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Disease on EC 3.6.1.29 - bis(5'-adenosyl)-triphosphatase

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DISEASE
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Adenocarcinoma
Abnormal fragile histidine triad (Fhit) expression in invasive cervical adenocarcinoma: association with tumor aggressiveness.
Altered expression of the fragile histidine triad gene in primary gastric adenocarcinomas.
Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients.
Correlation of aberrant expression of CD133 with FHIT and malignant phenotype of colorectal adenocarcinoma.
fhit Alterations in endometrial carcinoma and hyperplasia.
FHIT alterations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Fhit expression in gastric adenocarcinoma: correlation with disease stage and survival.
FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study.
Fhit protein expression in lung cancer studied by high-throughput tissue microarray.
FHIT protein is expressed in benign mesothelium and has no clinical value in detecting carcinoma in body cavity effusions.
Immunohistochemical expression of FHIT gene product in inflammatory bowel disease: significance and correlation with clinicopathological data.
Immunohistochemical expression of Fhit protein in Helicobacter pylori related chronic gastritis, gastric precancerous lesions and gastric carcinoma: correlation with conventional clinicopathologic parameters.
Impaired FHIT expression characterizes serous ovarian carcinoma.
Loss of fragile histidine triad and amplification of 1p36.22 and 11p15.5 in primary gastric adenocarcinomas.
Promoter hypermethylation of p16INK4a, E-cadherin, O6-MGMT, DAPK and FHIT in adenocarcinomas of the esophagus, esophagogastric junction and proximal stomach.
[Relationship between hMSH2 and FHIT gene expression in non-small cell lung cancer]
Adenoma
Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types.
Decreased fragile histidine triad expression in colorectal cancer and its association with apoptosis inhibition.
Expression of Fhit, Mlh1, and P53 protein in human gallbladder carcinoma.
Fragile histidine triad (FHIT) gene is overexpressed in colorectal cancer.
Frequent altered expression of fragile histidine triad protein in human colorectal adenomas.
Impaired FHIT expression characterizes serous ovarian carcinoma.
Molecular damage and lung tumors in cigarette smoke-exposed mice.
Prevalence and distinctive biologic features of flat colorectal adenomas in a North American population.
[Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]
Adenomatous Polyposis Coli
DNA hypermethylation profiles in squamous cell carcinoma of the vulva.
Hypermethylation of FHIT as a prognostic marker in nonsmall cell lung carcinoma.
Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer.
[Aberrant promoter methylation of tumor suppressor genes in serum from lung cancer patients: frequency and correlation with clinicopathological characteristics]
Ameloblastoma
Assessment of fragile histidine triad expression in ameloblastoma, odontogenic keratocyst and dentigerous cyst.
Anus Neoplasms
FHIT oncosuppressor gene expression profile in human anal cancers.
Bowen's Disease
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Breast Neoplasms
Alterations of the FHIT gene in breast cancer: association with tumor progression and patient survival.
Analysis of FHIT Gene Methylation in Egyptian Breast Cancer Women: Association with Clinicopathological Features.
Analysis of the fragile histidine triad (FHIT) gene in lobular breast cancer.
Clinicopathological significance of fragile histidine triad transcription protein expression in breast carcinoma.
Comparative analysis of loss of heterozygosity of specific chromosome 3, 13, 17, and X loci and TP53 mutations in human epithelial ovarian cancer.
Correlations of breast cancer FHIT gene with the incidence and prognosis of breast cancer.
Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with a high incidence of oesophageal cancer.
FHIT alterations in breast cancer.
Fhit expression protects against HER2-driven breast tumor development: unraveling the molecular interconnections.
FHIT loss of function in human primary breast cancer correlates with advanced stage of the disease.
Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer.
Loss of FHIT expression in breast cancer is correlated with poor prognostic markers.
Loss of FHIT protein expression is a marker of adverse evolution in good prognosis localized breast cancer.
Loss of heterozygosity on chromosomes 3, 9, 13, and 17, including the retinoblastoma locus, in uveal melanoma.
Loss of Msh2 is not associated with FHIT deletion in breast carcinomas.
Mutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir.
Promoter methylation status of the FHIT gene and Fhit expression: Association with HER2/neu status in breast cancer patients.
Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines.
The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma.
The Fragile Histidine Triad gene and breast cancer.
[Loss of fragile histidine triad expression and metastasis in breast cancer]
Burkitt Lymphoma
Frequent silencing of fragile histidine triad gene (FHIT) in Burkitt's lymphoma is associated with aberrant hypermethylation.
Carcinogenesis
A knockdown with smoke model reveals FHIT as a repressor of Heme oxygenase 1.
Abnormal Fhit protein expression and high frequency of microsatellite instability in sporadic colorectal cancer.
Abnormal FHIT transcripts found in both lung cancer and normal lung tissue.
Abnormalities of the FHIT gene in human oral carcinogenesis.
Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer.
Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities.
Alteration of the fragile histidine triad gene early in carcinogenesis: an update.
Alterations of the fragile histidine triad gene, FHIT, and its encoded products contribute to testicular germ cell tumorigenesis.
Altered expression of the fragile histidine triad gene in primary gastric adenocarcinomas.
Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer.
Analysis of FHIT allelic imbalance/loss of heterozygosity and FHIT expression in cutaneous squamous cell carcinomas.
Analysis of the fragile histidine triad (FHIT) gene in lobular breast cancer.
Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients.
Clinicopathological significance of the fragile histidine triad transcription protein expression in laryngeal carcinogenesis.
Cytogenetic studies of 24 renal epithelial tumors with von Hippel-Lindau and fragile histidine triad protein expression correlation.
Diadenosine oligophosphates (Ap(n)A), a novel class of signalling molecules?
Down-regulation of FHIT inhibits apoptosis of colorectal cancer: mechanism and clinical implication.
Expression of FHIT in esophageal epithelium and carcinoma: reference to drinking, smoking and multicentric carcinogenesis.
Expression of Fhit, Mlh1, and P53 protein in human gallbladder carcinoma.
Expression of selected miRNA, RAR? and FHIT genes in BALf of squamous cell lung cancer (squamous-cell carcinoma, SCC) patients: a pilot study.
Expression of the fragile histidine triad gene in normal rat tissues and human kidney cancer cell lines.
FHIT expression and hypermethylation in esophageal squamous cell carcinoma.
Fhit expression in human gastric adenomas and intramucosal carcinomas: correlation with Mlh1 expression and gastric phenotype.
FHIT expression in neoplastic, hyperplastic, and normal endometrium.
FHIT Gene Sequence Variants and Reduced Fhit Protein Expression in Glioblastoma Multiforme.
Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53.
Immunohistochemical evaluation of Fhit protein expression in oral squamous cell carcinomas.
Inverse correlation of aberrant expression of fragile histidine triad (FHIT) protein with cyclin D1 protein and prognosis in Chinese patients with cholangiocarcinoma.
Loss of FHIT expression in breast cancer is correlated with poor prognostic markers.
Loss of FHIT expression in squamous cell carcinoma and premalignant lesions of the larynx.
Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions.
Loss of fragile histidine triad protein expression in inflammatory bowel disease.
Loss of fragile histidine triad protein in human hepatocellular carcinoma.
MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family.
MSI/LOH and extron expression of the FHIT gene in gastric carcinoma.
Mutation and abnormal expression of the fragile histidine triad gene in nasopharyngeal carcinoma.
Nicotine induces the fragile histidine triad methylation in human esophageal squamous epithelial cells.
Novel missense mutation in FHIT gene: interpreting the effect in HPV-mediated cervical cancer in Indian women.
Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor.
Primary cervical carcinomas show 2 common regions of deletion at 3P, 1 within the FHIT gene: evaluation of allelic imbalance at FHIT, RB1 and TP53 in relation to survival.
Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis.
Relationship between abnormality of FHIT gene and EBV infection in gastric cancer.
Restored expression of fragile histidine triad protein and tumorigenicity of cervical carcinoma cells.
Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein.
[Alteration of FHIT gene and p16 gene in malignant transformed cells induced by crystalline nickel sulfide]
[Correlation between methylation of 5'-CpG islands and inactivation of FHIT gene in cervical cancer.]
[Effects of Methylation of FHIT Gene on it's Protein and mRNA Expression in Non-small Cell Lung Cancer.]
[Expression of FHIT and MDM2 in oral submucous fibrosis and canceration tissues]
[HPV detection and FHIT expression in esophageal squamous carcinoma from high incidence area in Cixian County]
[Interaction between fragile histidine triad methylation, protein expression and human papillomavirus 16 infection in cervical carcinogenesis].
[The biological significance of FHIT protein expression in lung cancer and precancerous tissues detected by tissue microarray.]
Carcinoid Tumor
Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors.
Carcinoma
5'-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas.
Aberrant methylation of Fragile Histidine Triad gene is associated with poor prognosis in early stage esophageal squamous cell carcinoma.
Abnormal fragile histidine triad (FHIT) expression in advanced cervical carcinoma: a poor prognostic factor.
Abnormalities of the FHIT gene in human oral carcinogenesis.
Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities.
Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma.
Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma.
Altered expression of the fragile histidine triad gene in primary gastric adenocarcinomas.
Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer.
Analysis of FHIT allelic imbalance/loss of heterozygosity and FHIT expression in cutaneous squamous cell carcinomas.
Analysis of the fragile histidine triad gene in primary gastric carcinomas and gastric carcinoma cell lines.
Assessment of the prognostic value of methylation status and expression levels of FHIT, GSTP1 and p16 in non-small cell lung cancer in Egyptian patients.
Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans.
Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types.
Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients.
Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma.
Clinicopathological significance of the fragile histidine triad transcription protein expression in laryngeal carcinogenesis.
Decreased fragile histidine triad gene protein expression is associated with worse prognosis in oral squamous carcinoma.
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas.
Differential susceptibility of renal carcinoma cell lines to tumor suppression by exogenous Fhit expression.
Down-regulation of fragile histidine triad expression in prostate carcinoma.
Effect of fragile histidine triad gene on biologic properties of muco-epidermoid carcinoma cells.
Epigenetic silencing contributes to frequent loss of the fragile histidine triad tumour suppressor in basal cell carcinomas.
Epithelial and stromal genetic instability linked to tumor suppressor genes in ulcerative colitis-associated tumorigenesis.
FHIT alterations in cancerous and non-cancerous cervical epithelium.
Fhit expression in gastric adenocarcinoma: correlation with disease stage and survival.
Fhit expression in human gastric adenomas and intramucosal carcinomas: correlation with Mlh1 expression and gastric phenotype.
Fhit protein expression in lung cancer studied by high-throughput tissue microarray.
FHIT protein is expressed in benign mesothelium and has no clinical value in detecting carcinoma in body cavity effusions.
Fhit Regulates EMT Targets through an EGFR/Src/ERK/Slug Signaling Axis in Human Bronchial Cells.
Fragile histidine triad expression in oral squamous cell carcinoma and precursor lesions.
Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma.
Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project.
Fragile histidine triad transcription abnormalities and human papillomavirus E6-E7 mRNA expression in the development of cervical carcinoma.
Frequent altered expression of fragile histidine triad protein in human colorectal adenomas.
Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer.
Immunohistochemical assessment of Fhit protein expression in advanced gastric carcinomas in correlation with Helicobacter pylori infection and survival time.
Immunohistochemical detection of cell cycle regulators, Fhit protein and apoptotic cells in parathyroid lesions.
Immunohistochemical evaluation of Fhit protein expression in oral squamous cell carcinomas.
Immunohistochemical expression of Fhit protein in Helicobacter pylori related chronic gastritis, gastric precancerous lesions and gastric carcinoma: correlation with conventional clinicopathologic parameters.
Immunohistochemical FHIT expression still exists in early lesions of basal cell carcinoma.
Impaired FHIT expression characterizes serous ovarian carcinoma.
In silico analysis of fragile histidine triad involved in regression of carcinoma.
Inactivation of the FHIT gene favors bladder cancer development.
Investigation of tumor suppressor genes apart from VHL on 3p by deletion mapping in sporadic clear cell renal cell carcinoma (cRCC).
Loss of FHIT expression in cervical carcinoma cell lines and primary tumors.
Loss of FHIT expression in gastric carcinoma.
Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection.
Loss of fhit expression in invasive cervical carcinomas and intraepithelial lesions associated with invasive disease.
Loss of FHIT expression in squamous cell carcinoma and premalignant lesions of the larynx.
Loss of Fhit protein expression in high-grade and advanced stage endometrial carcinomas.
Loss of Fhit protein in carcinoma of primary and secondary müllerian systems.
Loss of fragile histidine triad (FHIT) expression and microsatellite instability in periocular sebaceous gland carcinoma in patients with Muir-Torre syndrome.
Loss of fragile histidine triad gene expression is associated with progression of esophageal squamous cell carcinoma, but not with the patient's prognosis and smoking history.
Loss of fragile histidine triad protein expression in inflammatory bowel disease.
Loss of fragile histidine triad protein in human hepatocellular carcinoma.
Loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinoma.
Loss or reduction of Fhit expression in renal neoplasias: correlation with histogenic class.
Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma.
Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with myelodysplastic syndrome.
Microsatellite instability and loss of heterozygosity in oral squamous cell carcinoma in Malaysian population.
Microsatellite instability and loss of heterozygosity of fragile histidine triad gene in lung hyperplastic lesions.
Microsatellite instability is often observed in esophageal carcinoma patients with allelic loss in the FHIT/FRA3B locus.
Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors.
MSI/LOH and extron expression of the FHIT gene in gastric carcinoma.
Prognostic significance of p53 and FHIT in advanced oropharyngeal carcinoma.
Reduced acetylated histone H4 is associated with promoter methylation of the fragile histidine triad gene in resected esophageal squamous cell carcinoma.
Reduced Fhit expression in cervical carcinoma: correlation with tumor progression and poor prognosis.
Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma.
Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis.
Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients.
Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma.
Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines.
Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells.
Restored expression of fragile histidine triad protein and tumorigenicity of cervical carcinoma cells.
Role of 5'-CpG island hypermethylation of the FHIT gene in cervical carcinoma.
Significance of combined detection of p53 and FHIT in cervical carcinoma diagnosis.
The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance.
The role of the FHIT/FRA3B locus in cancer.
The significance of fragile histidine triad protein as a molecular prognostic marker of bladder urothelial carcinoma.
[Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]
[Expression of the genes FHIT, Bcl-2 and Bax in breast infiltrating ductal carcinoma and clinicopathological significance thereof]
[Expressions of FHIT and cyclin D1/CDK4 in oral cancer and oral precancerous lesions]
[Fragile histidine triad protein expression and correlation with apoptosis in rectal carcinoma]
[HPV detection and FHIT expression in esophageal squamous carcinoma from high incidence area in Cixian County]
[Hypermethylation of fragile histidine triad gene and 3p14 allelic deletion in ovarian carcinomas]
[Loss of exons of FHIT gene and FHIT protein expression in Yunnan tin miners with lung cancer]
[Microsatellite instability and loss of heterozygosity of fragile histidine triad gene in laryngeal squamous cell carcinoma]
[Relationship between hMSH2 and FHIT gene expression in non-small cell lung cancer]
[Relationship between the expression of fragile histidine (FHIT) and the development of vulvar carcinoma]
[Relationship between the reduction of FHIT expression and the development of cervical carcinoma]
[Study on the relationship between LOH and MI of FHIT gene and the development of cervical carcinoma]
[The relationship between expression of Fhit and biological behaviors of hypopharyngeal carcinoma]
Carcinoma in Situ
Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types.
Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis.
