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3-guanidinopropinonate + H2O
3-aminopropanoate + urea
-
-
-
-
?
3-guanidinopropionate + H2O
3-aminopropanoate + urea
-
-
-
?
3-guanidinopropionate + H2O
3-aminopropionate + urea
3-guanidopropionate + H2O
?
-
-
-
-
?
4-guanidinobutanoate + H2O
4-aminobutanoate + urea
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
4-guanidopropionic acid + H2O
3-aminopropionate + urea
-
-
-
-
?
5-guanidinovalerate + H2O
5-aminopentanoate + urea
6-guanidinocaproate + H2O
6-aminohexanoate + urea
arginine + H2O
2,5-diaminopentanoate + urea
D-arginine + H2O
D-ornithine + urea
-
-
-
?
L-arginine + H2O
L-ornithine + urea
-
-
-
?
L-canavanine + H2O
L-2-amino-4-(aminooxy)butanoic acid + urea
taurocyamine + H2O
taurine + urea
-
strain U2-3-3 is a taurocyamine utilizing mutant
-
?
additional information
?
-
3-guanidinopropionate + H2O
3-aminopropionate + urea
-
the enzyme acts 25times more efficiently on 4-guanidinobutyrate than on 3-guanidinopropionic acid
-
-
?
3-guanidinopropionate + H2O
3-aminopropionate + urea
-
the enzyme acts 25times more efficiently on 4-guanidinobutyrate than on 3-guanidinopropionic acid
-
-
?
4-guanidinobutanoate + H2O
4-aminobutanoate + urea
-
-
-
-
?
4-guanidinobutanoate + H2O
4-aminobutanoate + urea
-
-
-
?
4-guanidinobutanoate + H2O
4-aminobutanoate + urea
-
the enzyme acts 25times more efficiently on 4-guanidinobutyrate than on 3-guanidinopropionic acid
-
-
?
4-guanidinobutanoate + H2O
4-aminobutanoate + urea
-
-
-
-
?
4-guanidinobutanoate + H2O
4-aminobutanoate + urea
-
the enzyme acts 25times more efficiently on 4-guanidinobutyrate than on 3-guanidinopropionic acid
-
-
?
4-guanidinobutanoate + H2O
4-aminobutanoate + urea
-
-
-
?
4-guanidinobutanoate + H2O
4-aminobutanoate + urea
-
-
-
-
?
4-guanidinobutanoate + H2O
4-aminobutanoate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
preferred substrate
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
preferred substrate
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
Brevibacterium lipolyticum
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
Crotalus sp.
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
Gopherus sp.
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
ph 9.5
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
pH 9.5, 0.134 mM MnSO4, 37°C
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
enzyme shows no activity towards 3-guanidinopropionate
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
4-Guanidinobutyrate + H2O
4-Aminobutyrate + urea
-
-
-
-
?
5-guanidinovalerate + H2O
5-aminopentanoate + urea
-
-
-
-
?
5-guanidinovalerate + H2O
5-aminopentanoate + urea
-
-
-
-
?
5-guanidinovalerate + H2O
5-aminopentanoate + urea
-
-
-
-
?
5-guanidinovalerate + H2O
5-aminopentanoate + urea
-
-
-
-
?
6-guanidinocaproate + H2O
6-aminohexanoate + urea
-
-
-
-
?
6-guanidinocaproate + H2O
6-aminohexanoate + urea
-
-
-
-
?
6-guanidinocaproate + H2O
6-aminohexanoate + urea
-
-
-
-
?
6-guanidinocaproate + H2O
6-aminohexanoate + urea
-
-
-
-
?
arginine + H2O
2,5-diaminopentanoate + urea
-
weak activity towards L- and D-arginine
-
-
?
arginine + H2O
2,5-diaminopentanoate + urea
-
-
-
-
?
L-canavanine + H2O
L-2-amino-4-(aminooxy)butanoic acid + urea
-
-
-
-
?
L-canavanine + H2O
L-2-amino-4-(aminooxy)butanoic acid + urea
-
-
-
-
?
additional information
?
-
-
other guanidinium compounds, namely L-arginine, agmatine, 2-guanidinoacetic acid, D-arginine and L-homoarginine, are not substrates for this enzyme
-
-
?
additional information
?
-
-
other guanidinium compounds, namely L-arginine, agmatine, 2-guanidinoacetic acid, D-arginine and L-homoarginine, are not substrates for this enzyme
-
-
?
additional information
?
-
-
guanidinoacetate, L-guanidinosuccinate, 6-guanidinocaproate, 2-guanidinoethyl sulfate, 4-guanidinobutyramide, taurocyamine, creatine, methylguanidine, N-amidino-L-alanine and agmatine are inert as substrates
-
-
?
additional information
?
-
-
guanidinoacetate, creatine, N-amidinoalanine, L-arginine and guanidine are no substrates
-
-
?
additional information
?
