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Disease on EC 3.5.1.2 - glutaminase

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DISEASE
TITLE OF PUBLICATION
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Acidosis
A comparative study of the renal glutaminase response to acidosis.
A lack of correlation between rat kidney mitochondrial swelling and glutaminase activation in metabolic acidosis.
Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output.
Acidosis activation of the pituitary-adrenal-renal glutaminase I axis.
Adaptation of renal tricarboxylic acid cycle metabolism to various acid-base states: study with [3-13C,5-15N]glutamine.
Ammonia formation from glutamine isomers by nonacidotic and acidotic perfused rat kidneys.
Ammoniagenesis by cultured human renal cortical epithelial cells: study with 15N.
Biochemical and histocytochemical studies on response of ammonia-producing enzymes for nh4cl-induced acidosis.
Changes in the levels of translatable glutaminase mRNA during onset and recovery from metabolic acidosis.
Complexity and species variation of the kidney-type glutaminase gene.
Effect of acidosis on phosphoenolpyruvate carboxykinase and glutaminase mRNAs in rat kidney and in LLC-PK-F+ cells.
Effect of acidosis on the properties of the glutaminase mRNA pH-response element binding protein.
Effect of acute alterations in acid-base balance on rat renal glutaminase and phosphoenolpyruvate carboxykinase gene expression.
Effect of ischaemia and acidosis on glutaminase activity in the rat kidney.
Effect of pH on ammonia production by renal mitochondria.
Effects of age on renal function and enzyme activity in male C57BL/6 mice.
Glutamine metabolism in metabolic acidosis.
Hepatic enzymes of glutamine and ureagenesis in metabolic acidosis.
Hepatic glutaminase flux regulation of glutamine homeostasis. Studies in vivo.
Hormonal regulation of glutamine metabolism by OK cells.
Impact of Acidosis-Regulated MicroRNAs on the Expression of Their Target Genes in Experimental Tumors In Vivo.
Influence of acute metabolic acidosis on the monomer and polymer forms of renal phosphate-dependent glutaminase.
Interorgan glutamine flow in metabolic acidosis.
Mechanism of altered renal glutaminase gene expression in response to chronic acidosis.
Pathways of acute pH regulation of ammoniagenesis in LLC-PK1 cells: study with [15N]glutamine.
Perturbations in nitrogen metabolism of brain and liver of rat following repeated benthiocarb administration.
pH-responsive stabilization of glutamate dehydrogenase mRNA in LLC-PK1-F+ cells.
pH-responsive, gluconeogenic renal epithelial LLC-PK1-FBPase+cells: a versatile in vitro model to study renal proximal tubule metabolism and function.
Phosphate activation of glutaminase in sonicated mitochondria of normal and acidotic rat kidneys.
Phosphate-dependent glutaminase from rat kidney. Cause of increased activity in response to acidosis and identity with glutaminase from other tissues.
Phosphate-dependent glutaminase of rat skeletal muscle. Some properties and possible role in glutamine metabolism.
Phosphate-independent glutaminase from rat kidney. Partial purification and identity with gamma-glutamyltranspeptidase.
Properties of rat kidney glutaminase enzymes and their role in renal ammoniagenesis.
Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver.
Regulation of glutaminase activity and glutamine metabolism.
Regulation of interorganal glutamine flow in metabolic acidosis.
Regulation of renal glutaminase gene expression during metabolic acidosis.
Relationship of phosphate-dependent glutaminase activity to ammonia excretion in potassium deficiency and acidosis.
Renal ammoniagenesis and acid excretion in the dogfish, Squalus acanthias.
Renal ammonium production--une vue canadienne.
Renal enzymes during experimental diabetes mellitus in the rat. Role of insulin, carbohydrate metabolism, and ketoacidosis.
Renal metabolite concentrations and the activities of glutaminase and glutamate dehydrogenase during recovery from metabolic acidosis in the rat.
Renal phosphate-dependent glutaminase activity and ammonia excretion during acute acidosis in the rat.
Response of ammonia metabolism to acute acidosis: insights from cultured renal epithelium.
Response of LLC-PK1-F+ cells to metabolic acidosis.
Role of deadenylation and AUF1 binding in the pH-responsive stabilization of glutaminase mRNA.
The effect of metabolic acidosis on the synthesis and turnover of rat renal phosphate-dependent glutaminase.
The kidney of chicken adapts to chronic metabolic acidosis: in vivo and in vitro studies.
The maximal activity of phosphate-dependent glutaminase and glutamine metabolism in the colon and the small intestine of streptozotocin-diabetic rats.
The regulation of phosphate-activated glutaminase activity and glutamine metabolism in the streptozotocin-diabetic rat.
The role of pH and the lack of a requirement for hydorgencarbonate in the regulation of hepatic glutamine metabolism.
The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
Variations in the kinetic response of several different phosphate-dependent glutaminase isozymes during acute metabolic acidosis.
Zeta-crystallin mediates the acid pH-induced increase of BSC1 cotransporter mRNA stability.
[Activity of renal enzymes producing ammonia from glutamine in the absence of phosphate in the rat: 1. Effect of chronic metabolic acidosis]
[Nephrogenic metabolic acidosis]
Acidosis, Respiratory
The role of pH and the lack of a requirement for hydorgencarbonate in the regulation of hepatic glutamine metabolism.
Acute Kidney Injury
[Activity of glutamine deaminating enzymes in the kidneys, liver and serum of dogs with renal failure and under normal conditions]
Adenocarcinoma
Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters.
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.
Adenocarcinoma of Lung
Dual targeting of EGFR and glutaminase in lung cancer.
LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma.
Adenoma
Glutaminase isoform expression in cell lines derived from human colorectal adenomas and carcinomas.
AIDS Dementia Complex
Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders.
STAT1 Regulates Human Glutaminase 1 Promoter Activity through Multiple Binding Sites in HIV-1 Infected Macrophages.
Alkalosis
Metabolic alkalosis as driving force for urea synthesis in liver disease: pathogenetic model and therapeutic implications.
Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver.
The maximal activity of phosphate-dependent glutaminase and glutamine metabolism in the colon and the small intestine of streptozotocin-diabetic rats.
The regulation of phosphate-activated glutaminase activity and glutamine metabolism in the streptozotocin-diabetic rat.
Alzheimer Disease
APC/Cdh E3 ubiquitin ligase in the pathophysiology of Alzheimer?s disease.
Cortical glutaminase, beta-glucuronidase and glucose utilization in Alzheimer's disease.
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Excitatory amino acids and Alzheimer's disease: idle thoughts on an exciting subject.
Glutamate and GABA-Metabolizing Enzymes in Post-mortem Cerebellum in Alzheimer's Disease: Phosphate-Activated Glutaminase and Glutamic Acid Decarboxylase.
Glutamate metabolizing enzymes in prefrontal cortex of Alzheimer's disease patients.
Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release.
Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer's Disease.
Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients.
Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration.
Topographical distribution of neurochemical changes in Alzheimer's disease.
[Glutaminase in the cerebellum of patients with Alzheimer's disease: a postmortem brain study].
