Reference on EC 3.5.3.15 - protein-arginine deiminase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fujisaki, M.; Sugawara, K.
Properties of peptidylarginine deiminase from the epidermis of newborn rats
J. Biochem.
89
257-263
1981
Rattus norvegicus
Kubilus, J.; Baden, H.P.
Purification and properties of a brain enzyme which deiminates proteins
Biochim. Biophys. Acta
745
285-291
1983
Bos taurus, Rattus norvegicus
Rothnagel, J.A.; Rogers, G.E.
Citrulline in proteins from the enzymatic deimination of arginine residues
Methods Enzymol.
107
624-631
1984
Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Rattus norvegicus
Lamensa, K.W.E.; Moscarello, M.A.
Deimination of human myelin basic protein by a peptidylarginine deiminase from bovine brain
J. Neurochem.
61
987-996
1993
Bos taurus
Tarcsa, E.; Marekov, L.N.; Mei, G.; Melino, G.; Lee, S.C.; Steinert, P.M.
Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin
J. Biol. Chem.
271
30709-30716
1996
Oryctolagus cuniculus
Takahara, H.; Kusubata, M.; Tsuchida, M.; Kohsaka, T.; Tagami, S.; Sugawara, K.
Expression of peptidylarginine deiminase in the uterine epithelial cells of mouse is dependent on estrogen
J. Biol. Chem.
267
520-525
1992
Mus musculus
Pritzker, L.B.; Joshi, S.; Harauz, G.; Moscarello, M.A.
Deimination of myelin basic protein 3.5.3.15. Effect of methylation of MBP on its deimination by peptidylarginine deiminase
Biochemistry
39
5382-5388
2000
Bos taurus, Homo sapiens
Tsuchida, M.; Takahara, H.; Ninami, N.; Arai, T.; Kobayashi, Y.; Tsujimoto, H.; Fukazawa, C.; Sugawara, K.
cDNA nucleotide sequence and primary structure of mouse uterine peptidylarginine deiminase. Detection of a 3'-untranslated nucleotide sequence common to the mRNA of transiently expressed genes and rapid turnover of this enzymes mRNA in the estrous cycle
Eur. J. Biochem.
215
677-685
1993
Mus musculus
Eronina, T.B.; Livanova, N.B.; Chebotareva, N.A.; Kurganov, B.I.; Luo, S.; Graves, D.J.
Deimination of glycogen phosphorylase b by peptidylarginine deiminase. Influence on the kinetical characteristics and dimer-tetramer transition
Biochimie
78
253-258
1996
Oryctolagus cuniculus
Rogers, G.; Winter, B.; McLaughlan, C.; Powell, B.; Nesci, T.
Peptidylarginine deiminase of the hair follicle: characterization, localization, and function in keratinizing tissues
J. Invest. Dermatol.
108
700-707
1997
Ovis aries
Ohsugi, I.; Takahara, H.; Shiraiwa, M.; Sugawara, K.
Expression of mouse uterine peptidylarginine deiminase in Escherichia coli: construction of expression plasmid and properties of the recombinant enzyme
Arch. Biochem. Biophys.
317
62-68
1995
Mus musculus
Nomura, K.
Specificity and mode of action of the muscle-type protein-arginine deiminase
Arch. Biochem. Biophys.
293
362-369
1992
Oryctolagus cuniculus
Terakawa, H.; Takahara, H.; Sugawara, K.
Three types of mouse peptidylarginine deiminase: characterization and tissue distribution
J. Biochem.
110
661-666
1991
Mus musculus
Nishijo, T.; Kawada, A.; Kanno, T.; Shiraiwa, M.; Takahara, H.
Isolation and molecular cloning of epidermal- and hair follicle-specific peptidylarginine deiminase (type III) from rat
J. Biochem.
121
868-875
1997
Rattus norvegicus
Pritzker, L.B.; Moscarello, M.A.
A novel microtubule independent effect of paclitaxel: the inhibition of peptidylarginine deiminase from bovine brain
Biochim. Biophys. Acta
1388
154-160
1998
Bos taurus
McGraw, W.T.; Potempa, J.; Farley, D.; Travis, J.
Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis. Peptidylarginine deiminase
Infect. Immun.