[Loss of exons of FHIT gene and FHIT protein expression in Yunnan tin miners with lung cancer]
Carcinoma, Basal Cell
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Epigenetic silencing contributes to frequent loss of the fragile histidine triad tumour suppressor in basal cell carcinomas.
Immunohistochemical FHIT expression still exists in early lesions of basal cell carcinoma.
Carcinoma, Ductal
[Expression of the genes FHIT, Bcl-2 and Bax in breast infiltrating ductal carcinoma and clinicopathological significance thereof]
[Loss of fragile histidine triad expression and metastasis in breast cancer]
Carcinoma, Hepatocellular
Aberrant fragile histidine triad gene transcripts in primary hepatocellular carcinoma and liver cirrhosis.
Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma.
Effect of fragile histidine triad gene transduction on proliferation and apoptosis of human hepatocellular carcinoma cells.
Effect of interventional embolotherapy on FHIT and p16 expression in hepatocellular carcinoma patients.
Evaluation of Relationship between Occurrence of Liver Cancer and Methylation of Fragile Histidine Triad (FHIT) and P16 Genes.
Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis.
FHIT mRNA and protein expression in hepatocellular carcinoma.
FHIT overexpression in HepG2 hepatoma cells affects growth and cyclin D1 expression in vitro.
Fragile histidine triad gene alterations are not essential for hepatocellular carcinoma development in South Korea.
HIV-TAT-fused FHIT protein functions as a potential pro-apoptotic molecule in hepatocellular carcinoma cells.
Loss of fragile histidine triad protein in human hepatocellular carcinoma.
[Clinicopathological significance of aberrant methylation of the fragile histidine triad gene in patients with hepatocellular carcinoma]
Carcinoma, Mucoepidermoid
[The inhibition of fragile histidine triad gene on the proliferation and tumorigenicity of mucoepidermoid carcinoma cells]
Carcinoma, Neuroendocrine
Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors.
Carcinoma, Non-Small-Cell Lung
Clinicopathological significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer.
Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma.
FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-?B/Slug-mediated PUMA reduction.
Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53.
Increased Sensitivity to Cisplatin in Non-Small Cell Lung Cancer Cell Lines after FHIT Gene Transfer.
Loss of FHIT function in lung cancer and preinvasive bronchial lesions.
Carcinoma, Renal Cell
Different immunohistochemical patterns of Fhit protein expression in renal neoplasms.
Differential susceptibility of renal carcinoma cell lines to tumor suppression by exogenous Fhit expression.
Carcinoma, Small Cell
Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors.
Carcinoma, Squamous Cell
Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer.
Decreased fragile histidine triad gene protein expression is associated with worse prognosis in oral squamous carcinoma.
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Fhit protein expression in lung cancer studied by high-throughput tissue microarray.
Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project.
Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer.
Loss of FHIT expression in squamous cell carcinoma and premalignant lesions of the larynx.
Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma.
Microsatellite instability and loss of heterozygosity in oral squamous cell carcinoma in Malaysian population.
Microsatellite instability and loss of heterozygosity of fragile histidine triad gene in lung hyperplastic lesions.
Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis.
[HPV detection and FHIT expression in esophageal squamous carcinoma from high incidence area in Cixian County]
[Loss of exons of FHIT gene and FHIT protein expression in Yunnan tin miners with lung cancer]
[Relationship between hMSH2 and FHIT gene expression in non-small cell lung cancer]
Cervical Intraepithelial Neoplasia
The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions.
Cholangiocarcinoma
Aberrant transcription of FHIT gene in intrahepatic cholangiocellular carcinomas induced by N-nitrosobis(2-oxopropyl)amine in hamsters.
Alteration of the fragile histidine triad gene in intrahepatic cholangiocarcinoma.
Fragile histidine triad (FHIT) suppresses proliferation and promotes apoptosis in cholangiocarcinoma cells by blocking PI3K-Akt pathway.
Inverse correlation of aberrant expression of fragile histidine triad (FHIT) protein with cyclin D1 protein and prognosis in Chinese patients with cholangiocarcinoma.
Promoter methylation and loss of coding exons of the fragile histidine triad (FHIT) gene in intrahepatic cholangiocarcinomas.
Chordoma
High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesis.
Colitis, Ulcerative
Immunohistochemical expression of FHIT gene product in inflammatory bowel disease: significance and correlation with clinicopathological data.
Loss of fragile histidine triad protein expression in inflammatory bowel disease.
Overexpression of the fragile histidine triad (FHIT) gene in inflammatory bowel disease.
Colonic Neoplasms
Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines.
Colorectal Neoplasms
Aberrant crypt focus and fragile histidine triad protein in sporadic colorectal carcinoma.
Abnormal Fhit protein expression and high frequency of microsatellite instability in sporadic colorectal cancer.
Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma.
Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types.
Decreased fragile histidine triad expression in colorectal cancer and its association with apoptosis inhibition.
FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study.
Fhit protein expression in hereditary and sporadic colorectal cancers.
Fragile histidine triad (FHIT) gene is overexpressed in colorectal cancer.
Frequent altered expression of fragile histidine triad protein in human colorectal adenomas.
Loss of fragile histidine triad expression in colorectal carcinoma.
Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions.
Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma.
Usefulness of plasma epigenetic changes of five major genes involved in the pathogenesis of colorectal cancer.
[Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]
[Expression of nuclear factor-kappa-B/P65 and fragile histidine triad in colorectal carcinoma and clinical significance thereof]
[Impact of fragile histidine triad gene transfection on the proliferation and apoptosis of human colorectal cancer cell]
Crohn Disease
Genome-Wide Analysis of the DNA Methylation Profile Identifies the Fragile Histidine Triad (FHIT) Gene as a New Promising Biomarker of Crohn's Disease.
Immunohistochemical expression of FHIT gene product in inflammatory bowel disease: significance and correlation with clinicopathological data.
Loss of fragile histidine triad protein expression in inflammatory bowel disease.
Overexpression of the fragile histidine triad (FHIT) gene in inflammatory bowel disease.
Dentigerous Cyst
Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst.
Assessment of fragile histidine triad expression in ameloblastoma, odontogenic keratocyst and dentigerous cyst.
Digestive System Neoplasms
FHIT promotes the apoptosis of QBC939 by reducing the expression of cyclin D1.
Endometrial Neoplasms
Clinicopathological significance of fragile histidine triad transcription protein expression in endometrial carcinomas.
Fhit protein expression in endometrial cancers: no correlation with histological grade.
Loss of Fhit protein expression in high-grade and advanced stage endometrial carcinomas.
Upregulation of FHIT gene expression in endometrial carcinoma by RNA activation.
Endometriosis
[Expression of fragile histidine triad in endometriosis]
Epstein-Barr Virus Infections
Relationship between abnormality of FHIT gene and EBV infection in gastric cancer.
Esophageal Neoplasms
Aberrant methylation of Fragile Histidine Triad gene is associated with poor prognosis in early stage esophageal squamous cell carcinoma.
Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells.
Immunohistochemical evaluation of p53, FHIT, and IGF2 gene expression in esophageal cancer.
[Association of fragile histidine triad gene (FHIT) with susceptibility to esophageal cancer. A preliminary study]
Esophageal Squamous Cell Carcinoma
Aberrant methylation of Fragile Histidine Triad gene is associated with poor prognosis in early stage esophageal squamous cell carcinoma.
Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma.
Loss of fragile histidine triad gene expression is associated with progression of esophageal squamous cell carcinoma, but not with the patient's prognosis and smoking history.
Reduced acetylated histone H4 is associated with promoter methylation of the fragile histidine triad gene in resected esophageal squamous cell carcinoma.
Relationship between expression of P27, Fragile Histidine Triad (FHT), phosphatase and tensin homolog deleted on chromosome ten (PTEN), P73, and prognosis in esophageal squamous cell carcinoma.
Gallbladder Neoplasms
Fragile histidine triad (FHIT) gene and its association with p53 protein expression in the progression of gall bladder cancer.