[Impaired cerebral glutamate metabolism in mental diseases (Alzheimer's disease, schizophrenia]
Amyotrophic Lateral Sclerosis
Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration.
Anemia
[Glutaminase activity in rabbit reticulocytes: determination and behavior during a blood-loss anemia]
Anemia, Hemolytic, Autoimmune
Anti tissue transglutaminase antibody in idiopathic autoimmune haemolytic anemia.
Arthritis, Rheumatoid
Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis.
Asthma
Airway nitric oxide release is reduced after PBS inhalation in asthma.
Astrocytoma
Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness.
Ataxia
Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats.
Ataxia Telangiectasia
Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.
Brain Diseases
GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay.
Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy.
Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration.
THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy.
Brain Ischemia
Characterization of mitochondrial glutaminase and amino acids at prolonged times after experimental focal cerebral ischemia.
Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release.
Brain Neoplasms
Brain Tumor Stem Cell Dependence on Glutaminase Reveals a Metabolic Vulnerability through the Amino Acid Deprivation Response Pathway.
Glutaminases in brain: Multiple isoforms for many purposes.
Breast Neoplasms
Antisense glutaminase inhibition modifies the O-GlcNAc pattern and flux through the hexosamine pathway in breast cancer cells.
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer.
Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing.
Compound 968 reverses adriamycin resistance in breast cancer MCF-7ADR cells via inhibiting P-glycoprotein function independently of glutaminase.
Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells.
Design and evaluation of novel glutaminase inhibitors.
Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells.
ErbB2 activation upregulates glutaminase 1 expression which promotes breast cancer cell proliferation.
Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer.
Expression of recombinant human L-glutaminase in Escherichia coli: polyclonal antibodies production and immunological analysis of mouse tissues.
Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer.
Glutaminase isoform expression in cell lines derived from human colorectal adenomas and carcinomas.
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model.
Glutamine deprivation plus BPTES alters etoposide- and cisplatin-induced apoptosis in triple negative breast cancer cells.
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer.
In Situ Metabolic Characterisation of Breast Cancer and Its Potential Impact on Therapy.
Kinetic Modeling of 18F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism.
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer.
Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype.
Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase.
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.
N-terminal phosphorylation of glutaminase C decreases its enzymatic activity and cancer cell migration.
Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer.
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.
Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition.
The Biological and Clinical Significance of Glutaminase in Luminal Breast Cancer.
The role of glutaminase in cancer.
Vitamin D regulation of HAS2, hyaluronan synthesis and metabolism in triple negative breast cancer cells.
Carcinogenesis
Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma.
Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase.
Identifying strategies to target the metabolic flexibility of tumours.
Knockdown of PKM2 and GLS1 expression can significantly reverse oxaliplatin-resistance in colorectal cancer cells.
Metabolic fingerprinting reveals extensive consequences of GLS hyperactivity.
Molecular modeling and LC-MS-based metabolomics of a glutamine-valproic acid (Gln-VPA) derivative on HeLa cells.
Phosphorylation of glutaminase by PKC? is essential for its enzymatic activity and critically contributes to tumorigenesis.
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway.
Carcinoma
Amino acid metabolism in tumour-bearing mice.
Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.
Early differential expression of two glutaminase mRNAs in mouse spleen after tumor implantation.
Expanding Targets for a Metabolic Therapy of Cancer: L-Asparaginase.
Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma.
Glutaminase induced prolonged regression of established Ehrlich carcinoma.
Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models.
Glutaminase isoform expression in cell lines derived from human colorectal adenomas and carcinomas.
Localization of phosphate dependent glutaminase in ascites fluid of ovarian cancer patient.
Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase.
Phosphate-activated glutaminase expression during tumor development.
Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.
Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential.
The 'Achilles Heel' of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy.
[Action of swine kidney L-glutaminase on Ehrlich carcinoma]
[Concentration of free glutamine and glutaminase activity in the gastric mucosa of patients with precancerous diseases and cancer of the stomach]
Carcinoma, Ductal
The Biological and Clinical Significance of Glutaminase in Luminal Breast Cancer.
Carcinoma, Ehrlich Tumor
Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells.
Changes in mRNAs for enzymes of glutamine metabolism in the tumor-bearing mouse.
Ehrlich ascites tumor cells expressing anti-sense glutaminase mRNA lose their capacity to evade the mouse immune system.
Identification of genes downregulated in tumor cells expressing antisense glutaminase mRNA by differential display.
Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells.
Properties and intracellular localization of Ehrlich ascites tumor cell glutaminase.
Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase.
Carcinoma, Embryonal
Autocrine glutamatergic transmission for the regulation of embryonal carcinoma stem cells.
Carcinoma, Hepatocellular
1C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine.
Anomalous distribution of glutaminase isozyme in various hepatomas.
Biochemical Characterization and Antitumor Study of L-Glutaminase from Bacillus cereus MTCC 1305.
Biosynthesis and processing of mitochondrial glutaminase in HTC hepatoma cells.
Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma.
Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells.
Glutaminase activities and growth rates of rat hepatomas.
Glutaminase activity of glutamine-dependent carbamoyl-phosphate synthase from rat ascites hepatoma. Regulation by adenosine triphosphate-magensium and magnesium ion.
Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma.
Glutamine synthetase and glutaminase activities in various hepatoma cells.
Kidney-type glutaminase (GLS1) is a biomarker for pathologic diagnosis and prognosis of hepatocellular carcinoma.
Modulation of cellular proliferation alters glutamine transport and metabolism in human hepatoma cells.
Nuclear factor-?B p65 regulates glutaminase 1 expression in human hepatocellular carcinoma.
Purification and characterization of l-glutaminase enzyme from camel liver: Enzymatic anticancer property.
Rat hepatic glutaminase: identification of the full coding sequence and characterization of a functional promoter.
Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway.
The Glutaminase-1 Inhibitor 968 Enhances Dihydroartemisinin-Mediated Antitumor Efficacy in Hepatocellular Carcinoma Cells.
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
Carcinoma, Intraductal, Noninfiltrating
The Biological and Clinical Significance of Glutaminase in Luminal Breast Cancer.
Carcinoma, Lewis Lung
Amino acid metabolism in tumour-bearing mice.
Carcinoma, Non-Small-Cell Lung
A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway.
Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC.
Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer.
LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma.
Carcinoma, Renal Cell
The 'Achilles Heel' of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy.
Carcinoma, Squamous Cell
Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models.
Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential.
Carcinosarcoma
[The regulatory action of dipeptide "Deglutam" on the glutamine metabolized enzymes in the carcinosarcoma SM-1 cells]
Cardiovascular Diseases
Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy.
Cataract
GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay.
Celiac Disease
Small intestine glutaminase deficiency in celiac disease.
Central Nervous System Diseases
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.
Cholera
Evidence for glutamate, in addition to acetylcholine and GABA, neurotransmitter synthesis in basal forebrain neurons projecting to the entorhinal cortex.
Chondrosarcoma
Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation.
Colonic Neoplasms
A combination of inhibitors of glycolysis, glutaminolysis and de novo fatty acid synthesis decrease the expression of chemokines in human colon cancer cells.
