Reference on EC 3.5.4.37 - double-stranded RNA adenine deaminase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hough, R.F.; Bass, B.L.
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase
J. Biol. Chem.
269
9933-9939
1994
Xenopus laevis
Schwartz, T.; Shafer, K.; Lowenhaupt, K.; Hanlon, E.; Herbert, A.; Rich, A.
Crystallization and preliminary studies of the DNA-binding domain Za from ADAR1 complexed to left-handed DNA
Acta Crystallogr. Sect. D
55
1362-1364
1999
Homo sapiens
Wang, Q.
RNA editing catalyzed by ADAR1 and its function in mammalian cells
Biochemistry (Moscow)
76
900-911
2011
Mus musculus
Lehmann, K.A.; Bass, B.L.
Double-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities
Biochemistry
39
12875-12884
2000
Homo sapiens
Jacobs, M.M.; Fogg, R.L.; Emeson, R.B.; Stanwood, G.D.
ADAR1 and ADAR2 expression and editing activity during forebrain development
Dev. Neurosci.
31
223-237
2009
Mus musculus (Q99MU3), Mus musculus
Yang, L.; Zhao, L.; Gan, Z.; He, Z.; Xu, J.; Gao, X.; Wang, X.; Han, W.; Chen, L.; Xu, T.; Li, W.; Liu, Y.
Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis
FASEB J.
24
3720-3732
2010
Rattus norvegicus
Yang, C.; Su, J.; Li, Q.; Zhang, R.; Rao, Y.
Identification and expression profiles of ADAR1 gene, responsible for RNA editing, in responses to dsRNA and GCRV challenge in grass carp (Ctenopharyngodon idella)
Fish Shellfish Immunol.
33
1042-1049
2012
Ctenopharyngodon idella
Veliz, E.A.; Easterwood, L.M.; Beal, P.A.
Substrate analogues for an RNA-editing adenosine deaminase: mechanistic investigation and inhibitor design
J. Am. Chem. Soc.
125
10867-10876
2003
Homo sapiens
Cho, D.S.; Yang, W.; Lee, J.T.; Shiekhattar, R.; Murray, J.M.; Nishikura, K.
Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA
J. Biol. Chem.
278
17093-17102
2003
Homo sapiens, Homo sapiens (P55265), Mus musculus (Q99MU3), Mus musculus
Hartner, J.C.; Schmittwolf, C.; Kispert, A.; Mller, A.M.,; Higuchi, M.; Seeburg, P.H.
Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1
J. Biol. Chem.
279
4894-4902
2004
Mus musculus (Q99MU3), Mus musculus
Dawson, T.R.; Sansam, C.L.; Emeson, R.B.
Structure and sequence determinants required for the RNA editing of ADAR2 substrates
J. Biol. Chem.
279
4941-4951
2004
Rattus norvegicus
Wang, Q.; Miyakoda, M.; Yang, W.; Khillan, J.; Stachura, D.L.; Weiss, M.J.; Nishikura, K.
Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene
J. Biol. Chem.
279
4952-4961
2003
Mus musculus (Q99MU3)
Valente, L.; Nishikura, K.
RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions
J. Biol. Chem.
282
16054-16061
2007
Homo sapiens
Desterro, J.M.; Keegan, L.P.; Lafarga, M.; Berciano, M.T.; O'Connell, M.; Carmo-Fonseca, M.
Dynamic association of RNA-editing enzymes with the nucleolus
J. Cell Sci.
116
1805-1818
2003
Homo sapiens, Homo sapiens (P55265)
Lehmann, K.A.; Bass, B.L.
The importance of internal loops within RNA substrates of ADAR1
J. Mol. Biol.
291
1-13
1999
Xenopus laevis
Macbeth, M.R.; Bass, B.L.
Large-scale overexpression and purification of ADARs from Saccharomyces cerevisiae for biophysical and biochemical studies
Methods Enzymol.
424
319-331
2007
Homo sapiens
O'Connell, M.A.; Gerber, A.; Keegan, L.P.
Purification of native and recombinant double-stranded RNA-specific adenosine deaminases
Methods
15
51-62
1998
Bos taurus, Homo sapiens
Nie, Y.; Ding, L.; Kao, P.N.; Braun, R.; Yang, J.H.
ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing
Mol. Cell. Biol.
