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Disease on EC 3.5.4.5 - cytidine deaminase

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DISEASE
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Acidosis
Cytidine deaminase activity in synovial fluid of patients with rheumatoid arthritis: relation to lactoferrin, acidosis, and cartilage proteoglycan release.
Acquired Immunodeficiency Syndrome
A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes.
Adenocarcinoma
Bile acid-induced expression of activation-induced cytidine deaminase during the development of Barrett's oesophageal adenocarcinoma.
Biomarkers and pharmacogenetics in pancreatic cancer. Highlights from the "2011 ASCO Annual Meeting". Chicago, IL, USA; June 3-7, 2011.
Gemcitabine sensitivity-related mRNA expression in endoscopic ultrasound-guided fine-needle aspiration biopsy of unresectable pancreatic cancer.
Macrophages increase the resistance of pancreatic adenocarcinoma cells to gemcitabine by upregulating cytidine deaminase.
Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase.
The role of activation-induced cytidine deaminase expression in gastric adenocarcinoma.
Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy.
Adenocarcinoma of Lung
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Adenoma
AID, p53 and MLH1 expression in early gastric neoplasms and the correlation with the background mucosa.
Adenoma, Pleomorphic
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor.
Agammaglobulinemia
Novel mutations in hyper-IgM syndrome type 2 and X-linked agammaglobulinemia detected in three patients with primary immunodeficiency disease.
Patterns of Immune Dysregulation in Primary Immunodeficiencies: A Systematic Review.
Anaphylaxis
A Severe Anaphylactic Reaction Associated with IgM-Class Anti-Human IgG Antibodies in a Hyper-IgM Syndrome Type 2 Patient.
Anemia
[Successful treatment of acute myelomonocytic leukemia developed from MDS with cytarabine ocfosfate (SPAC)]
Anemia, Hemolytic, Autoimmune
Patterns of Immune Dysregulation in Primary Immunodeficiencies: A Systematic Review.
Arteritis
Cytidine deaminase may be a useful marker in differentiating elderly onset rheumatoid arthritis from polymyalgia rheumatica/giant cell arteritis.
Arthritis
Changes in biochemical markers of joint tissue metabolism in a randomized controlled trial of glucocorticoid in early rheumatoid arthritis.
Synovial fluid interleukin-8 and neutrophil function in rheumatoid arthritis and seronegative polyarthritis.
Arthritis, Psoriatic
Cytidine deaminase activity, C reactive protein, histidine, and erythrocyte sedimentation rate as measures of disease activity in psoriatic arthritis.
Arthritis, Rheumatoid
Circadian rhythm of serum cytidine deaminase in patients with rheumatoid arthritis during rest and exercise.
Cytidine deaminase activity as a measure of acute inflammation in rheumatoid arthritis.
Cytidine deaminase activity in synovial fluid of patients with rheumatoid arthritis: relation to lactoferrin, acidosis, and cartilage proteoglycan release.
Cytidine deaminase activity, C reactive protein, histidine, and erythrocyte sedimentation rate as measures of disease activity in psoriatic arthritis.
Cytidine deaminase in polymyalgia rheumatica and elderly onset rheumatoid arthritis.
Cytidine deaminase may be a useful marker in differentiating elderly onset rheumatoid arthritis from polymyalgia rheumatica/giant cell arteritis.
Effect of cyclosporin on the activity of cytidine deaminase and adenosine deaminase in the serum and polymorphonuclear leukocytes of patients with rheumatoid arthritis.
Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritis.
Serum cytidine deaminase as a laboratory test for acute inflammation in rheumatoid arthritis.
Serum cytidine deaminase as a measure of disease activity in rheumatoid arthritis and systemic lupus erythematosus.
Serum cytidine deaminase levels after withdrawal of non-steroidal anti-inflammatory treatment in rheumatoid arthritis.
Synovial fluid interleukin-8 and neutrophil function in rheumatoid arthritis and seronegative polyarthritis.
TP53 mutations coincide with the ectopic expression of activation-induced cytidine deaminase in the fibroblast-like synoviocytes derived from a fraction of patients with rheumatoid arthritis.
Asthma
Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels.
Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma.
Linkage and association of childhood asthma with the chromosome 12 genes.
Polymorphisms of IL-4, IL-4R alpha, and AICDA genes in adult allergic asthma.
[Correlation between activation-induced cytidine deaminase gene polymorphism and atopic asthma and plasma IgE in adult]
Astrocytoma
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Autoimmune Diseases
Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans.
Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.
Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experimental autoimmune encephalomyelitis.
Inhibition of the catalytic function of activation-induced cytidine deaminase (AICDA) promotes apoptosis of germinal center B cells.
Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodies.
Prospects for modulating the CD40/CD40L pathway in the therapy of the hyper-IgM syndrome.
Biliary Tract Neoplasms
Cytidine Deaminase as a Molecular Predictor of Gemcitabine Response in Patients with Biliary Tract Cancer.
Bloom Syndrome
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival.
Cytidine deaminase deficiency reveals new therapeutic opportunities against cancer.
Brain Neoplasms
Genetic variants of AICDA/CASP14 associated with childhood brain tumor.
Pyrimidine pathways enzymes in human tumors of brain and associated tissues: potentialities for the therapeutic use of N-(phosphonacetyl-L-aspartate and 1-beta-D-arabinofuranosylcytosine.
Translocator Protein (TSPO) ligand-Ara-C (Cytarabine) Conjugates as a Strategy to Deliver Antineoplastic Drugs and to Enhance Drug Clinical Potential.
Breast Neoplasms
APOBEC3A is a prominent cytidine deaminase in breast cancer.
APOBEC3B gene expression as a novel predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer.
Cytidine deaminase axis modulated by miR-484 differentially regulates cell proliferation and chemoresistance in breast cancer.
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.
Establishment of human pancreatic cancer gemcitabine?resistant cell line with ribonucleotide reductase overexpression.
Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines.
Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer.
Prediction of a Side Effect and Efficacy of Adjuvant Chemotherapy with Gemcitabine for Post Operative Patient of Pancreatic Cancer by a Genetic Polymorphism Analysis.
Burkitt Lymphoma
Activation-induced cytidine deaminase overexpression in double-hit lymphoma: potential target for novel anticancer therapy.
Cancer biomarkers in HIV patients.
Expression of activation-induced cytidine deaminase (AID) in Burkitt lymphoma cells: rare AID-negative cell lines with the unmutated rearranged VH gene.
Heat shock protein 70 (Hsp70)-stimulated deoxycytidine deaminases from a human lymphoma cell but not the activation-induced cytidine deaminase (AID) from Ramos 6.4 human Burkitt's lymphoma cells.
IL-10 regulates Aicda expression through miR-155.
Carcinogenesis
A model of liver carcinogenesis originating from hepatic progenitor cells with accumulation of genetic alterations.
A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction.
Acquisition of Genetic Aberrations by Activation-Induced Cytidine Deaminase (AID) during Inflammation-Associated Carcinogenesis.
Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations.
Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma.
Activation-Induced Cytidine Deaminase Links Ovulation-Induced Inflammation and Serous Carcinogenesis.
An alternatively spliced form of apobec-1 messenger RNA is overexpressed in human colon cancer.
APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells.
Bile acid-induced expression of activation-induced cytidine deaminase during the development of Barrett's oesophageal adenocarcinoma.
Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes.
Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils.
Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma.
Expression of activation-induced cytidine deaminase in ulcerative colitis-associated carcinogenesis.