A facile and sensitive method of quantifying glutaminase binding to its inhibitor CB-839 in tissues.
Epigenetic silencing of glutaminase 2 in human liver and colon cancers.
Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth.
Colorectal Neoplasms
5-fluorouracil enhances the anti-tumor activity of the glutaminase inhibitor CB-839 against PIK3CA-mutant colorectal cancers.
Expression of glutaminase is upregulated in colorectal cancer and of clinical significance.
GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway.
Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization.
Glutaminase sustains cell survival via the regulation of glycolysis and glutaminolysis in colorectal cancer.
Intratumoral heterogeneity of glutaminase and lactate dehydrogenase A protein expression in colorectal cancer.
L-Glutaminase Synthesis by Marine Halomonas meridiana Isolated from the Red Sea and Its Efficiency against Colorectal Cancer Cell Lines.
Coma
Acute metabolic effects of ammonia on the enzymes of glutamate metabolism in isolated astroglial cells.
Crohn Disease
Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation?
Crush Syndrome
[Enzymatic activity in the organism in experimental crush syndrome of the limbs. III. Arginase in kidney and liver, glutaminase in kidney.]
Dementia
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
HIV-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase.
Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic?
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.
Mitochondrial glutaminase enhances extracellular glutamate production in HIV-1-infected macrophages: linkage to HIV-1 associated dementia.
Potentiation of Excitotoxicity in HIV-1 Associated Dementia and the Significance of Glutaminase.
Small molecule glutaminase inhibitors block glutamate release from stimulated microglia.
Diabetes Mellitus
Role of diabetes mellitus on hepatic encephalopathy.
Diabetes Mellitus, Experimental
[Glutamine synthetase and glutaminase activity in the brain and liver homogenates and subcellular fractions of rats with alloxan diabetes (3)]
Diabetes Mellitus, Type 2
Role of diabetes mellitus on hepatic encephalopathy.
Diabetic Ketoacidosis
Effect of diabetic ketosis on jejunal glutaminase.
Down Syndrome
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Encephalitis
IL-1? and TNF-? induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase.
Encephalomyelitis
Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice.
Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Blockade of glutamate release from microglia attenuates experimental autoimmune encephalomyelitis in mice.
Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Endotoxemia
Activation of hepatic glutaminase in the endotoxin-treated rat.
Adaptive regulation in skeletal muscle glutamine metabolism in endotoxin-treated rats.
Eosinophilia
Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
Epilepsy
Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy.
The anticonvulsant actions of carisbamate associate with alterations in astrocyte glutamine metabolism in the lithium-pilocarpine epilepsy model.
The Glutamate-Glutamine Cycle in Epilepsy.
Epilepsy, Temporal Lobe
Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy.
Fatty Liver
Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly.
Fibrosarcoma
Adaptive alterations in cellular metabolism with malignant transformation.
Glioblastoma
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity.
Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells.
Augmented Therapeutic Potential of Glutaminase Inhibitor CB839 in Glioblastoma Stem Cells Using Gold Nanoparticle Delivery.
Cassane diterpenoid derivative induces apoptosis in IDH1 mutant glioma cells through the inhibition of glutaminase in vitro and in vivo.
Erratum: Majewska, E. et al. Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway. Cancers 2019, 11, 115.
Glutaminase 2 expression is associated with regional heterogeneity of 5-aminolevulinic acid fluorescence in glioblastoma.
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1.
MicroRNA-153 regulates glutamine metabolism in glioblastoma through targeting glutaminase.
Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells.
Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA repair gene MGMT and sensitizes the cells to alkylating agents.
Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway.
Upregulation of glutaminase 2 and neutrophil cytosolic factor 2 is associated with the poor prognosis of glioblastoma.
Glioma
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity.
Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.
Cassane diterpenoid derivative induces apoptosis in IDH1 mutant glioma cells through the inhibition of glutaminase in vitro and in vivo.
Clinical aggressiveness of malignant gliomas is linked to augmented metabolism of amino acids.
Glutamate/glutamine metabolism coupling between astrocytes and glioma cells: neuroprotection and inhibition of glioma growth.
Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma.
Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1.
Inhibition of Metabolic Shift can Decrease Therapy Resistance in Human High-Grade Glioma Cells.
Lack of expression of the liver-type glutaminase (LGA) mRNA in human malignant gliomas.
Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition.
SNAP25 Inhibits Glioma Progression by Regulating Synapse Plasticity via GLS-Mediated Glutaminolysis.
The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling.
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA repair gene MGMT and sensitizes the cells to alkylating agents.
Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells.
Gliosarcoma
Cell-density-dependent manifestation of partial characteristics for neuronal precursors in a newly established human gliosarcoma cell line.
glutamate dehydrogenase deficiency
The natural history of hyperuricemia among asymptomatic relatives of patients with gout.
glutaminase deficiency
Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice.
Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS.
Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS. Reply.
Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy.
Molecular Imaging of mGluR5 Availability with [11C]ABP68 in Glutaminase Heterozygous Mice.
Small intestine glutaminase deficiency in celiac disease.
Gout
Glutaminase activity in the kidney in gout.
Graves Disease
Metabolism of glucose and glutamine in lymphocytes from Graves' hyperthyroid patients: influence of methimazole treatment.
Head and Neck Neoplasms
Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase.
Hematologic Neoplasms
Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia.
Hepatic Encephalopathy
A genetic variant in the promoter of phosphate-activated glutaminase is associated with hepatic encephalopathy.
Gut ammonia production and its modulation.
Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy.
Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells.
Metformin inhibits glutaminase activity and protects against hepatic encephalopathy.
Pathophysiology of hepatic encephalopathy and future treatment options.
Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis.
Rat cerebral mitochondrial glutaminase activity is unaffected by moderate hyperammonemia in two models.
Role of diabetes mellitus on hepatic encephalopathy.
Role of phosphate-activated glutaminase in the pathogenesis of hepatic encephalopathy.
Serial deletion reveals structural basis and stability for the core enzyme activity of human glutaminase 1 isoforms: relevance to excitotoxic neurodegeneration.
THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy.
Validation study associating glutaminase promoter variations with hepatic encephalopathy in East Asian populations.
Variations in the promoter region of the glutaminase gene and the development of hepatic encephalopathy in patients with cirrhosis: a cohort study.
[Activity of l-glutamine amidohydrolase in the rat brain in experimental hepatic encephalopathy]
[Ammonia content and glutamine synthetase and glutaminase activity in the brain in experimental hepatic coma]
Hepatitis
Cloning, expression, purification and characterisation of Erwinia carotovora L-asparaginase in Escherichia coli.
Structural and functional insights into Erwinia carotovora L-asparaginase.
Herpes Simplex
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication.
Huntington Disease
Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and gamma-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases.
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Phosphate-activated glutaminase in relation to Huntington's disease and agonal state.
Hyperglycemia
Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia.
Targeting hepatic glutaminase activity to ameliorate hyperglycemia.
Hyperhomocysteinemia
Maternal vitamin B6 deficient or supplemented diets on expression of genes related to GABAergic, serotonergic or glutamatergic pathways in hippocampus of rat dams and their offspring.