Gastritis
Immunohistochemical expression of Fhit protein in Helicobacter pylori related chronic gastritis, gastric precancerous lesions and gastric carcinoma: correlation with conventional clinicopathologic parameters.
Glioblastoma
FHIT Gene Sequence Variants and Reduced Fhit Protein Expression in Glioblastoma Multiforme.
Head and Neck Neoplasms
Clinicopathological significance of the fragile histidine triad transcription protein expression in laryngeal carcinogenesis.
Hematologic Neoplasms
Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome.
Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35.
Hematuria
Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH).
Hepatitis C
Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma.
Hodgkin Disease
Aberrant FHIT protein expression in classical Hodgkin's lymphoma: a potential marker.
[Expression of fragile histidine triad (FHIT) protein and its significance in diagnosing classical Hodgkin lymphoma]
Hypertension
Fragile Histidine Triad (FHIT), a Novel Modifier Gene in Pulmonary Arterial Hypertension.
Idiopathic Pulmonary Fibrosis
Aberrations in the fragile histidine triad (FHIT) gene in idiopathic pulmonary fibrosis.
Infections
Abnormal Fhit expression is an independent poor prognostic factor for cervical cancer.
Effect of FHIT loss and p53 mutation on HPV-infected lung carcinoma development.
Effect of fragile histidine triad gene transduction on proliferation and apoptosis of human hepatocellular carcinoma cells.
Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential.
Immunohistochemical assessment of Fhit protein expression in advanced gastric carcinomas in correlation with Helicobacter pylori infection and survival time.
Immunohistochemical expression of Fhit protein in Helicobacter pylori related chronic gastritis, gastric precancerous lesions and gastric carcinoma: correlation with conventional clinicopathologic parameters.
Loss of Fhit expression as a potential marker of malignant progression in preinvasive squamous cervical cancer.
Mycobacterium tuberculosis infection and FHIT gene alterations in lung cancer.
Restored expression of fragile histidine triad protein and tumorigenicity of cervical carcinoma cells.
[Interaction between fragile histidine triad methylation, protein expression and human papillomavirus 16 infection in cervical carcinogenesis].
Inflammatory Bowel Diseases
Loss of fragile histidine triad protein expression in inflammatory bowel disease.
Overexpression of the fragile histidine triad (FHIT) gene in inflammatory bowel disease.
Keratosis, Actinic
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Kidney Neoplasms
Different immunohistochemical patterns of Fhit protein expression in renal neoplasms.
Expression of the fragile histidine triad gene in normal rat tissues and human kidney cancer cell lines.
Leukemia
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.
Methylation status of the FHIT gene in the transformed human mesenchymal F6 stem cell line.
Leukemia, Myeloid, Acute
Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome.
Leukemia-Lymphoma, Adult T-Cell
Germinal epimutation of Fragile Histidine Triad (FHIT) gene is associated with progression to acute and chronic adult T-cell leukemia diseases.
Leukoplakia
Abnormalities of the FHIT gene in human oral carcinogenesis.
Liver Cirrhosis
Aberrant fragile histidine triad gene transcripts in primary hepatocellular carcinoma and liver cirrhosis.
Liver Neoplasms
Association of FHIT expression and FHIT gene hypermethylation with liver cancer risk: a PRISMA-compliant meta-analysis.
Evaluation of Relationship between Occurrence of Liver Cancer and Methylation of Fragile Histidine Triad (FHIT) and P16 Genes.
HIV-TAT-fused FHIT protein functions as a potential pro-apoptotic molecule in hepatocellular carcinoma cells.
Relationship between Methylation of FHIT and CDH13 Gene Promoter Region and Liver Cancer.
Lung Neoplasms
Aberrant methylation of the FHIT gene in chronic smokers with early stage squamous cell carcinoma of the lung.
Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.
Aberrations in the fragile histidine triad(FHIT) gene may be involved in lung carcinogenesis in patients with chronic pulmonary tuberculosis.
Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities.
Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma.
Clinicopathological significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer.
Coexpression of fragile histidine triad and c-kit is relevant for prediction of survival in patients with small cell lung cancer.
Decreased fragile histidine triad gene messenger RNA expression in lung cancer.
Dose-dependent effect of FHIT-inducible expression in Calu-1 lung cancer cell line.
Early loss of Fhit in the respiratory tract of rodents exposed to environmental cigarette smoke.
Effect of FHIT loss and p53 mutation on HPV-infected lung carcinoma development.
Establishment of two data mining models of lung cancer screening based on three gene promoter methylations combined with telomere damage.
FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-?B/Slug-mediated PUMA reduction.
FHIT protein enhances paclitaxel-induced apoptosis in lung cancer cells.
Fhit protein expression in lung cancer studied by high-throughput tissue microarray.
Fhit, a tumor suppressor protein, induces autophagy via 14-3-3? in non-small cell lung cancer cells.
Fhit-Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells.
Fragile histidine triad (FHIT) gene abnormalities in lung cancer.
Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project.
Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch.
Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53.
Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers.
Frequent FHIT gene loss of heterozygosity in human papillomavirus-infected non-smoking female lung cancer in Taiwan.
Increased Sensitivity to Cisplatin in Non-Small Cell Lung Cancer Cell Lines after FHIT Gene Transfer.
Induction of apoptosis by tumor suppressor FHIT via death receptor signaling pathway in human lung cancer cells.
Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population.
Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features.
Loss of FHIT function in lung cancer and preinvasive bronchial lesions.
Loss of FHIT protein expression is related to high proliferation, low apoptosis and worse prognosis in non-small-cell lung cancer.
Loss of fragile histidine triad gene expression in advanced lung cancer is consequent to allelic loss at 3p14 locus and promoter methylation.
Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency.
Mutation analysis of the FHIT gene in bronchoscopic specimens from patients with suspected lung cancer.
Prognostic relevance of fragile histidine triad protein expression in patients with small cell lung cancer.
Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients.
Roles of Fhit and p53 in Taiwanese surgically treated non-small-cell lung cancers.
The apoptotic pathway triggered by the Fhit protein in lung cancer cell lines is not affected by Bcl-2 or Bcl-x(L) overexpression.
The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer.
The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control.
[Aberrant promoter methylation of tumor suppressor genes in serum from lung cancer patients: frequency and correlation with clinicopathological characteristics]
[Abnormalities of tumor suppressor genes at chromosome 3p in lung cancer]
[Alterations of FHIT gene and p16 gene in lung cancer and metastatic hilar lymph nodes]
[Clinicopathological analysis of loss of fragile histidine triad expression in lung cancer].
[Ectogenous fragile histidine triad gene inhibits the malignant phenotype of human lung cancer cell line A549 in vitro and in vivo]
[Expression of FHIT Protein in Lung Cancer by Cell Array.]
[FHIT protein expression during malignant transformation of human bronchial epithelial cells induced by NNK.]
[Frequent loss of fragile histidine triad gene transcripts in lung cancer]
[Loss of exons of FHIT gene and FHIT protein expression in Yunnan tin miners with lung cancer]
[Relationship between hMSH2 and FHIT gene expression in non-small cell lung cancer]
[The biological significance of FHIT protein expression in lung cancer and precancerous tissues detected by tissue microarray.]
Lymphatic Metastasis
Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma.
FHIT expression and hypermethylation in esophageal squamous cell carcinoma.
Fhit protein expression in lung cancer studied by high-throughput tissue microarray.
[Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]
[Clinicopathological analysis of loss of fragile histidine triad expression in lung cancer].
[Loss of fragile histidine triad expression and metastasis in breast cancer]
[Relationship between hMSH2 and FHIT gene expression in non-small cell lung cancer]
[Relationship between the reduction of FHIT expression and the development of cervical carcinoma]
[The biological significance of FHIT protein expression in lung cancer and precancerous tissues detected by tissue microarray.]
Lymphoma
Aberrant FHIT protein expression in classical Hodgkin's lymphoma: a potential marker.