Expression of Stathmin1 in gastric adenocarcinoma.
Gastric Carcinogenesis and Underlying Molecular Mechanisms: Helicobacter pylori and Novel Targeted Therapy.
Genetic Pathogenesis of Inflammation-Associated Cancers in Digestive Organs.
Genomic and epigenetic profiles of gastric cancer: potential diagnostic and therapeutic applications.
Helicobacter pylori-induced activation-induced cytidine deaminase expression and carcinogenesis.
Hepatic inflammation facilitates transcription-associated mutagenesis via AID activity and enhances liver tumorigenesis.
Induction of activation-induced cytidine deaminase by a not-directly mutagenic carcinogen: a novel potential molecular mechanism.
Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis.
Involvement of activation-induced cytidine deaminase in skin cancer development.
Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma.
Structural and biological function of NYD-SP15 as a new member of cytidine deaminases.
Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation.
The AID dilemma: infection, or cancer?
The role of activation-induced cytidine deaminase expression in gastric adenocarcinoma.
Up-regulation of Activation-Induced Cytidine Deaminase Causes Genetic Aberrations at the CDKN2b-CDKN2a in Gastric Cancer.
When bacteria become mutagenic and carcinogenic: Lessons from H. pylori.
Carcinoma
A novel affinity chromatography method for the co-purification of deoxycytidine kinase and cytidine deaminase.
Activation-Induced Cytidine Deaminase Expression Facilitates the Malignant Phenotype and Epithelial-to-Mesenchymal Transition in Clear Cell Renal Cell Carcinoma.
AID, p53 and MLH1 expression in early gastric neoplasms and the correlation with the background mucosa.
Correction: Role of Activation-Induced Cytidine Deaminase in the Development of Oral Squamous Cell Carcinoma.
Expression of activation-induced cytidine deaminase in Merkel cell carcinoma with lymph-node metastasis.
Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma.
Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer.
Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas.
Impact of cytidine deaminase activity on intrinsic resistance to cytarabine in carcinoma cells.
Metabolism and ribonucleotide reductase inhibition of (E)-2'-deoxy-2'-(fluoromethylene)cytidine, MDL 101,731, in human cervical carcinoma HeLa S3 cells.
Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma.
Sensitivity to gemcitabine and its metabolizing enzymes in neuroblastoma.
Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma.
Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy.
Carcinoma, Adenosquamous
Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report.
Carcinoma, Bronchogenic
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Carcinoma, Hepatocellular
APOBEC3B interaction with PRC2 modulates microenvironment to promote HCC progression.
Carcinoma, Lewis Lung
Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma.
Carcinoma, Merkel Cell
Expression of activation-induced cytidine deaminase in Merkel cell carcinoma with lymph-node metastasis.
Carcinoma, Non-Small-Cell Lung
Association of cytidine deaminase and xeroderma pigmentosum group D polymorphisms with response, toxicity, and survival in cisplatin/gemcitabine-treated advanced non-small cell lung cancer patients.
Association of xeroderma pigmentosum group D (Asp312Asn, Lys751Gln) and cytidine deaminase (Lys27Gln, Ala70Thr) polymorphisms with outcome in Chinese non-small cell lung cancer patients treated with cisplatin-gemcitabine.
Associations of cytosine deaminase gene polymorphisms with effectiveness of gemcitabine/cisplatin chemotherapy in patients of Xinjiang Uyghur and Han nationality with non-small cell lung cancer.
High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2'-deoxycytidine antimetabolite, 2'-deoxy-2'-methylidenecytidine.
Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines.
The impact of CDA A79C gene polymorphisms on the response and hematologic toxicity in gemcitabine-treated patients: A meta-analysis.
[Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines]
Carcinoma, Renal Cell
Activation-Induced Cytidine Deaminase Expression Facilitates the Malignant Phenotype and Epithelial-to-Mesenchymal Transition in Clear Cell Renal Cell Carcinoma.
Carcinoma, Squamous Cell
Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer.
Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy.
Cholangiocarcinoma
Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma.
Cholangiocarcinomas associated with long-term inflammation express the activation-induced cytidine deaminase and germinal center-associated nuclear protein involved in immunoglobulin V-region diversification.
Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages.
Chondrocalcinosis
Increased serum cytidine deaminase activity in gout and articular chondrocalcinosis.
Coinfection
Unmutated immunoglobulin M can protect mice from death by influenza virus infection.
Colitis
Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis.
Colitis, Ulcerative
Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis.
Colitis-Associated Neoplasms
Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers.
IL-21 Enhances the Development of Colitis-Associated Colon Cancer: Possible Involvement of Activation-Induced Cytidine Deaminase Expression.
Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancers.
Colonic Neoplasms
Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation.
Colorectal Neoplasms
Activation-induced cytidine deaminase expression in colorectal cancer.
Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis.
High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2'-deoxycytidine antimetabolite, 2'-deoxy-2'-methylidenecytidine.
Common Variable Immunodeficiency
AICDA single nucleotide polymorphism in common variable immunodeficiency and selective IgA deficiency.
Expression of activation-induced cytidine deaminase gene in B lymphocytes of patients with common variable immunodeficiency.
Coronavirus Infections
Dynamics of Virus-Specific Memory B Cells and Plasmablasts following Viral Infection of the Central Nervous System.
cytidine deaminase deficiency
Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice.
Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.
Aicda deficiency exacerbates high-fat diet-induced hyperinsulinemia but not gut dysbiosis in mice.
Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency.
Coexistence of Two Rare Autosomal Recessive Disorders: Activation-Induced Cytidine Deaminase Deficiency and Sjogren-Larsson Syndrome.
Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1 activity.
Cytidine deaminase deficiency in a child with combined immunodeficiency: more than a coincidence?
Cytidine deaminase deficiency reveals new therapeutic opportunities against cancer.
Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis.
From Dysgammaglobulinemia to Autosomal-Dominant Activation-Induced Cytidine Deaminase Deficiency: Unraveling an Inherited Immunodeficiency after 50 Years.
Hyper-immunoglobulin-M syndromes caused by an intrinsic B cell defect.
Novel and recurrent AID mutations underlie prevalent autosomal recessive form of HIGM in consanguineous patients.
Novel mutations in hyper-IgM syndrome type 2 and X-linked agammaglobulinemia detected in three patients with primary immunodeficiency disease.
Patterns of Immune Dysregulation in Primary Immunodeficiencies: A Systematic Review.
Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.
The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region.
Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.
Dehydration
The action of bacterial cytidine deaminase on 5,6-dihydrocytidine.
Dengue
Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.
Diabetes Mellitus, Type 1
Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice.
Down Syndrome
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia.
The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines.
Drug-Related Side Effects and Adverse Reactions
Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.
Dysgammaglobulinemia
From Dysgammaglobulinemia to Autosomal-Dominant Activation-Induced Cytidine Deaminase Deficiency: Unraveling an Inherited Immunodeficiency after 50 Years.
Encephalitis, Japanese
Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses.
Encephalomyelitis
Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experimental autoimmune encephalomyelitis.
B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue.
Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Antibodies to myelin oligodendrocyte glycoprotein are not involved in the severity of chronic non-remitting experimental autoimmune encephalomyelitis.
B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue.
Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis.
Epstein-Barr Virus Infections
EBV in T-/NK-Cell Tumorigenesis.
Elevated expression of activation-induced cytidine deaminase in T and NK cells from patients with chronic active Epstein-Barr virus infection.
Esophageal Neoplasms
Expression of immunoglobulin G in esophageal squamous cell carcinomas and its association with tumor grade and Ki67.