-
-
no activity with arginine, agmatine, 3-guanidinopropionate and guanidinoacetate
-
-
?
additional information
?
-
-
guanidinoacetate, creatine, N-amidinoalanine, L-arginine and guanidine are no substrates
-
-
?
additional information
?
-
-
guanidinoacetate, creatine, N-amidinoalanine, L-arginine and guanidine are no substrates
-
-
?
additional information
?
-
-
guanidinoacetate, beta-guanidinopropionate, L-alpha-amino-gamma-guanidinobutyrate, L-arginine, D-arginine, L-homoarginine and agmatine are no substrates
-
-
?
additional information
?
-
-
guanidinoacetate, 3-guanidinopropionate, 3-guanidino-n-butyrate, taurocyamine, creatine, N-amidinoalanine, L-arginine, D-arginine, DL-N-acetyl-arginine, canavanine, agmatine, methylguanidine and guanylurea are no substrates
-
-
?
additional information
?
-
-
taurocyamine and 3-guanidinopropionate are inducers, but no substrates
-
-
?
additional information
?
-
-
taurocyamine and 3-guanidinopropionate are inducers, but no substrates
-
-
?
additional information
?
-
-
guanidinoacetate, 3-guanidinopropionate, 3-guanidino-n-butyrate, taurocyamine, creatine, N-amidinoalanine, L-arginine, D-arginine, DL-N-acetyl-arginine, canavanine, agmatine, methylguanidine and guanylurea are no substrates
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
L-arginine, D-arginine, gamma-guanidinobutyramide, guanidinoacetate, beta-guanidinopropionate, delta-guanidinovalerate, agmatine, guanidinobutane, streptomycine and streptidine are no substrates
-
-
?
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Yorifuji, T.; Sugai, I.; Matsumoto, H.; Tabuchi, A.
Characterization of 3-guanidinopropionate amidinohydrolase from Pseudomonas aeruginosa and a comparative study with 4-guanidinobutyrate amidinohydrolase from another Pseudomonas
Agric. Biol. Chem.
46
1361-1367
1982
Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas sp., Pseudomonas sp. ATCC 14676
-
brenda
Yorifuji, T.; Sugai, I.
3-Guanidinopropionate amidinohydrolase and 4-guanidinobutyrate amidinohydrolase of Pseudomonas aeruginosa strain PAO1
Agric. Biol. Chem.
42
1789-1790
1978
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO1(ATTC 15692), Pseudomonas fluorescens, Raja clavata
-
brenda
Yorifuji, T.; Kobayashi, T.; Tabuchi, A.; Shiritani, Y.; Yonaha, K.
Distribution of amidinohydrolases among Pseudomonas and comparative studies of some purified enzymes by one-dimensional peptide mapping
Agric. Biol. Chem.
47
2825-2830
1983
Pseudomonas sp., Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas aeruginosa PAO1(ATTC 15692), Pseudomonas sp. ATCC 14676
-
brenda
Yorifuji, T.; Shiritani, Y.
Gratuitous induction of two omega-guanidino acid amidinohydrolases in Pseudomonas sp. ATCC 14676 by taurocyamine and 3-guanidinopropionate
Agric. Biol. Chem.
46
317-318
1982
Pseudomonas fluorescens, Pseudomonas sp., Pseudomonas sp. ATCC 14676
-
brenda
Yorifuji, T.; Shiritani, Y.; Eguchi, S.; Yonaha, K.
Taurocyamine-utilizing mutants from a wild-type strain of Pseudomonas
J. Appl. Biochem.
5
375-381
1983
Pseudomonas fluorescens
brenda
Mora, J.; Tarrab, R.; Martuscelli, J.; Soberom, G.
Characteristics of arginases from ureotelic and non-ureotelic animals
Biochem. J.
96
588-594
1965
Ambystoma mexicanum, Crotalus sp., Gallus sp., Gopherus sp., Kinosternon sp., Iguania, no activity in Neurospora crassa, Pseudemys sp., Rana sp., Streptomyces griseus, no activity in Neurospora crassa 74A
brenda
Van Thoai, N.; Thome-Beau, F.; Olomucki, A.
Induction et specificite des enzymes de la nouvelle voie catabolique de l'arginine
Biochim. Biophys. Acta
115
73-80
1966
Streptomyces griseus
brenda
Chou, C.S.; Rodwell, V.W.
Metabolism of basic amino acids in Pseudomonas putida gamma-guanidinobutyrate amidinohydrolase
J. Biol. Chem.
247
4486-4490
1972
Gallus sp., Helix pomatia, Iguania, Penicillium roqueforti, Pseudomonas fluorescens, Pseudomonas putida, Raja clavata, Streptomyces griseus
brenda
Yorifuji, T.; Kato, M.; Kobayashi, T.; Ozaki, S.; Ueno, S.
4-Guanidinobutyrate amidinohydrolase from Pseudomonas sp. ATCC 14676: Purification to homogeneity and properties
Agric. Biol. Chem.
