Reference on EC 3.4.25.1 - proteasome endopeptidase complex
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Goldberg, A.L.
Functions of the proteasome: The lysis at the end of the tunnel
Science
268
522
1995
Thermoplasma acidophilum
Peters, J.M.
Proteasomes: Protein degradation machines of the cell
Trends Biochem. Sci.
19
377-382
1994
Thermoplasma acidophilum
Maupin-Furlow, J.A.; Aldrich, H.C.; Ferry, J.G.
Biochemical characterization of the 20S proteasome from the methanoarchaeon Methanosarcina thermophila
J. Bacteriol.
180
1480-1487
1998
Methanosarcina thermophila
To, W.Y.; Wang, C.C.
Identification and characterization of an activated 20S proteasome in Trypanosoma brucei
FEBS Lett.
404
253-262
1997
Trypanosoma brucei
Zwickl, P.; Grziwa, A.; Puehler, G.; Dahlmann, B.; Lottspeich, F.; Baumeister, W.
Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase
Biochemistry
31
964-972
1992
Thermoplasma acidophilum
Haire, M.F.; Clark, J.J.; Jones, M.E.E.; Hendil, K.B.; Schwartz, L.M.; Mykles, D.L.
The multicatalytic proteinase (proteasome) of the hawkmoth, Manduca sexta: Catalytic properties and immunological comparison with the lobster enzyme complex
Arch. Biochem. Biophys.
318
15-24
1995
Manduca sexta
Vinitsky, A.; Cardozo, C.; Sepp-Lorenzino, L.; Michaud, C.; Orlowski, M.
Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes
J. Biol. Chem.
269
29860-29866
1994
Bos taurus
Fujinami, K.; Tanahashi, N.; Tanaka, K.; Ichihara, A.; Cejka, Z.; Baumeister, W.; Miyawaki, M.; Sato, T.; Nakagawa, H.
Purification and characterization of the 26S proteasome from spinach leaves
J. Biol. Chem.
269
25905-25910
1994
Spinacia oleracea
Ozaki, M.; Fujinami, K.; Tanaka, K.; Amemiya, Y.; Sato, T.; Ogura, N.; Nakagawa, H.
Purification and initial characterization of the proteasome from the higher plant Spinacia oleracea
J. Biol. Chem.
267
21678-21684
1992
Spinacia oleracea
Chu-Ping, M.; Slaughters, C.A.; DeMartino, G.N.
Identification, purification and characterization of a protein activator (PA28) of the 20S proteasome (macropain)
J. Biol. Chem.
267
10515-10523
1992
Bos taurus
Djaballah, H.; Rowe, A.J.; Harding, S.E.; Rivett, A.J.
The multicatalytic proteinase complex (proteasome): Structure and conformational changes associated with changes in proteolytic activity
Biochem. J.
292
857-862
1993
Rattus norvegicus
Dahlmann, B.; Kuehn, L.; Grziwa, A.; Zwickl, P.; Baumeister, W.
Biochemical properties of the proteasome from Thermoplasma acidophilum
Eur. J. Biochem.
208
789-797
1992
Thermoplasma acidophilum
Ugai, S.i.; Tamura, T.; Tanahashi, N.; Takai, S.; Komi, N.; Chung, C.H.; Tanaka, K.; Ichihara, A.
Purification and characterization of the 26S proteasome complex catalyzing ATP-dependent breakdown of ubiquitin-ligated proteins from rat liver
J. Biochem.
113
754-768
1993
Rattus norvegicus
Adams, J.; Palombella, V.J.; Sausville, E.A.; Johnson, J.; Destree, A.; Lazarus, D.D.; Maas, J.; Pien, C.S.; Prakash, S.; Elliott, P.J.
Proteasome inhibitors: A novel class of potent and effective antitumor agents
Cancer Res.
59
2615-2622
1999
Homo sapiens
Lee, L.W.; Moomaw, C.R.; Orth, K.; McGuire, M.J.; DeMartino, G.N.; Slaughter, C.A.
Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome)
Biochim. Biophys. Acta
1037
178-185
1990
Homo sapiens
Akaishi, T.; Sawada, H.; Yokosawa, H.
Properties of 26S proteasome purified from rat skeletal muscles: Comparison with those of 26S proteasome from the rat brain
Biochem. Mol. Biol. Int.
39
1017-1021
1996
Rattus norvegicus
Ishiura, S.; Tsukahara, T.; Sugita, H.
Molecular and biochemical properties of the ATP-stimulated multicatalytic proteinase, ingensin, from rat liver
Int. J. Biochem.
22
1195-1201
1990
Rattus norvegicus
Lomo, P.O.; Coetzer, T.H.T.; Lonsdale-Eccles, J.D.
Characterization of a multicatalytic proteinase complex (20S proteasome) from Trypanosoma brucei brucei
Immunopharmacology
36
285-293
1997
Trypanosoma brucei
Usha, R.; Singh, M.
Purification of a multicatalytic protease complex from developing winged bean seeds by indirect immunoaffinity chromatography
Protein Expr. Purif.
15
48-56
1999
Psophocarpus tetragonolobus
Tamura, T.; Nagy, I.; Lupas, A.; Lottspeich, F.; Cejka, Z.; Schoofs, G.; Tanaka, K.; De Mot, R.; Baumeister, W.
The first characterization of a eubacterial proteasome: The 20S complex of Rhodococcus
Curr. Biol.
5
766-774
1995
Rhodococcus sp.
Seufert, W.; Jentsch, S.
In vivo function of the proteasome in the ubiquitin pathway
EMBO J.
11
3077-3080
1992
Saccharomyces cerevisiae
Teicher, B.A.; Ara, G.; Herbst, R.; Palombella, V.J.; Adams, J.
The proteasome inhibitor PS-341 in cancer therapy
Clin. Cancer Res.