Focal Infection
Involvement of Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP)-1 in the potentiation of C epsilon mRNA expression in human tonsil-derived cells.
Food Hypersensitivity
Activation-induced cytidine deaminase plays crucial role in ovalbumin-induced food allergy and promoted by IL-21.
Gallstones
Decreased expression of cholesterol 7alpha hydroxylase and altered bile acid metabolism in Apobec-1 -/- mice leads to increased gallstone susceptibility.
Gastritis, Atrophic
No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese.
Genetic Diseases, Inborn
Cytidine deaminase deficiency reveals new therapeutic opportunities against cancer.
Glomerulonephritis, IGA
Increased frequencies of memory and activated B cells and follicular helper T cells are positively associated with high levels of activation?induced cytidine deaminase in patients with immunoglobulin A nephropathy.
Gout
Increased serum cytidine deaminase activity in gout and articular chondrocalcinosis.
Graves Disease
Epstein-Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease.
Hand-Foot Syndrome
A polymorphism in the cytidine deaminase promoter predicts severe capecitabine-induced hand-foot syndrome.
Heart Failure
[Successful treatment of acute myelomonocytic leukemia developed from MDS with cytarabine ocfosfate (SPAC)]
Hematologic Neoplasms
[Relationship between the expression of the genes encoding the key enzymes for cytarabine metabolism and the pharmacokinetics of cytarabine in the treatment of childhood acute leukemia with high-dose cytarabine]
Hepatitis B
A3G-induced mutations show low prevalence and exhibit plus strand regional distribution in hepatitis B virus DNA from patients with non-hepatocellular carcinoma (HCC) and HCC.
AID recruits the RNA exosome to degrade HIV-1 nascent transcripts through interaction with the Tat-P-TEFb-TAR RNP complex.
APOBEC deaminases-mutases with defensive roles for immunity.
APOBEC3G & HTLV-1: inhibition without deamination.
APOBEC3G is a restriction factor of EV71 and mediator of IMB-Z antiviral activity.
Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review).
Cell-specific regulation of APOBEC3F by interferons.
Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus.
Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression.
Effects of point mutations in the cytidine deaminase domains of APOBEC3B on replication and hypermutation of hepatitis B virus in vitro.
High expression of APOBEC3G in patients infected with hepatitis C virus.
Interleukin-1 and tumor necrosis factor-alpha trigger restriction of hepatitis B virus infection via a cytidine deaminase AID.
Polymorphic APOBEC3 modulates chronic hepatitis B in Moroccan population.
Reverse transcriptase- and RNA packaging signal-dependent incorporation of APOBEC3G into hepatitis B virus nucleocapsids.
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase.
The APOBEC-2 crystal structure and functional implications for the deaminase AID.
The innate antiviral factor APOBEC3G targets replication of measles, mumps and respiratory syncytial viruses.
Hepatitis C
APOBEC3G is a restriction factor of EV71 and mediator of IMB-Z antiviral activity.
Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.
Hepatitis C, Chronic
Lymphomagenesis-related gene expression in B cells from sustained virological responders with occult hepatitis C virus infection.
Herpes Simplex
A new set of positive/negative selectable markers for mammalian cells.
Induction of deoxycytidine deaminase activity in mammalian cell lines by infection with herpes simplex virus type 1.
HIV Infections
Elucidation of the time course of adenosine deaminase APOBEC3G and viral infectivity factor vif in HIV-2(287) -infected infant macaques.
Hodgkin Disease
Activation induced cytidine deaminase expression in lymphocyte predominant Hodgkin lymphoma.
Blood lymphocytes in chronic lymphocytic leukaemia and Hodgkin's disease: Immunological features and enzymes of nucleoside metabolism.
Differential expression of activation-induced cytidine deaminase (AID) in nodular lymphocyte-predominant and classical Hodgkin lymphoma.
Hyper-IgM Immunodeficiency Syndrome
A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.
A novel activation-induced cytidine deaminase gene mutation in a Tunisian family with hyper IgM syndrome.
A novel mouse model for the hyper-IgM syndrome: a spontaneous activation-induced cytidine deaminase mutation leading to complete loss of Ig class switching and reduced somatic hypermutation.
A Severe Anaphylactic Reaction Associated with IgM-Class Anti-Human IgG Antibodies in a Hyper-IgM Syndrome Type 2 Patient.
A Structural Basis for the Biochemical Behavior of Activation-induced Deoxycytidine Deaminase Class-switch Recombination-defective Hyper-IgM-2 Mutants.
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).
Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans.
Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome.
Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2.
Autosomal recessive hyper IgM syndrome associated with activation-induced cytidine deaminase gene in three Turkish siblings presented with tuberculosis lymphadenitis - Case report.
Clinical and Laboratory Findings in Hyper-IgM Syndrome with Novel CD40L and AICDA Mutations.
Clinical Features and Genetic Analysis of Taiwanese Patients with the Hyper IgM Syndrome Phenotype.
Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency.
Enrichment of rare variants in population isolates: single AICDA mutation responsible for hyper-IgM syndrome type 2 in Finland.
From Dysgammaglobulinemia to Autosomal-Dominant Activation-Induced Cytidine Deaminase Deficiency: Unraveling an Inherited Immunodeficiency after 50 Years.
Hyper-IgM syndrome with putative dominant negative mutation in activation-induced cytidine deaminase.
Hyper-IgM syndrome--a case report and a clinical perspective.
Hyper-IgM syndromes.
Molecular analysis of activation-induced cytidine deaminase gene in immunoglobulin-E deficient patients.
Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome.
Novel AICDA mutation in a case of autosomal recessive hyper-IgM syndrome, growth hormone deficiency and autoimmunity.
Novel mutations in hyper-IgM syndrome type 2 and X-linked agammaglobulinemia detected in three patients with primary immunodeficiency disease.
Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase.
Hyper-IgM Immunodeficiency Syndrome, Type 1
Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis.
Hyperinsulinism
Aicda deficiency exacerbates high-fat diet-induced hyperinsulinemia but not gut dysbiosis in mice.
IgA Deficiency
AICDA single nucleotide polymorphism in common variable immunodeficiency and selective IgA deficiency.
Immunoglobulin G4-Related Disease
Increased Expression of Activation-Induced Cytidine Deaminase in Sinus Mucosa from IgG4-Related Disease Patients with Comorbid Chronic Rhinosinusitis.
Pathogenesis of IgG4-related disease. Comparison with Sjögren's syndrome.
Up-regulation of activation-induced cytidine deaminase and its strong expression in extra-germinal centres in IgG4-related disease.
Infections
A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction.
Aberrant activation-induced cytidine deaminase expression is associated with mucosal intestinalization in the early stage of gastric cancer.
Activation of TNF-?-AID axis and co-inhibitory signals in coordination with Th1-type immunity in a mouse model recapitulating hepatitis B.
Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig Loci in activated B cells.
Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.
APOBEC3G and HIV-1: strike and counterstrike.
APOBEC3G and HIV-1:Strike and Counterstrike.
APOBEC3G targets human T-cell leukemia virus type 1.
APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection.
CD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection.
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells.
Cigarette smoke inhibits BAFF expression and mucosal immunoglobulin A responses in the lung during influenza virus infection.
Clinical Features and Genetic Analysis of Taiwanese Patients with the Hyper IgM Syndrome Phenotype.
Complex regulation and function of activation-induced cytidine deaminase.
Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes.