25
6956-6963
2005
Homo sapiens (P55265)
Kllman, A.M.; Sahlin, M.; Ohman, M.
ADAR2 A->I editing: site selectivity and editing efficiency are separate events
Nucleic Acids Res.
31
4874-4881
2003
Rattus norvegicus
Ikeda, T.; Ohsugi, T.; Kimura, T.; Matsushita, S.; Maeda, Y.; Harada, S.; Koito, A.
The antiretroviral potency of APOBEC1 deaminase from small animal species
Nucleic Acids Res.
36
6859-6871
2008
Homo sapiens (P41238)
Galeano, F.; Rossetti, C.; Tomaselli, S.; Cifaldi, L.; Lezzerini, M.; Pezzullo, M.; Boldrini, R.; Massimi, L.; Di Rocco, C.M.; Locatelli, F.; Gallo, A.
ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis
Oncogene
32
998-1009
2013
Homo sapiens
XuFeng, R.; Boyer, M.J.; Shen, H.; Li, Y.; Yu, H.; Gao, Y.; Yang, Q.; Wang, Q.; Cheng, T.
ADAR1 is required for hematopoietic progenitor cell survival via RNA editing
Proc. Natl. Acad. Sci. USA
106
17763-17768
2009
Mus musculus (Q99MU3)
Herbert, A.; Alfken, J.; Kim, Y.G.; Mian, I.S.; Nishikura, K.; Rich, A.
A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase
Proc. Natl. Acad. Sci. USA
94
8421-8426
1997
Homo sapiens
Wong, S.K.; Lazinski, D.W.
Replicating hepatitis delta virus RNA is edited in the nucleus by the small form of ADAR1
Proc. Natl. Acad. Sci. USA
99
15118-15123
2002
Homo sapiens
Morse, D.P.; Aruscavage, P.J.; Bass, B.L.
RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA
Proc. Natl. Acad. Sci. USA
99
7906-7911
2002
Caenorhabditis elegans, Homo sapiens
Gallo, A.; Galardi, S.
A-to-I RNA editing and cancer: from pathology to basic science
RNA Biol.
5
135-139
2008
Homo sapiens
Riedmann, E.M.; Schopoff, S.; Hartner, J.C.; Jantsch, M.F.
Specificity of ADAR-mediated RNA editing in newly identified targets
RNA
14
1110-1118
2008
Mus musculus
Palladino, M.J.; Keegan, L.P.; O'Connell, M.A.; Reenan, R.A.
dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing
RNA
6
1004-1018
2000
Drosophila melanogaster (Q9NII1)
Wong, S.K.; Sato, S.; Lazinski, D.W.
Substrate recognition by ADAR1 and ADAR2
RNA
7
846-858
2001
Homo sapiens, Homo sapiens (P78563)
Macbeth, M.R.; Schubert, H.L.; Vandemark, A.P.; Lingam, A.T.; Hill, C.P.; Bass B.L.
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing
Science
309
1534-1539
2005
Homo sapiens (P78563), Homo sapiens
Hundley, H.A.; Bass, B.L.
ADAR editing in double-stranded UTRs and other noncoding RNA sequences
Trends Biochem. Sci.
35
377-383
2010
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens
Li, Z.; Wolff, K.C.; Samuel, C.E.
RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment
Virology
396
316-322
2009
Homo sapiens (P55265)
Samuel, C.E.
Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral
Virology
411
180-193
2011
Homo sapiens
Qiu, W.; Wang, X.; Buchanan, M.; He, K.; Sharma, R.; Zhang, L.; Wang, Q.; Yu, J.
ADAR1 is essential for intestinal homeostasis and stem cell maintenance
Cell Death Dis.
4
e599
2013
Mus musculus
Weiden, M.D.; Hoshino, S.; Levy, D.N.; Li, Y.; Kumar, R.; Burke, S.A.; Dawson, R.; Hioe, C.E.; Borkowsky, W.; Rom, W.N.; Hoshino, Y.
Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HIV-1 replication in human alveolar macrophages
PLoS ONE
9
e108476
2014
Homo sapiens
Tang, Y.D.; Na, L.; Fu, L.H.; Yang, F.; Zhu, C.H.; Tang, L.; Li, Q.; Wang, J.Y.; Li, Z.; Wang, X.F.; Li, C.Y.; Wang, X.; Zhou, J.H.
Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity
Virology
476
364-371
2015
Equus caballus
Tang, Y.D.; Zhang, X.; Na, L.; Wang, X.F.; Fu, L.H.; Zhu, C.H.; Wang, X.; Zhou, J.H.
Double-stranded-RNA-specific adenosine deaminase 1 (ADAR1) is proposed to contribute to the adaptation of equine infectious anemia virus from horses to donkeys
Arch. Virol.
161
2667-2672
2016
Equus asinus asinus
Song, C.; Sakurai, M.; Shiromoto, Y.; Nishikura, K.
Functions of the RNA editing enzyme ADAR1 and their relevance to human diseases
Genes (Basel)
7
E129
2016
Homo sapiens (P55265), Homo sapiens
Tomaselli, S.; Galeano, F.; Alon, S.; Raho, S.; Galardi, S.; Polito, V.A.; Presutti, C.; Vincenti, S.; Eisenberg, E.; Locatelli, F.; Gallo, A.
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma
Genome Biol.
16
5
2015
Homo sapiens (P78563), Homo sapiens
George, C.X.; Ramaswami, G.; Li, J.B.; Samuel, C.E.
Editing of cellular self-RNAs by adenosine deaminase ADAR1 suppresses innate immune stress responses
J. Biol. Chem.
291
6158-6168
2016
Mus musculus (Q99MU3), Mus musculus
Samuel, C.E.
Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA-triggered innate immune responses
J. Biol. Chem.
294
1710-1720
2019
Homo sapiens (P55265)
Zhou, S.; Yang, C.; Zhao, F.; Huang, Y.; Lin, Y.; Huang, C.; Ma, X.; Du, J.; Wang, Y.; Long, G.; He, J.; Liu, C.; Zhang, P.
Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR
J. Biol. Chem.
294
18168-18180
2019
Homo sapiens (P55265), Homo sapiens
Gannon, H.S.; Zou, T.; Kiessling, M.K.; Gao, G.F.; Cai, D.; Choi, P.S.; Ivan, A.P.; Buchumenski, I.; Berger, A.C.; Goldstein, J.T.; Cherniack, A.D.; Vazquez, F.; Tsherniak, A.; Levanon, E.Y.; Hahn, W.C.; Meyerson, M.
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
Nat. Commun.
9
5450
2018
Homo sapiens (P55265)
Phelps, K.J.; Tran, K.; Eifler, T.; Erickson, A.I.; Fisher, A.J.; Beal, P.A.
Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2
Nucleic Acids Res.
43
1123-1132
2015
Homo sapiens (P78563), Homo sapiens
Wang, X.; Vukovic, L.; Koh, H.R.; Schulten, K.; Myong, S.
Dynamic profiling of double-stranded RNA binding proteins
Nucleic Acids Res.
43
7566-7576
2015
Homo sapiens (P55265), Homo sapiens
Li, Z.; Tian, Y.; Tian, N.; Zhao, X.; Du, C.; Han, L.; Zhang, H.
Aberrant alternative splicing pattern of ADAR2 downregulates adenosine-to-inosine editing in glioma
Oncol. Rep.
33
2845-2852
2015
Homo sapiens (P78563), Homo sapiens
Amin, E.M.; Liu, Y.; Deng, S.; Tan, K.S.; Chudgar, N.; Mayo, M.W.; Sanchez-Vega, F.; Adusumilli, P.S.; Schultz, N.; Jones, D.R.
The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK
Sci. Signal.
10
eaah3941
2017
Homo sapiens (P55265)
Liddicoat, B.J.; Piskol, R.; Chalk, A.M.; Ramaswami, G.; Higuchi, M.; Hartner, J.C.; Li, J.B.; Seeburg, P.H.; Walkley, C.R.
RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
Science
349
1115-1120
2015
Mus musculus (Q99MU3)
Dai, L.; Liu, X.C.; Ye, S.; Li, H.W.; Chen, D.F.; Yu, X.J.; Huang, X.T.; Zhang, L.; Yang, F.; Yang, J.S.; Yang, W.J.
The RNA-editing deaminase ADAR is involved in stress resistance of Artemia diapause embryos
Stress
19
609-620
2016
Artemia parthenogenetica (A0A3G1FKL8)
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