Hypersensitivity
Circumventing the side effects of L-asparaginase.
Hypertension, Pulmonary
Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension.
Hyperthyroidism
Effect of hypo- and hyperthyroidism on the function and metabolism of macrophages in rats.
Effects of hyperthyroidism on glucose, glutamine and ketone-body metabolism in the gut of the rat.
Hypoglycemia
[Parameters of energy and nitrogen metabolism in rats under insulin-induced hypoglycemia]
Ichthyosis, Lamellar
Efficient in vitro transfection of human keratinocytes with an adenovirus-enhanced receptor-mediated system.
Ileitis
Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation?
Infections
Cerebral ammonia levels and enzyme changes during Plasmodium yoelii infection in mice.
Endotoxin stimulates lymphocyte glutaminase expression.
Glutamate production by HIV-1 infected human macrophage is blocked by the inhibition of glutaminase.
Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity.
Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.
Glutamine was required for snakehead fish vesiculovirus (SHVV) propagation via replenishing the tricarboxylic acid cycle.
In vitro glutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage.
Interferon-? regulates glutaminase 1 promoter through STAT1 phosphorylation: relevance to HIV-1 associated neurocognitive disorders.
Mitochondrial Glutaminase Release Contributes to Glutamate-Mediated Neurotoxicity during Human Immunodeficiency Virus-1 Infection.
Proteomics and functional analyses of Arabidopsis nitrilases involved in the defense response to microbial pathogens.
[Influence of recombinant growth hormone on protein metabolism during severe infection: an animal experiment]
Influenza, Human
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication.
Insulin Resistance
Clinical science workshop: targeting the gut-liver-brain axis.
Ketosis
Renal enzymes during experimental diabetes mellitus in the rat. Role of insulin, carbohydrate metabolism, and ketoacidosis.
Kidney Neoplasms
Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.
Leukemia
A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias
Biochemical characterization of a novel L-Asparaginase with low glutaminase activity from Rhizomucor miehei and its application in food safety and leukemia treatment.
Cloning, expression, purification and characterisation of Erwinia carotovora L-asparaginase in Escherichia coli.
Effect of cold atmospheric plasma treatment on the metabolites of human leukemia cells.
Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines.
Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.
Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.
l-Asparaginase from Aspergillus spp.: production based on kinetics, thermal stability and biochemical characterization.
L-glutaminase activity in lymphocytes of patients with chronic lymphatic leukemia.
Purification and characterization of a novel and robust L-asparaginase having low-glutaminase activity from Bacillus licheniformis: in vitro evaluation of anti-cancerous properties.
Purification and characterization of glutaminase free asparaginase from Pseudomonas otitidis: Induce apoptosis in human leukemia MOLT-4 cells.
Structural and functional insights into Erwinia carotovora L-asparaginase.
Tumoricidal potential of nutritional manipulations.
[Cloning, expression and purification of Helicobater pylori L-asparaginase]
Leukemia, Erythroblastic, Acute
Prominent glutamine oxidation activity in mitochondria of hematopoietic tumors.
Leukemia, Lymphocytic, Chronic, B-Cell
L-glutaminase activity in lymphocytes of patients with chronic lymphatic leukemia.
Leukemia, Myeloid
Purification and Characterization of Glutaminase Free Asparaginase from Enterobacter cloacae: In-Vitro Evaluation of Cytotoxic Potential against Human Myeloid Leukemia HL-60 Cells.
Leukemia, Myeloid, Acute
Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia.
Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia.
Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.
Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations.
Liver Cirrhosis
Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.
Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy.
New technologies - new insights into the pathogenesis of hepatic encephalopathy.
The role of WNT/?-catenin signaling pathway and glutamine metabolism in the pathogenesis of CCl4-induced liver fibrosis: Repositioning of niclosamide and concerns about lithium.
Validation study associating glutaminase promoter variations with hepatic encephalopathy in East Asian populations.
[Enzymes participating in the formation of ammonia in various experimental liver diseases]
Liver Failure
Ornithine phenylacetate targets alterations in the expression and activity of glutamine synthase and glutaminase to reduce ammonia levels in bile duct ligated rats.
Liver Neoplasms
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer.
Circadian clock gene expression regulates cancer cell growth through glutaminase.
Lung Neoplasms
A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway.
An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues.
Dual targeting of EGFR and glutaminase in lung cancer.
Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC.
Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation.
Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer.
Inhibition of mitochondrial glutaminase activity reverses acquired erlotinib resistance in non-small cell lung cancer.
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.
KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition.
LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma.
Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.
Phosphorylation of glutaminase by PKC? is essential for its enzymatic activity and critically contributes to tumorigenesis.
Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.
Lymphatic Metastasis
Glutaminase expression is a poor prognostic factor in node-positive triple-negative breast cancer patients with a high level of tumor-infiltrating lymphocytes.
Lymphoma
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.
Lymphoma, T-Cell
Expanding Targets for a Metabolic Therapy of Cancer: L-Asparaginase.
Malnutrition
Alterations in rat brain glutaminase and aldolase induced by lead ingestion following malnutrition.
Effect of protein malnutrition on the glycolytic and glutaminolytic enzyme activity of rat thymus and mesenteric lymph nodes.
Melanoma
Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1+ Melanoma.
Expression of activated VEGFR2 by R1051Q mutation alters the energy metabolism of Sk-Mel-31 melanoma cells by increasing glutamine dependence.
Human cutaneous melanoma expresses a significant phosphate-dependent glutaminase activity: a comparison with the surrounding skin of the same patient.
Long noncoding RNA OIP5-AS1 acts as a competing endogenous RNA to promote glutamine catabolism and malignant melanoma growth by sponging miR-217.
miR-137 inhibits glutamine catabolism and growth of malignant melanoma by targeting glutaminase.
Modulation of metastatic potential of B16F10 melanoma cells by acivicin: synergistic action of alutaminase and potentiation of cisplatin cytotoxicity.
Memory Disorders
Curcumin Requires Tumor Necrosis Factor ? Signaling to Alleviate Cognitive Impairment Elicited by Lipopolysaccharide.
Meningioma
Glutamine anaplerosis is required for amino acid biosynthesis in human meningiomas.
Metabolic Diseases
Metabolic fingerprinting reveals extensive consequences of GLS hyperactivity.
Mouth Neoplasms
c-Myc Overexpression Promotes Oral Cancer Cell Proliferation and Migration by Enhancing Glutaminase and Glutamine Synthetase Activity.
Multiple Myeloma
Glutaminase inhibition in multiple myeloma induces apoptosis
Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells.
Multiple Sclerosis
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.
Small molecule glutaminase inhibitors block glutamate release from stimulated microglia.
Neoplasm Metastasis
Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.
Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells.
Glutaminase expression is a poor prognostic factor in node-positive triple-negative breast cancer patients with a high level of tumor-infiltrating lymphocytes.
NRH:quinone oxidoreductase 2 (NQO2) and glutaminase (GLS) both play a role in large extracellular vesicles (LEV) formation in preclinical LNCaP-C4-2B prostate cancer model of progressive metastasis.
Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies.
Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.