Endogenous APOBEC3B restricts LINE-1 retrotransposition in transformed cells and human embryonic stem cells.
Feline Lentivirus Evolution in Cross-Species Infection Reveals Extensive G-to-A Mutation and Selection on Key Residues in the Viral Polymerase.
Genomic and epigenetic profiles of gastric cancer: potential diagnostic and therapeutic applications.
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium.
Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.
Human immunodeficiency virus type 1 induces 1-beta-D-arabinofuranosylcytosine resistance in human H9 cell line.
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
IgM production by bone marrow plasmablasts contributes to long-term protection against intracellular bacterial infection.
In vitro Assay for Cytidine Deaminase Activity of APOBEC3 Protein.
Induction of deoxycytidine deaminase activity in mammalian cell lines by infection with herpes simplex virus type 1.
Induction of resistance to 1-beta-D-arabinofuranosylcytosine in human H9 cell line by simian immunodeficiency virus.
Infection of human B cells with Epstein-Barr virus results in the expression of somatic hypermutation-inducing molecules and in the accrual of oncogene mutations.
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID.
Lymphomagenesis-related gene expression in B cells from sustained virological responders with occult hepatitis C virus infection.
Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome.
Molecular analysis of lymphoid tissue from rhesus macaque rhadinovirus-infected monkeys identifies alterations in host genes associated with oncogenesis.
Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin-proteasome pathway.
Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits.
No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese.
Prospects for modulating the CD40/CD40L pathway in the therapy of the hyper-IgM syndrome.
Recombination in feline lentiviral genomes during experimental cross-species infection.
Requirements for nucleocapsid-mediated regulation of reverse transcription during the late steps of HIV-1 assembly.
Structural and biological function of NYD-SP15 as a new member of cytidine deaminases.
The Cellular Antiviral Protein APOBEC3G Interacts with HIV-1 Reverse Transcriptase and Inhibits Its Function during Viral Replication.
Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.
Vpr14-88-Apobec3G fusion protein is efficiently incorporated into Vif-positive HIV-1 particles and inhibits viral infection.
[A novel mechanism for H. pylori-induced cell damage--induction of gene mutation by AID]
Influenza, Human
Activation-Induced Cytidine Deaminase and Switched Memory B Cells as Predictors of Effective In Vivo Responses to the Influenza Vaccine.
Delta Inulin Adjuvant Enhances Plasmablast Generation, Expression of Activation-Induced Cytidine Deaminase and B-Cell Affinity Maturation in Human Subjects Receiving Seasonal Influenza Vaccine.
Unmutated immunoglobulin M can protect mice from death by influenza virus infection.
Leukemia
Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.
Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines.
Changes in the activities of cytidine deaminase during differentiation of HL60 cells induced by 1,25 dihydroxy D3.
Comparative study of a novel nucleoside analogue (Troxatyl, troxacitabine, BCH-4556) and AraC against leukemic human tumor xenografts expressing high or low cytidine deaminase activity.
Cytidine deamination of retroviral DNA by diverse APOBEC proteins.
Deamination of 5-azacytidine by a human leukemia cell cytidine deaminase.
Expression of cytidine deaminase in human solid tumors and its regulation by 1 alpha,25-dihydroxyvitamin D3.
Higher expression levels of activation-induced cytidine deaminase distinguish hairy cell leukemia from hairy cell leukemia-variant and splenic marginal zone lymphoma.
Human T cell leukemia virus type I is resistant to the antiviral effects of APOBEC3.
Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter.
Isolation and characterization of a murine P388 leukemia line resistant to thiarabine.
Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid.
Reversal of deamination-related cytotoxicity of 5-methyl-2'-deoxycytidine by tetrahydrouridine in human leukemia cells.
The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond.
The path to approval for oral hypomethylating agents in acute myeloid leukemia and myelodysplastic syndromes.
The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines.
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.
[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.
[Expression of cytidine deaminase mRNA in bone marrow cells from patients with acute leukemia]
[Relationship between the expression of the genes encoding the key enzymes for cytarabine metabolism and the pharmacokinetics of cytarabine in the treatment of childhood acute leukemia with high-dose cytarabine]
[Single-nucleotide polymorphisms of the cytidine deaminase gene in 53 children with acute leukemia]
[Single-nucleotide polymorphisms of the cytidine deaminase gene in childhood with acute leukemia and normal Chinese children]
[Study on the relationship between human cytidine deaminase gene polymorphisms and Ara-C sensitivity]
[Successful treatment of acute myelomonocytic leukemia developed from MDS with cytarabine ocfosfate (SPAC)]
[The assay of intracelluar cytidine deaminase activity and its clinical significance in patient with acute leukemia]
Leukemia, Erythroblastic, Acute
Hemin enhances the sensitivity of erythroleukemia cells to 1-beta-D-arabinofuranosylcytosine by both activation of deoxycytidine kinase and reduction of cytidine deaminase activity.
Leukemia, Hairy Cell
Higher expression levels of activation-induced cytidine deaminase distinguish hairy cell leukemia from hairy cell leukemia-variant and splenic marginal zone lymphoma.
Leukemia, Large Granular Lymphocytic
Squalenoyl nanomedicine of gemcitabine is more potent after oral administration in leukemia-bearing rats: study of mechanisms.
Leukemia, Lymphocytic, Chronic, B-Cell
Activation-induced cytidine deaminase and CD38 expression in B-cell chronic lymphocytic leukemia.
Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone.
Activation-induced cytidine deaminase mRNA levels in chronic lymphocytic leukemia.
Activation-induced cytidine deaminase splicing patterns in chronic lymphocytic leukemia.
AID protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma is associated with poor prognosis and complex genetic alterations.
Analysis of activation-induced cytidine deaminase mRNA levels in patients with chronic lymphocytic leukemia with different cytogenetic status.
Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition.
High expression of activation-induced cytidine deaminase (AID) and splice variants is a distinctive feature of poor-prognosis chronic lymphocytic leukemia.
Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients.
Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation.
Leukemia, Megakaryoblastic, Acute
GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia.
Leukemia, Myeloid, Acute
Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colony-stimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia.
Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1).
Cytidine deaminase - the methodological relevance of AraC deamination for ex vivo experiments using cultured cell lines, fresh leukemic blasts, and normal bone marrow cells.
Cytidine deaminase genetic variants influence RNA expression and cytarabine cytotoxicity in acute myeloid leukemia.
Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia.
Cytidine deaminase polymorphisms and worse treatment response in normal karyotype AML.
Deoxycytidine kinase and deoxycytidine deaminase values correspond closely to clinical response to cytosine arabinoside remission induction therapy in patients with acute myelogenous leukemia.
Downregulation of GLI3 Expression Mediates Chemotherapy Resistance in Acute Myeloid Leukemia.
Gene expression of hENT1, dCK, CDA, dCMPD and topoisomerase II? as an indicator of chemotherapy response in AML treated with cytarabine and daunorubicin.
Potential mechanisms of resistance to cytarabine in AML patients.
Role of Genetic Polymorphisms of Deoxycytidine Kinase and Cytidine Deaminase to Predict Risk of Death in Children with Acute Myeloid Leukemia.
Slower degradation rate of cytarabine in blood samples from acute myeloid leukemia by comparison with control samples.
The path to approval for oral hypomethylating agents in acute myeloid leukemia and myelodysplastic syndromes.
Leukemia, Myelomonocytic, Chronic
The path to approval for oral hypomethylating agents in acute myeloid leukemia and myelodysplastic syndromes.