5
2638-2645
1999
Homo sapiens
Groll, M.; Ditzel, L.; Loewe, J.; Stock, D.; Bochtler, M.; Bartunik, H.D.; Huber, R.
Structure of 20S proteasomes from yeast at 2.4 A resolution
Nature
386
463-471
1997
Saccharomyces cerevisiae
Klinkradt, S.; Naude, R.J.; Muramoto, K.; Oelofson, W.
Purification and characterization of proteasome from ostrich liver
Int. J. Biochem. Cell Biol.
29
611-622
1997
Struthio camelus
Dick, L.R.; Moomaw, C.R.; DeMartino, G.N.; Slaughter, C.A.
Degradation of oxidized insulin B chain by multiproteinase complex macropain (proteasome)
Biochemistry
30
2725-2734
1991
Homo sapiens
Hu, Z.; Zhang, Z.; Doo, E.; Coux, O.; Goldberg, A.L.; Liang, T.J.
Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex
J. Virol.
73
7231-7240
1999
Hepatitis B virus
Goldberg, A.L.; Stein, R.; Adams, J.
New insights into proteasome function: From archaebacteria to drug development
Chem. Biol.
2
503-508
1995
Thermoplasma acidophilum
Bahrami, A.R.; Gray, J.E.
Conservation of proteasome structure and activity between plants and other eukaryotes
Biochem. Soc. Trans.
26
S395
1998
Nicotiana tabacum
Iqbal, M.; Chatterjee, S.; Kauer, J.C.; Das, M.; Messina, P.; Freed, B.; Biazzo, W.; Siman, R.
Potent inhibitors of proteasome
J. Med. Chem.
38
2276-2277
1995
Homo sapiens, Thermoplasma acidophilum
Stock, D.; Nederlof, P.M.; Seemueller, E.; Baumeister, W.; Huber, R.; Loewe, J.
Proteasome: From structure to function
Curr. Opin. Biotechnol.
7
376-385
1996
Thermoplasma acidophilum
Drexler, H.C.A.
Activation of the cell death program by inhibition of proteasome function
Proc. Natl. Acad. Sci. USA
94
855-860
1997
Homo sapiens
Hilt, W.; Heinemeyer, W.; Wolf, D.H.
Studies on the yeast proteasome uncover its basic structural features and multiple in vivo functions
Enzyme Protein
47
189-201
1994
Saccharomyces cerevisiae, Oryctolagus cuniculus, Drosophila melanogaster, Homo sapiens, Schizosaccharomyces pombe, Thermoplasma acidophilum, Xenopus laevis
Dick, T.P.; Nussbaum, A.K.; Deeg, M.; Heinemeyer, W.; Groll, M.; Schirle, M.; Keilholz, W.; Stevanovic, S.; Wolf, D.H.; Huber, R.; Rammensee, H.G.; Schild, H.
Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants
J. Biol. Chem.
273
25637-25646
1998
Saccharomyces cerevisiae
Dahlmann, B.; Kopp, F.; Kuehn, L.; Niedel, B.; Pfeifer, G.; Hegerl, R.; Baumeister, W.
The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria
FEBS Lett.
251
125-131
1989
Thermoplasma acidophilum
Kwak, S.; Masaki, T.; Ishiura, S.; Sugita, H.
Multicatalytic proteinase is present in lewy bodies and neurofibrillary tangles in diffuse lewy body disease brains
Neurosci. Lett.
128
21-24
1991
Thermoplasma acidophilum
Rivett, J.
Proteasomes: Multicatalytic proteinase complexes
Biochem. J.
291
1-10
1993
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Thermoplasma acidophilum, Xenopus laevis
-
Coux, O.; Tanaka, K.; Goldberg, A.L.
Structure and functions of the 20S and 26S proteasomes
Annu. Rev. Biochem.
65
801-847
1996
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Rattus norvegicus, Rhodococcus sp., Spinacia oleracea, Thermoplasma acidophilum
Gerards, W.L.H.; de Jong, W.W.; Boelens, W.; Bloemendal, H.
Structure and assembly of the 20S proteasome
Cell. Mol. Life Sci.
54
253-262
1998
Rhodococcus sp., Thermoplasma acidophilum
Ito, N.; Tomizawa, K.; Tanaka, K.; Matsui, M.; Kendrick, R.E.; Sato, T.; Nakagawa, H.
Characterization of 26S proteasome alpha- and beta-type and ATPase subunits from spinach and their expression during early stages of seedling development
Plant Mol. Biol.
34
307-316
1997
Spinacia oleracea
Farout, L.; Lamare, M.C.; Cardozo, C.; Harrisson, M.; Briand, Y.; Briand, M.
Distribution of proteasomes and of the five proteolytic activities in rat tissues
Arch. Biochem. Biophys.
374
207-212
2000
Rattus norvegicus
Fernandez Murray, P.; Biscoglio, M.J.; Passeron, S.
Purification and characterization of Candida albicans 20S proteasome. Identification of 4 proteasomal subunits
Arch. Biochem. Biophys.
375
211-219
2000
Candida albicans
Orlowski, M.
Selective activation of the 20 S proteasome (multicatalytic proteinase complex) by histone H3
Biochemistry
40
15318-15326
2001
Bos taurus
Dahlmann, B.; Ruppert, T.; Kloetzel, P.M.; Kuehn, L.
Subtypes of 20S proteasomes from skeletal muscle
Biochimie
83
295-299
2001
Rattus norvegicus
Thomas, A.R.; Oosthuizen, V.; Naude, R.J.; Muramoto, K.
Purification and characterization of the 20S proteasome from ostrich skeletal muscle
Biol. Chem.
383
1267-1270
2002
Struthio camelus
Tanaka, E.; Takagi Sawada, M.; Sawada, H.
