Reference on EC 3.5.4.38 - single-stranded DNA cytosine deaminase
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Larijani, M.;Petrov, A.P.; Kolenchenko, O.; Berru, M.; Krylov, S.N.; Martin, A.
AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner
Mol. Cell. Biol.
27
20-30
2007
Homo sapiens (Q9GZX7)
Vallur, A.C.; Yabuki, M.; Larson, E.D.; Maizels, N.
AID in antibody perfection
Cell. Mol. Life Sci.
64
555-565
2007
Homo sapiens (Q9GZX7)
Brar, S.S.; Sacho, E.J.; Tessmer, I.; Croteau, D.L.; Erie, D.A.; Diaz, M.
Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA
DNA Repair
7
77-87
2007
Homo sapiens (Q9GZX7)
Carpenter, M.A.; Rajagurubandara, E.; Wijesinghe, P.; Bhagwat, A.S.
Determinants of sequence-specificity within human AID and APOBEC3G
DNA Repair
9
579-587
2010
Homo sapiens (Q9GZX7), Homo sapiens
Lee, S.A.; Parsa, J.Y.; Martin, A.; Baker, M.D.
Activation-induced cytidine deaminase induces DNA break repair events more frequently in the Ig switch region than other sites in the mammalian genome
Eur. J. Immunol.
37
3529-3539
2007
Homo sapiens (Q9GZX7)
Wang, J.H.
The role of activation-induced deaminase in antibody diversification and genomic instability
Immunol. Res.
55
287-297
2013
Homo sapiens (Q9GZX7), Mus musculus (Q9WVE0)
Muramatsu, M.; Sankaranand, V.S.; Anant, S.; Sugai, M.; Kinoshita, K.; Davidson, N.O.; Honjo, T.
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
J. Biol. Chem.
274
18470-18476
1999
Mus musculus (Q9WVE0), Mus musculus
Li, G.; Pone, E.J.; Tran, D.C.; Patel, P.J.; Dao, L.; Xu, Z.; Casali, P.
Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination
J. Biol. Chem.
287
21520-21529
2012
Mus musculus (Q9WVE0)
Dickerson, S.K.; Market, E.; Besmer, E.; Papavasiliou, F.N.
AID mediates hypermutation by deaminating single stranded DNA
J. Exp. Med.
197
1291-1296
2003
Homo sapiens (Q9GZX7)
Aoufouchi, S.; Faili, A.; Zober, C.; D'Orlando, O.; Weller, S.; Weill, J.C.; Reynaud, C.A.
Proteasomal degradation restricts the nuclear lifespan of AID
J. Exp. Med.
205
1357-1368
2008
Homo sapiens (Q9GZX7)
McBride, K.M.; Gazumyan, A.; Woo, E.M.; Schwickert, T.A.; Chait, B.T.; Nussenzweig, M.C.
Regulation of class switch recombination and somatic mutation by AID phosphorylation
J. Exp. Med.
205
2585-2594
2008
Mus musculus (Q9WVE0)
Miyazaki, Y.; Inoue, H.; Kikuchi, K.; Ochiai, K.; Kusama, K.
Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines
J. Oral Sci.
54
71-75
2012
Homo sapiens (Q9GZX7)
Larijani, M.; Martin, A.
Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID
Mol. Cell. Biol.
27
8038-8048
2007
Homo sapiens (Q9GZX7)
Gazumyan, A.; Timachova, K.; Yuen, G.; Siden, E.; Di Virgilio, M.; Woo, E.M.; Chait, B.T.; San-Martin, B.R.; Nussenzweig, M.C.; McBride, K.M.
Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation
Mol. Cell. Biol.
31
442-449
2011
Mus musculus (Q9WVE0)
Staszewski, O.; Baker, R.E.; Ucher, A.J.; Martier, R.; Stavnezer, J.; Guikema, J.E.
Activation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells
Mol. Cell.
41
232-242
2011
Mus musculus (Q9WVE0)
Bascove, M.; Frippiat, J.P.
Molecular characterization of Pleurodeles waltl activation-induced cytidine deaminase
Mol. Immunol.
47
1640-1649
2010
Pleurodeles waltl (D5GRW1)
Basu, U.; Chaudhuri, J.; Alpert, C.; Dutt, S.; Ranganath, S.; Li, G.; Schrum, J.P.; Manis, J.P.; Alt, F.W.