Leukemia, T-Cell
Human T cell leukemia virus type I is resistant to the antiviral effects of APOBEC3.
Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid.
Leukopenia
Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: A prospective clinical study.
Liver Diseases
Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review).
Liver Neoplasms
MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development.
Lung Injury
Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer.
Correction: Chronic Lung Injury by Constitutive Expression of Activation-Induced Cytidine Deaminase Leads to Focal Mucous Cell Metaplasia and Cancer.
Lung Neoplasms
A bug in the resistance to EGFR inhibitors: is there a role for Mycoplasma and cytidine deaminase in reducing the activity of osimertinib in lung cancer patients?
Association of cytidine deaminase and xeroderma pigmentosum group D polymorphisms with response, toxicity, and survival in cisplatin/gemcitabine-treated advanced non-small cell lung cancer patients.
Association of xeroderma pigmentosum group D (Asp312Asn, Lys751Gln) and cytidine deaminase (Lys27Gln, Ala70Thr) polymorphisms with outcome in Chinese non-small cell lung cancer patients treated with cisplatin-gemcitabine.
Associations of cytosine deaminase gene polymorphisms with effectiveness of gemcitabine/cisplatin chemotherapy in patients of Xinjiang Uyghur and Han nationality with non-small cell lung cancer.
Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced non-small-cell lung cancer patients.
Cytidine deaminase 435C>T polymorphism relates to gemcitabine-platinum efficacy and hematological toxicity in Chinese non-small-cell lung cancer patients.
Cytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer: a prospective validation study.
Genetic polymorphisms of XPD and CDA and lung cancer risk.
High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2'-deoxycytidine antimetabolite, 2'-deoxy-2'-methylidenecytidine.
Letter to the editor: pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism.
Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines.
Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism.
The impact of CDA A79C gene polymorphisms on the response and hematologic toxicity in gemcitabine-treated patients: A meta-analysis.
[Expression of Gemcitabine-resistance-related gene and polymorphism of ribonucleotide reductase M1 gene promoter in Gemcitabine-resistant A549/Gem and NCI-H460/Gem cell lines]
Lupus Erythematosus, Systemic
Increased spontaneous release of cytidine deaminase by polymorphonuclear neutrophils of patients with active systemic lupus erythematosus.
Serum adenosine deaminase and cytidine deaminase activities in patients with systemic lupus erythematosus.
Serum cytidine deaminase as a measure of disease activity in rheumatoid arthritis and systemic lupus erythematosus.
Lymphadenitis
Autosomal recessive hyper IgM syndrome associated with activation-induced cytidine deaminase gene in three Turkish siblings presented with tuberculosis lymphadenitis - Case report.
Lymphatic Metastasis
Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer.
Lymphoma
A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.
Activation induced cytidine deaminase expression in lymphocyte predominant Hodgkin lymphoma.
Activation-induced cytidine deaminase expression in diffuse large B-cell lymphoma with a paracortical growth pattern: a lymphoma of possible interfollicular large B-cell origin.
Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma.
Activation-induced cytidine deaminase overexpression in double-hit lymphoma: potential target for novel anticancer therapy.
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
AID and TET2 co-operation modulates FANCA expression by active demethylation in diffuse large B cell lymphoma.
AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines.
AID Induces Double-Strand Breaks at Immunoglobulin Switch Regions and c-MYC Causing Chromosomal Translocations in Yeast THO Mutants.
An efficient method to enrich for knock-out and knock-in cellular clones using the CRISPR/Cas9 system.
Bach2 regulates AID-mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells.
BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma.
CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response.
Chromosome Translocation, B Cell Lymphoma, and Activation-induced Cytidine Deaminase.
Diagnostic value of STMN1, LMO2, HGAL, AID expression and 1p36 chromosomal abnormalities in primary cutaneous B cell lymphomas.
Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells.
Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas.
Expression of activation-induced cytidine deaminase in malignant lymphomas infiltrating the bone marrow.
Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy.
Expression of activation-induced cytidine deaminase is confined to B-cell non-Hodgkin's lymphomas of germinal-center phenotype.
Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.
Heat shock protein 70 (Hsp70)-stimulated deoxycytidine deaminases from a human lymphoma cell but not the activation-induced cytidine deaminase (AID) from Ramos 6.4 human Burkitt's lymphoma cells.
Higher expression levels of activation-induced cytidine deaminase distinguish hairy cell leukemia from hairy cell leukemia-variant and splenic marginal zone lymphoma.
Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter.
Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.
Lymphomagenesis-related gene expression in B cells from sustained virological responders with occult hepatitis C virus infection.
Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene.
Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells.
Molecular evidence for antigen drive in the natural history of mantle cell lymphoma.
Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer.
Providing activation-induced cytidine deaminase (AID) to nuclear export inhibitors. Response to: "Complex downstream effects of nuclear export inhibition in B-cell lymphomas: a possible role for activation-induced cytidine deaminase".
Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients.
Safety and efficacy of an oncolytic viral strategy using bortezomib with ICE/R in relapsed/refractory HIV-positive lymphomas.
Translocation capture sequencing: a method for high throughput mapping of chromosomal rearrangements.
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes.
Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells.
[Single-nucleotide polymorphisms of the cytidine deaminase gene in childhood with acute leukemia and normal Chinese children]
Lymphoma, AIDS-Related
Pathogenesis of AIDS lymphoma: role of oncogenic viruses and B cell activation-associated molecular lesions.
Lymphoma, B-Cell
Aberrant somatic hypermutation and expression of activation-induced cytidine deaminase mRNA in mediastinal large B-cell lymphoma.
Activation-induced cytidine deaminase expression in diffuse large B-cell lymphoma with a paracortical growth pattern: a lymphoma of possible interfollicular large B-cell origin.
Activation-induced cytidine deaminase localizes to G-quadruplex motifs at mutation hotspots in lymphoma.
Activation-Induced Cytidine Deaminase Promotes Proliferation and Enhances Chemoresistance and Migration in B-cell Lymphoma.
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
AID and TET2 co-operation modulates FANCA expression by active demethylation in diffuse large B cell lymphoma.
AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines.
Antigen receptors and somatic hypermutation in B-cell chronic lymphocytic leukemia with Richter's transformation.
Bach2 regulates AID-mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells.
Chromosome Translocation, B Cell Lymphoma, and Activation-induced Cytidine Deaminase.
Complex downstream effects of nuclear export inhibition in B-cell lymphomas: a possible role for activation-induced cytidine deaminase (AID).
Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics.
Epstein-Barr virus latent membrane protein 1 increases genomic instability through Egr-1-mediated up-regulation of activation-induced cytidine deaminase in B-cell lymphoma.
Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy.
Frequent expression of activation induced cytidine deaminase in diffuse large B-cell lymphoma tissues from persons living with HIV.
Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene.
Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer.
Prognostic impact of activation-induced cytidine deaminase expression for patients with diffuse large B-cell lymphoma.
Providing activation-induced cytidine deaminase (AID) to nuclear export inhibitors. Response to: "Complex downstream effects of nuclear export inhibition in B-cell lymphomas: a possible role for activation-induced cytidine deaminase".
Role of activation-induced cytidine deaminase in the progression of follicular lymphoma.
Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma.
The new frontier of epigenetic heterogeneity in B-cell neoplasms.
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes.
Lymphoma, B-Cell, Marginal Zone
Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren's syndrome.
Comment on "Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjogren's syndrome".
Lymphoma, Follicular
Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL.
