Reference on EC 4.1.1.11 - aspartate 1-decarboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Williamson, J.M.
L-Aspartate alpha-decarboxylase
Methods Enzymol.
113
589-595
1985
Escherichia coli, Escherichia coli B / ATCC 11303
Williamson, J.M.; Brown, G.M.
Purification and properties of L-aspartate-alpha-decarboxylase, an enzyme that catalyzes the formation of beta-alanine in Escherichia coli
J. Biol. Chem.
254
8074-8082
1979
Escherichia coli, Escherichia coli B / ATCC 11303
Albert, A.; Dhanaraj, V.; Genschel, U.; Khan, G.; Ramjee, M.K.; Pulido, R.; Sibanda, B.L.; von Delft, F.; Witty, M.; Blundell, T.L.; Smith, A.G.; Abell, C.
Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing
Nat. Struct. Biol.
5
289-293
1998
Escherichia coli
Ramjee, M.K.; Genschel, U.; Abell, C.; Smith, A.G.
Escherichia coli L-aspartate alpha-decarboxylase: preprotein processing and observation of reaction intermediates by electrospray mass spectrometry
Biochem. J.
323
661-669
1997
Escherichia coli
Kwon, A.R.; Lee, B.I.; Han, B.W.; Ahn, H.J.; Yang, J.K.; Yoon, H.J.; Suh, S.W.
Crystallization and preliminary X-ray crystallographic analysis of aspartate 1-decarboxylase from Helicobacter pylori
Acta Crystallogr. Sect. D
58
861-863
2002
Helicobacter pylori
Dusch, N.; Phler, A.; Kalinowski, J.
Expression of the Corynebacterium glutamicum panD gene encoding L-aspartate-alpha-decarboxylase leads to pantothenate overproduction in Escherichia coli
Appl. Environ. Microbiol.
65
1530-1539
1999
Corynebacterium glutamicum (Q9X4N0), Corynebacterium glutamicum, Escherichia coli (P0A790), Escherichia coli, Escherichia coli MG1655 (P0A790)
Saldanha, S.A.; Birch, L.M.; Webb, M.E.; Nabbs, B.K.; von Delft, F.; Smith, A.G.; Abell, C.
Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction
Chem. Commun. (Camb.)
2001
1760-1761
2001
Escherichia coli
-
Schmitzberger, F.; Kilkenny, M.L.; Lobley, C.M.C.; Webb, M.E.; Vinkovic, M.; Matak-Vinkovic, D.; Witty, M.; Chirgadze, D.Y.; Smith, A.G.; Abell, C.; Blundell, T.L.
Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase
EMBO J.
22
6193-6204
2003
Escherichia coli (P0A790)
Chopra, S.; Pai, H.; Ranganathan, A.
Expression, purification, and biochemical characterization of Mycobacterium tuberculosis aspartate decarboxylase, PanD
Protein Expr. Purif.
25
533-540
2002
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Phillips, A.M.; Smart, R.; Strauss, R.; Brembs, B.; Kelly, L.E.
The Drosophila black enigma: The molecular and behavioural characterization of the black1 mutant allele
Gene
351
131-142
2005
Drosophila melanogaster
Lee, B.I.; Suh, S.W.
Crystal structure of the Schiff base intermediate prior to decarboxylation in the catalytic cycle of aspartate alpha-decarboxylase
J. Mol. Biol.
340
1-7
2004
Helicobacter pylori (P56065), Helicobacter pylori
Fouad, W.M.; Rathinasabapathi, B.
Expression of bacterial L-aspartate-alpha-decarboxylase in tobacco increases beta-alanine and pantothenate levels and improves thermotolerance
Plant Mol. Biol.
60
495-505
2006
Escherichia coli
Gopalan, G.; Chopra, S.; Ranganathan, A.; Swaminathan, K.
Crystal structure of uncleaved L-aspartate-alpha-decarboxylase from Mycobacterium tuberculosis
Proteins
65
796-802
2006
Mycobacterium tuberculosis
Arakane, Y.; Lomakin, J.; Beeman, R.W.; Muthukrishnan, S.; Gehrke, S.H.; Kanost, M.R.; Kramer, K.J.