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
Nature
438
508-511
2005
Mus musculus (Q9WVE0)
Sohail, A.; Klapacz, J.; Samaranayake, M.; Ullah, A.; Bhagwat, A.S.
Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations
Nucleic Acids Res.
31
2990-2994
2003
Homo sapiens (Q9GZX7)
Bransteitter, R.; Pham, P.; Scharff, M.D.; Goodman, M.F.
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
Proc. Natl. Acad. Sci. USA
100
4102-4107
2003
Homo sapiens (Q9GZX7)
Yang, G.; Obiakor, H.; Sinha, R.K.; Newman, B.A.; Hood, B.L.; Conrads, T.P.; Veenstra, T.D.; Mage, R.G.
Activation-induced deaminase cloning, localization, and protein extraction from young VH-mutant rabbit appendix
Proc. Natl. Acad. Sci. USA
102
17083-17088
2005
Oryctolagus cuniculus (Q3BAF8), Oryctolagus cuniculus
Pasqualucci, L.; Kitaura, Y.; Gu, H.; Dalla-Favera, R.
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
Proc. Natl. Acad. Sci. USA
103
395-400
2005
Homo sapiens (Q9GZX7)
McBride, K.M.; Gazumyan, A.; Woo, E.M.; Barreto, V.M.; Robbiani, D.F.; Chait, B.T.; Nussenzweig, M.C.
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation
Proc. Natl. Acad. Sci. USA
103
8798-8803
2006
Mus musculus (Q9WVE0)
Cheng, H.L.; Vuong, B.Q.; Basu, U.; Franklin, A.; Schwer, B.; Astarita, J.; Phan, R.T.; Datta, A.; Manis, J.; Alt, F.W.; Chaudhuri, J.
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice
Proc. Natl. Acad. Sci. USA
106
2717-2122
2009
Mus musculus (Q9WVE0)
Meyers, G.; Ng, Y.S.; Bannock, J.M.; Lavoie, A.; Walter, J.E.; Notarangelo, L.D.; Kilic, S.S.; Aksu, G.; Debre, M.; Rieux-Laucat, F.; Conley, M.E.; Cunningham-Rundles, C.; Durandy, A.; Meffre, E.
Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans
Proc. Natl. Acad. Sci. USA
108
11554-11559
2011
Homo sapiens
Kuraoka, M.; Holl, T.M.; Liao, D.; Womble, M.; Cain, D.W.; Reynolds, A.E.; Kelsoe, G.
Activation-induced cytidine deaminase mediates central tolerance in B cells
Proc. Natl. Acad. Sci. USA
108
11560-11565
2011
Mus musculus
Verma, S.; Goldammer, T.; Aitken, R.
Cloning and expression of activation induced cytidine deaminase from Bos taurus
Vet. Immunol. Immunopathol.
134
151-159
2010
Bos taurus (Q2PT36)
Bae, S.J.; Park, B.G.; Kim, B.G.; Hahn, J.S.
Multiplex gene disruption by targeted base editing of Yarrowia lipolytica genome using cytidine deaminase combined with the CRISPR/Cas9 system
Biotechnol. J.
2019
e1900238
2019
Petromyzon marinus
Hou, S.; Silvas, T.V.; Leidner, F.; Nalivaika, E.A.; Matsuo, H.; Kurt Yilmaz, N.; Schiffer, C.A.
Structural analysis of the active site and DNA binding of human cytidine deaminase APOBEC3B
J. Chem. Theory Comput.
15
637-647
2019
Homo sapiens (Q9UH17), Homo sapiens
Sharma, S.; Patnaik, S.K.; Taggart, R.T.; Kannisto, E.D.; Enriquez, S.M.; Gollnick, P.; Baysal, B.E.
APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages
Nat. Commun.
6
6881
2015
Homo sapiens (P31941)
Hu, W.; Begum, N.A.; Mondal, S.; Stanlie, A.; Honjo, T.
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
Proc. Natl. Acad. Sci. USA
112
5791-5796
2015
Homo sapiens (Q9GZX7)
Marx, A.; Galilee, M.; Alian, A.
Zinc enhancement of cytidine deaminase activity highlights a potential allosteric role of loop-3 in regulating APOBEC3 enzymes
Sci. Rep.
5
18191
2015
Homo sapiens (P31941), Homo sapiens (Q9HC16)
Sharma, S.; Patnaik, S.K.; Taggart, R.T.; Baysal, B.E.