Enzymatic properties of the proteasome purified from starfish oocytes and its catalytic subunits involved in oocyte maturation
Comp. Biochem. Physiol. C
125C
215-223
2000
Patiria pectinifera
-
Sitte, N.; Huber, M.; Grune, T.; Ladhoff, A.; Doecke, W.D.; Von Zglinicki, T.; Davies, K.J.A.
Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts
FASEB J.
14
1490-1498
2000
Homo sapiens
Eleuteri, A.M.; Angeletti, M.
The bovine lung 20S proteasome binding to reversible inhibitors: modulation by sodium ion
FEBS Lett.
547
7-10
2003
Bos taurus
Wang, C.C.; Bozdech, Z.; Liu, C.l.; Shipway, A.; Backes, B.J.; Harris, J.L.; Bogyo, M.
Biochemical analysis of the 20 S proteasome of Trypanosoma brucei
J. Biol. Chem.
278
15800-15808
2003
Homo sapiens, Trypanosoma brucei (O96780), Trypanosoma brucei (O96787), Trypanosoma brucei (O96788), Trypanosoma brucei (Q9BMX8), Trypanosoma brucei (Q9GU36), Trypanosoma brucei (Q9GU37), Trypanosoma brucei (Q9NDA1), Trypanosoma brucei (Q9NDA2), Trypanosoma brucei (Q9NDA3), Trypanosoma brucei (Q9NHC5), Trypanosoma brucei (Q9NHC6), Trypanosoma brucei (Q9U793), Trypanosoma brucei (Q9U794), Trypanosoma brucei (Q9XZG5), Trypanosoma brucei
Wojcikiewicz, R.J.H.; Xu, Q.; Webster, J.M.; Alzayady, K.; Gao, C.
Ubiquitination and proteasomal degrdn. of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in aT3-1 anterior pituitary cells
J. Biol. Chem.
278
940-947
2003
Saccharomyces cerevisiae, Oryctolagus cuniculus
Hlzl, H.; Kapelari, B.; Kellermann, J.; Seemuller, E.; Smegi, M.; Udvardy, A.; Medalia, O.; Sperling, J.; Mller, S.A.; Engel, A.; Baumeister, W.
The regulatory complex of Drosophila melanogaster 26S proteasomes: subunit composition and localization of a deubiquitylating enzyme
J. Cell Biol.
150
119-129
2000
Drosophila melanogaster, Drosophila melanogaster (O18413), Drosophila melanogaster (P25161), Drosophila melanogaster (P26270), Drosophila melanogaster (P48601), Drosophila melanogaster (P55035), Drosophila melanogaster (Q7KMP8), Drosophila melanogaster (Q9U7A2), Drosophila melanogaster (Q9V3G7), Drosophila melanogaster (Q9V3H2), Drosophila melanogaster (Q9V3P6), Drosophila melanogaster (Q9V3V6), Drosophila melanogaster (Q9V3Z4), Drosophila melanogaster (Q9V405), Drosophila melanogaster (Q9V436), Drosophila melanogaster (Q9VW54), Drosophila melanogaster (Q9XZ61)
Groll, M.; Koguchi, Y.; Huber, R.; Kohno, J.
Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor
J. Mol. Biol.
311
543-548
2001
Saccharomyces cerevisiae
Eleuteri, A.M.; Angeletti, M.; Lupidi, G.; Tacconi, R.; Bini, L.; Fioretti, E.
Isolation and characterization of bovine thymus multicatalytic proteinase complex
Protein Expr. Purif.
18
160-168
2000
Bos taurus
Frankenberg, R.J.; Hsu, T.S.; Yakota, H.; Kim, R.; Clark, D.S.
Chemical denaturation and elevated folding temperatures are required for wild-type activity and stability of recombinant Methanococcus jannaschii 20S proteasome
Protein Sci.
10
1887-1896
2001
Methanocaldococcus jannaschii
Piccinini, M.; Rinaudo, M.T.; Anselmino, A.; Ramondetti, C.; Buccinna, B.; Fiano, V.; Ghimenti, C.; Schiffer, D.
Characterization of the 20S proteasome in human glioblastomas
Anticancer Res.
25
3203-3210
2005
Homo sapiens
Amici, M.; Sagratini, D.; Pettinari, A.; Pucciarelli, S.; Angeletti, M.; Eleuteri, A.M.
20S proteasome mediated degradation of DHFR: implications in neurodegenerative disorders
Arch. Biochem. Biophys.
422
168-174
2004
Bos taurus
Lee, B.J.; Kwon, S.J.; Kim, S.K.; Kim, K.J.; Park, C.J.; Kim, Y.J.; Park, O.K.; Paek, K.H.
Functional study of hot pepper 26S proteasome subunit RPN7 induced by Tobacco mosaic virus from nuclear proteome analysis
Biochem. Biophys. Res. Commun.
351
405-411
2006
Capsicum annuum
Groll, M.; Huber, R.
Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach
Biochim. Biophys. Acta
1695
33-44
2004
Thermoplasma acidophilum
Alvarez-Castelao, B.; Castano, J.G.
Mechanism of direct degradation of IkappaBalpha by 20S proteasome
FEBS Lett.
579
4797-4802
2005
Rattus norvegicus
Adam, G.; Gausz, J.; Noselli, S.; Kurucz, E.; Ando, I.; Udvardy, A.
Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster
Gene Expr. Patterns
4
329-333
2004
Drosophila melanogaster
Malik, M.N.; Spivack, W.D.; Sheikh, A.M.; Fenko, M.D.
The 26S proteasome in garlic (Allium sativum): purification and partial characterization
J. Agric. Food Chem.
52
3350-3355
2004
Allium sativum
Yang, P.; Fu, H.; Walker, J.; Papa, C.M.; Smalle, J.; Ju, Y.; Vierstra, R.D.
