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Disease on EC 3.6.4.B10 - chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
Targeting ?-tubulin/CCT-? complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma.
Alzheimer Disease
The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in A?-expressing Caenorhabditis elegans.
Anthrax
CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.
Astrocytoma
Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas.
Autoimmune Diseases
Chaperonin-containing T-complex Protein 1 Subunit ? Serves as an Autoantigen Recognized by Human V?2 ?? T Cells in Autoimmune Diseases.
Bardet-Biedl Syndrome
MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis.
Blindness
Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis.
Breast Neoplasms
Systematic Characterization of Expression Profiles and Prognostic Values of the Eight Subunits of the Chaperonin TRiC in Breast Cancer.
Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes.
Carcinogenesis
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis.
Subcellular and functional proteomic analysis of the cellular responses induced by Helicobacter pylori.
Carcinoma
Expression and significance of p53 and mdm2 in atypical intestinal metaplasia and gastric carcinoma.
Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival.
Gatric carcinoma. A prospective study of tumour differentiation correlated to surgical procedures and survival rate.
[Cancer cells in the blood stream of patients with gatric carcinoma.]
Carcinoma, Hepatocellular
Prognostic Power of a Chaperonin Containing TCP-1 Subunit Genes Panel for Hepatocellular Carcinoma.
The TCP1 ring complex is associated with malignancy and poor prognosis in hepatocellular carcinoma.
Cardiovascular Diseases
Chaperonin-containing TCP-1 complex directly binds to the cytoplasmic domain of the LOX-1 receptor.
Colonic Neoplasms
A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery.
Characterization of TCP-1 probes for molecular imaging of colon cancer.
Colorectal Neoplasms
A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery.
A novel vascular-targeting peptide for gastric cancer delivers low-dose TNF? to normalize the blood vessels and improve the anti-cancer efficiency of 5-fluorouracil.
Modulated T-complex protein 1 ? and peptidyl-prolyl cis-trans isomerase B are two novel indicators for evaluating lymph node metastasis in colorectal cancer: Evidence from proteomics and bioinformatics.
Vascular-targeted TNF? and IFN? inhibits orthotopic colorectal tumor growth.
Vascular-targeted TNF? improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer.
Down Syndrome
Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1.
Epstein-Barr Virus Infections
Proteomics Analysis of Gastric Epithelial AGS Cells Infected with Epstein-Barr Virus.
Glioma
Analysis of the antibody repertoire of astrocytoma patients against antigens expressed by gliomas.
Hepatitis C
Chaperonin TRiC/CCT participates in replication of hepatitis C virus genome via interaction with the viral NS5B protein.
Hereditary Sensory and Autonomic Neuropathies
Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy.
Infections
Human Papillomavirus infection requires the CCT Chaperonin Complex.
Identification of candidate protein markers of Bovine Parainfluenza Virus Type 3 infection using an in vitro model.
[Preliminary investigation of Helicobacter pylori infection in Linqu County of Shandong province]
Leber Congenital Amaurosis
Mutation in the Zebrafish cct2 Gene Leads to Abnormalities of Cell Cycle and Cell Death in the Retina: A Model of CCT2-Related Leber Congenital Amaurosis.
Leukemia, Myeloid, Acute
Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions.
Lymphadenopathy
Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis.
Lymphatic Metastasis
Modulated T-complex protein 1 ? and peptidyl-prolyl cis-trans isomerase B are two novel indicators for evaluating lymph node metastasis in colorectal cancer: Evidence from proteomics and bioinformatics.
Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis.
Lymphoma
Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis.
Malaria
The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol.
Neoplasm Metastasis
Modulated T-complex protein 1 ? and peptidyl-prolyl cis-trans isomerase B are two novel indicators for evaluating lymph node metastasis in colorectal cancer: Evidence from proteomics and bioinformatics.
Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis.
Neoplasms
?133p53? isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells.
A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery.