Aberrations of the FHIT gene and Fhit protein in canine lymphoma cell lines.
Lymphoma, B-Cell
Decreased FHIT protein expression correlates with a worse prognosis in patients with diffuse large B-cell lymphoma.
High throughput tissue microarray analysis of FHIT expression in diffuse large cell B-cell lymphoma from Saudi Arabia.
Lymphoma, Large B-Cell, Diffuse
Decreased FHIT protein expression correlates with a worse prognosis in patients with diffuse large B-cell lymphoma.
High throughput tissue microarray analysis of FHIT expression in diffuse large cell B-cell lymphoma from Saudi Arabia.
Lymphoma, T-Cell, Cutaneous
Restoration of Fragile Histidine Triad (FHIT) Expression Inhibits Cell Growth and Induces Apoptosis in Cutaneous T-cell Lymphoma Cell Line.
Melanoma
Loss of heterozygosity on chromosomes 3, 9, 13, and 17, including the retinoblastoma locus, in uveal melanoma.
Mesothelioma
Role of fragile histidine triad protein expression in pathogenesis of malignant pleural mesothelioma.
Mesothelioma, Malignant
Reduced Fhit protein expression in human malignant mesothelioma.
Role of fragile histidine triad protein expression in pathogenesis of malignant pleural mesothelioma.
Mouth Neoplasms
[Expression and significance of fragile histidine triad in oral cancer and precancerous lesions]
Muir-Torre Syndrome
Loss of fragile histidine triad (FHIT) expression and microsatellite instability in periocular sebaceous gland carcinoma in patients with Muir-Torre syndrome.
Multiple Myeloma
Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with multiple myeloma.
Myelodysplastic Syndromes
Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome.
Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with myelodysplastic syndrome.
[Alteration of methylation status of fragile histidine triad gene promoter in patients with myelodysplastic syndrome]
Nasopharyngeal Carcinoma
Expression of Fragile Histidine Triad (FHIT) and WW-Domain Oxidoreductase Gene (WWOX) in Nasopharyngeal Carcinoma.
Mutation and abnormal expression of the fragile histidine triad gene in nasopharyngeal carcinoma.
Neoplasm Metastasis
Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma.
Characterization of the role of Fhit in suppression of DNA damage.
Clinicopathological significance and prognostic value of leukemia-related protein 16 expression in invasive ductal breast carcinoma.
Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients.
FHIT expression and hypermethylation in esophageal squamous cell carcinoma.
Fhit protein expression in lung cancer studied by high-throughput tissue microarray.
Fragile histidine triad (FHIT) gene is overexpressed in colorectal cancer.
Immunohistochemical assessment of Fhit protein expression in advanced gastric carcinomas in correlation with Helicobacter pylori infection and survival time.
Prognostic value of EUS combined with MSCT in predicting the recurrence and metastasis of patients with gastric cancer.
[Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]
[Clinicopathological analysis of loss of fragile histidine triad expression in lung cancer].
[Frequent loss of fragile histidine triad gene transcripts in lung cancer]
[Loss of fragile histidine triad expression and metastasis in breast cancer]
[Relationship between hMSH2 and FHIT gene expression in non-small cell lung cancer]
[Relationship between the expression of fragile histidine (FHIT) and the development of vulvar carcinoma]
[Relationship between the reduction of FHIT expression and the development of cervical carcinoma]
[The biological significance of FHIT protein expression in lung cancer and precancerous tissues detected by tissue microarray.]
Neoplasms
5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.
A Fhit-ing role in the DNA damage checkpoint response.
A mouse model of the fragile gene FHIT: From carcinogenesis to gene therapy and cancer prevention.
Aberrant FHIT Expression is Linked to Bladder Carcinogenesis and Apoptosis.
Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia.
Aberrant FHIT protein expression in classical Hodgkin's lymphoma: a potential marker.
Aberrant FHIT transcripts in squamous cell carcinoma of the uterine cervix.
Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit.
Aberrations in the fragile histidine triad(FHIT) gene may be involved in lung carcinogenesis in patients with chronic pulmonary tuberculosis.
Aberrations of the FHIT gene and Fhit protein in canine lymphoma cell lines.
Abnormal FHIT gene transcript and c-myc and c-erbB2 amplification in breast cancer.
Abnormal fragile histidine triad (Fhit) expression in invasive cervical adenocarcinoma: association with tumor aggressiveness.
Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type.
Absence of FHIT expression is associated with apoptosis inhibition in colorectal cancer.
Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities.
Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma.
Activation of G?q subunits up-regulates the expression of the tumor suppressor Fhit.
Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma.
Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer.
Alteration of the fragile histidine triad gene in intrahepatic cholangiocarcinoma.
Alterations of the FHIT gene in human hepatocellular carcinoma.
Alterations of the fragile histidine triad gene, FHIT, and its encoded products contribute to testicular germ cell tumorigenesis.
Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus.
Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53-/- mice.
Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer.
Analysis of FHIT allelic imbalance/loss of heterozygosity and FHIT expression in cutaneous squamous cell carcinomas.
Analysis of FHIT Gene Methylation in Egyptian Breast Cancer Women: Association with Clinicopathological Features.
Analysis of the fragile histidine triad (FHIT) gene in lobular breast cancer.
Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans.
Biochemical and immunochemical characterisation of human diadenosine triphosphatase provides evidence for its identification with the tumour suppressor Fhit protein.
Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses.
Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma.
Characterization of the role of Fhit in suppression of DNA damage.
Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features.
Chromosome 3p and breast cancer.
Clinicopathological significance and prognostic value of leukemia-related protein 16 expression in invasive ductal breast carcinoma.
Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients.
Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma.
Clinicopathological significance of fragile histidine triad transcription protein expression in breast carcinoma.
Clinicopathological significance of fragile histidine triad transcription protein expression in endometrial carcinomas.
Clinicopathological significance of the fragile histidine triad transcription protein expression in laryngeal carcinogenesis.
Common fragile genes and digestive tract cancers.
Comparative analysis of loss of heterozygosity of specific chromosome 3, 13, 17, and X loci and TP53 mutations in human epithelial ovarian cancer.
Comparative genomic mapping of the bovine Fragile Histidine Triad (FHIT) tumour suppressor gene: characterization of a 2 Mb BAC contig covering the locus, complete annotation of the gene, analysis of cDNA and of physiological expression profiles.
Computational Survey of FHIT, A Putative Human Tumor Suppressor, Truncates Structure.
Crystal structure of HINT from Helicobacter pylori.
Cytogenetic studies of 24 renal epithelial tumors with von Hippel-Lindau and fragile histidine triad protein expression correlation.
Decreased fragile histidine triad gene messenger RNA expression in lung cancer.
Decreased fragile histidine triad gene protein expression is associated with worse prognosis in oral squamous carcinoma.
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Deletion of the FHIT gene in human colorectal cancer is independent of high-risk HPV infection.
Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas.
Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice.
Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement.
Different immunohistochemical patterns of Fhit protein expression in renal neoplasms.
Differentially expressed genes in metastatic advanced Egyptian bladder cancer.
Distribution of Fhit protein in rat tissues and its intracellular localization.
DNA hypermethylation profiles in squamous cell carcinoma of the vulva.
Do FHIT gene alterations play a role in human solid tumors?
Dose-dependent effect of FHIT-inducible expression in Calu-1 lung cancer cell line.
Down-regulation of FHIT inhibits apoptosis of colorectal cancer: mechanism and clinical implication.
Down-regulation of fragile histidine triad expression in prostate carcinoma.
Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells.
Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX.
Effect of fragile histidine triad gene on biologic properties of muco-epidermoid carcinoma cells.
Effect of regulated expression of the fragile histidine triad gene on cell cycle and proliferation.
Enlightened protein: Fhit tumor suppressor protein structure and function and its role in the toxicity of protoporphyrin IX-mediated photodynamic reaction.
Epigenetic silencing contributes to frequent loss of the fragile histidine triad tumour suppressor in basal cell carcinomas.