Purification of the Arabidopsis 26 S proteasome: biochemical and molecular analyses revealed the presence of multiple isoforms
J. Biol. Chem.
279
6401-6413
2004
Arabidopsis thaliana
Mueller, D.; Nagel, A.C.; Maier, D.; Preiss, A.
A molecular link A molecular link between Hairless and Pros26.4, a member of the AAA-ATPase subunits of the proteasome 19S regulatory particle in Drosophila
J. Cell Sci.
119
250-258
2006
Drosophila melanogaster
Diaz-Hernandez, M.; Valera, A.G.; Moran, M.A.; Gomez-Ramos, P.; Alvarez-Castelao, B.; Castano, J.G.; Hernandez, F.; Lucas, J.J.
Inhibition of 26S proteasome activity by huntingtin filaments but not inclusion bodies isolated from mouse and human brain
J. Neurochem.
98
1585-1596
2006
Homo sapiens
Reshetnyak, Y.K.; Kitson, R.P.; Lu, M.; Goldfarb, R.H.
Conformational and enzymatic changes of 20S proteasome of rat natural killer cells induced by mono- and divalent cations
J. Struct. Biol.
145
263-271
2004
Rattus norvegicus
Groll, M.; Huber, R.
Purification, crystallization, and X-ray analysis of the yeast 20S proteasome
Methods Enzymol.
398
329-336
2005
Saccharomyces cerevisiae
Hong, B.; Wang, L.; Lammertyn, E.; Geukens, N.; Van Mellaert, L.; Li, Y.; Anne, J.
Inactivation of the 20S proteasome in Streptomyces lividans and its influence on the production of heterologous proteins
Microbiology
151
3137-3145
2005
Streptomyces lividans
Nakamura, A.; Kitami, T.; Mori, H.; Mizuno, Y.; Hattori, N.
Nuclear localization of the 20S proteasome subunit in Parkinsons disease
Neurosci. Lett.
406
43-48
2006
Homo sapiens
Huang, W.; Pi, L.; Liang, W.; Xu, B.; Wang, H.; Cai, R.; Huang, H.
The proteolytic function of the Arabidopsis 26S proteasome is required for specifying leaf adaxial identity
Plant Cell
18
2479-2492
2006
Arabidopsis thaliana
Han, Y.G.; Liu, H.L.; Zheng, H.J.; Li, S.G.; Bi, R.C.
Purification and refolding of human alpha5-subunit (PSMA5) of the 20S proteasome, expressed as inclusion bodies in Escherichia coli
Protein Expr. Purif.
35
360-365
2004
Homo sapiens
Farout, L.; Mary, J.; Vinh, J.; Szweda, L.I.; Friguet, B.
Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes
Arch. Biochem. Biophys.
453
135-142
2006
Rattus norvegicus
Tambyrajah, W.S.; Bowler, L.D.; Medina-Palazon, C.; Sinclair, A.J.
Cell cycle-dependent caspase-like activity that cleaves p27(KIP1) is the beta(1) subunit of the 20S proteasome
Arch. Biochem. Biophys.
466
186-193
2007
Homo sapiens
Verras, M.; Gourzi, P.; Kalosaka, K.; Zacharopoulou, A.; Mintzas, A.C.
cDNA cloning, characterization, and developmental expression of the 20S proteasome alpha5 subunit in the Mediterranean fruit fly Ceratitis capitata
Arch. Insect Biochem. Physiol.
67
120-129
2008
Ceratitis capitata (Q8I7N8), Ceratitis capitata
Collado, D.; Yoshihara, T.; Hamaguchi, M.
DBC2 resistance is achieved by enhancing 26S proteasome-mediated protein degradation
Biochem. Biophys. Res. Commun.
360
600-603
2007
Homo sapiens
Arlt, A.; Minkenberg, J.; Kruse, M.L.; Grohmann, F.; Foelsch, U.R.; Schaefer, H.
Immediate early gene-X1 interferes with 26 S proteasome activity by attenuating expression of the 19 S proteasomal components S5a/Rpn10 and S1/Rpn2
Biochem. J.
402
367-375
2007
Homo sapiens
Wang, X.; Chen, C.F.; Baker, P.R.; Chen, P.L.; Kaiser, P.; Huang, L.
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex
Biochemistry
46
3553-3565
2007
Homo sapiens
Amici, M.; Cecarini, V.; Pettinari, A.; Bonfili, L.; Angeletti, M.; Barocci, S.; Biagetti, M.; Fioretti, E.; Maria Eleuteri, A.
Binding of aflatoxins to the 20S proteasome: effects on enzyme functionality and implications for oxidative stress and apoptosis
Biol. Chem.
388
107-117
2007
Bos taurus
Yi, Y.J.; Nagyova, E.; Manandhar, G.; Prochazka, R.; Sutovsky, M.; Park, C.S.; Sutovsky, P.
Proteolytic activity of the 26S proteasome is required for the meiotic resumption, germinal vesicle breakdown, and cumulus expansion of porcine cumulus-oocyte complexes matured in vitro
Biol. Reprod.
78
115-126
2008
Sus scrofa
Fu, Y.; Xu, B.; Zou, X.; Ma, C.; Yang, X.; Mou, K.; Fu, G.; Lue, Y.; Xu, P.
Design and synthesis of a novel class of furan-based molecules as potential 20S proteasome inhibitors
Bioorg. Med. Chem. Lett.
17
1102-1106
2007
Homo sapiens
Perepechaeva, M.L.; Kolosova, N.G.; Grishanova, A.Y.
Activity of 20S proteosomes and content of oxidized proteins in rat liver after long-term cold exposure
Bull. Exp. Biol. Med.
142
182-185
2006
Rattus norvegicus
Milacic, V.; Chen, D.; Ronconi, L.; Landis-Piwowar, K.R.; Fregona, D.; Dou, Q.P.
A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts
Cancer Res.
66
10478-10486
2006
Oryctolagus cuniculus
Tsimokha, A.S.; Mittenberg, A.G.; Kulichkova, V.A.; Kozhukharova, I.V.; Gause, L.N.; Konstantinova, I.M.
Changes in composition and activities of 26S proteasomes under the action of doxorubicin - apoptosis inductor of erythroleukemic K562 cells
Cell Biol. Int.
31
338-348
2007
Homo sapiens
Zong, C.; Gomes, A.V.; Drews, O.; Li, X.; Young, G.W.; Berhane, B.; Qiao, X.; French, S.W.; Bardag-Gorce, F.; Ping, P.
Regulation of murine cardiac 20S proteasomes: role of associating partners
Circ. Res.
99
372-380
2006
Rattus norvegicus
Staszczak, M.
The 26S proteasome of the lignin-degrading basidiomycete Phlebia radiata
Enzyme Microb. Technol.
40
347-353
2007
Phlebia radiata
-
Quadrini, K.J.; Bieker, J.J.
EKLF/KLF1 is ubiquitinated in vivo and its stability is regulated by activation domain sequences through the 26S proteasome
FEBS Lett.
580
2285-2293
2006
Mus musculus
Madding, L.S.; Michel, J.K.; Shockley, K.R.; Conners, S.B.; Epting, K.L.; Johnson, M.R.; Kelly, R.M.
Role of the beta1 subunit in the function and stability of the 20S proteasome in the hyperthermophilic archaeon Pyrococcus furiosus
J. Bacteriol.
189
583-590
2007
Pyrococcus furiosus
Marques, A.J.; Glanemann, C.; Ramos, P.C.; Dohmen, R.J.
The C-terminal extension of the beta7 subunit and activator complexes stabilize nascent 20 S proteasomes and promote their maturation
J. Biol. Chem.
282
34869-34876
2007
Saccharomyces cerevisiae, Homo sapiens
Iwanczyk, J.; Sadre-Bazzaz, K.; Ferrell, K.; Kondrashkina, E.; Formosa, T.; Hill, C.P.; Ortega, J.
Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes
J. Mol. Biol.
363
648-659
2006
Saccharomyces cerevisiae
Klare, N.; Seeger, M.; Janek, K.; Jungblut, P.R.; Dahlmann, B.
Intermediate-type 20 S proteasomes in HeLa cells: "asymmetric" subunit composition, diversity and adaptation
J. Mol. Biol.
373
1-10
2007
Homo sapiens
Mishto, M.; Luciani, F.; Holzhuetter, H.G.; Bellavista, E.; Santoro, A.; Textoris-Taube, K.; Franceschi, C.; Kloetzel, P.M.; Zaikin, A.
Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics
J. Mol. Biol.
377
1607-1617
2008
Homo sapiens
Gillardon, F.; Kloss, A.; Berg, M.; Neumann, M.; Mechtler, K.; Hengerer, B.; Dahlmann, B.
The 20S proteasome isolated from Alzheimers disease brain shows post-translational modifications but unchanged proteolytic activity
J. Neurochem.
101
1483-1490
2007
Homo sapiens
Kwak, M.K.; Huang, B.; Chang, H.; Kim, J.A.; Kensler, T.W.
Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein
Life Sci.
80
2411-2420
2007
Mus musculus
Isono, E.; Nishihara, K.; Saeki, Y.; Yashiroda, H.; Kamata, N.; Ge, L.; Ueda, T.; Kikuchi, Y.; Tanaka, K.; Nakano, A.; Toh-e, A.
The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome
Mol. Biol. Cell
18
569-580
2007
Saccharomyces cerevisiae
Baert, J.L.; Beaudoin, C.; Monte, D.; Degerny, C.; Mauen, S.; de Launoit, Y.
The 26S proteasome system degrades the ERM transcription factor and regulates its transcription-enhancing activity
Oncogene
26
415-424
2007
Homo sapiens
Hua, Z.; Kao, T.H.
Identification of major lysine residues of S(3)-RNase of Petunia inflata involved in ubiquitin-26S proteasome-mediated degradation in vitro
Plant J.
54
1094-1104
2008
Petunia integrifolia subsp. inflata
Joo, S.; Liu, Y.; Lueth, A.; Zhang, S.
MAPK phosphorylation-induced stabilization of ACS6 protein is mediated by the non-catalytic C-terminal domain, which also contains the cis-determinant for rapid degradation by the 26S proteasome pathway
Plant J.
54
129-140
2008
Arabidopsis thaliana
Djebali, W.; Gallusci, P.; Polge, C.; Boulila, L.; Galtier, N.; Raymond, P.; Chaibi, W.; Brouquisse, R.
Modifications in endopeptidase and 20S proteasome expression and activities in cadmium treated tomato (Solanum lycopersicum L.) plants
Planta
227
625-639
2008
Solanum lycopersicum
Castro-Borges, W.; Cartwright, J.; Ashton, P.D.; Braschi, S.; Guerra Sa, R.; Rodrigues, V.; Wilson, R.A.; Curwen, R.S.
The 20S proteasome of Schistosoma mansoni: a proteomic analysis
Proteomics
7
1065-1075
2007
Schistosoma mansoni
Chen, C.; Huang, C.; Chen, S.; Liang, J.; Lin, W.; Ke, G.; Zhang, H.; Wang, B.; Huang, J.; Han, Z.; Ma, L.; Huo, K.; Yang, X.; Yang, P.; He, F.; Tao, T.
Subunit-subunit interactions in the human 26S proteasome
Proteomics
8
508-520
2008
Homo sapiens
Groll, M.; Berkers, C.R.; Ploegh, H.L.; Ovaa, H.
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome
Structure
14
451-456
2006
Saccharomyces cerevisiae
Huo, C.; Yang, H.; Cui, Q.C.; Dou, Q.P.; Chan, T.H.
Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs
Bioorg. Med. Chem.
18
1252-1258
2010
Homo sapiens
Nakamura, H.; Watanabe, M.; Ban, H.S.; Nabeyama, W.; Asai, A.
Synthesis and biological evaluation of boron peptide analogues of Belactosin C as proteasome inhibitors
Bioorg. Med. Chem. Lett.
19
3220-3224
2009
Homo sapiens
Waring, J.F.; Ciurlionis, R.; Marsh, K.; Klein, L.L.; Degoey, D.A.; Randolph, J.T.; Spear, B.; Kempf, D.J.
Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia
Arch. Toxicol.
84
263-270
2010
Rattus norvegicus
Elangovan, M.; Shin, D.Y.; Yoo, Y.J.
The ubiquitin-interacting motifs of S5a as a unique upstream inhibitor of the 26S proteasome
Biochem. Biophys. Res. Commun.
388
723-726
2009
Homo sapiens
Aoyagi, N.; Uemura, K.; Kuzuya, A.; Kihara, T.; Kawamata, J.; Shimohama, S.; Kinoshita, A.; Takahashi, R.
PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity
Biochem. Biophys. Res. Commun.
391
1240-1245
2010
Mus musculus, Phaseolus vulgaris
Miura, Y.; Sakurai, Y.; Hayakawa, M.; Shimada, Y.; Zempel, H.; Sato, Y.; Hisanaga, S.; Endo, T.
Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes
Biol. Pharm. Bull.
33
22-28
2010
Rattus norvegicus
Baldisserotto, A.; Marastoni, M.; Gavioli, R.; Tomatis, R.
New cyclic peptide proteasome inhibitors
Bioorg. Med. Chem. Lett.
19
1966-1969
2009
Homo sapiens
Baldisserotto, A.; Destro, F.; Vertuani, G.; Marastoni, M.; Gavioli, R.; Tomatis, R.
N-terminal-prolonged vinyl ester-based peptides as selective proteasome beta1 subunit inhibitors
Bioorg. Med. Chem.
17
5535-5540
2009
Homo sapiens
Roccaro, A.M.; Sacco, A.; Aujay, M.; Ngo, H.T.; Azab, A.K.; Azab, F.; Quang, P.; Maiso, P.; Runnels, J.; Anderson, K.C.; Demo, S.; Ghobrial, I.M.
Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia
Blood
115
4051-4060
2010
Homo sapiens
Baumann, P.; Mueller, K.; Mandl-Weber, S.; Leban, J.; Doblhofer, R.; Ammendola, A.; Baumgartner, R.; Oduncu, F.; Schmidmaier, R.
The peptide-semicarbazone S-2209, a representative of a new class of proteasome inhibitors, induces apoptosis and cell growth arrest in multiple myeloma cells
Br. J. Haematol.
144
875-886
2009
Homo sapiens, Rattus norvegicus
Seeger, J.M.; Schmidt, P.; Brinkmann, K.; Hombach, A.A.; Coutelle, O.; Zigrino, P.; Wagner-Stippich, D.; Mauch, C.; Abken, H.; Kroenke, M.; Kashkar, H.
The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack
Cancer Res.
70
1825-1834
2010
Homo sapiens
Kupperman, E.; Lee, E.C.; Cao, Y.; Bannerman, B.; Fitzgerald, M.; Berger, A.; Yu, J.; Yang, Y.; Hales, P.; Bruzzese, F.; Liu, J.; Blank, J.; Garcia, K.; Tsu, C.; Dick, L.; Fleming, P.; Yu, L.; Manfredi, M.; Rolfe, M.; Bolen, J.
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer
Cancer Res.
70
1970-1980
2010
Homo sapiens, Mus musculus
Kloss, A.; Meiners, S.; Ludwig, A.; Dahlmann, B.
Multiple cardiac proteasome subtypes differ in their susceptibility to proteasome inhibitors
Cardiovasc. Res.
85
367-375
2010
Rattus norvegicus
Chen, G.; Luo, Y.; Wang, X.; Zhao, Z.; Liu, H.; Zhang, H.; Li, Z.
A relatively simple and economical protocol for proteomic analyses of human 20S proteasome: compatible with both scaled-up and scaled-down purifications
Electrophoresis
30
2422-2430
2009
Homo sapiens
Hindo, S.S.; Frezza, M.; Tomco, D.; Heeg, M.J.; Hryhorczuk, L.; McGarvey, B.R.; Dou, Q.P.; Verani, C.N.
Metals in anticancer therapy: copper(II) complexes as inhibitors of the 20S proteasome
Eur. J. Med. Chem.
44
4353-4361
2009
Homo sapiens
Millet, V.; Moiola, C.P.; Pasquini, J.M.; Soto, E.F.; Pasquini, L.A.
Partial inhibition of proteasome activity enhances remyelination after cuprizone-induced demyelination
Exp. Neurol.
217
282-296
2009
Mus musculus
Alvarez-Castelao, B.; Martin-Guerrero, I.; Garcia-Orad, A.; Castano, J.G.
Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors
J. Biol. Chem.
284
28253-28262
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Tang, G.; Perng, M.D.; Wilk, S.; Quinlan, R.; Goldman, J.E.
Oligomers of mutant glial fibrillary acidic protein (GFAP) inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition
J. Biol. Chem.
285
10527-10537
2010
Homo sapiens
Berges, C.; Haberstock, H.; Fuchs, D.; Sadeghi, M.; Opelz, G.; Daniel, V.; Naujokat, C.
Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells
J. Cell. Biochem.
108
935-946
2009
Homo sapiens
Zhang, X.; Frezza, M.; Milacic, V.; Ronconi, L.; Fan, Y.; Bi, C.; Fregona, D.; Dou, Q.P.
