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Disease on EC 3.4.24.B4 - matrix metalloproteinase-13

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DISEASE
TITLE OF PUBLICATION
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Abscess
Colorectal adenocarcinoma with mucinous component: relation of MMP-13, EGFR, and E-cadherin expressions to clinicopathological features and prognosis.
Acute Lung Injury
Deficiency of matrix metalloproteinase-13 increases inflammation after acute lung injury.
Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism.
Adenocarcinoma
Active matrix metalloproteases are expressed early on and are high during the Barrett's esophagus malignancy sequence.
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Colorectal adenocarcinoma with mucinous component: relation of MMP-13, EGFR, and E-cadherin expressions to clinicopathological features and prognosis.
Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer.
Hypoxia induces oncogene yes-associated protein 1 nuclear translocation to promote pancreatic ductal adenocarcinoma invasion via epithelial-mesenchymal transition.
MMP-13 In-Vivo Molecular Imaging Reveals Early Expression in Lung Adenocarcinoma.
MMP13 is a potential prognostic marker for colorectal cancer.
[Expression and clinical significance of collagenase-3 (MMP-13) in gastric cancer]
Adenocarcinoma of Lung
?-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells.
MMP-13 In-Vivo Molecular Imaging Reveals Early Expression in Lung Adenocarcinoma.
Therapeutic effect of Resveratrol in the treatment of osteoarthritis via the MALAT1/miR-9/NF-?B signaling pathway.
Adenocarcinoma, Mucinous
Colorectal adenocarcinoma with mucinous component: relation of MMP-13, EGFR, and E-cadherin expressions to clinicopathological features and prognosis.
Differential expression of matrix metalloproteinase-13 in mucinous and nonmucinous colorectal carcinomas.
Adenoma
Matrix metalloproteinase-13 expression in the progression of colorectal adenoma to carcinoma : Matrix metalloproteinase-13 expression in the colorectal adenoma and carcinoma.
Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions.
MMP-13 In-Vivo Molecular Imaging Reveals Early Expression in Lung Adenocarcinoma.
The Expression and Significance of CXCR5 and MMP-13 in Colorectal Cancer.
Adenomatous Polyps
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
Matrix metalloproteinase-13 expression in the progression of colorectal adenoma to carcinoma : Matrix metalloproteinase-13 expression in the colorectal adenoma and carcinoma.
Adrenal Cortex Neoplasms
Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas.
Albuminuria
Absence of Gelatinase (MMP-9) or Collagenase (MMP-13) Attenuates Adriamycin-Induced Albuminuria and Glomerulosclerosis.
Alveolar Bone Loss
Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity.
Alzheimer Disease
Blood-brain barrier damage in vascular dementia.
Matrix metalloproteinase 13, a new target for therapy in Alzheimer's disease.
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Aneurysm
Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury.
MicroRNA and gene expression changes in unruptured human cerebral aneurysms.
Nitric oxide induces the progression of abdominal aortic aneurysms through the matrix metalloproteinase inducer EMMPRIN.
Angina, Unstable
High plasma levels of matrix metalloproteinase-8 in patients with unstable angina.
Angiofibroma
Metalloproteinases in juvenile angiofibroma--a collagen rich tumor.
Ankylosis
Abnormal Mechanical Loading Induces Cartilage Degeneration by Accelerating Meniscus Hypertrophy and Mineralization After ACL Injuries In Vivo.
The role of pyrophosphate/phosphate homeostasis in terminal differentiation and apoptosis of growth plate chondrocytes.
Aortic Aneurysm, Abdominal
Decreased collagen and increased matrix metalloproteinase-13 in experimental abdominal aortic aneurysms in males compared with females.
Elevated expression of matrix metalloproteinase-13 in abdominal aortic aneurysms.
Expression of collagenase-3 (MMP-13) in human abdominal aortic aneurysms and vascular smooth muscle cells in culture.
Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm.
Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome.
Arteriosclerosis
Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice.
Arthralgia
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
Arthritis
1,25-Dihydroxyvitamin D3 activates MMP13 gene expression in chondrocytes through p38 MARK pathway.
A correlation between knee cartilage degradation observed by arthroscopy and synovial proteinases activities.
A low ratio of n-6/n-3 polyunsaturated fatty acids suppresses matrix metalloproteinase 13 expression and reduces adjuvant-induced arthritis in rats.
A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis.
Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13).
Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice.
Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes.
Blockade of IL-17 alleviated inflammation in rat arthritis and MMP-13 expression.
CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis.
Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis.
Collagenase-3 (MMP-13) deficiency protects C57BL/6 mice from antibody-induced arthritis.
Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes.
Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor.
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.
Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13 (dagger).
Distal interleukin-1? (IL-1?) response element of human matrix metalloproteinase-13 (MMP-13) binds activator protein 1 (AP-1) transcription factors and regulates gene expression.
DPSCs Attenuate Experimental Progressive TMJ Arthritis by Inhibiting the STAT1 Pathway.
Effects of Intra-Articular Resveratrol Injections on Cartilage Destruction and Synovial Inflammation in Experimental Temporomandibular Joint Osteoarthritis.
Expression levels and association of gelatinases MMP-2 and MMP-9 and collagenases MMP-1 and MMP-13 with VEGF in synovial fluid of patients with arthritis.
Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2.
Gadd45beta deficiency in rheumatoid arthritis: Enhanced synovitis through JNK signaling.
Hesperidin inhibits synovial cell inflammation and macrophage polarization through suppression of the PI3K/AKT pathway in complete Freund's adjuvant-induced arthritis in mice.
Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites.
In Vivo Dual Fluorescence Imaging to Detect Joint Destruction.
In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis.
Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes.
Inhibition of interleukin 1-induced matrix metalloproteinase 13 expression in human chondrocytes by interferon gamma.
Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes.
Inhibition of joint inflammation and destruction induced by anti-type II collagen antibody/lipopolysaccharide (LPS)-induced arthritis in mice due to deletion of macrophage migration inhibitory factor (MIF).
Inhibition of Matrix Metalloproteinase-3 and -13 Synthesis Induced by IL-1{beta} in Chondrocytes from Mice Lacking Microsomal Prostaglandin E Synthase-1.
Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes.
Joint diseases and matrix metalloproteinases: a role for MMP-13.
Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1?-induced arthritis.
Levels of Matrix Metalloproteinases in Arthroplasty Patients and Their Correlation With Inflammatory and Thrombotic Activation Processes.
LncRNA H19 regulates macrophage polarization and promotes Freund's complete adjuvant-induced arthritis by upregulating KDM6A.
Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens.
Matrix metalloproteinase-13: A special focus on its regulation by signaling cascades and microRNAs in bone.
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.
Modulation of matrix metalloprotease 13 (collagenase 3) gene expression in equine chondrocytes by interleukin 1 and corticosteroids.
MyD88, IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1-induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation.
Norisoboldine alleviates joint destruction in rats with adjuvant-induced arthritis by reducing RANKL, IL-6, PGE2, and MMP-13 expression.
Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants.
PEP-1-FK506BP12 inhibits matrix metalloproteinase expression in human articular chondrocytes and in a mouse carrageenan-induced arthritis model.
Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13.
Serum and knee synovial fluid matrix metalloproteinase-13 and tumor necrosis factor-alpha levels in patients with late-stage osteoarthritis.
Serum and knee synovial fluid matrixmetalloproteinase-13 and tumor necrosis factor-alpha levels in patients with late stage osteoarthritis.
Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages.
Stromal cell-derived factor-1 induces matrix metalloprotease-13 expression in human chondrocytes.
Suppression of hyaluronan synthesis alleviates inflammatory response in murine arthritis and in human rheumatoid synovial fibroblasts.
TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model.
The promoting effect of MMP13 on mediating the development of HFLS-RA by the target of miR-19a through IL-17 signaling pathway.
Thrombin promotes matrix metalloproteinase-13 expression through the PKC? c-Src/EGFR/PI3K/Akt/AP-1 signaling pathway in human chondrocytes.
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors.
UP1306: A Composition Containing Standardized Extracts of Acacia catechu and Morus alba for Arthritis Management.
YB-1 binds to the MMP-13 promoter sequence and represses MMP-13 transactivation via the AP-1 site.
Arthritis, Experimental
In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis.
Madecassoside impedes invasion of rheumatoid fibroblast-like synoviocyte from adjuvant arthritis rats via inhibition of NF-?B-mediated matrix metalloproteinase-13 expression.
UP1306: A Composition Containing Standardized Extracts of Acacia catechu and Morus alba for Arthritis Management.
[Effect of electroacupuncture on articular morphological changes and serum inflammatory factors and synovial MMPs in collagen-induced arthritis rats].
Arthritis, Infectious
Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13.
Arthritis, Psoriatic
Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients.
Arthritis, Rheumatoid
15-deoxy-?(12,14) -prostaglandin-J2 and Ciglitazone Inhibit TNF-?-induced matrix metalloproteinase 13 production via the antagonism of NF-?B activation in human synovial fibroblasts.
Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators.
Anti-inflammatory and anti-arthritic effects of the ethanolic extract of Aralia continentalis Kitag. in IL-1?-stimulated human fibroblast-like synoviocytes and rodent models of polyarthritis and nociception.
CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis.
Characterisation of the cell type-specificity of collagenase 3 mRNA expression in comparison with membrane type 1 matrix metalloproteinase and gelatinase A in the synovial membrane in rheumatoid arthritis.
Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis.
Cheminformatics-based drug design approach for identification of inhibitors targeting the characteristic residues of MMP-13 hemopexin domain.
Cloning of collagenase 3 from the synovial membrane and its expression in rheumatoid arthritis and osteoarthritis.
Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1).
Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta.
Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus-hard tissue junction and inhibition by alendronate.
Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis.
Contribution of an adenine to guanine single nucleotide polymorphism of the matrix metalloproteinase-13 (MMP-13) -77 promoter region to the production of anticyclic citrullinated peptide antibodies in patients with HLA-DRB1*shared epitope-negative rheumatoid arthritis.
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.
Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis.
Effect of the oral application of a highly selective MMP-13 inhibitor in three different animal models of rheumatoid arthritis.
Effects of celecoxib on human chondrocytes--enhanced production of chemokines.
Expression of interleukin-1 beta, tumor necrosis factor alpha, interleukins-6, -10 and -4, and metalloproteases by freshly isolated mononuclear cells from early never-treated and non-acute treated rheumatoid arthritis patients.
In Vivo Dual Fluorescence Imaging to Detect Joint Destruction.
Indole Inhibitors of MMP-13 for Arthritic Disorders.
Induction of collagenase-3 (MMP-13) in rheumatoid arthritis synovial fibroblasts.
Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium.
Messenger-RNA expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and transcription factors in rheumatic synovial cells under mechanical stimuli.
MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts.
Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes.
RANTES/CCL5 Induces Collagen Degradation by Activating MMP-1 and MMP-13 Expression in Human Rheumatoid Arthritis Synovial Fibroblasts.
Reduction of cytokine-induced expression and activity of MMP-1 and MMP-13 by mechanical strain in MH7A rheumatoid synovial cells.
Retinoic Acid-Platinum (II) Complex [RT-Pt(II)] Protects Against Rheumatoid Arthritis in Mice via MEK/Nuclear Factor kappa B (NF-?B) Pathway Downregulation.
Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with early rheumatoid arthritis.
Stimulation of collagenase 3 expression in synovial fibroblasts of patients with rheumatoid arthritis by contact with a three-dimensional collagen matrix or with normal cartilage when coimplanted in NOD/SCID mice.
T cells regulate the expression of matrix metalloproteinase in human osteoblasts via a dual mitogen-activated protein kinase mechanism.
Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1beta stimulated fibroblast-like synoviocytes.
The expression of collagenase 3 (MMP-13) mRNA in the synovial tissue is associated with histopathologic type II synovitis in rheumatoid arthritis.
The influence of alpha1-acid glycoprotein on collagenase-3 activity in early rheumatoid arthritis.
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors.
Variation in the matrix metalloproteinase-3, -7, -12 and -13 genes is associated with functional status in rheumatoid arthritis.
Wild type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13).
[Dynamics of matrix metalloproteinase (MMP)-13 in the patients with rheumatoid arthritis]
Asthma
Targeting matrix metalloproteinase-13 in bronchial epithelial repair.
Ataxia Telangiectasia
Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.
Atherosclerosis
Activation of inflammatory mediators and potential role of ah-receptor ligands in foam cell formation.
Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury.
Endothelial nitric oxide deficiency reduces MMP-13-mediated cleavage of ICAM-1 in vascular endothelium: a role in atherosclerosis.
FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13).
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.
MMP13 promoter polymorphism is associated with atherosclerosis in the abdominal aorta of young black males.
Non-Invasive Detection of Extracellular Matrix Metalloproteinase Inducer EMMPRIN, a New Therapeutic Target against Atherosclerosis, Inhibited by Endothelial Nitric Oxide.
Role of matrix metalloproteinase-8 in atherosclerosis.
Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions.
Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis.
Bacterial Infections
Identification and characterization of matrix metalloproteinase-13 sequence structure and expression during embryogenesis and infection in channel catfish (Ictalurus punctatus).
Barrett Esophagus
Active matrix metalloproteases are expressed early on and are high during the Barrett's esophagus malignancy sequence.
Basal Cell Nevus Syndrome
MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts.
Blister
Increased expression of matrix metalloproteinase-2, matrix metalloproteinase-9 and matrix metalloproteinase-13 in lesional skin of bullous pemphigoid.
Bone Cysts
Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis.
Bone Diseases
Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease.
Bone Neoplasms
Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-beta1-stimulated collagenase-3 expression in human breast cancer cells.
Transcriptional activation of collagenase-3 by transforming growth factor-beta1 is via MAPK and Smad pathways in human breast cancer cells.
Bone Resorption
A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis.
Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction.
AU-rich elements in the collagenase 3 mRNA mediate stabilization of the transcript by cortisol in osteoblasts.
Catabolic activity of osteoblast lineage cells contributes to osteoclastic bone resorption in vitro.
Differential regulation of MMP-13 (collagenase-3) and MMP-3 (stromelysin-1) in mouse calvariae.
