metalloprotease domain in the beta subunit precursor region, but not in the mature protein, the alpha-subunit conatins a metalloprotease domain, which is the active site, in the mature from with the consensus sequence HEXXHXXGXXHE
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TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment.
T cell antigen receptor dependent signalling in human lymphocytes: cholera toxin inhibits interleukin-2 receptor expression but not interleukin-2 synthesis by preventing activation of a protein kinase C isotype, PKC-alpha.
Retraction Note: abstracts of the 47th Annual Meeting of the EASD, Lisbon 2011. 'Reduced syntaxin-5 in skeletal muscle of patients with type 2 diabetes is linked to increased diacylglycerol, activation of PKCtheta and impaired insulin signalling'.
isozyme a is partially processed to a 48 kDa mature protein in round and elongating spermatids, isozyme b precursor is totally processed to a 63 kDa intermediate during spermatogenesis and finally to a 60 kDa mature protein during sperm transit in the epididymis
ADAM1b deficient mice, no significant defect in sperm functions such as migration from the uterus into oviduct, binding to egg zona pellucida, and fusion with zona pellucida-free eggs, but severe reduction of ADAM2 on cell surface