Neoplasms
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity.
A Critical Role of Glutamine and Asparagine ?-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus.
A facile and sensitive method of quantifying glutaminase binding to its inhibitor CB-839 in tissues.
A general survey of glutamine level in different tissues of murine solid tumor bearing mice before and after therapy with purified glutaminase.
A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.
A Metabolomics Study of BPTES Altered Metabolism in Human Breast Cancer Cell Lines.
A natural inhibitor of kidney-type glutaminase: a withanolide from
A novel glutaminase inhibitor-968 inhibits the migration and proliferation of non-small cell lung cancer cells by targeting EGFR/ERK signaling pathway.
A Phase I Dose-Escalation and Expansion Study of Telaglenastat in Patients with Advanced or Metastatic Solid Tumors.
A series of transplantable rat mammary tumors with graded differentiation, growth rate, and glutaminase content.
A Time for MYC: Metabolism and Therapy.
Action at a distance: allostery and the development of drugs to target cancer cell metabolism.
Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids.
Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy.
Amino acid metabolism in tumour-bearing mice.
Angiogenesis a putative new approach in glutamine related therapy.
Anti-tumor efficacy of glutaminase-copper-ATP combination in mice bearing Ehrlich ascites carcinoma.
Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells.
Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.
Assessing Metabolic Intervention with a Glutaminase Inhibitor in Real-time by Hyperpolarized Magnetic Resonance in Acute Myeloid Leukemia.
Author Correction: Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.
Autophagy in the physiological endometrium and cancer.
Bcl-2 and Mn-SOD antisense oligodeoxynucleotides and a glutamine-enriched diet facilitate elimination of highly resistant B16 melanoma cells by tumor necrosis factor-alpha and chemotherapy.
Biomolecular Interaction Assays Identified Dual Inhibitors of Glutaminase and Glutamate Dehydrogenase That Disrupt Mitochondrial Function and Prevent Growth of Cancer Cells.
Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.
BPTES inhibition of hGA(124-551), a truncated form of human kidney-type glutaminase.
Breaking the ritual metabolic cycle in order to save acetyl CoA: A potential role for mitochondrial humanin in T2 bladder cancer aggressiveness.
Breast cancer-derived extracellular vesicles stimulate myofibroblast differentiation and pro-angiogenic behavior of adipose stem cells.
c-Myc Overexpression Promotes Oral Cancer Cell Proliferation and Migration by Enhancing Glutaminase and Glutamine Synthetase Activity.
Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1?-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines.
Cancer cell metabolism: implications for therapeutic targets.
Caudatan A, an undescribed human kidney-type glutaminase inhibitor with tetracyclic flavan from Ohwia caudata.
Changes in mRNAs for enzymes of glutamine metabolism in the tumor-bearing mouse.
Changes in the glutaminase activity of liver tissue from rats during the development of hepatic tumors by carcinogen feeding.
Characterisation and molecular dynamic simulations of J15 asparaginase from Photobacterium sp. strain J15.
Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.
Cholesterol inhibits glutamine metabolism in LLC WRC256 tumour cells but does not affect it in lymphocytes: possible implications for tumour cell proliferation.
Circadian clock gene expression regulates cancer cell growth through glutaminase.
Co-expression of glutaminase K and L isoenzymes in human tumour cells.
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.
Compound 968 reverses adriamycin resistance in breast cancer MCF-7ADR cells via inhibiting P-glycoprotein function independently of glutaminase.
Conformational Changes in the Activation Loop of Mitochondrial Glutaminase C: A Direct Fluorescence Read-Out that Distinguishes the Binding of Allosteric Inhibitors from Activators.
Cytokines decrease glutaminase expression in human fibroblasts.
Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.
Decrease of glutaminase expression by interferon-gamma in human intestinal epithelial cells.
Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.
Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors.
Dibenzophenanthridines as inhibitors of glutaminase C and cancer cell proliferation.
Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models.
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.
Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells.
Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling.
Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells.
Dual targeting of EGFR and glutaminase in lung cancer.
Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.
Dysregulation of glutaminase and glutamine synthetase in cancer.
Early differential expression of two glutaminase mRNAs in mouse spleen after tumor implantation.
EFFECT OF ADMINISTRATION OF THE ENZYME GLUTAMINASE ON THE GROWTH OF CANCER CELLS.
Effect of aging on the glutaminase activity of neoplastic and immune tissues.
Effect of glutaminase inhibition on cancer-induced bone pain.
Effect of He Plasma Jet Versus Surface Plasma on the Metabolites of Acute Myeloid Leukemia Cells.
Effect of purified glutaminase from human ascites fluid on experimental tumor bearing mice.
Effect of supplemental dietary glutamine on methotrexate concentrations in tumors.
Effects of various dietary fatty acids on enzyme activities of carbohydrate and glutamine metabolism and the metabolic response of lymphocytes and macrophages during Walker-256 ascites cell tumour growth in rats.
Ehrlich ascites tumor cells expressing anti-sense glutaminase mRNA lose their capacity to evade the mouse immune system.
Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition.
Erratum: Majewska, E. et al. Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway. Cancers 2019, 11, 115.
Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters.
Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors.
Expanding Targets for a Metabolic Therapy of Cancer: L-Asparaginase.
Expression of GLS1 in intrahepatic cholangiocarcinoma and its clinical significance.
Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer.
Expression of the glutamine metabolism-related proteins glutaminase 1 and glutamate dehydrogenase in canine mammary tumours.
Expression, purification and crystallization of Helicobacter pylori L-asparaginase.
GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency.
GLS1 depletion inhibited colorectal cancer proliferation and migration via redox/Nrf2/autophagy-dependent pathway.
GLS2 is protumorigenic in breast cancers.
Glucose and glutamine metabolism in relation to mutational status in NSCLC histological subtypes.
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-? signaling and contributes to neuronal death.
Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer.
Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization.
Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC.
Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma.
Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells.
Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.
Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma.
Glutaminase expression is a poor prognostic factor in node-positive triple-negative breast cancer patients with a high level of tumor-infiltrating lymphocytes.
Glutaminase GLS1 Inhibitors as Potential Cancer Treatment.
Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation.
Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models.
Glutaminase Inhibitor CB-839 Increases Radiation Sensitivity of Lung Tumor Cells and Human Lung Tumor Xenografts in Mice.
Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Resistant Cervical Cancers.
Glutaminase inhibitors: a patent review.
Glutaminase Isoenzymes as Key Regulators in Metabolic and Oxidative Stress against Cancer.
Glutaminase isoenzymes in the metabolic therapy of cancer.
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
Glutaminase regulation in cancer cells: a druggable chain of events.
Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma.
Glutaminase: a hot spot for regulation of cancer cell metabolism?
Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas.
Glutaminases in brain: Multiple isoforms for many purposes.
Glutaminases in slowly proliferating gastroenteropancreatic neuroendocrine neoplasms/tumors (GEP-NETs): Selective overexpression of mRNA coding for the KGA isoform.
Glutaminases regulate glutathione and oxidative stress in cancer.
Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6.
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model.
Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes.
Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism.
Glutamine facilitates chemotherapy while reducing toxicity.