67
3248-3256
1999
Porphyromonas gingivalis
Nagata, S.; Senshu, T.
Peptidylarginine deiminase in rat and mouse hemopoietic cells
Experientia
46
72-74
1990
Mus musculus, Rattus norvegicus
Senshu, T.; Akiyama, K.; Ishigami, A.; Nomura, K.
Studies on specificity of peptidylarginine deiminase reactions using an immunochemical probe that recognizes an enzymatically deiminated partial sequence of mouse keratin K1
J. Dermatol. Sci.
21
113-126
1999
Rattus norvegicus
Ishigami, A.; Ohsawa, T.; Watanabe, K.; Senshu, T.
all-trans Retinoic acid increases peptidylarginine deiminase in a newborn keratinocyte cell line
Biochem. Biophys. Res. Commun.
223
299-303
1996
Rattus norvegicus
Pritzker, L.B.; Nguyen, T.A.; Moscarello, M.A.
The developmental expression and activity of peptidylarginine deiminase in the mouse
Neurosci. Lett.
266
161-164
1999
Mus musculus
Koike, H.; Shiraiwa, M.; Sugawara, K.; Kohsaka, T.; Takahara, H.
Existence and differential changes of peptidylarginine deiminase type II in mouse yolk-sac erythroid cells
Biosci. Biotechnol. Biochem.
59
552-554
1995
Mus musculus
Arita, K.; Hashimoto, H.; Shimizu, T.; Yamada, M.; Sato, M.
Crystallization and preliminary X-ray crystallographic analysis of human peptidylarginine deiminase V
Acta Crystallogr. Sect. D
59
2332-2333
2003
Homo sapiens
Arita, K.; Hashimoto, H.; Shimizu, T.; Nakashima, K.; Yamada, M.; Sato, M.
Structural basis for Ca2+-induced activation of human PAD4
Nat. Struct. Mol. Biol.
11
777-783
2004
Homo sapiens (Q9UM07), Homo sapiens
Zhang, J.; Dai, J.; Zhao, E.; Lin, Y.; Zeng, L.; Chen, J.; Zheng, H.; Wang, Y.; Li, X.; Ying, K.; Xie, Y.; Mao, Y.
cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI
Acta Biochim. Pol.
51
1051-1058
2004
Homo sapiens
Vossenaar, E.R.; Radstake, T.R.; van der Heijden, A.; van Mansum, M.A.; Dieteren, C.; de Rooij, D.J.; Barrera, P.; Zendman, A.J.; van Venrooij, W.J.
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages
Ann. Rheum. Dis.
63
373-381
2004
Homo sapiens (Q9Y2J8), Homo sapiens
Sambandam, T.; Belousova, M.; Accaviti-Loper, M.A.; Blanquicett, C.; Guercello, V.; Raijmakers, R.; Nicholas, A.P.
Increased peptidylarginine deiminase type II in hypoxic astrocytes
Biochem. Biophys. Res. Commun.
325
1324-1329
2004
Homo sapiens (Q9Y2J8), Homo sapiens
Nakayama-Hamada, M.; Suzuki, A.; Kubota, K.; Takazawa, T.; Ohsaka, M.; Kawaida, R.; Ono, M.; Kasuya, A.; Furukawa, H.; Yamada, R.; Yamamoto, K.
Comparison of enzymatic properties between hPADI2 and hPADI4
Biochem. Biophys. Res. Commun.
327
192-200
2005
Homo sapiens
Dong, S.; Kanno, T.; Yamaki, A.; Kojima, T.; Shiraiwa, M.; Kawada, A.; Mechin, M.C.; Chavanas, S.; Serre, G.; Simon, M.; Takahara, H.
NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes
Biochem. J.
397
449-459
2006
Homo sapiens (Q9ULW8), Homo sapiens
Kearney, P.L.; Bhatia, M.; Jones, N.G.; Yuan, L.; Glascock, M.C.; Catchings, K.L.; Yamada, M.; Thompson, P.R.
Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis
Biochemistry
44
10570-10582
2005
Homo sapiens (Q9UM07), Homo sapiens
Stone, E.M.; Schaller, T.H.; Bianchi, H.; Person, M.D.; Fast, W.
Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase
Biochemistry
44
13744-13752
2005
Homo sapiens (Q9UM07), Homo sapiens
Hagiwara, T.; Hidaka, Y.; Yamada, M.
Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes
Biochemistry
44
5827-5834
2005
Homo sapiens
Cuthbert, G.L.; Daujat, S.; Snowden, A.W.; Erdjument-Bromage, H.; Hagiwara, T.; Yamada, M.; Schneider, R.; Gregory, P.D.; Tempst, P.; Bannister, A.J.; Kouzarides, T.
Histone deimination antagonizes arginine methylation
Cell
118
545-553
2004
Homo sapiens
Mechin, M.C.; Enji, M.; Nachat, R.; Chavanas, S.; Charveron, M.; Ishida-Yamamoto, A.; Serre, G.; Takahara, H.; Simon, M.
The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations
Cell. Mol. Life Sci.
62
1984-1995
2005
Homo sapiens, Homo sapiens (Q9ULC6), Homo sapiens (Q9ULW8)
Hidaka, Y.; Hagiwara, T.; Yamada, M.
Methylation of the guanidino group of arginine residues prevents citrullination by peptidylarginine deiminase IV
FEBS Lett.
579
4088-4092
2005
Homo sapiens (Q9UM07)
Bhattacharya, S.K.; Crabb, J.S.; Bonilha, V.L.; Gu, X.; Takahara, H.; Crabb, J.W.
Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis
Invest. Ophthalmol. Vis. Sci.
47
2508-2514
2006
Mus musculus (Q08642), Mus musculus
Nachat, R.; Mechin, M.C.; Takahara, H.; Chavanas, S.; Charveron, M.; Serre, G.; Simon, M.
Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin
J. Invest. Dermatol.
124
384-393
2005
Homo sapiens (Q9ULC6), Homo sapiens (Q9ULW8), Homo sapiens (Q9Y2J8), Homo sapiens
Nachat, R.; Mechin, M.C.; Charveron, M.; Serre, G.; Constans, J.; Simon, M.
Peptidylarginine deiminase isoforms are differentially expressed in the anagen hair follicles and other human skin appendages
J. Invest. Dermatol.
125
34-41
2005
Homo sapiens, Homo sapiens (Q9ULW8), Homo sapiens (Q9Y2J8)
Ishigami, A.; Ohsawa, T.; Hiratsuka, M.; Taguchi, H.; Kobayashi, S.; Saito, Y.; Murayama, S.; Asaga, H.; Toda, T.; Kimura, N.; Maruyama, N.
Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease
J. Neurosci. Res.
80
120-128
2005
Homo sapiens
Chang, X.; Han, J.
Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors
Mol. Carcinog.
45
183-196
2006
Homo sapiens (Q9UM07)
Arita, K.; Shimizu, T.; Hashimoto, H.; Hidaka, Y.; Yamada, M.; Sato, M.
Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4
Proc. Natl. Acad. Sci. USA
103
5291-5296
2006
Homo sapiens, Homo sapiens (Q9UM07)
Kubota, K.; Yoneyama-Takazawa, T.; Ichikawa, K.
Determination of sites citrullinated by peptidylarginine deiminase using 18O stable isotope labeling and mass spectrometry
Rapid Commun. Mass Spectrom.
19
683-688
2005
Homo sapiens
Liu, M.; Oh, A.; Calarco, P.; Yamada, M.; Coonrod, S.A.; Talbot, P.
Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in reimplantation embryonic development
Reprod. Biol. Endocrinol.
3
42
2005
Mus musculus (Q8K3V4), Mus musculus
Chang, X.; Yamada, R.; Suzuki, A.; Sawada, T.; Yoshino, S.; Tokuhiro, S.; Yamamoto, K.
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis
Rheumatology
44
40-50
2005
Homo sapiens
Harney, S.M.; Meisel, C.; Sims, A.M.; Woon, P.Y.; Wordsworth, B.P.; Brown, M.A.
Genetic and genomic studies of PADI4 in rheumatoid arthritis
Rheumatology
44
869-872
2005
Homo sapiens
Wang, Y.; Wysocka, J.; Sayegh, J.; Lee, Y.H.; Perlin, J.R.; Leonelli, L.; Sonbuchner, L.S.; McDonald, C.H.; Cook, R.G.; Dou, Y.; Roeder, R.G.; Clarke, S.; Stallcup, M.R.; Allis, C.D.; Coonrod, S.A.