The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme
Sci. Rep.
6
39100
2016
Homo sapiens (Q9HC16)
Li, X.; Caval, V.; Wain-Hobson, S.; Vartanian, J.P.
Elephant APOBEC3A cytidine deaminase induces massive double-stranded DNA breaks and apoptosis
Sci. Rep.
9
728
2019
Loxodonta africana (A0A4Y5QRZ7)
Kumar, R.; Evans, T.
Activation-induced cytidine deaminase regulates fibroblast growth factor/extracellular signal-regulated kinases signaling to achieve the naive pluripotent state during reprogramming
Stem Cells
37
1003-1017
2019
Mus musculus (Q9WVE0)
King, J.J.; Manuel, C.A.; Barrett, C.V.; Raber, S.; Lucas, H.; Sutter, P.; Larijani, M.
Catalytic pocket inaccessibility of activation-induced cytidine deaminase is a safeguard against excessive mutagenic activity
Structure
23
615-627
2015
Homo sapiens, Homo sapiens (P31941)
Adolph, M.B.; Love, R.P.; Chelico, L.
Biochemical basis of APOBEC3 deoxycytidine deaminase activity on diverse DNA substrates
ACS Infect. Dis.
4
224-238
2018
Homo sapiens (P31941), Homo sapiens (Q6NTF7), Homo sapiens (Q8IUX4), Homo sapiens (Q96AK3), Homo sapiens (Q9HC16), Homo sapiens (Q9NRW3), Homo sapiens (Q9UH17)
Pham, P.; Afif, S.A.; Shimoda, M.; Maeda, K.; Sakaguchi, N.; Pedersen, L.C.; Goodman, M.F.
Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification
DNA Repair
43
48-56
2016
Escherichia coli O157:H7 (P0AEY0)
Shi, K.; Carpenter, M.A.; Kurahashi, K.; Harris, R.S.; Aihara, H.
Crystal structure of the DNA deaminase APOBEC3B catalytic domain
J. Biol. Chem.
290
28120-28130
2015
Homo sapiens (Q9UH17)
Ito, F.; Fu, Y.; Kao, S.A.; Yang, H.; Chen, X.S.
Family-wide comparative analysis of cytidine and methylcytidine deamination by eleven human APOBEC proteins
J. Mol. Biol.
429
1787-1799
2017
Homo sapiens (P31941), Homo sapiens (Q6NTF7), Homo sapiens (Q8IUX4), Homo sapiens (Q96AK3), Homo sapiens (Q9HC16), Homo sapiens (Q9NRW3), Homo sapiens (Q9UH17), Homo sapiens
Feng, Y.; Wong, L.; Morse, M.; Rouzina, I.; Williams, M.C.; Chelico, L.
RNA-mediated dimerization of the human deoxycytidine deaminase APOBEC3H influences enzyme activity and interaction with nucleic acids
J. Mol. Biol.
430
4891-4907
2018
Homo sapiens (Q6NTF7), Homo sapiens
Fang, Y.; Xiao, X.; Li, S.X.; Wolfe, A.; Chen, X.S.
Molecular interactions of a DNA modifying enzyme APOBEC3F catalytic domain with a single-stranded DNA
J. Mol. Biol.
430
87-101
2018
Homo sapiens (Q8IUX4)
Maiti, A.; Myint, W.; Kanai, T.; Delviks-Frankenberry, K.; Sierra Rodriguez, C.; Pathak, V.K.; Schiffer, C.A.; Matsuo, H.
Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with sDNA
Nat. Commun.
9
2460
2018
Homo sapiens (Q9HC16)
Adolph, M.B.; Love, R.P.; Feng, Y.; Chelico, L.
Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B
Nucleic Acids Res.
45
11925-11940
2017
Homo sapiens (Q9UH17)
Wang, Y.; Wu, S.; Zheng, S.; Wang, S.; Wali, A.; Ezhilarasan, R.; Sulman, E.P.; Koul, D.; Alfred Yung, W.K.
APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death
Oncotarget
8
54285-54296
2017
Homo sapiens (Q9HC16)
Kamba, K.; Nagata, T.; Katahira, M.
Catalytic analysis of APOBEC3G involving real-time NMR spectroscopy reveals nucleic acid determinants for deamination
PLoS ONE
10
e0124142
2015
Homo sapiens (Q9HC16)
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