Effects of 17 beta-estradiol on the expression of interstitial collagenases-8 and -13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells.
Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone.
Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human.
Expression of MMP-8 and MMP-13 in the development of periradicular lesions.
High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage.
Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase-13 promoter activation.
Immunolocalization of matrix metalloproteinase-13 on bone surface under osteoclasts in rat tibia.
Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice.
In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Interface membrane fibroblasts around aseptically loosened endoprostheses express MMP-13.
LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis.
Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity.
Mechanisms of glucocorticoid action in bone.
MiR-126-5p regulates osteoclast differentiation and bone resorption in giant cell tumor through inhibition of MMP-13.
MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.
Neural crest-mediated bone resorption is a determinant of species-specific jaw length.
Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo.
Parathyroid hormone increases the expression level of matrix metalloproteinase-13 in vivo.
Platelet-derived growth factor induces collagenase 3 transcription in osteoblasts through the activator protein 1 complex.
Psychological stress and aging: role of glucocorticoids (GCs).
Role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in bone destruction by breast cancer metastasis.
Silencing matrix metalloproteinase-13 (Mmp-13) reduces inflammatory bone resorption associated with LPS-induced periodontal disease in vivo.
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
The use of different analgesics in orthodontic tooth movements.
Transcriptional induction of matrix metalloproteinase-13 (collagenase-3) by 1alpha,25-dihydroxyvitamin D3 in mouse osteoblastic MC3T3-E1 cells.
Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2.
Triclosan Blocks Mmp 13 Expression in Hormone-Stimulated Osteoblasts.
[Electroacupuncture Intervention Improves Cartilage Degeneration and Subchondral Bone Osteoporosis of Knee-joint Possibly by Adjusting OPG/RANK/RANKL Signaling in Ovariectomized Rats].
Bowen's Disease
Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas.
Brain Infarction
A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke.
Brain Injuries
A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke.
Blood biomarkers to guide stroke thrombolysis.
Blood-brain barrier damage in vascular dementia.
Stroke biomarkers: Can they help us to guide stroke thrombolysis?
Stroke biomarkers: can they help us to guide stroke thrombolysis?
Brain Ischemia
Focal cerebral ischemia induces changes in both MMP-13 and aggrecan around individual neurons.
Matrix metalloproteinase-13 is activated and is found in the nucleus of neural cells after cerebral ischemia.
Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice.
Brain Neoplasms
Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature.
Breast Neoplasms
A computational study of non-coding RNAs on the regulation of activating transcription factor 3 in human breast cancer cells.
A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas.
Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13).
An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer.
Biochemical characterization of human collagenase-3.
Breast cancer dissemination promoted by a neuregulin-collagenase 3 signalling node.
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Cloning of collagenase 3 from the synovial membrane and its expression in rheumatoid arthritis and osteoarthritis.
Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.
Cobalt chloride-induced hypoxia modulates the invasive potential and matrix metalloproteinases of primary and metastatic breast cancer cells.
Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.
Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor.
Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development.
Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx.
Constitutive expression and regulation of collagenase-3 in human breast cancer cells.
Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes.
Differential effects of transforming growth factor-beta on the expression of collagenase-1 and collagenase-3 in human fibroblasts.
Differential expression of matrix metalloproteinase-13 in association with invasion of breast cancer.
Elevated expression of MMP-13 and TIMP-1 in head and neck squamous cell carcinomas may reflect increased tumor invasiveness.
ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.
Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors.
Expression of collagenase-3 in the rat ovary during the ovulatory process.
Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) - experimental validation in human breast and colon cancer.
Golgi Membrane Protein 1 (GOLM1) Promotes Growth and Metastasis of Breast Cancer Cells via Regulating Matrix Metalloproteinase-13 (MMP13).
Gremlin-1 Promotes Metastasis of Breast Cancer Cells by Activating STAT3-MMP13 Signaling Pathway.
Human breast cancer cell-mediated bone collagen degradation requires plasminogen activation and matrix metalloproteinase activity.
In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Induction of MMP-13 expression in bone-metastasizing cancer cells by type I collagen through integrin ?1?1 and ?2?1-p38 MAPK signaling.
Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?
Long non-coding RNA LINC00511/miR-150/MMP13 axis promotes breast cancer proliferation, migration and invasion.
Many new down- and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancers.
Markers of breast cancer stromal fibroblasts in the primary tumour site associated with lymph node metastasis: a systematic review including our case series.
Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface.
Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability.
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.
Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression.
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: the role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.
MicroRNA-148a inhibits migration of breast cancer cells by targeting MMP-13.
miR-130b-3p inhibits cell invasion and migration by targeting the Notch ligand Delta-like 1 in breast carcinoma.
MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.
MMP13 is potentially a new tumor marker for breast cancer diagnosis.
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
New pathway links from cancer-progression determinants to gene expression of matrix metalloproteinases in breast cancer cells.
New signaling pathways from cancer progression modulators to mRNA expression of matrix metalloproteinases in breast cancer cells.
P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway.
Parathyroid hormone-related peptide regulates matrix metalloproteinase-13 gene expression in bone metastatic breast cancer cells.
Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis.
Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression.
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion.
Quantitative real-time RT-PCR of ITGA7, SVEP1, TNS1, LPHN3, SEMA3G, KLB and MMP13 mRNA expression in breast cancer.
Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions.
Regulation of the prometastatic neuregulin-MMP13 axis by SRC family kinases: therapeutic implications.
RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13.
RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion.
S100A4 Elevation Empowers Expression of Metastasis Effector Molecules in Human Breast Cancer.
S100A4 promotes invasion and angiogenesis in breast cancer MDA-MB-231 cells by upregulating matrix metalloproteinase-13.
Slit2 inhibits breast cancer metastasis by activating M1-like phagocytic and anti-fibrotic macrophages.
Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-beta1-stimulated collagenase-3 expression in human breast cancer cells.
Stimulation of ATF3 interaction with Smad4 via TGF-?1 for matrix metalloproteinase 13 gene activation in human breast cancer cells.
Stromal cells associated with early invasive foci in human mammary ductal carcinoma in situ coexpress urokinase and urokinase receptor.
Stromal matrix metalloprotease-13 knockout alters Collagen I structure at the tumor-host interface and increases lung metastasis of C57BL/6 syngeneic E0771 mammary tumor cells.
Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13).
The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain.
The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family.
Toll like receptor-9 agonists stimulate prostate cancer invasion in vitro.
Toll-Like Receptor 9 Agonists Promote Cellular Invasion by Increasing Matrix Metalloproteinase Activity.
Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity.
Transcriptional activation of collagenase-3 by transforming growth factor-beta1 is via MAPK and Smad pathways in human breast cancer cells.
Transforming growth factor-?1 regulation of ATF-3, c-Jun and JunB proteins for activation of matrix metalloproteinase-13 gene in human breast cancer cells.
Transforming growth factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells.
Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer.
Tumor-Derived Matrix Metalloproteinase-13 (MMP-13) Expression in Benign and Malignant Breast Lesions.
Upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer.
Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13.
[Relationship between the expression of matrix metalloproteinase-13 protein and other biomarkers, prognosis in invasive breast cancer]
Bursitis
Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: a case-control study.
Carcinogenesis
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.
Extracellular signal-regulated kinase transmits palytoxin-stimulated signals leading to altered gene expression in mouse keratinocytes.
Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production.
Human collagenase-3 is expressed in malignant squamous epithelium of the skin.
Increase of MMP-13 expression in multi-stage oral carcinogenesis and epigallocatechin-3-gallate suppress MMP-13 expression.
Matrix metalloproteinase-13 expression in the progression of colorectal adenoma to carcinoma : Matrix metalloproteinase-13 expression in the colorectal adenoma and carcinoma.
Mitogen activated protein kinases selectively regulate palytoxin-stimulated gene expression in mouse keratinocytes.
Olive Leaf Extract and Its Main Component Oleuropein Prevent Chronic Ultraviolet B Radiation-Induced Skin Damage and Carcinogenesis in Hairless Mice.
Overexpression of MMP13 is associated with clinical outcomes and poor prognosis in oral squamous cell carcinoma.
PLD1 promotes tumor invasion by regulation of MMP-13 expression via NF-?B signaling in bladder cancer.
The Sp1-mediaded allelic regulation of MMP13 expression by an ESCC susceptibility SNP rs2252070.
Tumor promoter-induced MMP-13 gene expression in a model of initiated epidermis.
Carcinoma
Activation of pro-MMP-2 mediated by MT1-MMP in human salivary gland carcinomas: possible regulation of pro-MMP-2 activation by TIMP-2.
Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells.
AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression.
Alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells.
Association of polymorphisms in IL-8, MMP-1 and MMP-13 with the risk and prognosis of oral and oropharyngeal squamous cell carcinoma.
Circulating IgG response to stromelysin-3, collagenase-3, galectin-3 and mesothelin in patients with pharynx/larynx squamous cell carcinoma.
Clinical relevance of matrix metalloproteinase-13 determined with a new highly specific and sensitive ELISA in ascitic fluid of advanced ovarian carcinoma patients.
Clinical significance of serum matrix metalloproteinase-13 levels in patients with esophageal squamous cell carcinoma (ESCC).
Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx.
Colorectal signet ring cell carcinoma: Influence of EGFR, E-cadherin and MMP-13 expression on clinicopathological features and prognosis.
Common polymorphism in the MMP-13 gene may contribute to the risk of human cancers: a meta-analysis.
Correlation Between the Expression of Matrix Metalloproteinase-9, Matrix Metalloproteinase-13, Tissue Inhibitor of Metalloproteinases-1, p16 and Differentiation of Head and Neck Squamous Cell Carcinoma: A Prospective Observational Study.
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.
Crosstalk between MMP-13, CD44, and TWIST1 and its role in regulation of EMT in patients with esophageal squamous cell carcinoma.
CXCR4 promotes oral squamous cell carcinoma migration and invasion through inducing expression of MMP-9 and MMP-13 via the ERK signaling pathway.
Differential expression of matrix metalloproteinase-13 in mucinous and nonmucinous colorectal carcinomas.
Effects of selective MMP-13 inhibition in Squamous Cell Carcinoma depend on estrogen.
Elevated expression of MMP-13 and TIMP-1 in head and neck squamous cell carcinomas may reflect increased tumor invasiveness.
ETS-1 regulates vascular endothelial growth factor-induced matrix metalloproteinase-9 and matrix metalloproteinase-13 expression in human ovarian carcinoma cell SKOV-3.
Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry
Expression of collagenase-1 (MMP-1), collagenase-3 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in laryngeal squamous cell carcinomas.
Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer.
Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck.
Expression of collagenase-3 (matrix metalloproteinase-13) in transitional-cell carcinoma of the urinary bladder.
Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase.
Expression of collagenase-3 (MMP-13) by tumor cells in squamous cell carcinomas of the head and neck.
Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells.
Expression of CXCR4, MMP-13 and ?-catenin in different histological subtypes of facial basal cell carcinoma.
Expression of matrix metalloproteinases and their specific inhibitors in normal and different human thyroid tumor cell lines.
Expression of MMP-13 is associated with invasion and metastasis of papillary thyroid carcinoma.
Expression of MMP-3, MMP-13, TIMP-2 and TIMP-3 in the VX2 carcinoma of the New Zealand white rabbit.
FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.
Human collagenase-3 is expressed in malignant squamous epithelium of the skin.
Identification of GOLM1 as a positively regulator of tumor metastasis by regulating MMP13 in gastric carcinoma.
Increase of MMP-13 expression in multi-stage oral carcinogenesis and epigallocatechin-3-gallate suppress MMP-13 expression.
Increased expression of collagenase-3 (MMP-13) and MT1-MMP in oesophageal cancer is related to cancer aggressiveness.
Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-gamma is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1.
Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression.
Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways.
Involvement of matrix metalloproteinase-13 in stromal-cell-derived factor 1 alpha-directed invasion of human basal cell carcinoma cells.
Matrix metalloproteinase (MMP)-1, -9 and -13 as prognostic factors in salivary gland cancer.
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.
Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma.
Matrix metalloproteinase-13 expression in the progression of colorectal adenoma to carcinoma : Matrix metalloproteinase-13 expression in the colorectal adenoma and carcinoma.
MicroRNA-27b-3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP-13.
MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1.
MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma.
MMP13 can be a useful differentiating marker between squamous cell carcinoma and benign hyperkeratotic lesions in recessive dystrophic epidermolysis bullosa.
MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13.
Nanocapsulated quercetin downregulates rat hepatic MMP-13 and controls diethylnitrosamine-induced carcinoma.
Nucleolin binds specifically to an AP-1 DNA sequence and represses AP1-dependent transactivation of the matrix metalloproteinase-13 gene.
Overexpression of MMP13 is associated with clinical outcomes and poor prognosis in oral squamous cell carcinoma.
Pathophysiological changes induced by Pseudomonas aeruginosa infection are involved in MMP-12 and MMP-13 upregulation in human carcinoma epithelial cells and a pneumonia mouse model.
Prognostic value of matrix metalloproteinases in oral squamous cell carcinoma.
Regulation of MMP13 by antitumor microRNA-375 markedly inhibits cancer cell migration and invasion in esophageal squamous cell carcinoma.
Role of matrix metalloproteinase 13 gene expression in the evaluation of radiation response in oral squamous cell carcinoma.
Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
Secretion of N- and O-linked Glycoproteins from 4T1 Murine Mammary Carcinoma Cells.
Serum and saliva collagenase-3 (MMP-13) in patients with oral lichen planus and oral squamous cell carcinoma.
Serum matrix metalloproteinase-13 as a diagnostic biomarker for cutaneous squamous cell carcinoma.
Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line.
Targeted inhibition of human collagenase-3 (MMP-13) expression inhibits squamous cell carcinoma growth in vivo.
The functional polymorphisms on promoter region of matrix metalloproteinase-12, -13 genes may alter the risk of epithelial ovarian carcinoma in chinese.
The immunoexpression of MMP-1 and MMP-13 in eyelid basal cell carcinoma.
The usefulness of new serum tumor markers in head and neck squamous cell carcinoma.
Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas.
Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer.
Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor ?B Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model.
Vascular expression of matrix metalloproteinase-13 (collagenase-3) in basal cell carcinoma.
Withdrawal: ETS-1 protein regulates vascular endothelial growth factor-induced matrix metalloproteinase-9 and matrix metalloproteinase-13 expression in human ovarian carcinoma cell line SKOV-3.
[Association of functional polymorphisms on MMP-12 and MMP-13 gene promoter region with epithelial ovarian carcinoma.]
[Collagenase 3 mRNA expression in squamous epithelial carcinomas of the oropharynx]
[Collagenase-3 (MMP-13) expression in epithelial cancers of the eyelids]
[Diagnostic value of E-cadherin, MMP-9, activated MMP-13 and anti-p53 antibodies in squamous cell carcinomas of head and neck]
[Expression and clinical significance of collagenase-3 (MMP-13) in gastric cancer]
[Matrix metalloproteinases and their tissue inhibitors in malignancies of the female genital tract]
[Relationship between the expression of matrix metalloproteinase-13 protein and other biomarkers, prognosis in invasive breast cancer]
[The association of MMP-13 polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adeno-carcinoma]
Carcinoma, Acinar Cell
Matrix metalloproteinase (MMP)-1, -9 and -13 as prognostic factors in salivary gland cancer.
Carcinoma, Basal Cell
Expression of CXCR4, MMP-13 and ?-catenin in different histological subtypes of facial basal cell carcinoma.
Human collagenase-3 is expressed in malignant squamous epithelium of the skin.
Involvement of matrix metalloproteinase-13 in stromal-cell-derived factor 1 alpha-directed invasion of human basal cell carcinoma cells.
The immunoexpression of MMP-1 and MMP-13 in eyelid basal cell carcinoma.
Vascular expression of matrix metalloproteinase-13 (collagenase-3) in basal cell carcinoma.
[Collagenase-3 (MMP-13) expression in epithelial cancers of the eyelids]
Carcinoma, Ductal
Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.
Tumor-Derived Matrix Metalloproteinase-13 (MMP-13) Expression in Benign and Malignant Breast Lesions.
Carcinoma, Hepatocellular
Functional polymorphisms in the promoters of MMP-1, MMP-2, MMP-3, MMP-9, MMP-12 and MMP-13 are not associated with hepatocellular carcinoma risk.
Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion.
No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population.
Carcinoma, Intraductal, Noninfiltrating
Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.
Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events.
Gene expression profiling during rat mammary carcinogenesis induced by 7,12-dimethylbenz[a]anthracene.
Carcinoma, Lobular
Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.
Carcinoma, Non-Small-Cell Lung
Association of MMP9-1562C/T and MMP13-77A/G Polymorphisms with Non-Small Cell Lung Cancer in Southern Chinese Population.
Matrix metalloproteinase 13: a potential intermediate between low expression of microRNA-125b and increasing metastatic potential of non-small cell lung cancer.
Matrix metalloproteinase-13 expression is associated with bone marrow microinvolvement and prognosis in non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
The functional polymorphisms on promoter region of matrix metalloproteinase-12, -13 genes may alter the risk of epithelial ovarian carcinoma in chinese.
[Association of functional polymorphisms on MMP-12 and MMP-13 gene promoter region with epithelial ovarian carcinoma.]
Carcinoma, Renal Cell
MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1.
Suppressed Expression but Not Activity of Collagenases MMP-1 and MMP-13 in Human Renal Carcinoma.
Suppression of tunicamycin-induced CD44v6 ectodomain shedding and apoptosis is correlated with temporal expression patterns of active ADAM10, MMP-9 and MMP-13 proteins in Caki-2 renal carcinoma cells.
Carcinoma, Signet Ring Cell
Colorectal signet ring cell carcinoma: Influence of EGFR, E-cadherin and MMP-13 expression on clinicopathological features and prognosis.
Carcinoma, Squamous Cell
Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells.
Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells.
Alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells.
Association of polymorphisms in IL-8, MMP-1 and MMP-13 with the risk and prognosis of oral and oropharyngeal squamous cell carcinoma.
Circulating IgG response to stromelysin-3, collagenase-3, galectin-3 and mesothelin in patients with pharynx/larynx squamous cell carcinoma.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx.
Complement factor I upregulates expression of matrix metalloproteinase-13 and -2 and promotes invasion of cutaneous squamous carcinoma cells.
Correlation Between the Expression of Matrix Metalloproteinase-9, Matrix Metalloproteinase-13, Tissue Inhibitor of Metalloproteinases-1, p16 and Differentiation of Head and Neck Squamous Cell Carcinoma: A Prospective Observational Study.
Effects of selective MMP-13 inhibition in Squamous Cell Carcinoma depend on estrogen.
Elevated expression of MMP-13 and TIMP-1 in head and neck squamous cell carcinomas may reflect increased tumor invasiveness.
Expression of collagenase-1 (MMP-1), collagenase-3 (MMP-13) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in laryngeal squamous cell carcinomas.
Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck.
Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase.
Expression of collagenase-3 (MMP-13) by tumor cells in squamous cell carcinomas of the head and neck.
Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells.
Human collagenase-3 is expressed in malignant squamous epithelium of the skin.
Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-gamma is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1.
MicroRNA-27b-3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP-13.
MMP13 can be a useful differentiating marker between squamous cell carcinoma and benign hyperkeratotic lesions in recessive dystrophic epidermolysis bullosa.
Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
Serum matrix metalloproteinase-13 as a diagnostic biomarker for cutaneous squamous cell carcinoma.
Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line.
Targeted inhibition of human collagenase-3 (MMP-13) expression inhibits squamous cell carcinoma growth in vivo.
The usefulness of new serum tumor markers in head and neck squamous cell carcinoma.
Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas.
[Collagenase 3 mRNA expression in squamous epithelial carcinomas of the oropharynx]
[Collagenase-3 (MMP-13) expression in epithelial cancers of the eyelids]
[Diagnostic value of E-cadherin, MMP-9, activated MMP-13 and anti-p53 antibodies in squamous cell carcinomas of head and neck]
[Matrix metalloproteinases and their tissue inhibitors in malignancies of the female genital tract]
Cardiovascular Diseases
Serum tissue-degrading proteinases and incident cardiovascular disease events.
Cholestasis
Secondary biliary cirrhosis in the rat is prevented by decreasing NF-?B nuclear translocation and TGF-? expression using allopurinol, an inhibitor of xanthine oxidase.
Cholesteatoma
Evaluation of significant gene expression changes in congenital and acquired cholesteatoma.
The localization of matrix metalloproteinases-8 and -13 in cholesteatoma, deep-meatal and post-auricular skin: a comparative analysis.
[The expression and significance of DDR2 and MMP-13in human middle ear cholesteatoma].
Cholesteatoma, Middle Ear
[The expression and significance of DDR2 and MMP-13in human middle ear cholesteatoma].
Chondroma
Expression of MMPs is dependent on the activity of mitogen-activated protein kinase in chondrosarcoma.
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma.
Chondrosarcoma
alpha-MSH inhibits TNF-alpha-induced matrix metalloproteinase-13 expression by modulating p38 kinase and nuclear factor kappaB signaling in human chondrosarcoma HTB-94 cells.
Bone morphogenetic protein-2 enhances the motility of chondrosarcoma cells via activation of matrix metalloproteinase-13.
Carnosol and Related Substances Modulate Chemokine and Cytokine Production in Macrophages and Chondrocytes.
CCAAT-Enhancer-binding protein beta activation of MMP-1 gene expression in SW1353 cells: independent roles of extracellular signal-regulated and p90/Ribosomal S6 kinases.
CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin dependent pathway.
Characterization and regulation of ADAMTS-16.
Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model.
Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression.
Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor.
Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis.
CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells.
Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells.
Cysteine proteinases in chondrosarcomas.
Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects.
Downregulation of Matrix Metalloproteinase-13 by the Root Extract of Cyathula officinalis Kuan and its Constituents in IL-1?-treated Chondrocytes.
Doxycycline and its quaternary ammonium derivative for adjuvant therapies of chondrosarcoma.
Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways.
Expression of collagenase-3 (matrix metalloproteinase-13) in transitional-cell carcinoma of the urinary bladder.
Expression of collagenase-3 (MMP-13) in c-fos-induced osteosarcomas and chondrosarcomas is restricted to a subset of cells of the osteo-/chondrogenic lineage.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas.
Expression of MMP-9 decreases metastatic potential of Chondrosarcoma: an immunohistochemical study.
Expression of MMPs is dependent on the activity of mitogen-activated protein kinase in chondrosarcoma.
Ginsenoside Rb1 inhibits matrix metalloproteinase 13 through down-regulating Notch signaling pathway in osteoarthritis.
IL-6 Increases MMP-13 Expression and Motility in Human Chondrosarcoma Cells.
Increased receptor activator of nuclear factor ?? ligand/osteoprotegerin ratio exacerbates cartilage destruction in osteoarthritis in vitro.
Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes.
Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3.
Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?
Matrix metalloproteinase-13 expression in IL-1?-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways.
Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes.
Novel p38 mitogen-activated protein kinase inhibitor R-130823 protects cartilage by down-regulating matrix metalloproteinase-1,-13 and prostaglandin E2 production in human chondrocytes.
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma.
Quercitrin alleviates cartilage extracellular matrix degradation and delays ACLT rat osteoarthritis development: An in vivo and in vitro study.
Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression.
Rho iso-alpha acids from hops inhibit the GSK-3/NF-kappaB pathway and reduce inflammatory markers associated with bone and cartilage degradation.
Roxatidine Attenuates Degradation of Extracellular Matrix.
SOX9 Knockout Induces Polyploidy and Changes Sensitivity to Tumor Treatment Strategies in a Chondrosarcoma Cell Line.
Suppressed invasive and migratory behaviors of SW1353 chondrosarcoma cells through the regulation of Src, Rac1 GTPase, and MMP13.
The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes.
Thrombin enhanced migration and MMPs expression of human chondrosarcoma cells involves PAR receptor signaling pathway.
Chorioamnionitis
Prolidase, matrix metalloproteinases 1 and 13 activity, oxidative-antioxidative status as a marker of preterm premature rupture of membranes and chorioamnionitis in maternal vaginal washing fluids.
Choriocarcinoma
Matrix metalloproteinases and their inhibitors in gestational trophoblastic diseases and normal placenta.
Choroidal Neovascularization
Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization.
Chronic Periodontitis
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells.
Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue.
Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation.
Evaluation of collagenase-3 matrix metalloproteinase-13 gene-associated polymorphisms 11A/12A and -77A/G and its associated alleles with and without periodontitis.
Immunohistochemical expression of matrix metalloproteinase 13 in chronic periodontitis.
Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity.
MMP-13 and TIMP-1 determinations in progressive chronic periodontitis.
MMP-13 promoter polymorphisms in patients with chronic periodontitis: effects on GCF MMP-13 levels and outcome of periodontal therapy.
MMP13, TIMP2 and TGFB3 Gene Polymorphisms in Brazilian Chronic Periodontitis and Periimplantitis Subjects.
Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade.
Colitis
Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice.
Cellular sources of MMP-7, MMP-13 and MMP-28 in ulcerative colitis.
Macrophage migration inhibitory factor contributes to the development of acute dextran sulphate sodium-induced colitis in Toll-like receptor 4 knockout mice.
TNF? cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis.
Colitis, Ischemic
Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.
Colitis, Ulcerative
Cellular sources of MMP-7, MMP-13 and MMP-28 in ulcerative colitis.
Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
Colonic Neoplasms
A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion.
Clinical value of microRNA-135a and MMP-13 in colon cancer.
Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) - experimental validation in human breast and colon cancer.
ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.
Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population.
ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging.
Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, -3, and -13 gene expression by multiplex PCR in colorectal carcinomas.
Colorectal Neoplasms
Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population.
Clinicopathological significance and prognostic value of MMP-13 expression in colorectal cancer.
Differential expression of Janus kinase 3 (JAK3), matrix metalloproteinase 13 (MMP13), heat shock protein 60 (HSP60), and mouse double minute 2 (MDM2) in human colorectal cancer progression using human cancer cDNA microarrays.
Differential expression of matrix metalloproteinase-13 in mucinous and nonmucinous colorectal carcinomas.
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
ING Proteins as Potential Anticancer Drug Targets.
ING2, a tumor associated gene, enhances PAI?1 and HSPA1A expression with HDAC1 and mSin3A through the PHD domain and C?terminal.
Low collagenase-1 (MMP-1) and MT1-MMP expression levels are favourable survival markers in advanced colorectal carcinoma.
Matrix metalloproteinase 13 activity is associated with poor prognosis in colorectal cancer.
Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration.
Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
Microcystin-LR promotes migration and invasion of colorectal cancer through matrix metalloproteinase-13 up-regulation.
MMP13 is a potential prognostic marker for colorectal cancer.
Overexpression of MMP-13 gene in colorectal cancer with liver metastasis.
Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, -3, and -13 gene expression by multiplex PCR in colorectal carcinomas.
The Expression and Significance of CXCR5 and MMP-13 in Colorectal Cancer.
Communicable Diseases
Differential expression of matrix metalloproteinases in bacterial meningitis.
Connective Tissue Diseases
Serum levels of matrix metalloproteinase-13 in patients with eosinophilic fasciitis.
Corneal Diseases
Thymic stromal lymphopoietin is expressed in human corneal stromal cells and secreted upon protease-activated receptor 1 activation.
Corneal Neovascularization
Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.
Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye.
Coronary Artery Disease
High plasma levels of matrix metalloproteinase-8 in patients with unstable angina.
Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome.
Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease.
The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease.
Craniofacial Abnormalities
Matrix Metalloproteinase-13 Is Required for Zebra fish (Danio rerio) Development and Is a Target for Glucocorticoids.
Crohn Disease
Distinct expression profiles of stromelysin-2 (MMP-10), collagenase-3 (MMP-13), macrophage metalloelastase (MMP-12), and tissue inhibitor of metalloproteinases-3 (TIMP-3) in intestinal ulcerations.
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
Cysts
High matrix metalloproteinase activity is a hallmark of periapical granulomas.
MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts.
MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma.
Dementia, Vascular
Blood-brain barrier damage in vascular dementia.
Dental Caries
Association of ENAM, TUFT1, MMP13, IL1B, IL10 and IL1RN gene polymorphism and dental caries susceptibility in Chinese children.
Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis.
Matrix metalloproteinases gene variants and dental caries in Czech children.
MMP13 Contributes to Dental Caries Associated with Developmental Defects of Enamel.
MMP13 polymorphism decreases risk for dental caries.
Dermatitis
Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis.
Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression.
Diabetes Mellitus
Crevicular fluid matrix metalloproteinase-8, -13, and TIMP-1 levels in type 2 diabetics.
Effect of Subantimicrobial Dose Doxycycline Treatment on Gingival Crevicular Fluid Levels of MMP-9 and MMP-13 in Periodontitis Stage 2, Grade B in Subjects with Type 2 Diabetes Mellitus.
Matrix metalloproteinase 13 in the ligamentum flavum from lumbar spinal canal stenosis patients with and without diabetes mellitus.
Diabetes Mellitus, Type 1
The skin remodeling in type 1 diabetes and insulin resistance animal models.
Diabetes Mellitus, Type 2
Crevicular fluid matrix metalloproteinase-8, -13, and TIMP-1 levels in type 2 diabetics.
Effect of Subantimicrobial Dose Doxycycline Treatment on Gingival Crevicular Fluid Levels of MMP-9 and MMP-13 in Periodontitis Stage 2, Grade B in Subjects with Type 2 Diabetes Mellitus.
Diabetic Neuropathies
Oxidative stress-dependent MMP-13 activity underlies glucose neurotoxicity.
Diverticulitis
Collagenase-3 (MMP-13) expression by inflamed mucosa in inflammatory bowel disease.
Comparative analysis of the expression of metalloproteases and their inhibitors in resected crohn's disease and complicated diverticular disease.
Dwarfism
FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.
Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway: a new model of osteoarthritis.
The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation.
Dysplastic Nevus Syndrome
Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma.
Endometriosis
Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression.
Matrix metalloproteinase-13 and membrane type-1 matrix metalloproteinase in peritoneal fluid of women with endometriosis.
[Association of matrix metalloproteinases' polymorphisms of MMP3 and MMP9 with development of genital endometriosis].
Epidermolysis Bullosa Dystrophica
MMP13 can be a useful differentiating marker between squamous cell carcinoma and benign hyperkeratotic lesions in recessive dystrophic epidermolysis bullosa.
Erythema
Noninvasive Assessment of UV-induced Skin Damage: Comparison of Optical Measurements to Histology and MMP Expression.
Esophageal Neoplasms
The Sp1-mediaded allelic regulation of MMP13 expression by an ESCC susceptibility SNP rs2252070.
Esophageal Squamous Cell Carcinoma
AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression.
Clinical significance of serum matrix metalloproteinase-13 levels in patients with esophageal squamous cell carcinoma (ESCC).
Crosstalk between MMP-13, CD44, and TWIST1 and its role in regulation of EMT in patients with esophageal squamous cell carcinoma.
FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.
Increase of MMP-13 expression in multi-stage oral carcinogenesis and epigallocatechin-3-gallate suppress MMP-13 expression.
Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma.
MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13.
Regulation of MMP13 by antitumor microRNA-375 markedly inhibits cancer cell migration and invasion in esophageal squamous cell carcinoma.
[The association of MMP-13 polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adeno-carcinoma]
Fasciitis
Serum levels of matrix metalloproteinase-13 in patients with eosinophilic fasciitis.
Fibroadenoma
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
Fibromatosis, Aggressive
Invasion and MMP expression profile in desmoid tumours.
Fibromatosis, Gingival
The Effect of MMP-13, MMP-12, and AMBN on Gingival Enlargement and Root Deformation In a New Type of Gingival Fibromatosis.
Fibrosarcoma
Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells.
Identification of matrix metalloproteinase inhibitors by chemical arrays.
Fluorosis, Dental
Polymorphisms in genes involved in enamel development are associated with dental fluorosis.
Gallbladder Neoplasms
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.
gelatinase b deficiency
Histochemical aspects of the vascular invasion at the erosion zone of the epiphyseal cartilage in MMP-9-deficient mice.
Giant Cell Tumor of Bone
AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone.
Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone.
Giant Cell Tumors
AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone.
Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone.
MiR-126-5p regulates osteoclast differentiation and bone resorption in giant cell tumor through inhibition of MMP-13.
Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor.
Gingival Overgrowth
The Effect of MMP-13, MMP-12, and AMBN on Gingival Enlargement and Root Deformation In a New Type of Gingival Fibromatosis.
Gingival Pocket
Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation.
Gingival Recession
Triclosan Blocks Mmp 13 Expression in Hormone-Stimulated Osteoblasts.
Gingivitis
Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases.
Glioblastoma
Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity.
Ginsenoside Rh2 inhibits metastasis of glioblastoma multiforme through Akt-regulated MMP13.
Osthole suppresses the migratory ability of human glioblastoma multiforme cells via inhibition of focal adhesion kinase-mediated matrix metalloproteinase-13 expression.
Glioma
Abnormal increase of miR-4262 promotes cell proliferation and migration by targeting large tumor suppressor 1 in gliomas.
Exogenous endothelin-1 induces cell migration and matrix metalloproteinase expression in U251 human glioblastoma multiforme.
Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in glioma cells.
Increased expression of matrix metalloproteinase-13 in glioma is associated with poor overall survival of patients.
Leptin induces migration and invasion of glioma cells through MMP-13 production.
RUNX2 Promotes Malignant Progression in Glioma.
Transactivation by Runt related factor-2 of matrix metalloproteinase-13 in astrocytes.
Granuloma
Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15II in Murine Model.
High matrix metalloproteinase activity is a hallmark of periapical granulomas.
Hamartoma
Expression of matrix metalloproteinases and their endogenous tissue inhibitors in skin lesions from patients with tuberous sclerosis.
Head and Neck Neoplasms
Association between high collagenase-3 expression levels and poor prognosis in patients with head and neck cancer.
Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma.
Heart Diseases
The cloning and functional analysis of canine matrix metalloproteinase-13 gene promoter.
Heart Neoplasms
[The association of MMP-13 polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adeno-carcinoma]
Hidradenitis Suppurativa
Adalimumab Induces a Wound Healing Profile in Patients with Hidradenitis Suppurativa by Regulating Macrophage Differentiation and Matrix Metalloproteinase Expression.
Hypercalcemia
Parathyroid hormone increases the expression level of matrix metalloproteinase-13 in vivo.
Hypercholesterolemia
Rosuvastatin therapy does not affect serum MMP-13 or TIMP-1 levels in hypercholesterolemic patients.
Hyperglycemia
Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non-osmotic pathways.
PPAR? is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages.
Hyperhomocysteinemia
Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis.
Hyperostosis
Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas.
Hypertension
Estrogen effects on MMP-13 and MMP-14 regulation of left ventricular mass in Dahl salt-induced hypertension.
Idiopathic Pulmonary Fibrosis
Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis.
Infections
Collagenase-3 (MMP-13) in fetal membranes and amniotic fluid during pregnancy.
Effect of adenovirus-mediated overexpression of decorin on metalloproteinases, tissue inhibitors of metalloproteinases and cytokines secretion by human gingival fibroblasts.
Expression analysis of matrix metalloproteinase-13 in human gastric cancer in the presence of Helicobacter Pylori infection.
Higher molecular weight polyethylene glycol increases cell proliferation while improving barrier function in an in vitro colon cancer model.
Identification and characterization of matrix metalloproteinase-13 sequence structure and expression during embryogenesis and infection in channel catfish (Ictalurus punctatus).
Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression.
Matrix Metalloproteinase-13 as a Target for Suppressing Corneal Ulceration Caused by Pseudomonas aeruginosa Infection.
Matrix Metalloproteinase-13 in Atherosclerotic Plaque Is Increased by Influenza A Virus Infection.
Mayaro Virus Infects Human Chondrocytes and Induces the Expression of Arthritis-Related Genes Associated with Joint Degradation.
NF-?B/TWIST1 Mediates Migration and Phagocytosis of Macrophages in the Mice Model of Implant-Associated Staphylococcus aureus Osteomyelitis.
Pathophysiological changes induced by Pseudomonas aeruginosa infection are involved in MMP-12 and MMP-13 upregulation in human carcinoma epithelial cells and a pneumonia mouse model.
Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis.
Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye.
TGFbeta directs gene expression of activated microglia to an anti-inflammatory phenotype strongly focusing on chemokine genes and cell migratory genes.
Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase.
Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor ?B Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model.
Inflammatory Bowel Diseases
Collagenase-3 (MMP-13) expression by inflamed mucosa in inflammatory bowel disease.
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
Influenza, Human
Matrix Metalloproteinase-13 in Atherosclerotic Plaque Is Increased by Influenza A Virus Infection.
Insulin Resistance
The skin remodeling in type 1 diabetes and insulin resistance animal models.
Intervertebral Disc Degeneration
17?-Estradiol inhibits intervertebral disc degeneration by down-regulating MMP-3 and MMP-13 and up-regulating type II collagen in a rat model.
Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats.
Autophagy-activated nucleus pulposus cells deliver exosomal miR-27a to prevent extracellular matrix degradation by targeting MMP-13.
Bone morphogenic protein-2 signaling in human disc degeneration and correlation to the Pfirrmann MRI grading system.
BRD4 inhibition regulates MAPK, NF-?B signals, and autophagy to suppress MMP-13 expression in diabetic intervertebral disc degeneration.
Downregulation of miR-27b is Involved in Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 13 (MMP13) in Human Intervertebral Disc Degeneration.
Dysregulated miR-127-5p contributes to type II collagen degradation by targeting matrix metalloproteinase-13 in human intervertebral disc degeneration.
Elevated expression of hypoxia-inducible factor-2alpha regulated catabolic factors during intervertebral disc degeneration.
Interleukin-1? exacerbates the catabolic effects of human nucleus pulposus cells through activation of the Nuclear Factor kappa B signaling pathway under hypoxic conditions.
Lumbar Disc Degeneration is Facilitated by MiR-100-Mediated FGFR3 Suppression.
Rhizoma drynariae total flavonoids inhibit the inflammatory response and matrix degeneration via MAPK pathway in a rat degenerative cervical intervertebral disc model.
Salubrinal Suppresses IL-17-Induced Upregulation of MMP-13 and Extracellular Matrix Degradation Through the NF-kB Pathway in Human Nucleus Pulposus Cells.
Specific inhibitory protein Dkk-1 blocking Wnt/?-catenin signaling pathway improve protectives effect on the extracellular matrix.
[Effects of electroacupuncture stimulation of "Jiaji" (EX-B 2) on expression of matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-1 in intervertebral disc tissue in rabbits with lumbar intervertebral disc degeneration].
[Mechanism of Yiqi Huayu Bushen Recipe in treating cervical syndrome with kidney deficiency in rats]
Intervertebral Disc Displacement
The increased expression of matrix metalloproteinases associated with elastin degradation and fibrosis of the ligamentum flavum in patients with lumbar spinal stenosis.
Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with lumbar disc herniation.
Iron Overload
The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.
Ischemic Attack, Transient
Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice.
Ischemic Stroke
Profiles of matrix metalloproteinases, their inhibitors, and laminin in stroke patients: influence of different therapies.
Jaw Cysts
Collagenase-3 expression in periapical lesions: an immunohistochemical study.
Joint Diseases
Basic Fibroblast Growth Factor Activates the MAPK and NF{kappa}B Pathways That Converge on Elk-1 to Control Production of Matrix Metalloproteinase-13 by Human Adult Articular Chondrocytes.
Characterisation of the cell type-specificity of collagenase 3 mRNA expression in comparison with membrane type 1 matrix metalloproteinase and gelatinase A in the synovial membrane in rheumatoid arthritis.
Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis.
Joint diseases and matrix metalloproteinases: a role for MMP-13.
Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction.
Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13).
TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha.
Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excess.
Joint Instability
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.
Matrix metalloproteinase-13 expression in rabbit knee joint connective tissues: influence of maturation and response to injury.
Kallmann Syndrome
Cigarette smoke modulates PC3 prostate cancer cell migration by altering adhesion molecules and the extracellular matrix.
Kashin-Beck Disease
Morphology and Phenotype Expression of Types I, II, III, and X Collagen and MMP-13 of Chondrocytes Cultured from Articular Cartilage of Kashin-Beck Disease.
Keloid
Extracorporeal shockwave therapy for treatment of keloid scars.
Suppressed TGF-beta1 expression is correlated with up-regulation of matrix metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment.
Tissue Engineering for In Vitro Analysis of Matrix Metalloproteinases in the Pathogenesis of Keloid Lesions.
Tretinoin reverses upregulation of matrix metalloproteinase-13 in human keloid-derived fibroblasts.
Keratitis
Corneal Cross-Linking Has No Effect on Matrix Metalloproteinase 9 and 13 Levels During Fungal Keratitis on the Early Stage.
Keratoacanthoma
Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas.
Keratoconus
Collagenolytic proteinases in keratoconus.
Keratoconus: an inflammatory disorder?
Keratosis, Seborrheic
Human collagenase-3 is expressed in malignant squamous epithelium of the skin.
Leg Ulcer
Biomarker directed chronic wound therapy - A new treatment paradigm.
Expression of matrix metalloproteinase (MMP)-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds.
Leukemia
Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta.
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
Leukemia inhibitory factor and oncostatin M stimulate collagenase-3 expression in osteoblasts.
Leukoplakia, Oral
Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry
Lichen Planus, Oral
Salivary MMP-1, MMP-2, MMP-3 and MMP-13 Levels in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
Serum and saliva collagenase-3 (MMP-13) in patients with oral lichen planus and oral squamous cell carcinoma.
Liver Cirrhosis
Activity of MMP1 and MMP13 and amino acid metabolism in patients with alcoholic liver cirrhosis.
Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis.
Antifibrotic effect of MMP13-encoding plasmid DNA delivered using polyethylenimine shielded with hyaluronic acid.