Molecular and functional analyses of amino acid decarboxylases involved in cuticle tanning in Tribolium castaneum
J. Biol. Chem.
284
16584-16594
2009
Tribolium castaneum (A7U8C7), Tribolium castaneum, Tribolium castaneum GA-1 (A7U8C7)
Fouad, W.M.; Altpeter, F.
Transplastomic expression of bacterial L-aspartate-alpha-decarboxylase enhances photosynthesis and biomass production in response to high temperature stress
Transgenic Res.
18
707-718
2009
Escherichia coli
Lomakin, J.; Huber, P.A.; Eichler, C.; Arakane, Y.; Kramer, K.J.; Beeman, R.W.; Kanost, M.R.; Gehrke, S.H.
Mechanical properties of the beetle elytron, a biological composite material
Biomacromolecules
12
321-335
2011
Tribolium castaneum
de Villiers, J.; Koekemoer, L.; Strauss, E.
3-Fluoroaspartate and pyruvoyl-dependant aspartate decarboxylase: exploiting the unique characteristics of fluorine to probe reactivity and binding
Chemistry
16
10030-10041
2010
Escherichia coli, Mycobacterium tuberculosis
Webb, M.; Yorke, B.; Kershaw, T.; Lovelock, S.; Lobley, C.; Kilkenny, M.; Smith, A.; Blundell, T.; Pearson, A.; Abell, C.
Threonine 57 is required for the post-translational activation of Escherichia coli aspartate alpha-decarboxylase
Acta Crystallogr. Sect. D
70
1166-1172
2014
Escherichia coli (P0A790)
Webb, M.E.; Lobley, C.M.; Soliman, F.; Kilkenny, M.L.; Smith, A.G.; Blundell, T.L.; Abell, C.
Structure of Escherichia coli aspartate alpha-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation
Acta Crystallogr. Sect. F
68
414-417
2012
Escherichia coli (P0A790)
Monteiro, D.C.; Rugen, M.D.; Shepherd, D.; Nozaki, S.; Niki, H.; Webb, M.E.
Formation of a heterooctameric complex between aspartate alpha-decarboxylase and its cognate activating factor, PanZ, is CoA-dependent
Biochem. Biophys. Res. Commun.
426
350-355
2012
Escherichia coli
Cui, W.; Shi, Z.; Fang, Y.; Zhou, L.; Ding, N.; Zhou, Z.
Significance of Arg3, Arg54, and Tyr58 of L-aspartate alpha-decarboxylase from Corynebacterium glutamicum in the process of self-cleavage
Biotechnol. Lett.
36
121-126
2014
Corynebacterium glutamicum (Q9X4N0), Corynebacterium glutamicum ATCC 13032 (Q9X4N0)
Shen, Y.; Zhao, L.; Li, Y.; Zhang, L.; Shi, G.
Synthesis of beta-alanine from L-aspartate using L-aspartate-alpha-decarboxylase from Corynebacterium glutamicum
Biotechnol. Lett.
36
1681-1686
2014
Corynebacterium glutamicum (Q9X4N0), Corynebacterium glutamicum ATCC 13032 (Q9X4N0)
Liu, P.; Ding, H.; Christensen, B.M.; Li, J.
Cysteine sulfinic acid decarboxylase activity of Aedes aegypti aspartate 1-decarboxylase: the structural basis of its substrate selectivity
Insect Biochem. Mol. Biol.
42
396-403
2012
Aedes aegypti, Drosophila melanogaster
Wang, Y.; Xu, H.; White, R.H.
beta-Alanine biosynthesis in Methanocaldococcus jannaschii
J. Bacteriol.
196
2869-2875
2014
Methanocaldococcus jannaschii (Q60358), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q60358)
Stuecker, T.; Tucker, A.; Escalante-Semerena, J.