Diagnostic value of STMN1, LMO2, HGAL, AID expression and 1p36 chromosomal abnormalities in primary cutaneous B cell lymphomas.
Duodenal and nodal follicular lymphomas are distinct: the former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations.
Isotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutation.
Role of activation-induced cytidine deaminase in the progression of follicular lymphoma.
Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression.
The architecture of neoplastic follicles in follicular lymphoma; analysis of the relationship between the tumor and follicular helper T-cells.
The expression of activation induced cytidine deaminase in follicular lymphoma is independent of prognosis and stage.
The new frontier of epigenetic heterogeneity in B-cell neoplasms.
Lymphoma, Large B-Cell, Diffuse
Activation-induced cytidine deaminase expression in diffuse large B-cell lymphoma with a paracortical growth pattern: a lymphoma of possible interfollicular large B-cell origin.
AID and TET2 co-operation modulates FANCA expression by active demethylation in diffuse large B cell lymphoma.
AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines.
Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy.
Frequent expression of activation induced cytidine deaminase in diffuse large B-cell lymphoma tissues from persons living with HIV.
Prognostic impact of activation-induced cytidine deaminase expression for patients with diffuse large B-cell lymphoma.
The new frontier of epigenetic heterogeneity in B-cell neoplasms.
Lymphoma, Mantle-Cell
Molecular evidence for antigen drive in the natural history of mantle cell lymphoma.
Quantitative RT-PCR analysis of activation-induced cytidine deaminase expression in tissue samples from mantle cell lymphoma and B-cell chronic lymphocytic leukemia patients.
Lymphoma, Non-Hodgkin
CD40 ligand (CD154) incorporated into HIV virions induces activation-induced cytidine deaminase (AID) expression in human B lymphocytes.
Lymphoproliferative Disorders
Overexpression of Activation-Induced Cytidine Deaminase in MTX- and Age-Related Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders of the Head and Neck.
Malaria
AID expression in peripheral blood of children living in a malaria holoendemic region is associated with changes in B cell subsets and Epstein-Barr virus.
Malaria - how this parasitic infection aids and abets EBV-associated Burkitt lymphomagenesis.
Measles
APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition.
KDELR2 Competes with Measles Virus Envelope Proteins for Cellular Chaperones Reducing Their Chaperone-Mediated Cell Surface Transport.
Melanoma
Melanoma's high C>T mutation rate: is deamination playing a role?
Mikulicz' Disease
Increased Expression of Activation-Induced Cytidine Deaminase in Sinus Mucosa from IgG4-Related Disease Patients with Comorbid Chronic Rhinosinusitis.
Monoclonal Gammopathy of Undetermined Significance
Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery.
Multiple Sclerosis
Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation.
Mumps
APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition.
Myelodysplastic Syndromes
Activation Induced Cytidine Deaminase Expression in Patients with Myelodysplastic Syndrome and its Relationship with Prognosis and Treatment.
The augmented expression of the cytidine deaminase gene by 5-azacytidine predicts therapeutic efficacy in myelodysplastic syndromes.
The path to approval for oral hypomethylating agents in acute myeloid leukemia and myelodysplastic syndromes.
Yin and yang of cytidine deaminase roles in clinical response to azacitidine in the elderly: a pharmacogenetics tale.
Neoplasm Metastasis
Expression of activation-induced cytidine deaminase in Merkel cell carcinoma with lymph-node metastasis.
Neoplasms
53BP1 Alters the Landscape of DNA Rearrangements and Suppresses AID-Induced B Cell Lymphoma.
A functional single-nucleotide polymorphism in the human cytidine deaminase gene contributing to ara-C sensitivity.
A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus.
A quantum chemical study of the catalysis for cytidine deaminase: contribution of the extra water molecule.
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival.
Aberrant somatic hypermutation and expression of activation-induced cytidine deaminase mRNA in mediastinal large B-cell lymphoma.
Activation of PD-1 Protects Intestinal Immune Defense Through IL-10/miR-155 Pathway After Intestinal Ischemia Reperfusion.
Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours.
Activation-induced cytidine deaminase (AID) linking immunity, chronic inflammation, and cancer.
Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations.
Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers.
Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models.
Activities of various enzymes of pyrimidine nucleotide and DNA syntheses in normal and neoplastic human tissues.
Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements.
An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.
Antitumor activity of a novel orally effective nucleoside, 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine.
Antitumor activity of sugar-modified cytosine nucleosides.
APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A.
APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context.
APOBEC3B gene overexpression in non-small-cell lung cancer.
APOBEC3B interaction with PRC2 modulates microenvironment to promote HCC progression.
APOBEC3B promotes hepatocarcinogenesis and metastasis through novel deaminase-independent activity.
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy.
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma.
Biomarkers and pharmacogenetics in pancreatic cancer. Highlights from the "2011 ASCO Annual Meeting". Chicago, IL, USA; June 3-7, 2011.
Calcitriol enhances gemcitabine anti-tumor activity in vitro and in vivo by promoting apoptosis in a human pancreatic carcinoma model system.
Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer.
Comparative studies on the antitumor and immunosuppressive effects of the new fluorouracil derivative N4-trimethoxybenzoyl-5'-deoxy-5-fluorocytidine and its parent drug 5'-deoxy-5-fluorouridine.
Comparative study of a novel nucleoside analogue (Troxatyl, troxacitabine, BCH-4556) and AraC against leukemic human tumor xenografts expressing high or low cytidine deaminase activity.
Comprehensive Mapping of Key Regulatory Networks that Drive Oncogene Expression.
Correction: Chronic Lung Injury by Constitutive Expression of Activation-Induced Cytidine Deaminase Leads to Focal Mucous Cell Metaplasia and Cancer.
Cross-talk between CD40 and CD40L: lessons from primary immune deficiencies.
CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer.
Cytidine and deoxycytidylate deaminase inhibition by uridine analogs.
Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-Dependent Manner.
Cytidine Deaminase as a Molecular Predictor of Gemcitabine Response in Patients with Biliary Tract Cancer.
Cytidine deaminase deficiency reveals new therapeutic opportunities against cancer.
Cytidine deaminase polymorphism predicts toxicity of gemcitabine-based chemotherapy.
Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis.
Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts.
Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue.
Determinants of the interindividual variability in serum cytidine deaminase activity of patients with solid tumours.
Determination of common genetic variants in cytidine deaminase (CDA) gene in Indian ethnic population.
Development of gemcitabine-resistant patient-derived xenograft models of pancreatic ductal adenocarcinoma.
Drug resistance to 5-aza-2'-deoxycytidine, 2',2'-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells.
Early relapse on adjuvant gemcitabine associated with an exceptional response to 2nd line capecitabine chemotherapy in a patient with pancreatic adenosquamous carcinoma with strong intra-tumoural expression of cytidine deaminase: a case report.
Ectopic expression of activation-induced cytidine deaminase caused by epigenetics modification.
Enhancement of cytarabine sensitivity in squamous cell carcinoma cell line transfected with deoxycytidine kinase.
Enzyme-Driven Chemo-and Radiation-Therapy with 12 Pyrimidine Nucleoside Analogs Not Yet in the Clinic.
Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours.
Eradication of gastric cancer is now both possible and practical.
Evaluation of the L-stereoisomeric nucleoside analog troxacitabine for the treatment of acute myeloid leukemia.
Expression and secretion of immunoglobulin alpha heavy chain with diverse VDJ recombinations by human epithelial cancer cells.
Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis.
Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma.