Antifibrotic Effects of a Recombinant Adeno-Associated Virus Carrying Small Interfering RNA Targeting TIMP-1 in Rat Liver Fibrosis.
Carvedilol Attenuates the Progression of Hepatic Fibrosis Induced by Bile Duct Ligation.
Disruption of tissue-type plasminogen activator gene in mice aggravated liver fibrosis.
Effect of all-trans retinoic acid on liver fibrosis induced by common bile duct ligation in rats.
Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model.
Effects of Fibrotic Tissue on Liver-targeted Hydrodynamic Gene Delivery.
Effects of sub-chronic exposure to atmospheric PM2.5 on fibrosis, inflammation, endoplasmic reticulum stress and apoptosis in the livers of rats.
Enhanced interstitial collagenase (matrix metalloproteinase-13) production of Kupffer cell by gadolinium chloride prevents pig serum-induced rat liver fibrosis.
Expression pattern of matrix metalloproteinases-13 in a rat model of alcoholic liver fibrosis.
Extracellular matrix metabolism-related gene expression in bile duct-ligated rats.
Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride.
Gynura Rhizoma containing pyrrolizidine alkaloids induces the hepatic sinusoidal obstruction syndrome in mice via upregulating fibrosis-related factors.
Interleukin-1? upregulates matrix metalloproteinase-13 gene expression via c-Jun N-terminal kinase and p38 MAPK pathways in rat hepatic stellate cells.
Involvement of fibroblast-specific protein 1 (S100A4) and matrix metalloproteinase-13 (MMP-13) in CCl4-induced reversible liver fibrosis.
Liver repair and regeneration after ischemia-reperfusion injury is associated with prolonged fibrosis.
Loss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasis.
Matrix Metalloproteinase-13 Promotes Recovery from Experimental Liver Cirrhosis in Rats.
MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice.
Modified synthetic siRNA targeting tissue inhibitor of metalloproteinase-2 inhibits hepatic fibrogenesis in rats.
Protective effects of curcumin, ?-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats.
Reversibility of hepatic fibrosis: from the first report of collagenase in the liver to the possibility of gene therapy for recovery.
S-Nitroso-N-acetylcysteine induces de-differentiation of activated hepatic stellate cells and promotes antifibrotic effects in vitro.
Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats.
Tgfb3 and Mmp13 regulated the initiation of liver fibrosis progression as dynamic network biomarkers.
Thalidomide Accelerates the Degradation of Extracellular Matrix in Rat Hepatic Cirrhosis via Down-Regulation of Transforming Growth Factor-?1.
Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes.
[Dynamic evolution of MMP-13, TIMP-1, type I and III collagen and their interaction in experimental liver fibrosis]
[Gene expression of interstitial collagenase MMP-13 in progressive phase of rat liver fibrosis induced by ethanol]
[Preventive and therapeutic effects of Qiwei Yugan Granule on hepatic fibrosis in rats].
Liver Cirrhosis, Alcoholic
Activity of MMP1 and MMP13 and amino acid metabolism in patients with alcoholic liver cirrhosis.
Liver Cirrhosis, Experimental
Matrix Metalloproteinase-13 Promotes Recovery from Experimental Liver Cirrhosis in Rats.
Liver Diseases
Bcl-2 overexpression in hepatic stellate cell line CFSC-2G, induces a pro-fibrotic state.
Lung Diseases
Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism.
Lung Injury
Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury.
Deficiency of matrix metalloproteinase-13 increases inflammation after acute lung injury.
Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3).
Lung Neoplasms
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer.
Association of matrix metalloproteinase family gene polymorphisms with lung cancer risk: logistic regression and generalized odds of published data.
Association of MMP9-1562C/T and MMP13-77A/G Polymorphisms with Non-Small Cell Lung Cancer in Southern Chinese Population.
Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.
Effect of lentivirus-mediated integrin ?V?3-shRNA on tumor growth of mice with lung cancer xenografts.
Matrix metalloproteinase 13: a potential intermediate between low expression of microRNA-125b and increasing metastatic potential of non-small cell lung cancer.
Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis.
Matrix metalloproteinase-13 expression is associated with bone marrow microinvolvement and prognosis in non-small cell lung cancer.
MMP-13 In-Vivo Molecular Imaging Reveals Early Expression in Lung Adenocarcinoma.
MMP-2 and MMP-13 affect vasculogenic mimicry formation in large cell lung cancer.
Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk.
Somatic Copy-Number Alterations Contribute to Brain Metastasis.
Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1.
The relationship of metalloproteinase gene polymorphisms and lung cancer.
Thrombospondin 2 promotes tumor metastasis by inducing matrix metalloproteinase-13 production in lung cancer cells.
[Expression and significance of matrix metalloproteinases and their tissue inhibitors in the infiltration and metastasis of lung cancer.]
Lupus Erythematosus, Systemic
Elevated serum levels of MMP-2, MMP-3, and MMP-13 in Chinese patients with systemic lupus erythematosus.
Lyme Disease
Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.
Lymphatic Metastasis
Clinical significance of serum matrix metalloproteinase-13 levels in patients with esophageal squamous cell carcinoma (ESCC).
Clinicopathological significance and prognostic value of MMP-13 expression in colorectal cancer.
Differential expression of matrix metalloproteinase-13 in mucinous and nonmucinous colorectal carcinomas.
Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer.
Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases.
Increased expression of collagenase-3 (MMP-13) and MT1-MMP in oesophageal cancer is related to cancer aggressiveness.
Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production.
Matrix metalloproteinase 13: a potential intermediate between low expression of microRNA-125b and increasing metastatic potential of non-small cell lung cancer.
MMP13 is a potential prognostic marker for colorectal cancer.
MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13.
Overexpression of MMP13 is associated with clinical outcomes and poor prognosis in oral squamous cell carcinoma.
Role of matrix metalloproteinase 13 gene expression in the evaluation of radiation response in oral squamous cell carcinoma.
S100A4 promotes invasion and angiogenesis in breast cancer MDA-MB-231 cells by upregulating matrix metalloproteinase-13.
SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.
The usefulness of new serum tumor markers in head and neck squamous cell carcinoma.
[Diagnostic value of E-cadherin, MMP-9, activated MMP-13 and anti-p53 antibodies in squamous cell carcinomas of head and neck]
Lymphoma
Blocking HOTAIR protects human chondrocytes against IL-1?-induced cell apoptosis, ECM degradation, inflammatory response and oxidative stress via regulating miR-222-3p/ADAM10 axis.
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1?-Induced Osteoarthritis Progression Through Regulating DNMT3A.
Lymphoma, B-Cell
Blocking HOTAIR protects human chondrocytes against IL-1?-induced cell apoptosis, ECM degradation, inflammatory response and oxidative stress via regulating miR-222-3p/ADAM10 axis.
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1?-Induced Osteoarthritis Progression Through Regulating DNMT3A.
Overexpression of long non-coding RNA XIST promotes IL-1?-induced degeneration of nucleus pulposus cells through targeting miR-499a-5p.
Sirt1 regulates apoptosis and extracellular matrix degradation in resveratrol-treated osteoarthritis chondrocytes via the Wnt/?-catenin signaling pathways.
Macular Degeneration
Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization.
Malocclusion
Malocclusion model of temporomandibular joint osteoarthritis in mice with and without receptor for advanced glycation end products.
Marfan Syndrome
Gelatinolytic activity in gingival crevicular fluid and saliva of growing patients with Marfan syndrome: a case-control study.
matrix metalloproteinase-13 deficiency
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.
Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3).
Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis.
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.
Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice.
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis.
Melanoma
Anti-Metastasis Effects of Ginsenoside Rg3 in B16F10 Cells.
AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells.
Collagenase-3 (MMP-13) expression in cutaneous malignant melanoma.
Cumulative influence of matrix metalloproteinase-1 and -2 in the migration of melanoma cells within three-dimensional type I collagen lattices.
Development of a solid-phase assay for analysis of matrix metalloproteinase activity.
Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.
Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry.
Expression and prognostic role of MMP2, MMP9, MMP13, and MMP14 matrix metalloproteinases in sinonasal and oral malignant melanomas.
Expression of collagenase-3 (matrix metalloproteinase-13) in transitional-cell carcinoma of the urinary bladder.
High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma.
High serum levels of matrix metalloproteinase-9 and matrix metalloproteinase-1 are associated with rapid progression in patients with metastatic melanoma.
Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production.
Matrix metalloproteinases in human melanoma.
Matrix metalloproteinases MMP-1, MMP-2, and MMP-13 are overexpressed in primary nodular melanoma.
MMP-21 is upregulated at early stages of melanoma progression but disappears with more aggressive phenotype.
MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.
Stromal collagenase in melanoma: a vascular connection.
Stromal expression of MMP-13 is required for melanoma invasion and metastasis.
Studies of the humoral factors produced by layered chondrocyte sheets.
Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1.
[Inhibition of matrix metalloproteinases 9 and 13 affects the degree of lymphocytic infiltration and the expression levels of microRNA miR-21 and miR-let-7b in melanoma cells in vivo].
Meningioma
Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas.
Meningitis, Bacterial
Differential expression of matrix metalloproteinases in bacterial meningitis.
Mouth Neoplasms
A metalloproteinase-13 polymorphism affecting its gene expression is associated with advanced stages of oral cancer.
Corrigendum: Matrix metalloproteinase-13 is a target gene of high-mobility group box-containing protein 1 in modulating oral cancer cell invasion.
MMP-13 is involved in oral cancer cell metastasis.
Retraction: MMP-13 is involved in oral cancer cell metastasis.
Multiple Myeloma
Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival.
MMP13 Regulates Aggressiveness of Pediatric Multiple Myeloma Through VEGF-C.
Regulation of metastasis of pediatric multiple myeloma by MMP13.
[Expression of IL-17 and MMP-13 in Bone Marrow Biopsy of Pafsents with Multiple Myeloma and Its Clicnical Significomce].
Muscular Atrophy
Knocking-out matrix metalloproteinase-13 exacerbates rotator cuff muscle fatty infiltration.
Musculoskeletal Diseases
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1 beta (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.
Myocardial Infarction
Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction.
Relationship of long-term prognosis to MMP and TIMP polymorphisms in patients after ST elevation myocardial infarction.
Nasal Polyps
Involvement of the extracellular matrix proteins periostin and tenascin C in nasal polyp remodeling by regulating the expression of MMPs.
Nasopharyngeal Carcinoma
Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases.
Regulation of matrix metalloproteinase-1 by Epstein-Barr virus proteins.
Neoplasm Metastasis
(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone.
Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells.
An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer.
Anti-Metastasis Effects of Ginsenoside Rg3 in B16F10 Cells.
Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population.
Astragalus Polysaccharide (PG2) Suppresses Macrophage Migration Inhibitory Factor and Aggressiveness of Lung Adenocarcinoma Cells.
Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Cancer-Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer.
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Clinical significance of serum matrix metalloproteinase-13 levels in patients with esophageal squamous cell carcinoma (ESCC).
Clinicopathological significance and prognostic value of MMP-13 expression in colorectal cancer.
Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Constitutive expression and regulation of collagenase-3 in human breast cancer cells.
Correlation Between the Expression of Matrix Metalloproteinase-9, Matrix Metalloproteinase-13, Tissue Inhibitor of Metalloproteinases-1, p16 and Differentiation of Head and Neck Squamous Cell Carcinoma: A Prospective Observational Study.
Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis.
Crosstalk between MMP-13, CD44, and TWIST1 and its role in regulation of EMT in patients with esophageal squamous cell carcinoma.
Different matrix micro-environments in colon cancer and diverticular disease.
Differential expression of matrix metalloproteinase-13 in association with invasion of breast cancer.
Differential expression of matrix metalloproteinase-13 in mucinous and nonmucinous colorectal carcinomas.
Differential expression of matrix metalloproteinases and miRNAs in the metastasis of oral squamous cell carcinoma.
Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry.
ETS-1 regulates vascular endothelial growth factor-induced matrix metalloproteinase-9 and matrix metalloproteinase-13 expression in human ovarian carcinoma cell SKOV-3.
Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer.
Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck.
Expression of MMP-13 is associated with invasion and metastasis of papillary thyroid carcinoma.
Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas.
Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma.
Ginsenoside Rh2 inhibits metastasis of glioblastoma multiforme through Akt-regulated MMP13.
Golgi Membrane Protein 1 (GOLM1) Promotes Growth and Metastasis of Breast Cancer Cells via Regulating Matrix Metalloproteinase-13 (MMP13).
Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion.
High expression levels of collagenase-1 and stromelysin-1 correlate with shorter disease-free survival in human metastatic melanoma.
Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver.
Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production.
Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases.
Hypoxia-Inducible Factor-1? (HIF-1?) Promotes Hypoxia-Induced Invasion and Metastasis in Ovarian Cancer by Targeting Matrix Metallopeptidase 13 (MMP13).
Identification of GOLM1 as a positively regulator of tumor metastasis by regulating MMP13 in gastric carcinoma.
Increased expression of collagenase-3 (MMP-13) and MT1-MMP in oesophageal cancer is related to cancer aggressiveness.
Induction of MMP-13 expression in bone-metastasizing cancer cells by type I collagen through integrin ?1?1 and ?2?1-p38 MAPK signaling.
Infiltrating neutrophils increase bladder cancer cell invasion via modulation of androgen receptor (AR)/MMP13 signals.
ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.
Inhibition of epidermal growth factor receptor signaling prohibits metastasis of gastric cancer via downregulation of MMP7 and MMP13.
Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma.
Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production.
LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negatively regulating phosphoinositide 3-kinase/AKT pathway.
Low collagenase-1 (MMP-1) and MT1-MMP expression levels are favourable survival markers in advanced colorectal carcinoma.
Markers of breast cancer stromal fibroblasts in the primary tumour site associated with lymph node metastasis: a systematic review including our case series.
Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface.
Matrix Metalloproteinase 13 Inhibitors for Modulation of Osteoclastogenesis: Enhancement of Solubility and Stability.
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.
Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis.
Matrix metalloproteinase 13: a potential intermediate between low expression of microRNA-125b and increasing metastatic potential of non-small cell lung cancer.
Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration.
Matrix metalloproteinases as diagnostic (MMP-13) and prognostic (MMP-2, MMP-9) markers of prostate cancer.
Melatonin impedes prostate cancer metastasis by suppressing MMP-13 expression.
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: the role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.
Microcystin-LR promotes melanoma cell invasion and enhances matrix metalloproteinase-2/-9 expression mediated by NF-?B activation.
MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression.
MiR99a modulates MMP7 and MMP13 to regulate invasiveness of Kaposi's sarcoma.
MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts.
MMP-13 is involved in oral cancer cell metastasis.
MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1.
MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.
MMP-21 is upregulated at early stages of melanoma progression but disappears with more aggressive phenotype.
MMP13 is a potential prognostic marker for colorectal cancer.
MMP13 Regulates Aggressiveness of Pediatric Multiple Myeloma Through VEGF-C.
MUC1 induces metastasis in esophageal squamous cell carcinoma by upregulating matrix metalloproteinase 13.
Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells.
Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis.
Overexpression of MMP-13 gene in colorectal cancer with liver metastasis.
Overexpression of MMP13 is associated with clinical outcomes and poor prognosis in oral squamous cell carcinoma.
PAI-1, a target gene of miR-143, regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma.
Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13.
Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies.
Quantitative real-time RT-PCR of ITGA7, SVEP1, TNS1, LPHN3, SEMA3G, KLB and MMP13 mRNA expression in breast cancer.
Regulation of metastasis of pediatric multiple myeloma by MMP13.
Regulation of programmed-death ligand in the human head and neck squamous cell carcinoma microenvironment is mediated through matrix metalloproteinase-mediated proteolytic cleavage.
Retraction: MMP-13 is involved in oral cancer cell metastasis.
RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13.
Role of matrix metalloproteinase 13 gene expression in the evaluation of radiation response in oral squamous cell carcinoma.
Role of matrix metalloproteinases and their inhibitors in tumor invasion and metastasis.
Role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in bone destruction by breast cancer metastasis.
Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions.
S100A4 promotes invasion and angiogenesis in breast cancer MDA-MB-231 cells by upregulating matrix metalloproteinase-13.
SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1.
SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.
Small leucine zipper protein promotes the metastasis of castration-resistant prostate cancer through transcriptional regulation of matrix metalloproteinase-13.
Somatic Copy-Number Alterations Contribute to Brain Metastasis.
Stromal collagenase in melanoma: a vascular connection.
Stromal expression of MMP-13 is required for melanoma invasion and metastasis.
Stromal matrix metalloprotease-13 knockout alters Collagen I structure at the tumor-host interface and increases lung metastasis of C57BL/6 syngeneic E0771 mammary tumor cells.
SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells.
Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1.
Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line.
The CBM Complex Underwrites NF-?B Activation to Promote HER2-Associated Tumor Malignancy.
The Expression and Significance of CXCR5 and MMP-13 in Colorectal Cancer.
The Prolactin Inducible Protein Modulates Antitumor Immune Responses and Metastasis in a Mouse Model of Triple Negative Breast Cancer.
The Role of Matrix Metalloproteinases in the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma.
The Transcription Factor SPDEF Suppresses Prostate Tumor Metastasis.
The usefulness of new serum tumor markers in head and neck squamous cell carcinoma.
Thrombospondin 2 promotes tumor metastasis by inducing matrix metalloproteinase-13 production in lung cancer cells.
Transforming growth factor-?1 regulation of ATF-3, c-Jun and JunB proteins for activation of matrix metalloproteinase-13 gene in human breast cancer cells.
Transforming growth factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells.
Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals.
Tumor-Derived Matrix Metalloproteinase-13 (MMP-13) Expression in Benign and Malignant Breast Lesions.
Tunicamycin promotes metastasis through upregulating endoplasmic reticulum stress induced GRP78 expression in thyroid carcinoma.
Upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer.
[Collagenase 3 mRNA expression in squamous epithelial carcinomas of the oropharynx]
[Diagnostic value of E-cadherin, MMP-9, activated MMP-13 and anti-p53 antibodies in squamous cell carcinomas of head and neck]
[Relationship between the expression of matrix metalloproteinase-13 protein and other biomarkers, prognosis in invasive breast cancer]
Neoplasms
7,8-Dihydroxyflavone activates Nrf2/HO-1 signaling pathways and protects against osteoarthritis.
A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis.
A dietary polysaccharide from Eucheuma cottonii downregulates proinflammatory cytokines and ameliorates osteoarthritis-associated cartilage degradation in obese rats.
A feedback inhibition between miRNA-127 and TGF?/c-Jun cascade in HCC cell migration via MMP13.
A novel cyclo-oxygenase-2 inhibitor modulates catabolic and antiinflammatory mediators in osteoarthritis.
A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential.
Abnormal increase of miR-4262 promotes cell proliferation and migration by targeting large tumor suppressor 1 in gliomas.
Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2.
Activation of inflammatory mediators and potential role of ah-receptor ligands in foam cell formation.
Active matrix metalloproteases are expressed early on and are high during the Barrett's esophagus malignancy sequence.
ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo.
Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells.
Advanced oxidation protein products induce inflammatory responses and invasive behaviour in fibroblast-like synoviocytes via the RAGE-NF-?B pathway.
Alogliptin inhibits IL-1?-induced inflammatory response in fibroblast-like synoviocytes.
Alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells.
Altered Gene and Protein Expressions in Torn Rotator Cuff Tendon Tissues in Diabetic Patients.
An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer.
An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies.
Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis.
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer.
Analysis of the cell infiltrate and expression of proinflammatory cytokines and matrix metalloproteinases in arthroscopic synovial biopsies: comparison with synovial samples from patients with end stage, destructive rheumatoid arthritis.
Anti-inflammatory and anti-nociceptive effect of Betula platyphylla var. japonica in human interleukin-1?-stimulated fibroblast-like synoviocytes and in experimental animal models.
Anti-Inflammatory Effects of Conditioned Medium of Periodontal Ligament-Derived Stem Cells on Chondrocytes, Synoviocytes, and Meniscus Cells.
Anti-Metastasis Effects of Ginsenoside Rg3 in B16F10 Cells.
AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone.
Aqueous garlic extract alleviates liver fibrosis and renal dysfunction in bile-duct-ligated rats.
Artificial Intelligence Approach to Find Lead Compounds for Treating Tumors.
Association between high collagenase-3 expression levels and poor prognosis in patients with head and neck cancer.
Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population.
Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis.
Astragalus Polysaccharide (PG2) Suppresses Macrophage Migration Inhibitory Factor and Aggressiveness of Lung Adenocarcinoma Cells.
Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.
Avocado soybean unsaponifiables ameliorates cartilage and subchondral bone degeneration in mono-iodoacetate-induced knee osteoarthritis in rats.
Bergapten alleviates osteoarthritis by regulating the ANP32A/ATM signaling pathway.
Blueberries Improve Pain, Gait Performance, and Inflammation in Individuals with Symptomatic Knee Osteoarthritis.
Bone marrow-derived myofibroblasts are the providers of pro-invasive matrix metalloproteinase 13 in primary tumor.
Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials.
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity.
Cancer-Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer.
Carnosine Prevents Type 2 Diabetes-Induced Osteoarthritis Through the ROS/NF-?B Pathway.
CCR4 promotes metastasis via ERK/NF-?B/MMP13 pathway and acts downstream of TNF-? in colorectal cancer.
CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.
Cellular sources of MMP-7, MMP-13 and MMP-28 in ulcerative colitis.
Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression.
Changes of synovial fluid biomarker levels after opening wedge high tibial osteotomy in patients with knee osteoarthritis.
Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis.
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells.
Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression and solid-tumor cell invasion.
Chondroprotective Effects and Mechanisms of Dextromethorphan: Repurposing Antitussive Medication for Osteoarthritis Treatment.
Chondroprotective effects of platelet lysate towards monoiodoacetate-induced arthritis by suppression of TNF-?-induced activation of NF-?B pathway in chondrocytes.
Circulating IgG response to stromelysin-3, collagenase-3, galectin-3 and mesothelin in patients with pharynx/larynx squamous cell carcinoma.
Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1).
Co-expression of TLR-9 and MMP-13 is associated with the degree of tumour differentiation in prostate cancer.
Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.
Collagenase-3 (matrix metalloproteinase-13) expression is induced in oral mucosal epithelium during chronic inflammation.
Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor.
Collagenase-3 (MMP-13) expression in cutaneous malignant melanoma.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Collagenase-3 expression by tumor cells and gelatinase B expression by stromal fibroblast-like cells are associated with biochemical recurrence after radical prostatectomy in patients with prostate cancer.
Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx.
Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury.
Collagenases (MMP-1, -8 and -13) and trypsinogen-2 in fluid from benign and malignant ovarian cysts.
Common polymorphism in the MMP-13 gene may contribute to the risk of human cancers: a meta-analysis.
Comparative gene expression profiling of normal and degenerative discs: analysis of a rabbit annular laceration model.
Considering Rotatability of Hydroxyl Groups for the Active Site Residues of MMP-13 in Retrospective Virtual Screening Campaigns.
Constitutive expression and regulation of collagenase-3 in human breast cancer cells.
Correlation Between the Expression of Matrix Metalloproteinase-9, Matrix Metalloproteinase-13, Tissue Inhibitor of Metalloproteinases-1, p16 and Differentiation of Head and Neck Squamous Cell Carcinoma: A Prospective Observational Study.
Correlation between the immune checkpoints and EMT genes proposes potential prognostic and therapeutic targets in ESCC.
Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis.
Correlation of Synovial Fluid Biomarkers With Cartilage Pathology and Associated Outcomes in Knee Arthroscopy.
Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis.
Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK.
Crosstalk between MMP-13, CD44, and TWIST1 and its role in regulation of EMT in patients with esophageal squamous cell carcinoma.
Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats.
CXCR4 promotes oral squamous cell carcinoma migration and invasion through inducing expression of MMP-9 and MMP-13 via the ERK signaling pathway.
Cyclophilin C-associated protein is a mediator for fibronectin fragment-induced matrix metalloproteinase-13 expression.
Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi.
Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes.
Cytokine profile in the gingival crevicular fluid of rheumatoid arthritis patients with chronic periodontitis.
Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients.
Development and Validation of a Serum Biomarker Panel for the Detection of Esophageal Squamous Cell Carcinoma through RNA Transcriptome Sequencing.
Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor.
Development of a Rat Model of Mechanically Induced Tunable Pain and Associated Temporomandibular Joint Responses.
Different matrix micro-environments in colon cancer and diverticular disease.
Differential expression of Janus kinase 3 (JAK3), matrix metalloproteinase 13 (MMP13), heat shock protein 60 (HSP60), and mouse double minute 2 (MDM2) in human colorectal cancer progression using human cancer cDNA microarrays.
Differential expression of matrix metalloproteinase-13 in association with invasion of breast cancer.
Differential expression of matrix metalloproteinases and miRNAs in the metastasis of oral squamous cell carcinoma.
Differential expression of matrix metalloproteinases and their inhibitors in non-small cell lung cancer.
Differential regulation of MMP-13 by chemical modified tetracyclines in osteoblasts.
Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.
Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13 (dagger).
Down-regulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin-10 knockout mice.
Dual effects of collagenase-3 on melanoma: metastasis promotion and disruption of vasculogenic mimicry.
Dynamic biophysical strain modulates proinflammatory gene induction in meniscal fibrochondrocytes.
Effect of lentivirus-mediated integrin ?V?3-shRNA on tumor growth of mice with lung cancer xenografts.
Effects of bevacizumab in mouse model of endometrial cancer: Defining the molecular basis for resistance.
Effects of bromopride on expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study.
Effects of matrix metalloproteinase 13 on vascular smooth muscle cells migration via Akt-ERK dependent pathway.
Effects of selective MMP-13 inhibition in Squamous Cell Carcinoma depend on estrogen.
Elevated expression of MMP-13 and TIMP-1 in head and neck squamous cell carcinomas may reflect increased tumor invasiveness.
Elevation of matrix metalloproteinases and interleukin-6 in the culprit coronary artery of myocardial infarction.
Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinase.
Enhanced expression of MMP-7 and MMP-13 in inflammatory bowel disease: a precancerous potential?
Enhanced tendon restoration effects of anti-inflammatory, lactoferrin-immobilized, heparin-polymeric nanoparticles in an Achilles tendinitis rat model.
Epithelial cells up-regulate matrix metalloproteinases in cells within the same mammary carcinoma that have undergone an epithelial-mesenchymal transition.
Estrogenic and antiestrogenic regulation of MMP-2 and MMP-13 mRNA in RUCA-I endometrial tumor cells in vitro and in vivo.
ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.
Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry
Evaluation of the post-treatment anti-inflammatory capacity of osteoarthritic chondrocytes: An in vitro study using baicalein.
Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone.
Exenatide ameliorates inflammatory response in human rheumatoid arthritis fibroblast-like synoviocytes.
Experimental periodontitis in mice selected for maximal or minimal inflammatory reactions: increased inflammatory immune responsiveness drives increased alveolar bone loss without enhancing the control of periodontal infection.
Expression analysis of matrix metalloproteinase-13 in human gastric cancer in the presence of Helicobacter Pylori infection.
Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors.
Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer.
Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neck.
Expression of collagenase-3 (MMP-13) by tumor cells in squamous cell carcinomas of the head and neck.
Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells.
Expression of collagenase-3 (MMP-13) in c-fos-induced osteosarcomas and chondrosarcomas is restricted to a subset of cells of the osteo-/chondrogenic lineage.
Expression of CXCR4, MMP-13 and ?-catenin in different histological subtypes of facial basal cell carcinoma.
Expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and MT1-MMP in skin tumors of human papillomavirus type 8 transgenic mice.
Expression of matrix metalloproteinase (MMP)-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds.
Expression of Matrix Metalloproteinase-13 and Ki-67 in Nonmelanoma Skin Cancer in Xeroderma Pigmentosum and Non-xeroderma Pigmentosum.
Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck.
Expression of matrix metalloproteinases and their specific inhibitors in normal and different human thyroid tumor cell lines.