Human PAD4 regulates histone arginine methylation levels via demethylimination
Science
306
279-283
2004
Homo sapiens
Zendman, A.J.; Raijmakers, R.; Nijenhuis, S.; Vossenaar, E.R.; Tillaart, M.; Chirivi, R.G.; Raats, J.M.; van Venrooij, W.J.; Drijfhout, J.W.; Pruijn, G.J.
ABAP: antibody-based assay for peptidylarginine deiminase activity
Anal. Biochem.
369
232-240
2007
Oryctolagus cuniculus, Mus musculus, Homo sapiens (Q9Y2J8), Homo sapiens, Mus musculus C57BL/6 / 129S
Hung, H.C.; Lin, C.Y.; Liao, Y.F.; Hsu, P.C.; Tsay, G.J.; Liu, G.Y.
The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells
Apoptosis
12
475-487
2007
Homo sapiens
Luo, Y.; Arita, K.; Bhatia, M.; Knuckley, B.; Lee, Y.H.; Stallcup, M.R.; Sato, M.; Thompson, P.R.
Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization
Biochemistry
45
11727-11736
2006
Homo sapiens (Q9UM07)
Knuckley, B.; Luo, Y.; Thompson, P.R.
Profiling protein arginine deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors
Bioorg. Med. Chem.
16
739-745
2008
Homo sapiens
Asaga, H.; Ishigami, A.
Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain
Cell. Mol. Biol. Lett.
12
536-544
2007
Rattus norvegicus
Keilhoff, G.; Prell, T.; Langnaese, K.; Mawrin, C.; Simon, M.; Fansa, H.; Nicholas, A.P.
Expression pattern of peptidylarginine deiminase in rat and human Schwann cells
Dev. Neurobiol.
68
101-114
2007
Homo sapiens, Homo sapiens (Q9ULC6), Homo sapiens (Q9Y2J8), Rattus norvegicus
Algeciras, M.E.; Bhattacharya, S.K.
Targeting optic nerve citrullination in glaucoma: a role for protein-arginine deiminase 2 (PAD2) inhibitors
Drugs Future
32
999-1005
2007
Homo sapiens, Homo sapiens (Q6TGC4), Homo sapiens (Q9ULC6), Homo sapiens (Q9ULW8), Homo sapiens (Q9Y2J8), Rattus norvegicus, Rattus norvegicus (O88806), Rattus norvegicus (O88807), Rattus norvegicus (P20717), Rattus norvegicus (P70708)
-
Dong, S.; Ying, S.; Kojima, T.; Shiraiwa, M.; Kawada, A.; Mechin, M.C.; Adoue, V.; Chavanas, S.; Serre, G.; Simon, M.; Takahara, H.
Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes
J. Invest. Dermatol.
128
549-557
2008
Homo sapiens (Q9ULC6), Homo sapiens
Wood, D.D.; Ackerley, C.A.; Brand, B.; Zhang, L.; Raijmakers, R.; Mastronardi, F.G.; Moscarello, M.A.
Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities
Lab. Invest.
88
354-364
2008
Homo sapiens, Mus musculus (Q08642), Mus musculus (Q9Z183), Mus musculus CD-1 (Q08642), Mus musculus CD-1 (Q9Z183)
Esposito, G.; Vitale, A.M.; Leijten, F.P.; Strik, A.M.; Koonen-Reemst, A.M.; Yurttas, P.; Robben, T.J.; Coonrod, S.; Gossen, J.A.
Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility
Mol. Cell. Endocrinol.
273
25-31
2007
Mus musculus (Q8K3V4)
Jang, B.; Kim, E.; Choi, J.K.; Jin, J.K.; Kim, J.I.; Ishigami, A.; Maruyama, N.; Carp, R.I.; Kim, Y.S.; Choi, E.K.
Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis
Am. J. Pathol.
173
1129-1142
2008
Mus musculus (Q08642)
Makrygiannakis, D.; Hermansson, M.; Ulfgren, A.K.; Nicholas, A.P.; Zendman, A.J.; Eklund, A.; Grunewald, J.; Skold, C.M.; Klareskog, L.; Catrina, A.I.
Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells
Ann. Rheum. Dis.
67
1488-1492
2008
Homo sapiens
Musse, A.A.; Polverini, E.; Raijmakers, R.; Harauz, G.
Kinetics of human peptidylarginine deiminase 2 (hPAD2)--reduction of Ca2+ dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains
Biochem. Cell Biol.
86
437-447
2008
Homo sapiens
Stensland, M.E.; Pollmann, S.; Molberg, ?.; Sollid, L.M.; Fleckenstein, B.
Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4
Biol. Chem.
390
99-107
2009
Homo sapiens
Loos, T.; Mortier, A.; Gouwy, M.; Ronsse, I.; Put, W.; Lenaerts, J.P.; Van Damme, J.; Proost, P.
Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation
Blood
112
2648-2656
2008
Oryctolagus cuniculus, Homo sapiens
Algeciras, M.E.; Takahara, H.; Bhattacharya, S.K.
Mechanical stretching elevates peptidyl arginine deiminase 2 expression in astrocytes
Curr. Eye Res.
33
994-1001
2008
Rattus norvegicus (P20717)
Musse, A.A.; Li, Z.; Ackerley, C.A.; Bienzle, D.; Lei, H.; Poma, R.; Harauz, G.; Moscarello, M.A.; Mastronardi, F.G.
Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system
Dis. Model. Mech.
1
229-240
2008
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8)
Touz, M.C.; Ropolo, A.S.; Rivero, M.R.; Vranych, C.V.; Conrad, J.T.; Svard, S.G.; Nash, T.E.
Arginine deiminase has multiple regulatory roles in the biology of Giardia lamblia
J. Cell Sci.
121
2930-2938
2008
Giardia intestinalis
Ying, S.; Dong, S.; Kawada, A.; Kojima, T.; Chavanas, S.; Mechin, M.C.; Adoue, V.; Serre, G.; Simon, M.; Takahara, H.
Transcriptional regulation of peptidylarginine deiminase expression in human keratinocytes
J. Dermatol. Sci.
53
2-9
2009
Homo sapiens (Q6TGC4), Homo sapiens (Q9ULC6), Homo sapiens (Q9ULW8), Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Proost, P.; Loos, T.; Mortier, A.; Schutyser, E.; Gouwy, M.; Noppen, S.; Dillen, C.; Ronsse, I.; Conings, R.; Struyf, S.; Opdenakker, G.; Maudgal, P.C.; Van Damme, J.
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation
J. Exp. Med.
205
2085-2097
2008
Oryctolagus cuniculus, Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8)
Li, P.; Yao, H.; Zhang, Z.; Li, M.; Luo, Y.; Thompson, P.R.; Gilmour, D.S.; Wang, Y.
Regulation of p53 target gene expression by peptidylarginine deiminase 4
Mol. Cell. Biol.
28
4745-4758
2008
Homo sapiens (Q9UM07)
Abdeen, S.M.; Olusi, S.O.
Peptidyl arginine deiminase: A novel immunohistochemical marker for liver fibrosis in patients with chronic hepatitis
Acta Histochem.
112
592-603
2010
Homo sapiens
Rodriguez, S.B.; Stitt, B.L.; Ash, D.E.
Cysteine 351 is an essential nucleophile in catalysis by Porphyromonas gingivalis peptidylarginine deiminase
Arch. Biochem. Biophys.
504
190-196
2010
Porphyromonas gingivalis
Knuckley, B.; Causey, C.P.; Jones, J.E.; Bhatia, M.; Dreyton, C.J.; Osborne, T.C.; Takahara, H.; Thompson, P.R.
Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3
Biochemistry
49
4852-4863
2010
Homo sapiens
Knuckley, B.; Causey, C.P.; Pellechia, P.J.; Cook, P.F.; Thompson, P.R.
Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation
ChemBioChem
11
161-165
2010
Homo sapiens
Jones, J.E.; Causey, C.P.; Knuckley, B.; Slack-Noyes, J.L.; Thompson, P.R.
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential
Curr. Opin. Drug Discov. Devel.