Expression of AID in malignant melanoma with BRAF(V) (600E) mutation.
Expression of cytidine deaminase in human solid tumors and its regulation by 1 alpha,25-dihydroxyvitamin D3.
FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis.
Frame-shifted APOBEC3A encodes two alternative proapoptotic proteins that target the mitochondrial network.
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer.
Generation of Genomic Alteration from Cytidine Deamination.
Genetic and in vitro assays of DNA deamination.
Genome-wide discovery of somatic coding and non-coding mutations in pediatric endemic and sporadic Burkitt lymphoma.
Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways.
Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.
Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.
High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects.
High susceptibility of human cancer xenografts with higher levels of cytidine deaminase to a 2'-deoxycytidine antimetabolite, 2'-deoxy-2'-methylidenecytidine.
High-resolution melting analysis of sequence variations in the cytidine deaminase gene (CDA) in patients with cancer treated with gemcitabine.
HPV induction of APOBEC3 enzymes mediate overall survival and response to cisplatin in head and neck cancer.
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor.
Immunoglobulin G expression in lung cancer and its effects on metastasis.
Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide.
In vitro and in vivo antitumor activity of a novel nucleoside, 4'-thio-2'-deoxy-2'-methylidenecytidine.
In-situ cytidine-deaminase activity and chromosome 1P deletion in human neuroblastoma cells.
Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation.
Inhibition of EGFR phosphorylation in a panel of human breast cancer cells correlates with synergistic interactions between gefitinib and 5'-DFUR, the bioactive metabolite of Xeloda(®).
Interleukin-1 and tumor necrosis factor-alpha trigger restriction of hepatitis B virus infection via a cytidine deaminase AID.
Intravesical administration of gemcitabine in superficial bladder cancer: a phase I study with pharmacodynamic evaluation.
Involvement of activation-induced cytidine deaminase in skin cancer development.
Lack of activation-induced cytidine deaminase expression in in situ follicular neoplasia.
Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.
Malaria - how this parasitic infection aids and abets EBV-associated Burkitt lymphomagenesis.
Mechanistic Multiscale Pharmacokinetic Model for the Anticancer Drug 2',2'-difluorodeoxycytidine (Gemcitabine) in Pancreatic Cancer.
Modulation of Cancer-Associated Fibrotic Stroma by An Integrin ?v?3 Targeting Protein for Pancreatic Cancer Treatment.
Monocyte fructose 1,6-bisphosphatase and cytidine deaminase enzyme activities: potential pharmacodynamic measures of calcitriol effects in cancer patients.
Msh6 protects mature B cells from lymphoma by preserving genomic stability.
Myc translocations in B cell and plasma cell neoplasms.
No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese.
Nucleosides of 1,4-thiazin-3-one and derivatives as tetrahedral intermediate analogues of enzymes in pyrimidine nucleoside metabolism.
Optimized high-fidelity 3DPCR to assess potential mitochondrial targeting by activation-induced cytidine deaminase.
Oral clarithromycin enhances airway IgA immunity through induction of IgA class switching recombination and B-cell activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza A virus.
Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression.
Origin of increased deoxycytidine excretion into urine of rats bearing Yoshida ascites sarcoma.
Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase.
Pharmacokinetics of gemcitabine in Japanese cancer patients: the impact of a cytidine deaminase polymorphism.
Protective, tumor-selective dual pathway activation of 5-fluoro-2'-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755.
Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation.
Pyrimidine pathways enzymes in human tumors of brain and associated tissues: potentialities for the therapeutic use of N-(phosphonacetyl-L-aspartate and 1-beta-D-arabinofuranosylcytosine.
Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots.
Rational design of new tumoractivated cytotoxic agents.
Resistance to cytosine arabinoside by retrovirally mediated gene transfer of human cytidine deaminase into murine fibroblast and hematopoietic cells.
Role of activation-induced cytidine deaminase in inflammation-associated cancer development.
Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.
RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment.
S(mu) mutation patterns suggest different progression pathways in follicular lymphoma: early direct or late from FL progenitor cells.
Scheduling nab-paclitaxel combined with gemcitabine as first-line treatment for metastatic pancreatic adenocarcinoma.
Selective radiosensitization and cytotoxicity of human melanoma cells using halogenated deoxycytidines and tetrahydrouridine.
Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.
SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome.
Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.
Stratification of nucleoside analog chemotherapy using 1-(2'-deoxy-2'-18F-fluoro-?-D-arabinofuranosyl)cytosine and 1-(2'-deoxy-2'-18F-fluoro-?-L-arabinofuranosyl)-5-methylcytosine PET.
Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s.
Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation.
Study Probes Burkitt Lymphoma-Malaria Link.
Sustained delivery of cytarabine-loaded vesicular phospholipid gels for treatment of xenografted glioma.
Synthesis, characterization and mechanistic-insight into the anti-proliferative potential of PLGA-gemcitabine conjugate.
Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma.
Targeting Activation-Induced Cytidine Deaminase Overcome Tumor Evasion of Immunotherapy by CTLs.
The antiproliferative activity of DMDC is modulated by inhibition of cytidine deaminase.
The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond.
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
The impact of CDA A79C gene polymorphisms on the response and hematologic toxicity in gemcitabine-treated patients: A meta-analysis.
The new frontier of epigenetic heterogeneity in B-cell neoplasms.
The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies.
Therapeutic tools in pancreatic cancer.
Thymic stromal lymphopoietin in tonsillar follicular dendritic cells correlates with elevated serum immunoglobulin A titer by promoting tonsillar immunoglobulin A class switching in immunoglobulin A nephropathy.
Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.
Transfection of murine fibroblast cells with human cytidine deaminase cDNA confers resistance to cytosine arabinoside.
Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma.
Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.
Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma.
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Use of a lipid-coated mesoporous silica nanoparticle platform for synergistic gemcitabine and paclitaxel delivery to human pancreatic cancer in mice.
Validation of real-time reverse-transcription-polymerase chain reaction for quantification of capecitabine-metabolizing enzymes.
Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation.
[Discovery and development of novel anticancer drug capecitabine]
[Treatment of myelodysplastic syndromes (MDS) with oral administration of N4-palmitoyl-1-beta-D-arabinofuranosyl cytosine (PLAC)]
Neoplasms, Germ Cell and Embryonal
Activation-induced cytidine deaminase (AID) is expressed in normal spermatogenesis but only infrequently in testicular germ cell tumours.
Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.
Neoplastic Cells, Circulating
Biomarkers and pharmacogenetics in pancreatic cancer. Highlights from the "2011 ASCO Annual Meeting". Chicago, IL, USA; June 3-7, 2011.
Neuroblastoma
In-situ cytidine-deaminase activity and chromosome 1P deletion in human neuroblastoma cells.
Sensitivity to gemcitabine and its metabolizing enzymes in neuroblastoma.
Neurodegenerative Diseases
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability.
Pancreatic Neoplasms
A pilot clinical trial of the cytidine deaminase inhibitor tetrahydrouridine combined with decitabine to target DNMT1 in advanced, chemorefractory pancreatic cancer.
Contribution of thymidylate synthase to gemcitabine therapy for advanced pancreatic cancer.
Cytidine deaminase single-nucleotide polymorphism is predictive of toxicity from gemcitabine in patients with pancreatic cancer: RTOG 9704.
In vitro assessment of a synergistic combination of gemcitabine and zebularine in pancreatic cancer cells.