Glutamine homeostasis and mitochondrial dynamics.
Glutamine in neoplastic cells: focus on the expression and roles of glutaminases.
Glutamine Metabolism in Gliomas.
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Glutamine Skipping the Q into Mitochondria.
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer.
Glutamine-Directed Migration of Cancer-Activated Fibroblasts Facilitates Epithelial Tumor Invasion.
Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth.
Glutaminolysis and carcinogenesis of oral squamous cell carcinoma.
Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness.
Harry M. Vars Research Award. Glutamine enhances immunoregulation of tumor growth.
Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase.
Hepatic glutaminase gene expression in the tumor-bearing rat.
HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer.
Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.
Identification of genes downregulated in tumor cells expressing antisense glutaminase mRNA by differential display.
Identifying strategies to target the metabolic flexibility of tumours.
Imaging tumour cell metabolism using hyperpolarized 13C magnetic resonance spectroscopy.
Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer.
Impact of Acidosis-Regulated MicroRNAs on the Expression of Their Target Genes in Experimental Tumors In Vivo.
Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma.
Improvement in the persistence of microbial asparaginase and glutaminase in the circulation of the rat by chemical modifications.
In Silico Analysis of Glutaminase from Different Species of Escherichia and Bacillus.
In vivo and in vitro liver cancer metabolism observed with hyperpolarized [5-(13)C]glutamine.
Influence of progressive tumor growth on glutamine metabolism in skeletal muscle and kidney.
Influence of reduced concentration of L-glutamine on growth and viability of cells in monolayer, in spheroids, and in experimental tumours.
Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.
Inhibition of GLS suppresses proliferation and promotes apoptosis in prostate cancer.
Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth.
Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells.
Inhibition of glutaminase expression increases Sp1 phosphorylation and Sp1/Sp3 transcriptional activity in Ehrlich tumor cells.
Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer.
Inhibition of the MYC-regulated glutaminase metabolic axis is an effective synthetic lethal approach for treating chemoresistant cancers.
Intratumoral heterogeneity of glutaminase and lactate dehydrogenase A protein expression in colorectal cancer.
Investigation on glutamine amidohydrolase (EC 3.5.1.2) and glutamine aminotransferase (EC 2.5.1.15) activity in liver and plasma of EAC-bearing mice following glutaminase therapy.
Investigation on phosphate dependent glutaminase (EC 3.5.1.2) activity in host tissues of EAC-bearing mice and response of liver EC 3.5.1.2 on Cu-ATP therapy.
Involvement of essential cysteine and histidine residues in the activity of isolated glutaminase from tumour cells.
Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate.
Isolation and purification of phosphate dependent glutaminase from sarcoma-180 tumor and its antineoplastic effects on murine model system.
Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran.
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.
Kidney-Type Glutaminase Inhibitor Hexylselen Selectively Kills Cancer Cells via a Three-Pronged Mechanism.
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors.
Kinetic properties of Streptomyces canarius L- Glutaminase and its anticancer efficiency.
L-Glutaminase Synthesis by Marine Halomonas meridiana Isolated from the Red Sea and Its Efficiency against Colorectal Cancer Cell Lines.
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer.
LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma.
LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2.
Mammalian glutaminase Gls2 gene encodes two functional alternative transcripts by a surrogate promoter usage mechanism.
Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.
Mechanistic Basis of Glutaminase Activation: A Key Enzyme that Promotes Glutamine Metabolism in Cancer Cells.
Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition.
Metabolic and OXPHOS Activities Quantified by Temporal ex vivo Analysis Display Patient-Specific Metabolic Vulnerabilities in Human Breast Cancers.
Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy.
Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma.
Metabolic reprogramming of cancer by chemicals that target glutaminase isoenzymes.
Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment.
Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells.
miR-1-3p Contributes to Cell Proliferation and Invasion by Targeting Glutaminase in Bladder Cancer Cells.
miR-137 inhibits glutamine catabolism and growth of malignant melanoma by targeting glutaminase.
Mitochondrial glutathione depletion by glutamine in growing tumor cells.
Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Modulation of metastatic potential of B16F10 melanoma cells by acivicin: synergistic action of alutaminase and potentiation of cisplatin cytotoxicity.
Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase.
Molecular modeling and LC-MS-based metabolomics of a glutamine-valproic acid (Gln-VPA) derivative on HeLa cells.
Molecular targeting of glutaminase sensitizes ovarian cancer cells to chemotherapy.
Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation.
Multiomics Analysis Reveals that GLS and GLS2 Differentially Modulate the Clinical Outcomes of Cancer.
MYC, microRNAs and glutamine addiction in cancers.
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.
N-terminal phosphorylation of glutaminase C decreases its enzymatic activity and cancer cell migration.
Neovascularisation offers a new perspective to glutamine related therapy.
Novel 1,3,4-Selenadiazole Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity.
Novel glutaminase free L-asparaginase from Nocardiopsis alba NIOT-VKMA08: production, optimization, functional and molecular characterization.
NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism.
Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
p63 regulates glutaminase 2 expression.
Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells.
Patents targeting the Warburg effect for cancer therapy: an interview with William P Katt.
PEG-PHB-glutaminase nanoparticle inhibits cancer cell proliferation in vitro through glutamine deprivation.
Pharmacokinetic Assessment of 18F-(2S,4R)-4-Fluoroglutamine in Patients with Cancer.
Phase 1 Trial of MLN0128 (Sapanisertib) and CB-839 HCl (Telaglenastat) in Patients With Advanced NSCLC (NCI 10327): Rationale and Study Design.
Phosphate-activated glutaminase expression during tumor development.
Phosphorylation of glutaminase by PKC? is essential for its enzymatic activity and critically contributes to tumorigenesis.
Physapubescin I from husk tomato suppresses SW1990 cancer cell growth by targeting kidney-type glutaminase.
Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor.
Probing the structure and function of human glutaminase-interacting protein: a possible target for drug design.
Production, optimization, purification, characterization, and anti-cancer application of extracellular L-glutaminase produced from the marine bacterial isolate.
Promiscuous Binding at the Crossroads of Numerous Cancer Pathways: Insight from the Binding of Glutaminase Interacting Protein with Glutaminase L.
Properties and intracellular localization of Ehrlich ascites tumor cell glutaminase.
Purification and characterization of l-glutaminase enzyme from camel liver: Enzymatic anticancer property.
Purification, characterization, and anticancer and antioxidant activities of L-glutaminase from Aspergillus versicolor Faesay4.
Q-ing tumor glutaminase for therapy.
Recent Development of Small Molecule Glutaminase Inhibitors.
Relative expression of mRNAS coding for glutaminase isoforms in CNS tissues and CNS tumors.
Replication of the Shrimp Virus WSSV Depends on Glutamate-Driven Anaplerosis.
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.
Rho GTPases and their roles in cancer metabolism.
Selection of metastatic breast cancer cells based on adaptability of their metabolic state.
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.
Selective reduction in glutaminase activity of l?Asparaginase by asparagine 248 to serine mutation: A combined computational and experimental effort in blood cancer treatment.
Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase.
Several Faces of Glutaminase Regulation in Cells.