Expression of MMP-13 is associated with invasion and metastasis of papillary thyroid carcinoma.
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.
Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury.
Expression pattern and circulating levels of endostatin in patients with pancreas cancer.
Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.
Expression profiling of murine intestinal adenomas reveals early deregulation of multiple matrix metalloproteinase (Mmp) genes.
Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2.
Follistatin-like protein 1 promotes inflammatory reactions in nucleus pulposus cells by interacting with the MAPK and NF?B signaling pathways.
FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13.
Free Energy Calculations on Snake Venom Metalloproteinase BaP1.
Function of microRNA-143 in different signal pathways in cancer: New insights into cancer therapy.
Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) - experimental validation in human breast and colon cancer.
Gelatinase A and membrane-type 1 matrix metalloproteinase mRNA: expressed in adrenocortical cancers but not in adenomas.
Ghrelin protects against nucleus pulposus degeneration through inhibition of NF-?B signaling pathway and activation of Akt signaling pathway.
Ginkgolide B attenuates collagen-induced rheumatoid arthritis and regulates fibroblast-like synoviocytes-mediated apoptosis and inflammation.
Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion.
Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes.
High collagenase-1 expression correlates with a favourable chemoimmunotherapy response in human metastatic melanoma.
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
High molecular weight hyaluronic acid regulates MMP13 expression in chondrocytes via DUSP10/MKP5.
High-Frequency Near-Infrared Diode Laser Irradiation Attenuates IL-1?-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes.
High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization.
Histone Deacetylase Inhibitor Vorinostat (SAHA) Suppresses IL-1?-Induced Matrix Metallopeptidase-13 Expression by Inhibiting IL-6 in Osteoarthritis Chondrocyte.
Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver.
Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production.
Human collagenase-3 is expressed in malignant squamous epithelium of the skin.
Human macrophage metalloelastase (MMP-12) expression is induced in chondrocytes during fetal development and malignant transformation.
Hyaluronan in part mediates IL-1beta-induced inflammation in mouse chondrocytes by up-regulating CD44 receptors.
Hyaluronan-oligosaccharide-induced transcription of metalloproteases.
Identification of GOLM1 as a positively regulator of tumor metastasis by regulating MMP13 in gastric carcinoma.
Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor.
Immunohistochemical analysis of MMP-13 and EMMPRIN in epithelial odontogenic lesions.
Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes.
In Vitro Anti-Inflammation and Chondrogenic Differentiation Effects of Inclusion Nanocomplexes of Hyaluronic Acid-Beta Cyclodextrin and Simvastatin.
In vitro effects of meloxicam on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis.
Increase of MMP-13 expression in multi-stage oral carcinogenesis and epigallocatechin-3-gallate suppress MMP-13 expression.
Increased expression of collagenase-3 (MMP-13) and MT1-MMP in oesophageal cancer is related to cancer aggressiveness.
Increased expression of matrix metalloproteinase-13 in glioma is associated with poor overall survival of patients.
Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.
Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes.
Induction of MMP-13 expression by soluble human glucocorticoid-induced tumor necrosis factor receptor in fibroblast-like synovial cells.
Induction of MMP-13 expression in bone-metastasizing cancer cells by type I collagen through integrin ?1?1 and ?2?1-p38 MAPK signaling.
Inflammation suppression by dexamethasone via inhibition of CD147-mediated NF-?B pathway in collagen-induced arthritis rats.
Influence of the Molecular Weight of Poly(Lactide-Co-Glycolide) on the In Vivo Cartilage Repair by a Construct of Poly(Lactide-Co-Glycolide)/Fibrin Gel/Mesenchymal Stem Cells/Transforming Growth Factor-?1.
ING Proteins as Potential Anticancer Drug Targets.
ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.
Inhibition effect of curcumin on TNF-? and MMP-13 expression induced by advanced glycation end products in chondrocytes.
Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-gamma is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1.
Inhibition of epidermal growth factor receptor signaling prohibits metastasis of gastric cancer via downregulation of MMP7 and MMP13.
Inhibition of SOX9 Promotes Inflammatory and Immune Responses of Dental Pulp.
Insulin receptor substrate 1 regulates the cellular differentiation and the matrix metallopeptidase expression of preosteoblastic cells.
Interferon ?2b increases MMP-13 and IL-10 expression in Kupffer cells through MAPK signaling pathways.
Interpretation of immunohistochemistry data of tumor should consider microenvironmental factors.
Interstitial collagenases as markers of tumor progression.
Invasion and MMP expression profile in desmoid tumours.
Involvement of H-Ras and reactive oxygen species in proinflammatory cytokine-induced matrix metalloproteinase-13 expression in human articular chondrocytes.
Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?
Is exclusion of leukocytes from platelet-rich plasma (PRP) a better choice for early intervertebral disc regeneration?
Joint hemorrhage accelerates cartilage degeneration in a rat immobilized knee model.
Levels of Matrix Metalloproteinases in Arthroplasty Patients and Their Correlation With Inflammatory and Thrombotic Activation Processes.
LINC01534 Promotes the Aberrant Metabolic Dysfunction and Inflammation in IL-1?-Simulated Osteoarthritic Chondrocytes by Targeting miR-140-5p.
LncRNA TUG1 promotes osteoarthritis-induced degradation of chondrocyte extracellular matrix via miR-195/MMP-13 axis.
Local cytokines induce differential expression of matrix metalloproteinases but not their tissue inhibitors in human endometrial fibroblasts.
Low collagenase-1 (MMP-1) and MT1-MMP expression levels are favourable survival markers in advanced colorectal carcinoma.
Many new down- and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancers.
Matrilysin-1 (MMP-7) and MMP-19 are expressed by Paget's cells in extramammary Paget's disease.
Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface.
Matrix metalloproteinase 13 activity is associated with poor prognosis in colorectal cancer.
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.
Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis.
Matrix metalloproteinase 13: a potential intermediate between low expression of microRNA-125b and increasing metastatic potential of non-small cell lung cancer.
Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis.
Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma.
Matrix metalloproteinase-13 expression in the progression of colorectal adenoma to carcinoma : Matrix metalloproteinase-13 expression in the colorectal adenoma and carcinoma.
Matrix metalloproteinase-13 expression is associated with bone marrow microinvolvement and prognosis in non-small cell lung cancer.
Matrix metalloproteinase-13: A special focus on its regulation by signaling cascades and microRNAs in bone.
Matrix metalloproteinase-13 is a target gene of high-mobility group box-containing protein 1 in modulating oral cancer cell invasion.
Matrix Metalloproteinase-3 is Key Effector of TNF-?-Induced Collagen Degradation in Skin.
Matrix metalloproteinases and E-cadherin immunoreactivity in different basal cell carcinoma histological types.
Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression.
Matrix metalloproteinases play an active role in Wnt1-induced mammary tumorigenesis.
Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1.
Mesenchymal stem cells induce a fibrolytic phenotype by regulating mmu-miR-6769b-5p expression in macrophages.
Microcystin-LR promotes melanoma cell invasion and enhances matrix metalloproteinase-2/-9 expression mediated by NF-?B activation.
Microcystin-LR promotes migration and invasion of colorectal cancer through matrix metalloproteinase-13 up-regulation.
MicroRNA Mediate Visfatin and Resistin Induction of Oxidative Stress in Human Osteoarthritic Synovial Fibroblasts Via NF-?B Pathway.
MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and Invasion.
MiR-126-5p regulates osteoclast differentiation and bone resorption in giant cell tumor through inhibition of MMP-13.
miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer.
MK801 regulates the expression of key osteoarthritis factors in osteoarthritis synovial fibroblasts through complement C5.
MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts.
MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors.
MMP-13 In-Vivo Molecular Imaging Reveals Early Expression in Lung Adenocarcinoma.
MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1.
MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.
MMP-2 and MMP-13 affect vasculogenic mimicry formation in large cell lung cancer.
MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma.
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
MMP13 is a potential prognostic marker for colorectal cancer.
MMP13 is potentially a new tumor marker for breast cancer diagnosis.
MMP13 Regulates Aggressiveness of Pediatric Multiple Myeloma Through VEGF-C.
MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression.
Muscone Protects Vertebral End-plate Degeneration by Antiinflammatory Property.
Myeloperoxidase is increased in human cerebral aneurysms and increases formation and rupture of cerebral aneurysms in mice.
New pathway links from cancer-progression determinants to gene expression of matrix metalloproteinases in breast cancer cells.
Non-bone metastatic cancers promote osteocyte-induced bone destruction.
Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells.
Olive Leaf Extract and Its Main Component Oleuropein Prevent Chronic Ultraviolet B Radiation-Induced Skin Damage and Carcinogenesis in Hairless Mice.
Oral administration of EP4-selective agonist KAG-308 suppresses mouse knee osteoarthritis development through reduction of chondrocyte hypertrophy and TNF secretion.
Ovariectomy Exacerbates Apical Periodontitis in Rats with an Increase in Expression of Proinflammatory Cytokines and Matrix Metalloproteinases.
Overexpression of MMP-13 gene in colorectal cancer with liver metastasis.
Overexpression of MMP13 is associated with clinical outcomes and poor prognosis in oral squamous cell carcinoma.
p63 transcriptionally regulates the expression of matrix metallopeptidase 13.
Peroxisome proliferator--activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes.
PI3K, Erk signaling in BMP7-induced epithelial-mesenchymal transition (EMT) of PC-3 prostate cancer cells in 2- and 3-dimensional cultures.
Piperine inhibit inflammation, alveolar bone loss and collagen fibers breakdown in a rat periodontitis model.
Platycodi Radix attenuates dimethylnitrosamine-induced liver fibrosis in rats by inducing Nrf2-mediated antioxidant enzymes.
PLD1 promotes tumor invasion by regulation of MMP-13 expression via NF-?B signaling in bladder cancer.
Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies.
Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas.
Preconditioning of Adipose-Derived Mesenchymal Stem-Like Cells with Eugenol Potentiates Their Migration and Proliferation In Vitro and Therapeutic Abilities in Rat Hepatic Fibrosis.
Primary ductal adenocarcinoma of the lacrimal gland: case report.
Prognostic significance of matrix metalloproteinase-2, -8, -9, and -13 in oral tongue cancer.
Prognostic value of matrix metalloproteinases in oral squamous cell carcinoma.
Proinflammatory cytokines and lipopolysaccharides up regulate MMP-3 and MMP-13 production in Asian elephant (Elephas maximus) chondrocytes: attenuation by anti-arthritic agents.
Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes.
Protective effects of cilengitide on inflammation in chondrocytes under excessive mechanical stress.
Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors.
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines.
Proteolysis of the collagen fibril in osteoarthritis.
Rational design of matrix metalloproteinase-13 activatable probes for enhanced specificity.
Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cells.
Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice.
Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions.
Regulation of matrix metalloproteinase 13 expression by androgen in prostate cancer.
Regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) by bone resorptive factors in osteoblastic cells.
Regulation of metastasis of pediatric multiple myeloma by MMP13.
Regulation of MMP13 by antitumor microRNA-375 markedly inhibits cancer cell migration and invasion in esophageal squamous cell carcinoma.
Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy.
Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and tumor expression of metalloproteases and their inhibitors in invasive breast cancer.
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
Retraction Note to: Common polymorphism in the MMP-13 gene may contribute to the risk of human cancers: a meta-analysis.
Rhizoma drynariae total flavonoids inhibit the inflammatory response and matrix degeneration via MAPK pathway in a rat degenerative cervical intervertebral disc model.
Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation.
Rice Porridge Containing Welsh Onion Root Water Extract Alleviates Osteoarthritis-Related Pain Behaviors, Glucose Levels, and Bone Metabolism in Osteoarthritis-Induced Ovariectomized Rats.
RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13.
Roflumilast prevents lymphotoxin ? (TNF-?)-induced inflammation activation and degradation of type 2 collagen in chondrocytes.
Role of matrix metalloproteinases and their inhibitors in tumor invasion and metastasis.
Rosa multiflora Thunb Flower Extract Attenuates Ultraviolet-Induced Photoaging in Skin Cells and Hairless Mice.
Runt-related gene 2 is involved in the inhibition of matrix metalloproteinase-13 expression by roxithromycin in human gingival epithelial cell cultures.
Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions.
RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion.
S100A4 Elevation Empowers Expression of Metastasis Effector Molecules in Human Breast Cancer.
Salvia miltiorrhiza-asarum ointment combined with Chinese medical massage alleviates symptoms of osteoarthritis in a rat model through the Notch1/ matrix metalloproteinase-13 signaling pathway.
Scutellarin Attenuates the IL-1?-Induced Inflammation in Mouse Chondrocytes and Prevents Osteoarthritic Progression.
Serum and knee synovial fluid matrix metalloproteinase-13 and tumor necrosis factor-alpha levels in patients with late-stage osteoarthritis.
Serum and saliva collagenase-3 (MMP-13) in patients with oral lichen planus and oral squamous cell carcinoma.
Serum matrix metalloproteinase-13 as a diagnostic biomarker for cutaneous squamous cell carcinoma.
SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.
SP600125, a JNK-Specific Inhibitor, Regulates in vitro Auricular Cartilage Regeneration by Promoting Cell Proliferation and Inhibiting Extracellular Matrix Metabolism.
Stromal collagenase in melanoma: a vascular connection.
Stromal expression of MMP-13 is required for melanoma invasion and metastasis.
Stromal matrix metalloprotease-13 knockout alters Collagen I structure at the tumor-host interface and increases lung metastasis of C57BL/6 syngeneic E0771 mammary tumor cells.
Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13).
SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells.
Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line.
Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis.
Systems Biology-Derived Biomarkers to Predict Progression of Renal Function Decline in Type 2 Diabetes.
T cells regulate the expression of matrix metalloproteinase in human osteoblasts via a dual mitogen-activated protein kinase mechanism.
T-614 attenuates knee osteoarthritis via regulating Wnt/?-catenin signaling pathway.
Targeted inhibition of human collagenase-3 (MMP-13) expression inhibits squamous cell carcinoma growth in vivo.