PanM, an acetyl-coenzyme a sensor required for maturation of L-aspartate decarboxylase (PanD)
mBio
3
e00158-12
2012
Salmonella enterica, Salmonella enterica DM10310
-
Nozaki, S.; Webb, M.E.; Niki, H.
An activator for pyruvoyl-dependent l-aspartate alpha-decarboxylase is conserved in a small group of the gamma-proteobacteria including Escherichia coli
MicrobiologyOpen
1
298-310
2012
Escherichia coli, Escherichia coli MG1655
Stuecker, T.N.; Hodge, K.M.; Escalante-Semerena, J.C.
The missing link in coenzyme A biosynthesis: PanM (formerly YhhK), a yeast GCN5 acetyltransferase homologue triggers aspartate decarboxylase (PanD) maturation in Salmonella enterica
Mol. Microbiol.
84
608-619
2012
Corynebacterium glutamicum, Salmonella enterica
Sharma, R.; Kothapalli, R.; Van Dongen, A.M.; Swaminathan, K.
Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate alpha-decarboxylase
PLoS ONE
7
e33521
2012
Mycobacterium tuberculosis
Sharma, R.; Florea, M.; Nau, W.M.; Swaminathan, K.
Validation of drug-like inhibitors against Mycobacterium tuberculosis L-aspartate alpha-decarboxylase using nuclear magnetic resonance (1H NMR)
PLoS ONE
7
e45947
2012
Mycobacterium tuberculosis
Lee, E.; Kim, H.; Kim, D.; Kim, Y.; Nam, S.; Kim, B.; Jeon, S.
Gene expression and characterization of thermostable glutamate decarboxylase from Pyrococcus furiosus
Biotechnol. Bioprocess Eng.
18
375-381
2013
Pyrococcus furiosus (Q8U1P6)
-
Gopal, P.; Tasneen, R.; Yee, M.; Lanoix, J.; Sarathy, J.; Rasic, G.; Li, L.; Dartois, V.; Nuermberger, E.; Dick, T.
In vivo-selected pyrazinoic acid-resistant Mycobacterium tuberculosis strains harbor missense mutations in the aspartate decarboxylase PanD and the unfoldase ClpC1
ACS Infect. Dis.
3
492-501
2017
Mycobacterium tuberculosis
Pei, W.; Zhang, J.; Deng, S.; Tigu, F.; Li, Y.; Li, Q.; Cai, Z.; Li, Y.
Molecular engineering of L-aspartate-alpha-decarboxylase for improved activity and catalytic stability
Appl. Microbiol. Biotechnol.
101
6015-6021
2017
Escherichia coli (P0A790), Bacillus subtilis (P52999), Corynebacterium glutamicum (Q9X4N0), Bacillus subtilis 168 (P52999), Corynebacterium glutamicum ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025 (Q9X4N0), Escherichia coli K-12 / DH5alpha (P0A790)
Arnott, Z.L.P.; Nozaki, S.; Monteiro, D.C.F.; Morgan, H.E.; Pearson, A.R.; Niki, H.; Webb, M.E.
The mechanism of regulation of pantothenate biosynthesis by the PanD-PanZ-AcCoA complex reveals an additional mode of action for the antimetabolite N-pentyl pantothenamide (N5-Pan)
Biochemistry
56
4931-4939
2017
Escherichia coli
Shen, Y.; Zhao, L.; Li, Y.; Zhang, L.; Shi, G.
Synthesis of beta-alanine from L-aspartate using L-aspartate-alpha-decarboxylase from Corynebacterium glutamicum
Biotechnol. Lett.
36
1681-1686
2014
Corynebacterium glutamicum (Q9X4N0), Corynebacterium glutamicum ATCC 13032 (Q9X4N0)
Stuecker, T.N.; Bramhacharya, S.; Hodge-Hanson, K.M.; Suen, G.; Escalante-Semerena, J.C.