Epithelial and stromal genetic instability linked to tumor suppressor genes in ulcerative colitis-associated tumorigenesis.
Evaluation of influence of Ap(4)A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis.
Expression and Prognostic Role of FHIT, Fibronectin, and PTEN in Hepatocellular Carcinoma.
Expression and simple, one-step purification of fragile histidine triad (Fhit) tumor suppressor mutant forms in Escherichia coli and their interaction with protoporphyrin IX
Expression and simple, one-step purification of fragile histidine triad (Fhit) tumor suppressor mutant forms in Escherichia coli and their interaction with protoporphyrin IX.
Expression characteristics of FHIT, p53, BRCA2 and MLH1 in families with a history of oesophageal cancer in a region with a high incidence of oesophageal cancer.
Expression of Fhit protein during mouse development.
Expression of Fhit, cell adhesion molecules and matrix metalloproteinases in atypical adenomatous hyperplasia and pulmonary adenocarcinoma.
Expression of Fhit, Mlh1, and P53 protein in human gallbladder carcinoma.
Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.
Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis.
Expression of Ki-67, galectin-3, fragile histidine triad, and parafibromin in malignant and benign parathyroid tumors.
Expression of the fragile histidine triad gene in normal rat tissues and human kidney cancer cell lines.
Expressions of miR-30c and let-7a are inversely correlated with HMGA2 expression in squamous cell carcinoma of the vulva.
FHIT alterations in breast cancer.
fhit Alterations in endometrial carcinoma and hyperplasia.
Fhit and CHK1 have opposing effects on homologous recombination repair.
FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance.
Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.
FHIT expression and hypermethylation in esophageal squamous cell carcinoma.
FHIT expression in clear cell renal carcinomas: versatility of protein levels and correlation with survival.
Fhit expression in gastric adenocarcinoma: correlation with disease stage and survival.
Fhit expression in human gastric adenomas and intramucosal carcinomas: correlation with Mlh1 expression and gastric phenotype.
FHIT expression in neoplastic, hyperplastic, and normal endometrium.
Fhit expression protects against HER2-driven breast tumor development: unraveling the molecular interconnections.
FHIT gene and flanking region on chromosome 3p are subjected to extensive allelic loss in Egyptian breast cancer patients.
FHIT gene expression in human ovarian, endometrial, and cervical cancer cell lines.
FHIT gene expression in human urinary bladder transitional cell carcinomas.
FHIT gene expression is repressed by mitogenic signaling through the PI3K/AKT/FOXO pathway.
FHIT Gene Sequence Variants and Reduced Fhit Protein Expression in Glioblastoma Multiforme.
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.
FHIT loss of function in human primary breast cancer correlates with advanced stage of the disease.
FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.
Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential.
Fhit Nuclear Import Following EGF Stimulation Sustains Proliferation of Breast Cancer Cells.
FHIT oncosuppressor gene expression profile in human anal cancers.
FHIT promoter DNA methylation and expression analysis in childhood acute lymphoblastic leukemia.
FHIT promotes the apoptosis of QBC939 by reducing the expression of cyclin D1.
FHIT protein expression and its relation to apoptosis, tumor histologic grade and prognosis in colorectal adenocarcinoma: an immunohistochemical and image analysis study.
Fhit protein expression in endometrial cancers: no correlation with histological grade.
Fhit protein expression in human gastric cancer and related precancerous lesions.
Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines.
FHIT protein is expressed in benign mesothelium and has no clinical value in detecting carcinoma in body cavity effusions.
Fhit protein is preferentially expressed in the nucleus of monocyte-derived cells and its possible biological significance.
Fhit Regulates EMT Targets through an EGFR/Src/ERK/Slug Signaling Axis in Human Bronchial Cells.
Fhit regulates invasion of lung tumor cells.
FHIT RNA and protein expression in oral squamous cell carcinomas.
FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs.
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.
Fhit, a tumor suppressor protein, induces autophagy via 14-3-3? in non-small cell lung cancer cells.
Fhit-Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells.
FHIT: doubts are clear now.
FHITlow /pHER2high signature in non-small cell lung cancer is predictive of anti-HER2 molecule efficacy.
Fluorimetric detection of enzymatic activity associated with the human tumor suppressor Fhit protein.
Folate deficiency and aberrant DNA methylation and expression of FHIT gene were associated with cervical pathogenesis.
FRA3B and other common fragile sites: the weakest links.
Fragile gene product, Fhit, in oxidative and replicative stress responses.
Fragile Genes That Are Frequently Altered in Cancer: Players Not Passengers.
Fragile histidine triad (FHIT) gene is overexpressed in colorectal cancer.
Fragile histidine triad (FHIT) suppresses proliferation and promotes apoptosis in cholangiocarcinoma cells by blocking PI3K-Akt pathway.
Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.
Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma.
Fragile histidine triad gene expression in primary prostate cancer and in an in vitro model.
Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project.
Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch.
Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53.
Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer.
Fragile histidine triad protein: structure, function, and its association with tumorogenesis.
Fragile histidine triad transcription abnormalities and human papillomavirus E6-E7 mRNA expression in the development of cervical carcinoma.
Frequent allelic deletion at the FHIT locus associated with p53 overexpression in squamous cell carcinoma subtype of Taiwanese non-small-cell lung cancers.
Frequent altered expression of fragile histidine triad protein in human colorectal adenomas.
Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas.
Frequent silencing of fragile histidine triad gene (FHIT) in Burkitt's lymphoma is associated with aberrant hypermethylation.
Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
Germinal epimutation of Fragile Histidine Triad (FHIT) gene is associated with progression to acute and chronic adult T-cell leukemia diseases.
Helicobacter pylori infection and family history of gastric cancer decrease expression of FHIT tumor suppressor gene in gastric mucosa of dyspeptic patients.
High-Risk HPV Infection and CIN Grade Correlates to the Expression of c-myc, CD4+, FHIT, E-cadherin, Ki-67, and p16INK4a.
HIV-TAT-fused FHIT protein functions as a potential pro-apoptotic molecule in hepatocellular carcinoma cells.
Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma.
Homozygous deletions on the short arm of chromosome 3 in human oral squamous cell carcinomas.
Human diadenosine triphosphate hydrolase: preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor.
Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad treatment.
Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors.
Immunohistochemical assessment of Fhit protein expression in advanced gastric carcinomas in correlation with Helicobacter pylori infection and survival time.
Immunohistochemical evaluation of p53, FHIT, and IGF2 gene expression in esophageal cancer.
Immunohistochemical expression of Fhit protein in Helicobacter pylori related chronic gastritis, gastric precancerous lesions and gastric carcinoma: correlation with conventional clinicopathologic parameters.
Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples.
Impaired FHIT expression characterizes serous ovarian carcinoma.
Implication of mitochondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy.
In silico study of fragile histidine triad interaction domains with MDM2 and p53.
In vitro inhibition of the enzymatic activity of tumor suppressor FHIT gene product by carcinogenic transition metals.
Inactivation of the FHIT gene favors bladder cancer development.
Inactivation of the human fragile histidine triad gene at 3p14.2 in monochromosomal human/mouse microcell hybrid-derived severe combined immunodeficient mouse tumors.
Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression.
Investigation of mutations and expression of the FHIT gene in Turkish patients with brain metastases derived from non-small cell lung cancer.
Investigation of tumor suppressor genes apart from VHL on 3p by deletion mapping in sporadic clear cell renal cell carcinoma (cRCC).
Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway.
Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population.
Location of candidate tumour suppressor gene loci at chromosomes 3p, 8p and 9p for oral squamous cell carcinomas.
Loss of FHIT expression in breast cancer is correlated with poor prognostic markers.
Loss of FHIT expression in cervical carcinoma cell lines and primary tumors.
Loss of FHIT expression in gastric carcinoma.
Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection.
Loss of fhit expression in invasive cervical carcinomas and intraepithelial lesions associated with invasive disease.