Short-term metabolic fate of L-[13N]glutamate in the Walker 256 carcinosarcoma in vivo.
Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic intervention.
SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
Small Angle X-Ray Scattering Studies of Mitochondrial Glutaminase C Reveal Extended Flexible Regions, and Link Oligomeric State with Enzyme Activity.
Small molecule glutaminase inhibitors block glutamate release from stimulated microglia.
Starving the Devourer: Cutting Cancer Off from Its Favorite Foods.
STK11/LKB1 Mutations in NSCLC Are Associated with KEAP1/NRF2-Dependent Radiotherapy Resistance Targetable by Glutaminase Inhibition.
Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).
Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.
Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site.
Studies on the mechanism of inhibition of tumor growth by the enzyme glutaminase.
Studies on two types of glutaminase in normal and tumour bearing mice.
Submitochondrial localization and membrane topography of Ehrlich ascitic tumour cell glutaminase.
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.
Targeted inhibition of glutaminase as a potential new approach for the treatment of
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
Targeting cellular metabolism to improve cancer therapeutics.
Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma.
Targeting glutamine metabolism and autophagy: the combination for prostate cancer radiosensitization.
Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation.
Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies.
Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition.
Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.
Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential.
The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled.
The effects of glutamine-enriched total parenteral nutrition on tumor growth and host tissues.
The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer.
The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.
The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
The NF-?B member p65 controls glutamine metabolism through miR-23a.
The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.
The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme.
The potential of halophilic and halotolerant bacteria for the production of antineoplastic enzymes: L-asparaginase and L-glutaminase.
The proportionality of glutaminase content to growth rate and morphology of rat neoplasms.
The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ.
The role of glutaminase in cancer.
The role of intestinal endotoxemia in a rat model of aluminum neurotoxicity.
The SIRT1/HIF2? axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.
Therapeutic strategies impacting cancer cell glutamine metabolism.
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer.
Therapeutic Targeting of Myc-Reprogrammed Cancer Cell Metabolism.
Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.
Tumor glutaminase purification.
Tumor regulation of hepatic glutamine metabolism.
TUMOUR-DERIVED GLUTAMATE: LINKING ABERRANT CANCER CELL METABOLISM TO PERIPHERAL SENSORY PAIN PATHWAYS.
Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer.
Upregulation of glutaminase 2 and neutrophil cytosolic factor 2 is associated with the poor prognosis of glioblastoma.
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
[13N]Ammonia and L-[amide-13N]glutamine metabolism in glutaminase-sensitive and glutaminase-resistant murine tumors.
[Concentration of free glutamine and glutaminase activity in the gastric mucosa of patients with precancerous diseases and cancer of the stomach]
[Effect of L-glutaminase from Pseudomonas aureofaciens in experimental tumors]
[Study of glutaminase and asparaginase activities in normal tissues and malignant tumors]
[The regulatory action of dipeptide "Deglutam" on the glutamine metabolized enzymes in the carcinosarcoma SM-1 cells]
Nephritis
[Glutaminase activity of rat kidney tissue in experimental nephritis]
Nephrosis
Glutaminase activity in the kidney of experimental nephrosis.
Neural Tube Defects
Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects.
Neuroblastoma
Kinetics of a Novel Isoform of Phosphate Activated Glutaminase (PAG) in SH-SY5Y Neuroblastoma Cells.
MiR-513c suppresses neuroblastoma cell migration, invasion, and proliferation through direct targeting glutaminase (GLS).
Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2.
Novel form of phosphate activated glutaminase in cultured astrocytes and human neuroblastoma cells, PAG in brain pathology and localization in the mitochondria.
Neurodegenerative Diseases
Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome.
Glutaminase inhibitory activities of pentacyclic triterpenes isolated from Thymus vulgaris L.
IL-1? and TNF-? induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase.
Potentiation of Excitotoxicity in HIV-1 Associated Dementia and the Significance of Glutaminase.
Unaltered cytochrome oxidase, glutamate dehydrogenase and glutaminase activities in platelets from patients with sporadic amyotrophic lateral sclerosis--a study of potential pathogenetic mechanisms in neurodegenerative diseases.
Neuroinflammatory Diseases
?1-Integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats.
Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release.
Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate.
Glutaminase C overexpression in the brain induces learning deficits, synaptic dysfunctions, and neuroinflammation in mice.
Glutaminase in microglia: A novel regulator of neuroinflammation.
Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity.
Gut microbiota drive the development of neuroinflammatory response in cirrhosis in mice.
TNF-? promotes extracellular vesicle release in mouse astrocytes through glutaminase.
Osteoporosis
MicroRNA-200a-3p accelerates the progression of osteoporosis by targeting glutaminase to inhibit osteogenic differentiation of bone marrow mesenchymal stem cells.
Osteosarcoma
Acetone immersion enhanced MALDI-MS imaging of small molecule metabolites in biological tissues.
Glutaminase-1 (GLS1) inhibition limits metastatic progression in osteosarcoma.
Significance of neoadjuvant chemotherapy (NACT) in limb salvage treatment of osteosarcoma and its effect on GLS1 expression.
[13N]Ammonia and L-[amide-13N]glutamine metabolism in glutaminase-sensitive and glutaminase-resistant murine tumors.
Ovarian Neoplasms
Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study.
Altered glutamine metabolism in platinum resistant ovarian cancer.
Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.
Effect of purified glutaminase from human ascites fluid on experimental tumor bearing mice.
Glutaminase inhibitor compound 968 inhibits cell proliferation and sensitizes paclitaxel in ovarian cancer.
Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models.
Inhibition of the MYC-regulated glutaminase metabolic axis is an effective synthetic lethal approach for treating chemoresistant cancers.
Localization of phosphate dependent glutaminase in ascites fluid of ovarian cancer patient.
Modulation of tumor induced angiogenesis in Ehrlich ascites tumor.
Molecular targeting of glutaminase sensitizes ovarian cancer cells to chemotherapy.
Pancreatic Neoplasms
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.
Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition.
Nutrient stress-dysregulated antisense lncRNA GLS-AS impairs GLS-mediated metabolism and represses pancreatic cancer progression.
TFEB Supports Pancreatic Cancer Growth through the Transcriptional Regulation of Glutaminase.
Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers.
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
Pancreatitis
L: -Asparaginase as Potent Anti-leukemic Agent and Its Significance of Having Reduced Glutaminase Side Activity for Better treatment of Acute Lymphoblastic Leukaemia.
Pick Disease of the Brain
Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias.
Polycystic Kidney Diseases
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Polycythemia Vera
[L-asparaginase and L-glutaminase activities in leukocytes and plasma in polycythemia vera]
Potassium Deficiency
Relationship of phosphate-dependent glutaminase activity to ammonia excretion in potassium deficiency and acidosis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Engineering the substrate specificity of Escherichia coli asparaginase. II. Selective reduction of glutaminase activity by amino acid replacements at position 248.
Enhanced catalysis of l-asparaginase from Bacillus licheniformis by a rational redesign.
Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.
In silico engineering of L-asparaginase to have reduced glutaminase side activity for effective treatment of acute lymphoblastic leukemia.
