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Information on EC 3.5.2.1 - barbiturase

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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.1 barbiturase
IUBMB Comments
Contains zinc and is specific for barbiturate as substrate . Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC 1.17.99.4 (uracil/thymine dehydrogenase) and EC 3.5.1.95 (N-malonylurea hydrolase). It was previously thought that the end-products of the reaction were malonate and urea but this has since been disproved . May be involved in the regulation of pyrimidine metabolism, along with EC 2.4.2.9, uracil phosphoribosyltransferase.
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The enzyme appears in viruses and cellular organisms
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
barbiturate + H2O = 3-oxo-3-ureidopropanoate
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PATHWAY SOURCE
PATHWAYS
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