Loss of Fhit expression in testicular germ cell tumors and intratubular germ cell neoplasia.
Loss of FHIT function in lung cancer and preinvasive bronchial lesions.
Loss of FHIT protein expression correlates with disease progression and poor differentiation in gastric cancer.
Loss of Fhit protein expression in high-grade and advanced stage endometrial carcinomas.
Loss of FHIT protein expression is related to high proliferation, low apoptosis and worse prognosis in non-small-cell lung cancer.
Loss of fragile histidine triad (FHIT) expression and microsatellite instability in periocular sebaceous gland carcinoma in patients with Muir-Torre syndrome.
Loss of fragile histidine triad expression in colorectal carcinomas and premalignant lesions.
Loss of fragile histidine triad gene expression is associated with progression of esophageal squamous cell carcinoma, but not with the patient's prognosis and smoking history.
Loss of fragile histidine triad protein in human hepatocellular carcinoma.
Loss of heterozygosity in the fragile histidine triad (FHIT) locus and expression analysis of FHIT protein in patients with breast disorders.
Loss of heterozygosity on chromosomes 3, 9, 13, and 17, including the retinoblastoma locus, in uveal melanoma.
Loss or reduction of Fhit expression in renal neoplasias: correlation with histogenic class.
Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma.
Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency.
MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family.
Mechanisms shaping the mutational landscape of the FRA3B/FHIT-deficient cancer genome.
Methylation Analysis of Several Tumour Suppressor Genes Shows a Low Frequency of Methylation of CDKN2A and RARB in Uveal Melanomas.
Methylation status of the FHIT gene in the transformed human mesenchymal F6 stem cell line.
Microarray sampling-platform fabrication using bubble-jet technology for a biochip system.
microRNA-143 protects cells from DNA damage-induced killing by downregulating FHIT expression.
Microsatellite instability and loss of heterozygosity in oral squamous cell carcinoma in Malaysian population.
Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH).
Molecular and epigenetic analysis of the fragile histidine triad tumour suppressor gene in equine sarcoids.
Molecular diagnosis and prognostic significance of lymph node micrometastasis in patients with histologically node-negative non-small cell lung cancer.
Muir-Torre-like syndrome in Fhit-deficient mice.
Multiple Patterns of FHIT Gene Homozygous Deletion in Egyptian Breast Cancer Patients.
Multiple regions with allelic loss at chromosome 3 in superficial multifocal bladder tumors.
Mutation analysis of the FHIT gene in bronchoscopic specimens from patients with suspected lung cancer.
Mutational and promoter hypermethylation status of FHIT gene in breast cancer patients of Kashmir.
Mycobacterium tuberculosis infection and FHIT gene alterations in lung cancer.
N-Terminal Domain of Fragile Histidine Triad Exerts Potent Cytotoxic Effect in HT1080 Cells and Increases Doxorubicin Cytotoxicity.
New interactions between tumor suppressor Fhit protein and a nonhydrolyzable analog of its AP4 A substrate.
Nit1 and Fhit tumor suppressor activities are additive.
Potential cancer therapy with the fragile histidine triad gene: review of the preclinical studies.
Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35.
Prevalence of fragile histidine triad expression in tumors from saudi arabia: a tissue microarray analysis.
Primary cervical carcinomas show 2 common regions of deletion at 3P, 1 within the FHIT gene: evaluation of allelic imbalance at FHIT, RB1 and TP53 in relation to survival.
Prognostic relevance of fragile histidine triad protein expression in patients with small cell lung cancer.
Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer.
Promoter hypermethylation of p16INK4a, E-cadherin, O6-MGMT, DAPK and FHIT in adenocarcinomas of the esophagus, esophagogastric junction and proximal stomach.
Promoter methylation and loss of coding exons of the fragile histidine triad (FHIT) gene in intrahepatic cholangiocarcinomas.
Promoter methylation status of the FHIT gene and Fhit expression: Association with HER2/neu status in breast cancer patients.
Protein expression and functional analysis of the FHIT gene in human tumor cells.
Protein expression of Fragile Histidine Triad and cyclooxgenase-2 in serrated neoplasia of the colorectum.
Protein expression profiling identifies cyclophilin A as a molecular target in Fhit-mediated tumor suppression.
Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein.
Re-splicing of mature mRNA in cancer cells promotes activation of distant weak alternative splice sites.
Reduced acetylated histone H4 is associated with promoter methylation of the fragile histidine triad gene in resected esophageal squamous cell carcinoma.
Reduced Fhit expression in cervical carcinoma: correlation with tumor progression and poor prognosis.
Reduced Fhit expression in sporadic and BRCA2-linked breast carcinomas.
Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma.
Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients.
Reduced Fhit protein expression in human malignant mesothelioma.
Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas.
Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation.
Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis.
Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in breast cancer cell lines.
Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines.
Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells.
Restored expression of fragile histidine triad protein and tumorigenicity of cervical carcinoma cells.
Role of 5'-CpG island hypermethylation of the FHIT gene in cervical carcinoma.
Significance of FHIT expression in chronic myelogenous leukemia.
Simultaneous detection of the tumor suppressor FHIT gene and protein using the multi-functional biochip.
Specific and nonspecific enzymes involved in the catabolism of mononucleoside and dinucleoside polyphosphates.
Strong signature of natural selection within an FHIT intron implicated in prostate cancer risk.
T4 DNA ligase synthesizes dinucleoside polyphosphates.
The apoptotic pathway triggered by the Fhit protein in lung cancer cell lines is not affected by Bcl-2 or Bcl-x(L) overexpression.
The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers.
The Fragile Histidine Triad gene and breast cancer.
The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer.
The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers.
The role of human papillomavirus type 16 and the fragile histidine triad gene in the outcome of cervical neoplastic lesions.
The role of the FHIT/FRA3B locus in cancer.
The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.
The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.
Tissue tumor marker expression in smokers, including serum cotinine concentrations, in women with cervical intraepithelial neoplasia or normal squamous cervical epithelium.
TRAIL-induced apoptosis of FHIT-negative lung cancer cells is inhibited by FHIT re-expression.
Tumor suppressor Fhit protein interacts with protoporphyrin IX in vitro and enhances the response of HeLa cells to photodynamic therapy.
Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer.
Two-hit inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer.
Ubc9-induced inhibition of diadenosine triphosphate hydrolase activity of the putative tumor suppressor protein Fhit.
Upregulation of FHIT gene expression in endometrial carcinoma by RNA activation.
[Aberrant promoter methylation of tumor suppressor genes in serum from lung cancer patients: frequency and correlation with clinicopathological characteristics]
[Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]
[Abnormalities of tumor suppressor genes at chromosome 3p in lung cancer]
[Allelic loss and down-regulation of FHIT gene expression in esophageal squamous cell carcinoma]
[Clinicopathological analysis of loss of fragile histidine triad expression in lung cancer].
[Correlation between methylation of 5'-CpG islands and inactivation of FHIT gene in cervical cancer.]
[Correlation of FHIT expression to cell proliferation and metastasis of laryngeal squamous cell carcinoma.]
[Effects of Methylation of FHIT Gene on it's Protein and mRNA Expression in Non-small Cell Lung Cancer.]
[Expression of FHIT gene in precancerous lesions and primary lung cancer tissues].
[Expression of FHIT gene protein in laryngeal carcinoma]
[Expression of FHIT Protein in Lung Cancer by Cell Array.]
[Fragile histidine triad expression in rhabdomyosarcoma]
[HPV detection and FHIT expression in esophageal squamous carcinoma from high incidence area in Cixian County]
[Methylation status of FHIT gene in plasma and expression of FHIT gene in cancer tissue of cervical cancer patients]
[Mutations of fragile histidine triad gene in Peutz-Jeghers syndrome and canceration]
[Sequence analyses of aberrant FHIT transcripts in gastric cancer cell lines]
[The biological significance of FHIT protein expression in lung cancer and precancerous tissues detected by tissue microarray.]