Inhibition of tumor proteasome activity by gold-dithiocarbamato complexes via both redox-dependent and -independent processes
J. Cell. Biochem.
109
162-172
2010
Oryctolagus cuniculus, Homo sapiens
Basler, M.; Lauer, C.; Beck, U.; Groettrup, M.
The proteasome inhibitor bortezomib enhances the susceptibility to viral infection
J. Immunol.
183
6145-6150
2009
Mus musculus
Basse, N.; Montes, M.; Marechal, X.; Qin, L.; Bouvier-Durand, M.; Genin, E.; Vidal, J.; Villoutreix, B.O.; Reboud-Ravaux, M.
Novel organic proteasome inhibitors identified by virtual and in vitro screening
J. Med. Chem.
53
509-513
2010
Homo sapiens
Matondo, M.; Bousquet-Dubouch, M.P.; Gallay, N.; Uttenweiler-Joseph, S.; Recher, C.; Payrastre, B.; Manenti, S.; Monsarrat, B.; Burlet-Schiltz, O.
Proteasome inhibitor-induced apoptosis in acute myeloid leukemia: a correlation with the proteasome status
Leuk. Res.
34
498-506
2010
Homo sapiens
Radhakrishnan, S.K.; Lee, C.S.; Young, P.; Beskow, A.; Chan, J.Y.; Deshaies, R.J.
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
Mol. Cell
38
17-28
2010
Homo sapiens, Mus musculus
Singh, L.R.; Gupta, S.; Honig, N.H.; Kraus, J.P.; Kruger, W.D.
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70
PLoS Genet.
6
e1000807
2010
Homo sapiens
Clerc, J.; Groll, M.; Illich, D.J.; Bachmann, A.S.; Huber, R.; Schellenberg, B.; Dudler, R.; Kaiser, M.
Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition
Proc. Natl. Acad. Sci. USA
106
6507-6512
2009
Homo sapiens
Kautto, L.; Grinyer, J.; Birch, D.; Kapur, A.; Baker, M.; Traini, M.; Bergquist, P.; Nevalainen, H.
Rapid purification method for the 26S proteasome from the filamentous fungus Trichoderma reesei
Protein Expr. Purif.
67
156-163
2009
Trichoderma reesei
Lupfer, C.; Patton, K.M.; Pastey, M.K.
Treatment of human respiratory syncytial virus infected Balb/C mice with the proteasome inhibitor bortezomib (Velcade, PS-341) results in increased inflammation and mortality
Toxicology
268
25-30
2010
Mus musculus
Bardag-Gorce, F.
Nuclear effects of ethanol-induced proteasome inhibition in liver cells
World J. Gastroenterol.
15
1163-1167
2009
Homo sapiens
Kim, H.M.; Yu, Y.; Cheng, Y.
Structure characterization of the 26S proteasome
Biochim. Biophys. Acta
1809
67-79
2011
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Methanocaldococcus jannaschii, Mycobacterium tuberculosis, Thermoplasma acidophilum
Deriziotis, P.; Andre, R.; Smith, D.M.; Goold, R.; Kinghorn, K.J.; Kristiansen, M.; Nathan, J.A.; Rosenzweig, R.; Krutauz, D.; Glickman, M.H.; Collinge, J.; Goldberg, A.L.; Tabrizi, S.J.
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry
EMBO J.
30
3065-3077
2011
Homo sapiens
Tai, H.C.; Besche, H.; Goldberg, A.L.; Schuman, E.M.
Characterization of the brain 26S proteasome and its interacting proteins
Front. Mol. Neurosci.
3
0000
2010
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Book, A.J.; Gladman, N.P.; Lee, S.S.; Scalf, M.; Smith, L.M.; Vierstra, R.D.
Affinity purification of the Arabidopsis 26 S proteasome reveals a diverse array of plant proteolytic complexes
J. Biol. Chem.
285
25554-25569
2010
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Goetze, S.; Saborowski, R.
Proteasomal activities in the claw muscle tissue of European lobster, Homarus gammarus, during larval development
J. Comp. Physiol. B
181
861-871
2011
Homarus gammarus
Zheng, J.; Bizzozero, O.A.
Reduced proteasomal activity contributes to the accumulation of carbonylated proteins in chronic experimental autoimmune encephalomyelitis
J. Neurochem.
115
1556-1567
2010
Mus musculus, Mus musculus C57BL/6
Kaake, R.M.; Milenkovic, T.; Przulj, N.; Kaiser, P.; Huang, L.
Characterization of cell cycle specific protein interaction networks of the yeast 26S proteasome complex by the QTAX strategy
J. Proteome Res.
9
2016-2029
2010
Saccharomyces cerevisiae
Liepe, J.; Mishto, M.; Textoris-Taube, K.; Janek, K.; Keller, C.; Henklein, P.; Kloetzel, P.M.; Zaikin, A.
The 20S proteasome splicing activity discovered by SpliceMet
PLoS Comput. Biol.
6
e1000830
2010
Homo sapiens
Sun, Q.; Xu, B.; Niu, Y.; Xu, F.; Liang, L.; Wang, C.; Yu, J.; Yan, G.; Wang, W.; Jin, H.; Xu, P.
Synthesis, bioactivity, docking and molecular dynamics studies of furan-based peptides as 20S proteasome inhibitors
ChemMedChem
10
498-510
2015
Homo sapiens
Campbell, M.; Veesler, D.; Cheng, A.; Potter, C.; Carragher, B.
2.8 A resolution reconstruction of the Thermoplasma acidophilum 20 S proteasome using cryo-electron microscopy
eLife
2015
1-22
2015
Thermoplasma acidophilum (P25156 and P28061), Thermoplasma acidophilum
Ma, X.; Loo, J.A.; Wysocki, V.H.
Surface induced dissociation yields substructure of Methanosarcina thermophila 20S proteasome complexes
Int. J. Mass Spectrom.