Phylogenetic and amino acid conservation analyses of bacterial L-aspartate-alpha-decarboxylase and of its zymogen-maturation protein reveal a putative interaction domain
BMC Res. Notes
8
354
2015
Halalkalibacterium halodurans, Legionella pneumophila, Klebsiella pneumoniae (A6T4S8), Helicobacter pylori (P56065), Salmonella enterica subsp. enterica serovar Typhimurium (P65662), Moorella thermoacetica (Q2RM59), Magnetospirillum magneticum (Q2VZZ9), Neisseria gonorrhoeae (Q5F8Y9), Bordetella pertussis (Q7VXF8), Ralstonia solanacearum (Q8XVU6), Pseudomonas aeruginosa (Q9HV68), Corynebacterium glutamicum (Q9X4N0), Neisseria gonorrhoeae ATCC 700825 / FA 1090 (Q5F8Y9), Corynebacterium glutamicum ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025 (Q9X4N0), Magnetospirillum magneticum AMB-1 / ATCC 700264 (Q2VZZ9), Helicobacter pylori 26695 (P56065), Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 (Q9HV68), Salmonella enterica subsp. enterica serovar Typhimurium LT2 / SGSC1412 / ATCC 700720 (P65662), Halalkalibacterium halodurans ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125, Klebsiella pneumoniae ATCC 700721 / MGH 78578 (A6T4S8), Moorella thermoacetica ATCC 39073 / JCM 9320 (Q2RM59), Bordetella pertussis Tohama I / ATCC BAA-589 / NCTC 13251 (Q7VXF8)
Monteiro, D.C.F.; Patel, V.; Bartlett, C.P.; Nozaki, S.; Grant, T.D.; Gowdy, J.A.; Thompson, G.S.; Kalverda, A.P.; Snell, E.H.; Niki, H.; Pearson, A.R.; Webb, M.E.
The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A
Chem. Biol.
22
492-503
2015
Escherichia coli
Deng, S.; Zhang, J.; Cai, Z.; Li, Y.
Characterization of L-aspartate-alpha-decarboxylase from Bacillus subtilis
Chin. J. Biotechnol.
31
1184-1193
2015
Escherichia coli (P0A790), Bacillus subtilis (P52999), Corynebacterium glutamicum (Q9X4N0), Bacillus subtilis 168 (P52999), Corynebacterium glutamicum DSM 20300 (Q9X4N0)
Gliessman, J.R.; Kremer, T.A.; Sangani, A.A.; Jones-Burrage, S.E.; McKinlay, J.B.
Pantothenate auxotrophy in Zymomonas mobilis ZM4 is due to a lack of aspartate decarboxylase activity
FEMS Microbiol. Lett.
364
fnx113
2017
no activity in Zymomonas mobilis, Escherichia coli (P0A790), Escherichia coli, no activity in Zymomonas mobilis ZM4 / ATCC 31821 / CP4
Tomita, H.; Yokooji, Y.; Ishibashi, T.; Imanaka, T.; Atomi, H.
An archaeal glutamate decarboxylase homolog functions as an aspartate decarboxylase and is involved in beta-alanine and coenzyme A biosynthesis
J. Bacteriol.
196
1222-1230
2014
Thermococcus kodakarensis (Q5JJ82), Thermococcus kodakarensis, Thermococcus kodakarensis ATCC BAA-918 / JCM 12380 / KOD1 (Q5JJ82)
Zhang, T.; Zhang, R.; Xu, M.; Zhang, X.; Yang, T.; Liu, F.; Yang, S.; Rao, Z.
Glu56Ser mutation improves the enzymatic activity and catalytic stability of Bacillus subtilis L-aspartate alpha-decarboxylase for an efficient beta-alanine production
Process Biochem.
70
117-123
2018
Escherichia coli (P0A790), Bacillus subtilis (P52999), Lactiplantibacillus plantarum (Q88Z02), Corynebacterium glutamicum (Q9X4N0), Bacillus subtilis 168 (P52999), Corynebacterium glutamicum ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025 (Q9X4N0), Lactiplantibacillus plantarum ATCC BAA-793 / NCIMB 8826 / WCFS1 (Q88Z02)
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