Neoplasms, Germ Cell and Embryonal
Alterations of the fragile histidine triad gene, FHIT, and its encoded products contribute to testicular germ cell tumorigenesis.
Loss of Fhit expression in testicular germ cell tumors and intratubular germ cell neoplasia.
Neoplasms, Squamous Cell
Reduced acetylated histone H4 is associated with promoter methylation of the fragile histidine triad gene in resected esophageal squamous cell carcinoma.
Odontogenic Cysts
Assessment of fragile histidine triad expression in ameloblastoma, odontogenic keratocyst and dentigerous cyst.
Odontogenic Tumors
Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst.
Oral Submucous Fibrosis
[Expression of FHIT and MDM2 in oral submucous fibrosis and canceration tissues]
Osteosarcoma
Effects of FHIT gene on proliferation and apoptosis of osteosarcoma cells.
Pancreatic Neoplasms
Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.
The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers.
Papillomavirus Infections
Cervical dysplasia, ploidy, and human papillomavirus status correlate with loss of Fhit expression.
Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas.
[HPV detection and FHIT expression in esophageal squamous carcinoma from high incidence area in Cixian County]
Parathyroid Neoplasms
Expression of Ki-67, galectin-3, fragile histidine triad, and parafibromin in malignant and benign parathyroid tumors.
Peutz-Jeghers Syndrome
[Mutations of fragile histidine triad gene in Peutz-Jeghers syndrome and canceration]
Pleural Effusion
Diagnostic value of the FHIT and p16 mRNA loss and the K-ras gene mutation in pleural fluids for malignant pleural effusion.
Pneumonia
Microsatellite instability and loss of heterozygosity of fragile histidine triad gene in lung hyperplastic lesions.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clinical significance of fragile histidine triad gene expression in adult acute lymphoblastic leukemia.
FHIT Gene Expression in Acute Lymphoblastic Leukemia and its Clinical Significance.
Gene expression of WWOX, FHIT and p73 in acute lymphoblastic leukemia.
Prostatic Neoplasms
Fragile histidine triad gene expression in primary prostate cancer and in an in vitro model.
Strong signature of natural selection within an FHIT intron implicated in prostate cancer risk.
Pulmonary Arterial Hypertension
Fragile Histidine Triad (FHIT), a Novel Modifier Gene in Pulmonary Arterial Hypertension.
Radicular Cyst
Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst.
Retinoblastoma
Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer.
Comparative analysis of loss of heterozygosity of specific chromosome 3, 13, 17, and X loci and TP53 mutations in human epithelial ovarian cancer.
Loss of heterozygosity on chromosomes 3, 9, 13, and 17, including the retinoblastoma locus, in uveal melanoma.
Rhabdomyosarcoma
[Fragile histidine triad expression in rhabdomyosarcoma]
Sarcoma
Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas.
Skin Neoplasms
Deletion mapping of chromosome 3p and 13q and preliminary analysis of the FHIT gene in human nonmelanoma skin cancer.
Fragile histidine triad gene and skin cancer.
Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation.
Small Cell Lung Carcinoma
Coexpression of fragile histidine triad and c-kit is relevant for prediction of survival in patients with small cell lung cancer.
Prognostic relevance of fragile histidine triad protein expression in patients with small cell lung cancer.
Squamous Cell Carcinoma of Head and Neck
Aberration of FHIT gene is associated with increased tumor proliferation and decreased apoptosis-clinical evidence in lung and head and neck carcinomas.
Abnormalities of the FHIT gene in human oral carcinogenesis.
Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer.
Analysis of FHIT allelic imbalance/loss of heterozygosity and FHIT expression in cutaneous squamous cell carcinomas.
Clinicopathological significance of the fragile histidine triad transcription protein expression in laryngeal carcinogenesis.
Decreased fragile histidine triad gene protein expression is associated with worse prognosis in oral squamous carcinoma.
Fragile histidine triad expression in oral squamous cell carcinoma and precursor lesions.
Immunohistochemical evaluation of Fhit protein expression in oral squamous cell carcinomas.
Loss of Fhit expression in head and neck squamous cell carcinoma and its potential clinical implication.
Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma.
Microsatellite instability and loss of heterozygosity in oral squamous cell carcinoma in Malaysian population.
Prognostic significance of p53 and FHIT in advanced oropharyngeal carcinoma.
Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells.
[Expressions of FHIT and cyclin D1/CDK4 in oral cancer and oral precancerous lesions]
[Microsatellite instability and loss of heterozygosity of fragile histidine triad gene in laryngeal squamous cell carcinoma]
Stomach Neoplasms
Abnormal FHIT protein expression may be correlated with poor prognosis in gastric cancer: a meta-analysis.
Fhit expression in gastric adenocarcinoma: correlation with disease stage and survival.
Fhit protein expression in human gastric cancer and related precancerous lesions.
Immunohistochemical expression of Fhit protein in Helicobacter pylori related chronic gastritis, gastric precancerous lesions and gastric carcinoma: correlation with conventional clinicopathologic parameters.
Loss of FHIT expression in gastric carcinoma.
Loss of FHIT protein expression correlates with disease progression and poor differentiation in gastric cancer.
Prognostic value of EUS combined with MSCT in predicting the recurrence and metastasis of patients with gastric cancer.
Relationship between abnormality of FHIT gene and EBV infection in gastric cancer.
[Effect of fragile histidine triad gene on apoptosis of MGC-803 gastric cancer cells]
Teratoma
Alterations of the fragile histidine triad gene, FHIT, and its encoded products contribute to testicular germ cell tumorigenesis.
Thyroid Neoplasms
Altered gene expression in immunogenic poorly differentiated thyroid carcinomas from RET/PTC3p53-/- mice.
Association of the promoter methylation and protein expression of Fragile Histidine Triad (FHIT) gene with the progression of differentiated thyroid carcinoma.
Comparative analysis of protein expression in differentiated thyroid tumours: a multicentre study.
Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma.
Urinary Bladder Neoplasms
Homozygous deletion of the FHIT gene, p21WAF1 protein expression and apoptosis in bilharzial bladder cancer.
Inactivation of the FHIT gene favors bladder cancer development.
Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor.
The Clinical Relevance of Fragile Histidine Triad Protein (FHIT) in Patients with Bladder Cancer.
Uterine Cervical Neoplasms
Abnormal Fhit expression is an independent poor prognostic factor for cervical cancer.
Abnormal fragile histidine triad expression in advanced cervical cancer and evaluation of its utility as a prognostic factor.
Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type.
Folate deficiency and aberrant DNA methylation and expression of FHIT gene were associated with cervical pathogenesis.
Folate deficiency and FHIT hypermethylation and HPV 16 infection promote cervical cancerization.
Frequent FHIT gene loss of heterozygosity in human papillomavirus-infected non-smoking female lung cancer in Taiwan.
Loss of FHIT expression in cervical carcinoma cell lines and primary tumors.
Methylation status of the fragile histidine triad and E-cadherin genes in plasma of cervical cancer patients.
Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad (FHIT) predicts the transition of cervical lesions.
Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines.
Restored expression of fragile histidine triad protein and tumorigenicity of cervical carcinoma cells.
The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer.
Understanding the mechanisms of FHIT inactivation in cervical cancer for biomarker development.
[Abnormal fragile histidine triad and cervical cancer]
[Correlation between methylation of 5'-CpG islands and inactivation of FHIT gene in cervical cancer.]
[Influence of folate on fragile histidine triad gene expression, cell proliferation and apoptosis in cervical cancer cell lines].
[Interaction between folate deficiency and aberrant expression related to fragile histidine triad gene in the progression of cervical cancerization].
[Interaction between fragile histidine triad methylation, protein expression and human papillomavirus 16 infection in cervical carcinogenesis].
[Methylation status of FHIT gene in plasma and expression of FHIT gene in cancer tissue of cervical cancer patients]
von Hippel-Lindau Disease
Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma.
Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer.