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Information on EC 3.5.99.5 - 2-aminomuconate deaminase

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IUBMB Comments
2-Aminomuconate is an intermediate in the bacterial biodegradation of nitrobenzene. The enzyme has been isolated from several species, including Pseudomonas pseudocaligenes JS45, Pseudomonas fluorescens KU-7, Pseudomonas sp. AP3 and Burkholderia cenocepacia J2315. The reaction is spontaneous in acid conditions.
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The enzyme appears in viruses and cellular organisms
Synonyms
2-AM deaminase, 2-aminomuconate deaminase, AMD, amnD, deaminase, 2-aminomuconate, nbzE, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-aminomuconate + H2O = (3E)-2-oxohex-3-enedioate + NH3
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Intermediate in the biodegradation of nitrobenzene by Pseudomonas pseudocaligenes JS45. The reaction is spontaneous in acid conditions
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