12
616-627
2009
Homo sapiens
Choi, M.; Lee, O.H.; Jeon, S.; Park, M.; Lee, D.R.; Ko, J.J.; Yoon, T.K.; Rajkovic, A.; Choi, Y.
The oocyte-specific transcription factor, Nobox, regulates the expression of Pad6, a peptidylarginine deiminase in the oocyte
FEBS Lett.
584
3629-3634
2010
Mus musculus
Mortier, A.; Loos, T.; Gouwy, M.; Ronsse, I.; Van Damme, J.; Proost, P.
Posttranslational modification of the NH2-terminal region of CXCL5 by proteases or peptidylarginine deiminases (PAD) differently affects its biological activity
J. Biol. Chem.
285
29750-29759
2010
Oryctolagus cuniculus
Shimada, N.; Handa, S.; Uchida, Y.; Fukuda, M.; Maruyama, N.; Asaga, H.; Choi, E.K.; Lee, J.; Ishigami, A.
Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain
J. Neurosci. Res.
88
798-806
2010
Mus musculus
Cherrington, B.D.; Morency, E.; Struble, A.M.; Coonrod, S.A.; Wakshlag, J.J.
Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones
PLoS ONE
5
e11768
2010
Canis lupus familiaris
Jang, B.; Jeon, Y.C.; Choi, J.K.; Park, M.; Kim, J.I.; Ishigami, A.; Maruyama, N.; Carp, R.I.; Kim, Y.S.; Choi, E.K.
Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases
Biochem. J.
445
183-192
2012
Oryctolagus cuniculus, Homo sapiens
Slack, J.L.; Jones, L.E.; Bhatia, M.M.; Thompson, P.R.
Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity
Biochemistry
50
3997-4010
2011
Homo sapiens
Lee, H.J.; Joo, M.; Abdolrasulnia, R.; Young, D.G.; Choi, I.; Ware, L.B.; Blackwell, T.S.; Christman, B.W.
Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages
J. Biol. Chem.
285
39655-39662
2010
Mus musculus
Rose, R.; Rose, M.; Ottmann, C.
Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI
J. Struct. Biol.
180
65-72
2012
Homo sapiens
Mohlake, P.; Whiteley, C.G.
Arginine metabolising enzymes as therapeutic tools for Alzheimers disease: peptidyl arginine deiminase catalyses fibrillogenesis of beta-amyloid peptides
Mol. Neurobiol.
41
149-158
2010
Bos taurus
Liu, Y.L.; Chiang, Y.H.; Liu, G.Y.; Hung, H.C.
Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4)
PLoS ONE
6
e21314
2011
Homo sapiens
Brahmajosyula, M.; Miyake, M.
Localization and expression of peptidylarginine deiminase 4 (PAD4) in mammalian oocytes and preimplantation embryos
Zygote
21
314-324
2013
Mus musculus, Sus scrofa
Unno, M.; Kizawa, K.; Ishihara, M.; Takahara, H.
Crystallization and preliminary X-ray crystallographic analysis of human peptidylarginine deiminase type III
Acta Crystallogr. Sect. F
68
668-670
2012
Homo sapiens (Q9ULW8), Homo sapiens
Unno, M.; Kinjo, S.; Kizawa, K.; Takahara, H.
Crystallization and preliminary X-ray crystallographic analysis of human peptidylarginine deiminase type I
Acta Crystallogr. Sect. F
69
1357-1359
2013
Homo sapiens (Q9ULC6), Homo sapiens
Abdullah, S.N.; Farmer, E.A.; Spargo, L.; Logan, R.; Gully, N.
Porphyromonas gingivalis peptidylarginine deiminase substrate specificity
Anaerobe
23
102-108
2013
Porphyromonas gingivalis, Porphyromonas gingivalis W50
Darrah, E.; Rosen, A.; Giles, J.; Andrade, F.
Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: Novel insights into autoantigen selection in rheumatoid arthritis
Ann. Rheum. Dis.
71
92-98
2012
Homo sapiens (Q9ULW8), Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Dreyton, C.J.; Knuckley, B.; Jones, J.E.; Lewallen, D.M.; Thompson, P.R.
Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism
Biochemistry
53
4426-4433
2014
Homo sapiens (Q9Y2J8)
Assohou-Luty, C.; Raijmakers, R.; Benckhuijsen, W.E.; Stammen-Vogelzangs, J.; de Ru, A.; van Veelen, P.A.; Franken, K.L.; Drijfhout, J.W.; Pruijn, G.J.
The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities
Biochim. Biophys. Acta
1844
829-836
2014
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8)
Bozdag, M.; Dreker, T.; Henry, C.; Tosco, P.; Vallaro, M.; Fruttero, R.; Scozzafava, A.; Carta, F.; Supuran, C.T.
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors
Bioorg. Med. Chem. Lett.
23
715-719
2013
Homo sapiens (Q9UM07)
Shimizu, A.; Handa, K.; Honda, T.; Abe, N.; Kojima, T.; Takahara, H.
Three isozymes of peptidylarginine deiminase in the chicken: molecular cloning, characterization, and tissue distribution
Comp. Biochem. Physiol. B
167
65-73
2014
Gallus gallus (E1C0W6), Gallus gallus (F1NP39), Gallus gallus (S6BNL5), Gallus gallus
Jamali, H.; Khan, H.A.; Stringer, J.R.; Chowdhury, S.; Ellman, J.A.
Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method
J. Am. Chem. Soc.
137
3616-3621
2015
Homo sapiens (Q9ULW8)
Subramanian, V.; Knight, J.S.; Parelkar, S.; Anguish, L.; Coonrod, S.A.; Kaplan, M.J.; Thompson, P.R.
Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors
J. Med. Chem.
58
1337-1344
2015
Homo sapiens (Q9ULC6), Homo sapiens (Q9ULW8), Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Slade, D.J.; Fang, P.; Dreyton, C.J.; Zhang, Y.; Fuhrmann, J.; Rempel, D.; Bax, B.D.; Coonrod, S.A.; Lewis, H.D.; Guo, M.; Gross, M.L.; Thompson, P.R.
Protein arginine deiminase 2 binds calcium in an ordered fashion implications for inhibitor design
ACS Chem. Biol.
10
1043-1053
2015
Homo sapiens (Q9Y2J8)
Jamali, H.; Khan, H.A.; Tjin, C.C.; Ellman, J.A.
Cellular activity of new small molecule protein arginine deiminase 3 (PAD3) inhibitors
ACS Med. Chem. Lett.
7
847-851
2016
Homo sapiens (Q9ULW8), Homo sapiens
Montgomery, A.B.; Kopec, J.; Shrestha, L.; Thezenas, M.L.; Burgess-Brown, N.A.; Fischer, R.; Yue, W.W.; Venables, P.J.
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase implications for autoimmunity in rheumatoid arthritis
Ann. Rheum. Dis.
75
1255-1261
2016
Porphyromonas gingivalis (Q9RQJ2), Porphyromonas gingivalis, Porphyromonas gingivalis W83 (Q9RQJ2)
Kunieda, K.; Kawaguchi, M.; Ieda, N.; Nakagawa, H.
Development of a highly sensitive fluorescence probe for peptidyl arginine deiminase (PAD) activity
Bioorg. Med. Chem. Lett.
29
923-928
2019
Homo sapiens (Q9UM07)
Teo, C.Y.; Tejo, B.A.; Leow, A.T.C.; Salleh, A.B.; Abdul Rahman, M.B.
Novel furan-containing peptide-based inhibitors of protein arginine deiminase type IV (PAD4)
Chem. Biol. Drug Des.
90
1134-1146
2017
Homo sapiens (Q9UM07)
Olson, J.S.; Lubner, J.M.; Meyer, D.J.; Grant, J.E.
An in silico analysis of primary and secondary structure specificity determinants for human peptidylarginine deiminase types 2 and 4
Comput. Biol. Chem.
70
107-115
2017
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
El-Sayed, A.S.A.; Shindia, A.A.; AbouZaid, A.A.; Yassin, A.M.; Ali, G.S.; Sitohy, M.Z.
Biochemical characterization of peptidylarginine deiminase-like orthologs from thermotolerant Emericella dentata and Aspergillus nidulans
Enzyme Microb. Technol.