44
1127-1134
1980
Flavobacterium sp., Pseudomonas sp., Pseudomonas fluorescens, Pseudomonas sp. ATCC 14676
-
brenda
Campo, M.L.; Fuentes, J.M.; Soler, G.
An arginine regulated gamma-guanidobutyrate ureahydrolase from tench liver (Tinca tinca L.)
Arch. Int. Physiol. Biochim. Biophys.
100
55-60
1992
Gallus sp., Helix pomatia, Iguania, Penicillium roqueforti, Pseudomonas putida, Pseudomonas fluorescens, Raja clavata, Streptomyces griseus, Tinca tinca
brenda
Yorifuji, T.; Shimizu, E.; Hirata, H.; Imada, K.; Katsumi, T.; Sawamura, S.
Guanidinobutyrase for L-arginine degradation in Brevibacterium helvolum
Biosci. Biotechnol. Biochem.
56
773-777
1992
Arthrobacter globiformis, Pimelobacter simplex, Corynebacterium ammoniagenes, Brevibacterium helvolum, Brevibacterium linens, Brevibacterium lipolyticum, Corynebacterium stationis, Pseudomonas fluorescens, Streptomyces griseus
brenda
Yorifuji, T.; Kaneoke, M.; Okazaki, T.; Shimizu, E.
Degradation of 2-ketoarginine by guanidinobutyrase in arginine aminotransferase pathway of Brevibacterium helvolum
Biosci. Biotechnol. Biochem.
59
512-513
1995
Arthrobacter globiformis, Pimelobacter simplex, Brevibacterium helvolum, Brevibacterium linens, Streptomyces griseus
brenda
Arakawa, N.; Igarashi, M.; Kazuoka, T.; Oikawa, T.; Soda, K.
D-arginase of Arthrobacter sp. KUJ 8602: characterization and its identity with Zn(2+)-guanidinobutyrase
J. Biochem.
133
33-42
2003
Arthrobacter sp. (Q8KZT5), Arthrobacter sp., Arthrobacter sp. KUJ 8602 (Q8KZT5)
brenda
Nakada, Y.; Itoh, Y.
Characterization and regulation of the gbuA gene, encoding guanidinobutyrase in the arginine dehydrogenase pathway of Pseudomonas aeruginosa PAO1
J. Bacteriol.
184
3377-3384
2002
Pseudomonas aeruginosa
brenda
Nakada, Y.; Itoh, Y.
Pseudomonas aeruginosa PAO1 genes for 3-guanidinopropionate and 4-guanidinobutyrate utilization may be derived from a common ancestor
Microbiology
151
4055-4062
2005
Pseudomonas aeruginosa
brenda
Lee, S.J.; Kim, d.o..J.; Kim, H.S.; Lee, B.I.; Yoon, H.J.; Yoon, J.Y.; Kim, K.H.; Jang, J.Y.; Im, H.N.; An, D.R.; Song, J.S.; Kim, H.J.; Suh, S.W.
Crystal structures of Pseudomonas aeruginosa guanidinobutyrase and guanidinopropionase, members of the ureohydrolase superfamily
J. Struct. Biol.
175
329-338
2011
Pseudomonas aeruginosa
brenda
Romagnoli, G.; Verhoeven, M.D.; Mans, R.; Fleury Rey, Y.; Bel-Rhlid, R.; van den Broek, M.; Seifar, R.M.; Ten Pierick, A.; Thompson, M.; Mueller, V.; Wahl, S.A.; Pronk, J.T.; Daran, J.M.
An alternative, arginase-independent pathway for arginine metabolism in Kluyveromyces lactis involves guanidinobutyrase as a key enzyme
Mol. Microbiol.
93
369-389
2014
Kluyveromyces lactis, no activity in Kluyveromyces lactis strain GG1632, Kluyveromyces lactis IMS0367
brenda
Kumar, S.; Saragadam, T.; Punekar, N.S.
Novel route for agmatine catabolism in Aspergillus niger involves 4-guanidinobutyrase
Appl. Environ. Microbiol.
81
5593-5603
2015
Aspergillus niger (W8R465), Aspergillus niger, Aspergillus niger NCIM 565 (W8R465)
brenda
Jagmann, N.; Bleicher, V.; Busche, T.; Kalinowski, J.; Philipp, B.
The guanidinobutyrase GbuA is essential for the alkylquinolone-regulated pyocyanin production during parasitic growth of Pseudomonas aeruginosa in co-culture with Aeromonas hydrophila
Environ. Microbiol.
18
3550-3564
2016
Pseudomonas aeruginosa (Q9I3S3), Pseudomonas aeruginosa
brenda
Saragadam, T.; Kumar, S.; Punekar, N.S.
Characterization of 4-guanidinobutyrase from Aspergillus niger
Microbiology
165
396-410
2019
Aspergillus niger, Aspergillus niger NCIM 565
brenda