The role of protein synthesis in the decay of phosphoenolpyruvate carboxykinase messenger RNA.
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Cholangitis
Environmental basis of primary biliary cholangitis.
Novel biomarkers for primary biliary cholangitis to improve diagnosis and understand underlying regulatory mechanisms.
Cholangitis, Sclerosing
Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2.
Serum reactivity against bacterial pyruvate dehydrogenase: increasing the specificity of anti-mitochondrial antibodies for the diagnosis of primary biliary cirrhosis.
Diabetes Mellitus
Phenolic Diterpenes from Rosemary Suppress cAMP Responsiveness of Gluconeogenic Gene Promoters.
Diabetes Mellitus, Type 2
A Leu184Val polymorphism in PCK1 gene is associated with type 2 diabetes in Eastern Chinese population with BMI<23 kg/m2.
Expression of phosphoenolpyruvate carboxykinase gene in human adipose tissue: induction by rosiglitazone and genetic analyses of the adipocyte-specific region of the promoter in type 2 diabetes.
Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase.
Glyceroneogenesis revisited.
PCK1 and PCK2 as candidate diabetes and obesity genes.
Phosphoenolpyruvate carboxykinase (GTP): characterization of the human PCK1 gene and localization distal to MODY on chromosome 20.
Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes.
Two Alkaloids from Bulbs of Lycoris sanguinea MAXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB.
[Glyceroneogenesis and PEPCK-C: pharmacological targets in type 2 diabetes]
Endotoxemia
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase.
Fatty Liver
PCK1 and PCK2 as candidate diabetes and obesity genes.
Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism.
Hematologic Neoplasms
Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis.
Hepatitis C, Chronic
Granulomatous cholangitis in chronic hepatitis C: a new diagnostic problem in liver pathology.
Hepatitis, Autoimmune
Immunoreactivity to pyruvate dehydrogenase complex-E2 in well-defined patients with autoimmune hepatitis: Western blot analysis.
Serum reactivity against bacterial pyruvate dehydrogenase: increasing the specificity of anti-mitochondrial antibodies for the diagnosis of primary biliary cirrhosis.
Hyperglycemia
Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi.
Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice.
Hyperlactatemia
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase.
Hyperthyroidism
3,5,3'-Triiodothyronine-induced synthesis of rat liver phosphoenolpyruvate carboxykinase.
Renal phosphoenolpyruvate carboxykinase turnover in hypo- and hyperthyroid rat in vivo.
Hypoglycemia
Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Cause of Hypoglycemia-Induced Seizure and Death.
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase.
PCK1 and PCK2 as candidate diabetes and obesity genes.
PEPCK-C reexpression in the liver counters neonatal hypoglycemia in Pck1 (del/del) mice, unmasking role in non-gluconeogenic tissues.
Infections
Autoimmune disease triggered by infection with alphaproteobacteria.
Environmental basis of primary biliary cholangitis.
Liver autoimmunity triggered by microbial activation of natural killer T cells.
Novosphingobium aromaticivorans: a potential initiator of primary biliary cirrhosis.
Intestinal Volvulus
Phosphoenolpyruvate carboxykinase from Onchocerca volvulus and O. gibsoni.
Lipodystrophy
PCK1 and PCK2 as candidate diabetes and obesity genes.
Liver Cirrhosis, Biliary
Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary biliary cirrhosis.
Analysis of T-cell receptor beta of the T-cell clones reactive to the human PDC-E2 163-176 peptide in the context of HLA-DR53 in patients with primary biliary cirrhosis.
Antibody to two forms of dihydrolipoamide acetyltransferase (PDC-E2) in primary biliary cirrhosis.
Apotopes and innate immune system: Novel players in the primary biliary cirrhosis scenario.
Catalase and estradiol inhibit mitochondrial protein S-glutathionylation.
Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis.
CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis.
Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis.
Chromosome localization and RFLP analysis of PDC-E2: the major autoantigen of primary biliary cirrhosis.
Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic.
Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis.
Definition of antigen specificity for antimitochondrial proteins detected by Western blotting using native mitochondrial proteins in primary biliary cirrhosis.
Development of an enzyme immune assay for detecting M2 autoantibodies specific for primary biliary cirrhosis.
Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis.
Environmental basis of primary biliary cholangitis.
Expression of pyruvate-dehydrogenase complex PDC-E2 on biliary epithelial cells induced by lymph nodes from primary biliary cirrhosis.
Fine specificity of T cells reactive to human PDC-E2 163-176 peptide, the immunodominant autoantigen in primary biliary cirrhosis: implications for molecular mimicry and cross-recognition among mitochondrial autoantigens.
Granulomatous cholangitis in chronic hepatitis C: a new diagnostic problem in liver pathology.
Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis.
Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic.
HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases.
Human combinatorial autoantibodies and mouse monoclonal antibodies to PDC-E2 produce abnormal apical staining of salivary glands in patients with coexistent primary biliary cirrhosis and Sjögren's syndrome.
Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis.
Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis.
Immunoreactivity of antimitochondrial autoantibodies in Japanese patients with primary biliary cirrhosis.
Immunoreactivity of porcine heart dihydrolipoamide acetyl- and succinyl-transferases (PDC-E2, OGDC-E2) with primary biliary cirrhosis sera: characterization of the autoantigenic region and effects of enzymatic delipoylation and relipoylation.
In situ nucleic acid detection of PDC-E2, BCOADC-E2, OGDC-E2, PDC-E1alpha, BCOADC-E1alpha, OGDC-E1, and the E3 binding protein (protein X) in primary biliary cirrhosis.
Lipoylated and unlipoylated domains of human PDC-E2 as autoantigens in primary biliary cirrhosis: significance of lipoate attachment.
Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis.
Mimicry peptides of human PDC-E2 163-176 peptide, the immunodominant T-cell epitope of primary biliary cirrhosis.
Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2.
Novel biomarkers for primary biliary cholangitis to improve diagnosis and understand underlying regulatory mechanisms.
Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis.
Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation for primary biliary cirrhosis.
Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis.
Primary biliary cirrhosis following lactobacillus vaccination for recurrent vaginitis.
Proteasome is required for class I-restricted presentation by Fcgamma receptor-mediated endocytosis in primary biliary cirrhosis.
Sidechain biology and the immunogenicity of PDC-E2, the major autoantigen of primary biliary cirrhosis.
Synthesis of diastereomerically pure Lys(N?-lipoyl) building blocks and their use in Fmoc/tBu solid phase synthesis of lipoyl-containing peptides for diagnosis of primary biliary cirrhosis.
[Cloning and expressing the E2 subunit of pyruvate dehydrogenase complex]
[Prediction and identification of autoepitopes of PDC-E2 specific CD8+ CTL in primary biliary cirrhosis patients]
Liver Diseases
Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis.
Liver Failure
[The significance of anti-nuclear envelope (gp210) antibody in primary biliary cirrhosis]
Liver Neoplasms
Hepatic gluconeogenic key enzymes in patients with hepatic cancer.
Lung Neoplasms
Computational evaluation of natural compounds as potential inhibitors of human PEPCK-M: an alternative for lung cancer therapy.
Construction of human monoclonal single-chain Fv antibodies against small-cell lung cancer by phage display libraries derived from cell-immunized SCID mice engrafted with human peripheral blood lymphocytes.
The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.
Lymphopenia
IL-2 receptor alpha deficiency and features of primary biliary cirrhosis.
Neoplasms
Context Dependent Regulation of Human Phosphoenolpyruvate Carboxykinase Isoforms by DNA Promoter Methylation and RNA Stability.
Down-regulation of the phosphoenolpyruvate carboxykinase gene in human colon tumors and induction by omega-3 fatty acids.
Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease.
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability.
PEPCK-M recoups tumor cell anabolic potential in a PKC-?-dependent manner.
Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M.
PHOSPHOPYRUVATE CARBOXYLASE IN LIVER TUMORS OF DIFFERENT GROWTH RATES.
The effect of phorbol esters and diacylglycerol on expression of the phosphoenolpyruvate carboxykinase (GTP) gene in rat hepatoma H4IIE cells.
The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.
Obesity
Glyceroneogenesis revisited.
Novel splice variants of the bovine PCK1 gene.
PCK1 and PCK2 as candidate diabetes and obesity genes.
Obesity, Maternal
Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring.
Overweight
Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes.
Rheumatic Diseases
Apotopes and the biliary specificity of primary biliary cirrhosis.
Sjogren's Syndrome
Primary biliary cirrhosis an epithelitis: evidence of abnormal salivary gland immunohistochemistry.
Starvation
3,5,3'-Triiodothyronine-induced synthesis of rat liver phosphoenolpyruvate carboxykinase.
cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei.
Dietary and hormonal regulation of some enzyme activities associated with gluconeogenesis in rabbit liver.
Induction of rat liver phosphoenolpyruvate carbonxykinase (GTP) by cyclic AMP during starvation. The permissive action of glucocorticoids.
P-enolpyruvate carboxykinase ferroactivator. Distribution, and the influence of diabetes and starvation.
Physiologic significance of glucocorticoids and insulin in the regulation of hepatic gluconeogenesis during starvation in rats.
Regulation of phosphoenolpyruvate carboxykinase (GTP) in adipose tissue in vivo by glucocorticoids and insulin.
The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.
[Effect of starvation, cortisol and insulin on the activities of pyruvate carboxylase, phosphopyruvate carboxylase (PEP-carboxykinase) and pyruvate kinase in the liver of NZo mice in various stages of diabetes]
Tuberculosis, Pulmonary
Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis.
Urinary Tract Infections
Environmental basis of primary biliary cholangitis.