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Disease on EC 3.4.24.B8 - ADAM1 endopeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
Altered cell-matrix associated ADAM proteins in Alzheimer disease.
Herpes Zoster
Characterization of the binding of recombinant mouse sperm fertilin alpha subunit to mouse eggs: evidence for function as a cell adhesion molecule in sperm-egg binding.
Characterization of the binding of recombinant mouse sperm fertilin beta subunit to mouse eggs: evidence for adhesive activity via an egg beta1 integrin-mediated interaction.
Disruption of ADAM3 Impairs the Migration of Sperm into Oviduct in Mouse.
Fertilization defects in sperm from mice lacking fertilin beta.
Mechanisms of Fertilization--A View from the Perspective of Gene Manipulated Mice.
Mice expressing aberrant sperm-specific protein PMIS2 produce normal-looking but fertilization-incompetent spermatozoa.
Mouse Sperm Lacking ADAM1b/ADAM2 Fertilin Can Fuse with the Egg Plasma Membrane and Effect Fertilization.
Infertility
Initial evaluation of fertilin as an immunocontraceptive antigen and molecular cloning of the cynomolgus monkey fertilin beta subunit.
Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization.
Sperm from the calmegin-deficient mouse have normal abilities for binding and fusion to the egg plasma membrane.
Infertility, Male
Possible function of the ADAM1a/ADAM2 Fertilin complex in the appearance of ADAM3 on the sperm surface.
The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion.