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Information on EC 3.6.4.12 - DNA helicase

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IUBMB Comments
DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. Some of them unwind duplex DNA with a 3' to 5' polarity [1,3,5,8], others show 5' to 3' polarity [10,11,12,13] or unwind DNA in both directions [14,15]. Some helicases unwind DNA as well as RNA [9,10]. May be identical with EC 3.6.4.13 (RNA helicase).
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
3' to 5' DNA helicase, 3'-5' DNA helicase, 3'-5' PfDH, 5' to 3' DNA helicase, AddA, AddAB, AddAB helicase, adenosine triphosphate-dependent helicase-nuclease, ATP-dependent DNA helicase Hel308, ATP-dependent DNA helicase Q1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O = ADP + phosphate
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