Isolation and identification of actinomycetes for production of novel extracellular glutaminase free L-asparaginase.
L-glutaminase and L-asparaginase by extracorporeal route in acute lymphoblastic leukemia therapy.
Low glutamine concentrations induce phenotypical and functional differentiation of U937 myelomonocytic cells.
Novel mutant of Escherichia coli asparaginase II to reduction of the glutaminase activity in treatment of acute lymphocytic leukemia by molecular dynamics simulations and QM-MM studies.
Purification and Characterization of Asparaginase from Phaseolus vulgaris Seeds.
Purification and characterization of glutaminase free asparaginase from Pseudomonas otitidis: Induce apoptosis in human leukemia MOLT-4 cells.
The potential of halophilic and halotolerant bacteria for the production of antineoplastic enzymes: L-asparaginase and L-glutaminase.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia.
Prostatic Neoplasms
A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.
c-Myc-driven glycolysis via TXNIP suppression is dependent on glutaminase-MondoA axis in prostate cancer.
Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer.
Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters.
NRH:quinone oxidoreductase 2 (NQO2) and glutaminase (GLS) both play a role in large extracellular vesicles (LEV) formation in preclinical LNCaP-C4-2B prostate cancer model of progressive metastasis.
Targeting glutamine metabolism and autophagy: the combination for prostate cancer radiosensitization.
Psoriasis
GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.
Pulmonary Fibrosis
Inhibition of Glutaminase 1 Attenuates Experimental Pulmonary Fibrosis.
SIRT7-mediated modulation of glutaminase 1 regulates TGF-?-induced pulmonary fibrosis.
Pyelonephritis
[Renal glutaminase I activities in experimental and human chronic pyelonephritis (author's transl)]
Renal Insufficiency
Glutaminase activity of the kidney in experimental renal failure of rats.
Renal Insufficiency, Chronic
[Activity of glutamine deaminating enzymes in the kidneys, liver and serum of dogs with renal failure and under normal conditions]
Reperfusion Injury
Mitochondrial Metabolism behind Region-Specific Resistance to Ischemia-Reperfusion Injury in Gerbil Hippocampus. Role of PKC?II and Phosphate-Activated Glutaminase.
The effects of administration of nitric oxide inhibitors during small bowel preservation and reperfusion.
Respiratory Insufficiency
Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy.
Rett Syndrome
Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome.
Sarcoma, Myeloid
Prominent glutamine oxidation activity in mitochondria of hematopoietic tumors.
Seizures
Acute and long-term effects of chlorpromazine on glutamine synthetase and glutaminase in rat brain.
Functional significance of the activities of glutaminase and ornithine-?-aminotransferase in rat brain.
Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy.
Pentylenetetrazol-induced seizures in adult rats are associated with plastic changes to the dendritic spines on hippocampal CA1 pyramidal neurons.
Studies on sound-induced epilepsy in mice.
[Metabolic studies on epileptic seizures. The activity of glutaminase and glutamine synthetase and ammonia metabolism before and during cerebral convulsions]
Sepsis
Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat.
Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure.
Increased glutamine consumption in small intestine epithelial cells during sepsis in rats.
[Influence of recombinant growth hormone on protein metabolism during severe infection: an animal experiment]
Squamous Cell Carcinoma of Head and Neck
Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models.
Starvation
Distribution of phosphate-activated glutaminase isozymes in the chicken: absence from liver but presence of high activity in pectoralis muscle.
Drug-induced amino acid deprivation as strategy for cancer therapy.
Effect of starvation or streptozotocin-diabetes on phosphate-activated glutaminase of different rat brain regions.
Effects of starvation on the maximal activities of some glycolytic and citric acid-cycle enzymes and glutaminase in mucosa of the small intestine of the rat.
Fuel utilization in colonocytes of the rat.
Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Resistant Cervical Cancers.
Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation.
Hepatic glutaminase expression: relationship to kidney-type glutaminase and to the urea cycle.
Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells.
Isolation and screening of extracellular anticancer enzymes from halophilic and halotolerant bacteria from different saline environments in Iran.
LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation.
Regulation of glutaminase activity and glutamine metabolism.
Starvation alters the activity and mRNA level of glutaminase and glutamine synthetase in the rat intestine.
Targeting glutamine metabolism slows soft tissue sarcoma growth.
Transcriptional control of rat hepatic glutaminase expression by dietary protein level and starvation.
[Features of the interconversion of alpha-ketoglutarate--glutamate in brain mitochondria of exothermic animals during hibernation]
Stomach Neoplasms
iTRAQ-Based Quantitative Proteomics Approach Identifies Novel Diagnostic Biomarkers That Were Essential for Glutamine Metabolism and Redox Homeostasis for Gastric Cancer.
Pyruvate kinase isozyme M2 and glutaminase might be promising molecular targets for the treatment of gastric cancer.
[Concentration of free glutamine and glutaminase activity in the gastric mucosa of patients with precancerous diseases and cancer of the stomach]
Thrombosis
L: -Asparaginase as Potent Anti-leukemic Agent and Its Significance of Having Reduced Glutaminase Side Activity for Better treatment of Acute Lymphoblastic Leukaemia.
Thyroid Cancer, Papillary
Targeting glutaminase-mediated glutamine dependence in papillary thyroid cancer.
Triple Negative Breast Neoplasms
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer.
Discovery and optimization of withangulatin A derivatives as novel glutaminase 1 inhibitors for the treatment of triple-negative breast cancer.
Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells.
Glutamate-Weighted Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Detects Glutaminase Inhibition in a Mouse Model of Triple-Negative Breast Cancer.
Glutaminase expression is a poor prognostic factor in node-positive triple-negative breast cancer patients with a high level of tumor-infiltrating lymphocytes.
Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition.
Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells.
Tuberculosis
Regulation of active site coupling in glutamine-dependent NAD(+) synthetase.
[Glutaminase activity and intensity of glutamine metabolism in the lungs and lymph nodes in tuberculosis]
Tuberculosis, Pulmonary
[Activity of blood glutaminase in patients with pulmonary tuberculosis and other diseases]
Uremia
[Amylase metabolism and changes in glutaminase and glutamate-synthetase activity in brain during experimental uremia]
Urinary Bladder Neoplasms
LincRNA-p21 suppresses glutamine catabolism and bladder cancer cell growth through inhibiting glutaminase expression.
miR-1-3p Contributes to Cell Proliferation and Invasion by Targeting Glutaminase in Bladder Cancer Cells.
Uterine Cervical Neoplasms
Glutaminase Inhibitors Induce Thiol-Mediated Oxidative Stress and Radiosensitization in Treatment-Resistant Cervical Cancers.
Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation.
Vitamin E Deficiency
[GLUTAMINASE ACTIVITY OF THE SKELETAL MUSCLE CELLS UNDER NORMAL CONDITIONS AND IN VITAMIN E DEFICIENCY.]
Xeroderma Pigmentosum
Physical and genetic linkage of glutaminase (Gls), signal transducer and activator of transcription 1 (Stat1), and xeroderma pigmentosum complementation group G (Xpg) on mouse proximal chromosome 1.