A novel vascular-targeting peptide for gastric cancer delivers low-dose TNF? to normalize the blood vessels and improve the anti-cancer efficiency of 5-fluorouracil.
Anti-tumor effect and mechanism of SEA-Fab' coupled protein on gastric tumor.
Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth.
Chaperonin Containing-TCP-1 Protein Level in Breast Cancer Cells Predicts Therapeutic Application of a Cytotoxic Peptide.
Chaperonin-Containing TCP1 Complex (CCT) Promotes Breast Cancer Growth Through Correlations With Key Cell Cycle Regulators.
Characterization of TCP-1 probes for molecular imaging of colon cancer.
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis.
Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity.
Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.
Gatric carcinoma. A prospective study of tumour differentiation correlated to surgical procedures and survival rate.
Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins.
Matrine induces papillary thyroid cancer cell apoptosis in vitro and suppresses tumor growth in vivo by downregulating miR-182-5p.
Molecular and Clinical Characterization of CCT2 Expression and Prognosis via Large-Scale Transcriptome Profile of Breast Cancer.
Multiple malignant primary neoplasms in patients with gatric neoplasms in the health district of León.
p53: the TRiC is knowing when to fold 'em.
Systematic Characterization of Expression Profiles and Prognostic Values of the Eight Subunits of the Chaperonin TRiC in Breast Cancer.
The cytosolic chaperonin CCT/TRiC and cancer cell proliferation.
The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex.
The TCP1 ring complex is associated with malignancy and poor prognosis in hepatocellular carcinoma.
Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding.
Understanding the Molecular Mechanism of miR-877-3p Could Provide Potential Biomarkers and Therapeutic Targets in Squamous Cell Carcinoma of the Cervix.
Vascular-targeted TNF? and IFN? inhibits orthotopic colorectal tumor growth.
Vascular-targeted TNF? improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer.
[Cancer cells in the blood stream of patients with gatric carcinoma.]
[Effects of RNA interference of CTHRC1 on proliferation and apoptosis of thyroid papillary cancer TCP-1 cells in vitro].
[Preliminary investigation of Helicobacter pylori infection in Linqu County of Shandong province]
[Prescription rules of Chinese herbal medicines in treatment of gastric cancer]
Neurodegenerative Diseases
Sirt1’s beneficial roles in neurodegenerative diseases - a chaperonin containing TCP-1 (CCT) connection?
Neurofibromatoses
Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress.
Neurofibromatosis 1
Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress.
Papillomavirus Infections
Human Papillomavirus infection requires the CCT Chaperonin Complex.
Pleural Effusion
Identification of 10 Candidate Biomarkers Distinguishing Tuberculous and Malignant Pleural Fluid by Proteomic Methods.
Pleural Effusion, Malignant
Identification of 10 Candidate Biomarkers Distinguishing Tuberculous and Malignant Pleural Fluid by Proteomic Methods.
Pulmonary Disease, Chronic Obstructive
Effects of genetic variations in Acads gene on the risk of chronic obstructive pulmonary disease.
Starvation
Regeneration in starved planarians depends on TRiC/CCT subunits modulating the unfolded protein response.
Stomach Diseases
Subcellular and functional proteomic analysis of the cellular responses induced by Helicobacter pylori.
Stomach Neoplasms
A novel vascular-targeting peptide for gastric cancer delivers low-dose TNF? to normalize the blood vessels and improve the anti-cancer efficiency of 5-fluorouracil.
Chaperonin containing TCP-1 subunit 3 is critical for gastric cancer growth.
Stroke
A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle.
Teratozoospermia
T-complex protein 1 subunit zeta-2 (CCT6B) deficiency induces murine teratospermia.
Thyroid Neoplasms
Effect of Interferon-? on the Basal and the TNF?-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation.
Tuberculosis
Duodenal tuberculosis presenting as gatric outlet obstruction.
Zika Virus Infection
TRiC/CCT Complex, a Binding Partner of NS1 Protein, Supports the Replication of Zika Virus in Both Mammalians and Mosquitoes.