Intracellular Cytidine Deaminase Regulates Gemcitabine Metabolism in Pancreatic Cancer Cell Lines.
m6A Methyltransferase METTL14-Mediated Upregulation of Cytidine Deaminase Promoting Gemcitabine Resistance in Pancreatic Cancer.
MiR-608 regulating the expression of ribonucleotide reductase M1 and cytidine deaminase is repressed through induced gemcitabine chemoresistance in pancreatic cancer cells.
nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer.
Prediction of a Side Effect and Efficacy of Adjuvant Chemotherapy with Gemcitabine for Post Operative Patient of Pancreatic Cancer by a Genetic Polymorphism Analysis.
Study of apoptosis induction and deoxycytidine kinase/cytidine deaminase modulation in the synergistic interaction of a novel ceramide analog and gemcitabine in pancreatic cancer cells.
The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance.
Therapeutic tools in pancreatic cancer.
Use of a lipid-coated mesoporous silica nanoparticle platform for synergistic gemcitabine and paclitaxel delivery to human pancreatic cancer in mice.
Zebularine suppressed gemcitabine-induced senescence and improved the cellular and plasma pharmacokinetics of gemcitabine, augmented by liposomal co-delivery.
Paraproteinemias
Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery.
Parasitic Diseases
Study Probes Burkitt Lymphoma-Malaria Link.
Plasmacytoma
Activation of Aicda gene transcription by Pax5 in plasmacytoma cells.
AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements.
Pneumonia, Pneumococcal
Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: evidence of a subpopulation of protective anti-pneumococcal B1a cells.
Polymyalgia Rheumatica
Cytidine deaminase in polymyalgia rheumatica and elderly onset rheumatoid arthritis.
Pre-Eclampsia
Cytidine deaminase--a marker for pre-eclampsia?
The measurement of nucleoside deaminases by high performance liquid chromatography and their use in clinical chemistry.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Aberrant activation-induced cytidine deaminase expression in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia.
Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia.
Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells.
Activation-induced cytidine deaminase prevents pro-B cell acute lymphoblastic leukemia by functioning as a negative regulator in Rag1 deficient pro-B cells.
Different isoforms of the B-cell mutator activation-induced cytidine deaminase are aberrantly expressed in BCR-ABL1-positive acute lymphoblastic leukemia patients.
Presence of somatic hypermutation and activation-induced cytidine deaminase in acute lymphoblastic leukemia L2 with t(14;18)(q32;q21).
The clinical characteristics and prognostic significance of AID, miR-181b, and miR-155 expression in adult patients with de novo B-cell acute lymphoblastic leukemia.
Protein Deficiency
Patterns of Immune Dysregulation in Primary Immunodeficiencies: A Systematic Review.
Pseudorabies
Highly Efficient Base Editing in Viral Genome Based on Bacterial Artificial Chromosome Using a Cas9-Cytidine Deaminase Fused Protein.
Retroviridae Infections
Deaminase-Dead Mouse APOBEC3 is an
Rheumatic Diseases
Changes in biochemical markers of joint tissue metabolism in a randomized controlled trial of glucocorticoid in early rheumatoid arthritis.
Rubella
Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic.
Sepsis
Bioactive cytidine deaminase, an inhibitor of granulocyte-macrophage colony-forming cells, is massively released in fulminant meningococcal sepsis.
Sialadenitis
Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjögren's syndrome.
Comment on "Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjogren's syndrome".
Sjogren-Larsson Syndrome
Coexistence of Two Rare Autosomal Recessive Disorders: Activation-Induced Cytidine Deaminase Deficiency and Sjogren-Larsson Syndrome.
Skin Neoplasms
Involvement of activation-induced cytidine deaminase in skin cancer development.
Spondylitis, Ankylosing
Expression of activation-induced cytidine deaminase splicing variants in patients with ankylosing spondylitis.
Squamous Cell Carcinoma of Head and Neck
APOBEC mutagenesis is tightly linked to the immune landscape and immunotherapy biomarkers in head and neck squamous cell carcinoma.
Correction: Role of Activation-Induced Cytidine Deaminase in the Development of Oral Squamous Cell Carcinoma.
Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma.
Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma.
Stomach Neoplasms
Aberrant activation-induced cytidine deaminase expression is associated with mucosal intestinalization in the early stage of gastric cancer.
Aberrant expression of AID and AID activators of NF-?B and PAX5 is irrelevant to EBV-associated gastric cancers, but is associated with carcinogenesis in certain EBV-non-associated gastric cancers.
Activation-induced cytidine deaminase expression in gastric cancer.
Adenosine deaminase, 5'-nucleotidase, guanase and cytidine deaminase activities in gastric tissues from patients with gastric cancer.
AID, p53 and MLH1 expression in early gastric neoplasms and the correlation with the background mucosa.
Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes.
Enhanced expression of activation-induced cytidine deaminase in human gastric mucosa infected by Helicobacter pylori and its decrease following eradication.
Genomic and epigenetic profiles of gastric cancer: potential diagnostic and therapeutic applications.
Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells.
No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese.
Up-regulation of Activation-Induced Cytidine Deaminase Causes Genetic Aberrations at the CDKN2b-CDKN2a in Gastric Cancer.
Thyroid Cancer, Papillary
Immunoglobulin G expression and its colocalization with complement proteins in papillary thyroid cancer.
Tuberculosis
Autosomal recessive hyper IgM syndrome associated with activation-induced cytidine deaminase gene in three Turkish siblings presented with tuberculosis lymphadenitis - Case report.
Combining molecular dynamics and docking simulations of the cytidine deaminase from Mycobacterium tuberculosis H37Rv.
Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages.
Crystal structure determination and dynamic studies of Mycobacterium tuberculosis Cytidine deaminase in complex with products.
Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase.
Urinary Bladder Neoplasms
Cytidine Deaminase Activity Assessment to Select Perioperative Chemotherapy Regimen in Localized Bladder Cancer.
Uterine Cervical Neoplasms
APOBEC3A possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer.
Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor.
Vasculitis
Activation-induced cytidine deaminase in B cells of hepatits C virus-related cryoglobulinaemic vasculitis.
Elevated cytidine deaminase activity in patients with vasculitis of the small and medium-sized vessels.
Viremia
Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection.
Virus Diseases
AID and APOBECs span the gap between innate and adaptive immunity.
Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection.
Elucidation of the time course of adenosine deaminase APOBEC3G and viral infectivity factor vif in HIV-2(287) -infected infant macaques.
The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.
Unmutated immunoglobulin M can protect mice from death by influenza virus infection.
Waldenstrom Macroglobulinemia
Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery.
X-Linked Combined Immunodeficiency Diseases
Molecular genetic analysis of Hungarian patients with the hyper-immunoglobulin M syndrome.
Xeroderma Pigmentosum
Association of cytidine deaminase and xeroderma pigmentosum group D polymorphisms with response, toxicity, and survival in cisplatin/gemcitabine-treated advanced non-small cell lung cancer patients.
Association of xeroderma pigmentosum group D (Asp312Asn, Lys751Gln) and cytidine deaminase (Lys27Gln, Ala70Thr) polymorphisms with outcome in Chinese non-small cell lung cancer patients treated with cisplatin-gemcitabine.
Correlation of CDA, ERCC1, and XPD Polymorphisms with Response and Survival in Gemcitabine/Cisplatin-Treated Advanced Non-Small Cell Lung Cancer Patients.
Genetic polymorphisms of XPD and CDA and lung cancer risk.
Phase II studies of gemcitabine and cisplatin in heavily and minimally pretreated metastatic breast cancer.