377
201-204
2015
Methanosarcina thermophila
Yashiroda, H.; Toda, Y.; Otsu, S.; Takagi, K.; Mizushima, T.; Murata, S.
N-terminal alpha7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function
Mol. Cell. Biol.
35
141-152
2015
Saccharomyces cerevisiae (P21243), Saccharomyces cerevisiae
Yu, D.; Yu, F.; Du, C.; Li, X.; Zhao, X.; Liu, X.
RPN1a, a subunit of the 26S proteasome, controls trichome development in Arabidopsis
Plant Physiol. Biochem.
88
82-88
2015
Arabidopsis thaliana
Pereira-Neves, A.; Gonzaga, L.; Menna-Barreto, R.F.; Benchimol, M.
Characterisation of 20S proteasome in Tritrichomonas foetus and its role during the cell cycle and transformation into endoflagellar form
PLoS ONE
10
e0129165
2015
Tritrichomonas foetus (A0A075KK20), Tritrichomonas foetus
Harshbarger, W.; Miller, C.; Diedrich, C.; Sacchettini, J.
Crystal structure of the human 20S proteasome in complex with carfilzomib
Structure
23
418-424
2015
Homo sapiens (P25789), Homo sapiens
Zwickl, P.; Grziwa, A.; Piihler, G.; Lottspeich, F.; Baumeister, W.; Dahlmann, B.
Primary structure of the Thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase
Biochemistry
31
964-972
1992
Thermoplasma acidophilum (P28061 AND P25156), Thermoplasma acidophilum
Aufderheide, A.; Beck, F.; Stengel, F.; Hartwig, M.; Schweitzer, A.; Pfeifer, G.; Goldberg, A.L.; Sakata, E.; Baumeister, W.; Foerster, F.
Structural characterization of the interaction of Ubp6 with the 26S proteasome
Proc. Natl. Acad. Sci. USA
112
8626-8631
2015
Saccharomyces cerevisiae (P38624)
Gruba, N.; Wysocka, M.; Brzezinska, M.; Debowski, D.; Rolka, K.; Martin, N.; Lesner, A.
Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome
Anal. Biochem.
508
38-45
2016
Homo sapiens
Hasinoff, B.B.
Progress curve analysis of the kinetics of slow-binding anticancer drug inhibitors of the 20S proteasome
Arch. Biochem. Biophys.
639
52-58
2018
Homo sapiens
Kravchuk, O.; Lyupina, Y.; Erokhov, P.; Finoshin, A.; Adameyko, K.; Mishyna, M.; Moiseenko, A.; Sokolova, O.; Orlova, O.; Beljelarskaya, S.; Serebryakova, M.; Indeykina, M.; Bugrova, A.; Kononikhin, A.; Mikhailov, V.
Characterization of the 20S proteasome of the lepidopteran, Spodoptera frugiperda
Biochim. Biophys. Acta
1867
840-853
2019
Spodoptera frugiperda (A0A2H1WB52), Spodoptera frugiperda
Baudisch, B.; Pfort, I.; Sorge, E.; Conrad, U.
Nanobody-directed specific degradation of proteins by the 26s-proteasome in plants
Front. Plant Sci.
9
00130
2018
Nicotiana tabacum
Gogliettino, M.; Cocca, E.; Fusco, C.; Agrillo, B.; Riccio, A.; Balestrieri, M.; Facchiano, A.; Pepe, A.; Palmieri, G.
Unusual antioxidant properties of 26S proteasome isolated from cold-adapted organisms
Int. J. Mol. Sci.
18
1605
2017
Chionodraco hamatus (A0A286S218 and A0A286S1Z7 and A0A286S200), Chionodraco hamatus, Dicentrarchus labrax
Yoo, E.; Stokes, B.H.; de Jong, H.; Vanaerschot, M.; Kumar, T.; Lawrence, N.; Njoroge, M.; Garcia, A.; Van der Westhuyzen, R.; Momper, J.D.; Ng, C.L.; Fidock, D.A.; Bogyo, M.
Defining the determinants of specificity of Plasmodium proteasome inhibitors
J. Am. Chem. Soc.
140
11424-11437
2018
Plasmodium falciparum, Plasmodium falciparum W2
Rut, W.; Poreba, M.; Kasperkiewicz, P.; Snipas, S.J.; Drag, M.
Selective substrates and activity-based probes for imaging of the human constitutive 20S proteasome in cells and blood samples
J. Med. Chem.
61
5222-5234
2018
Homo sapiens
Zhang, Q.; Ji, S.; Busayavalasa, K.; Shao, J.; Yu, C.
Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome
Nat. Commun.
10
31358751
2019
Mus musculus (Q9CWH6)
-
Da Fonseca, P.; Morris, E.
Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core
Nat. Commun.
6
7573
2015
Homo sapiens
Braten, O.; Livneh, I.; Ziv, T.; Admon, A.; Kehat, I.; Caspi, L.; Gonen, H.; Bercovich, B.; Godzik, A.; Jahandideh, S.; Jaroszewski, L.; Sommer, T.; Kwon, Y.; Guharoy, M.; Tompa, P.; Ciechanover, A.
Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination
Proc. Natl. Acad. Sci. USA
113
E4639-E4647
2016
Saccharomyces cerevisiae, Homo sapiens
Banerjee, S.; Ji, C.; Mayfield, J.E.; Goel, A.; Xiao, J.; Dixon, J.E.; Guo, X.
Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2
Proc. Natl. Acad. Sci. USA
115
8155-8160
2018
Homo sapiens
Witkowska, J.; Gizynska, M.; Grudnik, P.; Golik, P.; Karpowicz, P.; Gieldon, A.; Dubin, G.; Jankowska, E.
Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome - insights into the enzyme activation mechanism
Sci. Rep.
7
6177
2017
Homo sapiens
html completed