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Disease on EC 3.5.4.9 - methenyltetrahydrofolate cyclohydrolase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
MTHFD2 promotes tumorigenesis and metastasis in lung adenocarcinoma by regulating AKT/GSK-3?/?-catenin signalling.
Adenocarcinoma, Bronchiolo-Alveolar
mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice.
Adenoma
mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice.
Anemia, Megaloblastic
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Atrial Fibrillation
GCH1 attenuates cardiac autonomic nervous remodeling in canines with atrial-tachypacing via tetrahydrobiopterin pathway regulated by microRNA-206.
Atypical Hemolytic Uremic Syndrome
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Brain Neoplasms
Activity of 5-formyl tetrahydrofolate cyclodehydrase and 5,10-methenyl tetrahydrofolate cyclohydrolase in primary brain tumors in children.
Breast Neoplasms
A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP.
High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion.
Increased MTHFD2 expression is associated with poor prognosis in breast cancer.
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.
MicroRNA-9 Inhibition of Cell Proliferation and Identification of Novel miR-9 Targets by Transcriptome Profiling in Breast Cancer Cells.
MTHFD2 facilitates breast cancer cell proliferation via the AKT signaling pathway.
Quantitative proteomics study of breast cancer cell lines isolated from a single patient: discovery of TIMM17A as a marker for breast cancer.
Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion.
Carcinogenesis
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications.
MTHFD2 promotes tumorigenesis and metastasis in lung adenocarcinoma by regulating AKT/GSK-3?/?-catenin signalling.
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
Carcinoma
Identification of MTHFD2 as a novel prognosis biomarker in esophageal carcinoma patients based on transcriptomic data and methylation profiling.
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma.
MTHFD2 Overexpression Predicts Poor Prognosis in Renal Cell Carcinoma and is Associated with Cell Proliferation and Vimentin-Modulated Migration and Invasion.
The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma.
Carcinoma, Ehrlich Tumor
NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells. Purification and properties.
Carcinoma, Hepatocellular
Methylenetetrahydrofolate dehydrogenase 2 overexpression is associated with tumor aggressiveness and poor prognosis in hepatocellular carcinoma.
[The preliminary study on the function of methylenetetrahydrofolate dehydrogenase 2 in hepatocellular carcinoma].
Carcinoma, Non-Small-Cell Lung
Down-regulation of MTHFD2 inhibits NSCLC progression by suppressing cycle-related genes.
Carcinoma, Renal Cell
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma.
MTHFD2 Overexpression Predicts Poor Prognosis in Renal Cell Carcinoma and is Associated with Cell Proliferation and Vimentin-Modulated Migration and Invasion.
Carcinoma, Squamous Cell
The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma.
Cleft Palate
Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis.
Colorectal Neoplasms
Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell.
MicroRNA-33a-5p suppresses colorectal cancer cell growth by inhibiting MTHFD2.
Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications.
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines.
Congenital Abnormalities
A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group.
Diabetes Mellitus
Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.
Dyskinesias
Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia.
Dystonia
Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: a case report.
Common and rare GCH1 variants are associated with Parkinson's disease.
Levodopa-responsive dystonia. GTP cyclohydrolase I or parkin mutations?
Metabolism of tetrahydrobiopterin: its relevance in monoaminergic neurons and neurological disorders.
Missense mutants inactivate guanosine triphosphate cyclohydrolase I in hereditary progressive dystonia.
Molecular mechanisms of hereditary progressive dystonia with marked diurnal fluctuation, Segawa's disease.
Mutant GTP cyclohydrolase I in autosomal dominant dystonia and recessive hyperphenylalaninemia.
[GTP cyclohydrolase 1-deficient dopa-responsive hereditary dystonia.]
Fibromyalgia
Identification of candidate genes associated with fibromyalgia susceptibility in southern Spanish women: the al-Ándalus project.
Glaucoma
Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells.
Glioma
Glioma cells require one-carbon metabolism to survive glutamine starvation.
MicroRNA-940 inhibits glioma progression by blocking mitochondrial folate metabolism through targeting of MTHFD2.