124
41-53
2019
Aspergillus nidulans, Aspergillus nidulans var. dentatus
Zhou, Y.; Mittereder, N.; Sims, G.
Perspective on protein arginine deiminase activity-bicarbonate is a pH-independent regulator of citrullination
Front. Immunol.
9
34
2018
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8)
Trabocchi, A.; Pala, N.; Krimmelbein, I.; Menchi, G.; Guarna, A.; Sechi, M.; Dreker, T.; Scozzafava, A.; Supuran, C.; Carta, F.
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors
J. Enzyme Inhib. Med. Chem.
30
466-471
2015
Homo sapiens (Q9UM07)
Damgaard, D.; Bjorn, M.E.; Jensen, P.O.; Nielsen, C.H.
Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase
J. Enzyme Inhib. Med. Chem.
32
1203-1208
2017
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Kriebel, K.; Hieke, C.; Engelmann, R.; Potempa, J.; Mueller-Hilke, B.; Lang, H.; Kreikemeyer, B.
Porphyromonas gingivalis peptidyl arginine deiminase can modulate neutrophil activity via infection of human dental stem cells
J. Innate Immun.
10
264-278
2018
Porphyromonas gingivalis (Q9RQJ2), Porphyromonas gingivalis, Porphyromonas gingivalis W83 (Q9RQJ2)
Subramanian, V.; Knight, J.S.; Parelkar, S.; Anguish, L.; Coonrod, S.A.; Kaplan, M.J.; Thompson, P.R.
Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors
J. Med. Chem.
58
1337-1344
2015
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Saijo, S.; Nagai, A.; Kinjo, S.; Mashimo, R.; Akimoto, M.; Kizawa, K.; Yabe-Wada, T.; Shimizu, N.; Takahara, H.; Unno, M.
Monomeric form of peptidylarginine deiminase type I revealed by X-ray crystallography and small-angle X-ray scattering
J. Mol. Biol.
428
3058-3073
2016
Homo sapiens (Q9ULC6), Homo sapiens
Karkowska-Kuleta, J.; Bartnicka, D.; Zawrotniak, M.; Zielinska, G.; Kieronska, A.; Bochenska, O.; Ciaston, I.; Koziel, J.; Potempa, J.; Baster, Z.; Rajfur, Z.; Rapala-Kozik, M.
The activity of bacterial peptidylarginine deiminase is important during formation of dual-species biofilm by periodontal pathogen Porphyromonas gingivalis and opportunistic fungus Candida albicans
Pathog. Dis.
76
fty033
2018
Porphyromonas gingivalis (Q9RQJ2), Porphyromonas gingivalis, Porphyromonas gingivalis W83 (Q9RQJ2)
Bereta, G.; Goulas, T.; Madej, M.; Bielecka, E.; Sola, M.; Potempa, J.; Xavier Gomis-Rueth, F.
Structure, function, and inhibition of a genomic/clinical variant of Porphyromonas gingivalis peptidylarginine deiminase
Protein Sci.
28
478-486
2019
Porphyromonas gingivalis, Porphyromonas gingivalis (Q9RQJ2), Porphyromonas gingivalis ATCC 33277, Porphyromonas gingivalis T2 (Q9RQJ2)
Zhao, C.; Ling, B.; Dong, L.; Liu, Y.
Theoretical insights into the protonation states of active site cysteine and citrullination mechanism of Porphyromonas gingivalis peptidylarginine deiminase
Proteins
85
1518-1528
2017
Porphyromonas gingivalis (Q9RQJ2), Porphyromonas gingivalis, Porphyromonas gingivalis W83 (Q9RQJ2)
Lee, C.; Lin, C.; Liu, Y.; Liu, G.; Liu, J.; Hung, H.
Molecular interplay between the dimer interface and the substrate-binding site of human peptidylarginine deiminase 4
Sci. Rep.
7
42662
2017
Homo sapiens (Q9UM07), Homo sapiens
Tsuji-Hosokawa, A.; Kashimada, K.; Kato, T.; Ogawa, Y.; Nomura, R.; Takasawa, K.; Lavery, R.; Coschiera, A.; Schlessinger, D.; Harley, V.R.; Takada, S.; Morio, T.
Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development
Sci. Rep.
8
13263
2018
Mus musculus (Q08642)
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