The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis.
Graft vs Host Disease
Cyclosporine and methotrexate-related pharmacogenomic predictors of acute graft-versus-host disease.
gtp cyclohydrolase i deficiency
Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency.
Hypertension
Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation.
Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension.
Infarction, Middle Cerebral Artery
Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia.
Infections
Cerebrospinal fluid and serum neopterin and biopterin in D-retrovirus-infected rhesus macaques (Macaca mulatta): relationship to clinical and viral status.
Role of potential COVID-19 immune system associated genes and the potential pathways linkage with type-2 diabetes.
Intellectual Disability
Mental retardation with hyperfolic-acidemia not associated with formiminoglutamic-acciduria: cyclohydrolase deficiency syndrome.
Intervertebral Disc Degeneration
Polymorphic variation of the guanosine triphosphate cyclohydrolase 1 gene predicts outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.
Laryngeal Neoplasms
Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer.
Leukemia
5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence, and inhibitors.
Targeting MTHFD2 in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Targeting MTHFD2 in acute myeloid leukemia.
Upregulation of miR-504-3p is associated with favorable prognosis of acute myeloid leukemia and may serve as a tumor suppressor by targeting MTHFD2.
Liver Neoplasms
Correlation between methylation profile of promoter cpg islands of seven metastasis-associated genes and their expression states in six cell lines of liver origin.
Lung Neoplasms
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Down-regulation of MTHFD2 inhibits NSCLC progression by suppressing cycle-related genes.
Modulating redox homeostasis and cellular reprogramming through inhibited methylenetetrahydrofolate dehydrogenase 2 enzymatic activities in lung cancer.
Lymphatic Metastasis
Increased MTHFD2 expression is associated with poor prognosis in breast cancer.
Lymphoma, T-Cell
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.
methenyltetrahydrofolate cyclohydrolase deficiency
GTP-cyclohydrolase deficiency responsive to sapropterin and 5-HTP supplementation: relief of treatment-refractory depression and suicidal behaviour.
Mental retardation with hyperfolic-acidemia not associated with formiminoglutamic-acciduria: cyclohydrolase deficiency syndrome.
Migraine Disorders
Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.
Musculoskeletal Pain
Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.
Myocardial Infarction
Empagliflozin improves post-infarction cardiac remodeling through GTP enzyme cyclohydrolase 1 and irrespective of diabetes status.
Neoplasm Metastasis
Increased MTHFD2 expression is associated with poor prognosis in breast cancer.
Methylenetetrahydrofolate dehydrogenase 2 overexpression is associated with tumor aggressiveness and poor prognosis in hepatocellular carcinoma.
Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications.
MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway.
MTHFD2 promotes tumorigenesis and metastasis in lung adenocarcinoma by regulating AKT/GSK-3?/?-catenin signalling.
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines.
[The preliminary study on the function of methylenetetrahydrofolate dehydrogenase 2 in hepatocellular carcinoma].
Neoplasms
A Review of Small-Molecule Inhibitors of One-Carbon Enzymes: SHMT2 and MTHFD2 in the Spotlight.
Author's reply to Kapoor S. GTP cyclohydrolase and cancer pain.
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Cisplatin inhibits SIRT3-deacetylation MTHFD2 to disturb cellular redox balance in colorectal cancer cell.
Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy.
Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Detection and characterisation of novel alternative splicing variants of the mitochondrial folate enzyme MTHFD2.
Divergence in regulation of nitric-oxide synthase and its cofactor tetrahydrobiopterin by tumor necrosis factor-alpha. Ceramide potentiates nitric oxide synthesis without affecting GTP cyclohydrolase I activity.
Drug discovery of anticancer drugs targeting methylenetetrahydrofolate dehydrogenase 2.
Enhanced activation of NAD(P)H: quinone oxidoreductase 1 attenuates spontaneous hypertension by improvement of endothelial nitric oxide synthase coupling via tumor suppressor kinase liver kinase B1/adenosine 5'-monophosphate-activated protein kinase-mediated guanosine 5'-triphosphate cyclohydrolase 1 preservation.
Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy.
Glioma cells require one-carbon metabolism to survive glutamine starvation.
High Expression of Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) in Esophageal Squamous Cell Carcinoma and its Clinical Prognostic Significance.
High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion.
Identification of anaplastic lymphoma kinase variant translocations using 5'RACE.
Increased MTHFD2 expression is associated with poor prognosis in breast cancer.
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.
Methylenetetrahydrofolate dehydrogenase 2 overexpression is associated with tumor aggressiveness and poor prognosis in hepatocellular carcinoma.
MicroRNA-9 Inhibition of Cell Proliferation and Identification of Novel miR-9 Targets by Transcriptome Profiling in Breast Cancer Cells.
miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) Expression in Acute Myeloid Leukemia.
Mitochondrial MTHFD isozymes display distinct expression, regulation, and association with cancer.
Modulating redox homeostasis and cellular reprogramming through inhibited methylenetetrahydrofolate dehydrogenase 2 enzymatic activities in lung cancer.
More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?
MTHFD2 Blockade Enhances the Efficacy of ?-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer.
MTHFD2 facilitates breast cancer cell proliferation via the AKT signaling pathway.
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma.
MTHFD2 Overexpression Predicts Poor Prognosis in Renal Cell Carcinoma and is Associated with Cell Proliferation and Vimentin-Modulated Migration and Invasion.
MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway.
NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells. Purification and properties.
p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage.
Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation.
Quantitative proteomics study of breast cancer cell lines isolated from a single patient: discovery of TIMM17A as a marker for breast cancer.
Somatic mutations in early onset luminal breast cancer.
SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function.
Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease Progression.
Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
Suppression of MTHFD2 in MCF-7 Breast Cancer Cells Increases Glycolysis, Dependency on Exogenous Glycine, and Sensitivity to Folate Depletion.
Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells.
Targeting MTHFD2 in acute myeloid leukemia.
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines.
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation.
The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD.
The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review).
The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma.
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential.
Upregulation of miR-504-3p is associated with favorable prognosis of acute myeloid leukemia and may serve as a tumor suppressor by targeting MTHFD2.
Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2).
[The preliminary study on the function of methylenetetrahydrofolate dehydrogenase 2 in hepatocellular carcinoma].
Neoplasms, Squamous Cell
MTHFD2 Blockade Enhances the Efficacy of ?-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer.
Neural Tube Defects
A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group.
Neuroblastoma
Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy.
Effect of lipopolysaccharide on the gene expression of the enzymes involved in tetrahydrobiopterin de novo biosynthesis in murine neuroblastoma cell line N1E-115.
Neurologic Manifestations
Pediatric neurological syndromes and inborn errors of purine metabolism.
Ovarian Neoplasms
MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway.
Pancreatic Neoplasms
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
Parkinson Disease
Genetic diagnosis of two dopa-responsive dystonia families by exome sequencing.
Parkinsonian Disorders
Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: a case report.
Genetic diagnosis of two dopa-responsive dystonia families by exome sequencing.
Phenylketonurias
Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension.
Lessons from 30 years of selective screening for tetrahydrobiopterin deficiency.
Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.
Prostatic Neoplasms
Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease Progression.
Reperfusion Injury
Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia.
Severe Combined Immunodeficiency
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Spinal Dysraphism
118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
Squamous Cell Carcinoma of Head and Neck
MTHFD2 Blockade Enhances the Efficacy of ?-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer.
The Prognostic Significance of Immune-Related Metabolic Enzyme MTHFD2 in Head and Neck Squamous Cell Carcinoma.
Stomach Neoplasms
Effect of circ MTHFD2 on resistance to pemetrexed in gastric cancer through regulating expression of miR-124.
MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine.
Tuberculosis
Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide.
The crystal structure reveals the molecular mechanism of bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II (Rv1415) from Mycobacterium tuberculosis.
Whooping Cough
Comparative structural analysis of bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase from Bordetella pertussis and Bordetella parapertussis: a drug target against pertussis.