Teneligliptin inhibits IL-1?-induced degradation of extracellular matrix in human chondrocytes.
The CBM Complex Underwrites NF-?B Activation to Promote HER2-Associated Tumor Malignancy.
The Clinical Significance and Molecular Features of the Spatial Tumor Shapes in Breast Cancers.
The complexity of molecular processes in osteoarthritis of the knee joint.
The differential effects of leukocyte-containing and pure platelet-rich plasma (PRP) on tendon stem/progenitor cells - implications of PRP application for the clinical treatment of tendon injuries.
The Expression and Significance of CXCR5 and MMP-13 in Colorectal Cancer.
The fibroblastic coconspirator in cancer progression.
The IGF-I Receptor Can Alter the Matrix Metalloproteinase Repertoire of Tumor Cells through Transcriptional Regulation of PKC-{alpha}
The immunoexpression of MMP-1 and MMP-13 in eyelid basal cell carcinoma.
The Prolactin Inducible Protein Modulates Antitumor Immune Responses and Metastasis in a Mouse Model of Triple Negative Breast Cancer.
The relationship of metalloproteinase gene polymorphisms and lung cancer.
The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.
The Transcription Factor SPDEF Suppresses Prostate Tumor Metastasis.
Theobromine mitigates IL-1?-induced oxidative stress, inflammatory response, and degradation of type II collagen in human chondrocytes.
Thrombospondin 2 promotes tumor metastasis by inducing matrix metalloproteinase-13 production in lung cancer cells.
TIMP-1 overexpression promotes tumorigenesis of MDA-MB-231 breast cancer cells and alters expression of a subset of cancer promoting genes in vivo distinct from those observed in vitro.
TNF?-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting CXCR2(+) neutrophils.
Toll-like receptor-4 agonist inhibits motility and invasion of hepatoblastoma HepG2 cells in vitro.
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors.
Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas.
Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas.
Transforming growth factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells.
Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production.
Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model.
Tripterygium wilfordii Hook F extract suppresses proinflammatory cytokine-induced expression of matrix metalloproteinase genes in articular chondrocytes by inhibiting activating protein-1 and nuclear factor-kappaB activities.
Trivalent metal ions based on inorganic compounds with in vitro inhibitory activity of matrix metalloproteinase 13.
Tropomodulin 1 expression driven by NF-?B enhances breast cancer growth.
Tumor promoter-induced MMP-13 gene expression in a model of initiated epidermis.
Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer.
Tumor-Derived Matrix Metalloproteinase-13 (MMP-13) Expression in Benign and Malignant Breast Lesions.
Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma.
Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13.
Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor.
Ursolic acid protects chondrocytes, exhibits anti-inflammatory properties via regulation of the NF-?B/NLRP3 inflammasome pathway and ameliorates osteoarthritis.
Urtica dioica extract suppresses miR-21 and metastasis-related genes in breast cancer.
Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes.
Vascular expression of matrix metalloproteinase-13 (collagenase-3) in basal cell carcinoma.
Vitamin D Inhibits Activities of Metalloproteinase-9/-13 in Articular Cartilage In Vivo and In Vitro.
YB-1 binds to the MMP-13 promoter sequence and represses MMP-13 transactivation via the AP-1 site.
[Collagenase 3 mRNA expression in squamous epithelial carcinomas of the oropharynx]
[Collagenase-3 (MMP-13) expression in epithelial cancers of the eyelids]
[Diversity of invasiveness and matrix metalloproteinases expression profile of human gastric carcinoma xenografted in different tissue environments]
[Effect of leptin on inducible NO and MMP-13 in rabbit articular chondrocytes in vitro]
[Expression and clinical significance of collagenase-3 (MMP-13) in gastric cancer]
[Inhibition of matrix metalloproteinases 9 and 13 affects the degree of lymphocytic infiltration and the expression levels of microRNA miR-21 and miR-let-7b in melanoma cells in vivo].
[Relationship between the expression of matrix metalloproteinase-13 protein and other biomarkers, prognosis in invasive breast cancer]
[The association of MMP-13 polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adeno-carcinoma]
Nerve Sheath Neoplasms
MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors.
Neurofibroma
Differentially expressed genes in neurofibromatosis 1-associated neurofibromas and malignant peripheral nerve sheath tumors.
MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors.
Neurofibroma, Plexiform
Differentially expressed genes in neurofibromatosis 1-associated neurofibromas and malignant peripheral nerve sheath tumors.
Neurofibromatoses
MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors.
Neurofibromatosis 1
MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors.
Neurofibrosarcoma
Differentially expressed genes in neurofibromatosis 1-associated neurofibromas and malignant peripheral nerve sheath tumors.
High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization.
MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors.
Nevus, Pigmented
Collagenase-3 (MMP-13) expression in cutaneous malignant melanoma.
Non-alcoholic Fatty Liver Disease
Host and tumor derived MMP13 regulate extravasation and establishment of colorectal metastases in the liver.
Short-Term Intake of a Fructose-, Fat- and Cholesterol-Rich Diet Causes Hepatic Steatosis in Mice: Effect of Antibiotic Treatment.
Obesity
Inhibition of MMP-13 prevents diet-induced obesity in mice and suppresses adipogenesis in 3T3-L1 preadipocytes.
Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis.
Tissue-specific differences in inflammatory infiltrate and matrix metalloproteinase expression in adipose tissue and liver of mice with diet-induced obesity.
Odontogenic Cysts
Collagenase-3 expression in periapical lesions: an immunohistochemical study.
Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions.
Laminin-5 gamma 2 chain is colocalized with gelatinase-A (MMP-2) and collagenase-3 (MMP-13) in odontogenic keratocysts.
MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts.
Odontogenic Tumors
MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts.
Oral Submucous Fibrosis
Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry
Osteoarthritis
15-deoxy-?(12,14) -prostaglandin-J2 and Ciglitazone Inhibit TNF-?-induced matrix metalloproteinase 13 production via the antagonism of NF-?B activation in human synovial fibroblasts.
A low ratio of n-6/n-3 polyunsaturated fatty acids suppresses matrix metalloproteinase 13 expression and reduces adjuvant-induced arthritis in rats.
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
A systematic computational analysis of human matrix metalloproteinase 13 (MMP-13) crystal structures and structure-based identification of prospective drug candidates as MMP-13 inhibitors repurposable for osteoarthritis.
A Systematic Review of Basic Science and Animal Studies on the Use of Doxycycline to Reduce the Risk of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Rupture/Transection.
Activating enhancer binding protein 2 epsilon (AP-2?)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development.
Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice.
Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators.
Allogeneic adipose-derived mesenchymal stem cells promote the expression of chondrocyte redifferentiation markers and retard the progression of knee osteoarthritis in rabbits.
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage.
Analysis of the Relationship between RELA Gene Expression and MMP-13 Gene Expression in Synoviocyte Cells after Mesenchymal Stem Cell Wharton Jelly.
Anti-Inflammatory Effect of Geniposide on Osteoarthritis by Suppressing the Activation of p38 MAPK Signaling Pathway.
Assessment of cartilage degradation effects of matrix metalloproteinase-13 in equine cartilage cocultured with synoviocytes.
Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis.
Basic Fibroblast Growth Factor Activates the MAPK and NF{kappa}B Pathways That Converge on Elk-1 to Control Production of Matrix Metalloproteinase-13 by Human Adult Articular Chondrocytes.
Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-?B pathways in the cartilage tissue of rats with osteoarthritis.
cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.
Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes.
Cartilage in facet joints of patients with ankylosing spondylitis (AS) shows signs of cartilage degeneration rather than chondrocyte hypertrophy: implications for joint remodeling in AS.
Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs.
CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis.
Changes in Synovial Fluid Biomarkers after Experimental Equine Osteoarthritis.
Characterization of an exosite binding inhibitor of matrix metalloproteinase 13.
Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.
Cheminformatics-based drug design approach for identification of inhibitors targeting the characteristic residues of MMP-13 hemopexin domain.
Chondrocyte-intrinsic Smad3 represses Runx2-inducible MMP-13 expression to maintain articular cartilage and prevent osteoarthritis.
CircTMBIM6 promotes osteoarthritis-induced chondrocyte extracellular matrix degradation via miR-27a/MMP13 axis.
Circ_0136474 and MMP-13 suppressed cell proliferation by competitive binding to miR-127-5p in osteoarthritis.
Cirsium japonicum var. maackii and apigenin block Hif-2?-induced osteoarthritic cartilage destruction.
Cloning of collagenase 3 from the synovial membrane and its expression in rheumatoid arthritis and osteoarthritis.
Cloning of the gene for interstitial collagenase-3 (matrix metalloproteinase-13) from rabbit synovial fibroblasts: differential expression with collagenase-1 (matrix metalloproteinase-1).
Cloning, sequencing and characterization of the 5'-flanking region of the human collagenase-3 gene.
Colchicine protects against cartilage degeneration by inhibiting MMP13 expression via PLC-?1 phosphorylation.
Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis.
Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta.
Considering Rotatability of Hydroxyl Groups for the Active Site Residues of MMP-13 in Retrospective Virtual Screening Campaigns.
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.
Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats.
Cytokine-induced interleukin-1 receptor antagonist protein expression in genetically engineered equine mesenchymal stem cells for osteoarthritis treatment.
Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation.
Delay in articular cartilage degeneration of the knee joint by the conditional removal of discoidin domain receptor 2 in a spontaneous mouse model of osteoarthritis.
Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors.
Development of a neutralizing antibody specific for the active form of matrix metalloproteinase-13.
Development of a selective matrix metalloproteinase 13 (MMP-13) inhibitor for the treatment of Osteoarthritis.
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.
Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis.
Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis.
Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach.
Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13 (dagger).
Does low level laser therapy has effects on inflammatory biomarkers IL-1?, IL-6, TNF-?, and MMP-13 in osteoarthritis of rat models-a systemic review and meta-analysis.
Downregulation of microRNA-9 increases matrix metalloproteinase-13 expression levels and facilitates osteoarthritis onset.
Effect of estrogen on the expression of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and tissue inhibitor of metalloproternase-1 in osteoarthritis chondrocytes.
Effect of inhibiting MMP13 and ADAMTS5 by intra-articular injection of small interfering RNA in a surgically induced osteoarthritis model of mice.
Effective knock down of matrix metalloproteinase-13 by an intra-articular injection of small interfering RNA (siRNA) in a murine surgically-induced osteoarthritis model.
Effects of an aqueous extract of Eucommia on articular cartilage in a rat model of osteoarthritis of the knee.
Effects of celecoxib on human chondrocytes--enhanced production of chemokines.
Effects of Controlling Abnormal Joint Movement on Expression of MMP13 and TIMP-1 in Osteoarthritis.
Effects of platycodin D on IL-1?-induced inflammatory response in human osteoarthritis chondrocytes.
Effects of ultrasound on estradiol level, bone mineral density, bone biomechanics and matrix metalloproteinase-13 expression in ovariectomized rabbits.
Elf3 Contributes to Cartilage Degradation in vivo in a Surgical Model of Post-Traumatic Osteoarthritis.
Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production.
Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention.
Estrogen receptor alpha regulates matrix metalloproteinase-13 promoter activity primarily through the AP-1 transcriptional regulatory site.
Evidence that estrogen receptor beta enhances MMP-13 promoter activity in HIG-82 cells and that this enhancement can be influenced by ligands and involves specific promoter sites.
Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis.
Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients.
Expression of MMP-13 in human temporomandibular joint disc derangement and osteoarthritis.
Ferulic acid suppresses interleukin-1?-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1? signaling pathway.
Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets.
Ginsenoside Rb1 inhibits matrix metalloproteinase 13 through down-regulating Notch signaling pathway in osteoarthritis.
Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation.
Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1?.
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.
Histamine stimulates matrix metalloproteinase-3 and -13 production by human articular chondrocytes in vitro.
Histone Methylation and STAT-3 Differentially Regulate Interleukin-6-Induced Matrix Metalloproteinase Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts.
Human osteoarthritis cartilage-derived stromal cells activate joint degeneration through TGF-beta lateral signaling.
Hyaluronic acid alkyl derivative: A novel inhibitor of metalloproteases and hyaluronidases.
Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.
Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis.
Impairment of the collagenase-3 endocytotic receptor system in cells from patients with osteoarthritis.
In silico study combining docking and QSAR methods on a series of matrix metalloproteinase 13 inhibitors.
In Vivo Dual Fluorescence Imaging to Detect Joint Destruction.
Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice.
Inflammatory markers associated with osteoarthritis after destabilization surgery in young mice with and without Receptor for Advanced Glycation End-products (RAGE).
Inhibition of matrix metalloproteinase-13 expression in IL-1?-treated articular chondrocytes by a steroidal saponin, spicatoside A, and its cellular mechanisms of action.
Interaction of HIF1? and ?-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice.
Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3.
Intra-Articular Injection of (-)-Epigallocatechin 3-Gallate (EGCG) Ameliorates Cartilage Degeneration in Guinea Pigs with Spontaneous Osteoarthritis.
Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes.
Involvement of SOX9 and FGF23 in RUNX2 regulation in osteoarthritic chondrocytes.
In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis.
LncRNA FAS-AS1 promotes the degradation of extracellular matrix of cartilage in osteoarthritis.
LncRNA TUG1 promotes osteoarthritis-induced degradation of chondrocyte extracellular matrix via miR-195/MMP-13 axis.
Low-Intensity Pulsed Ultrasound Treatment at an Early Osteoarthritis Stage Protects Rabbit Cartilage From Damage via the Integrin/Focal Adhesion Kinase/Mitogen-Activated Protein Kinase Signaling Pathway.
Maresin-1 suppresses IL-1?-induced MMP-13 secretion by activating the PI3K/AKT pathway and inhibiting the NF-?B pathway in synovioblasts of an osteoarthritis rat model with treadmill exercise.
Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium.
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.
Matrix metalloproteinase-13 expression in IL-1?-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways.
Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes.
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.
Mechanical impact induces cartilage degradation via mitogen activated protein kinases.
Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E2.
Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis.
Metabolic Syndrome Predisposes to Osteoarthritis: Lessons from Model System.
MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis.
MicroRNA-27b regulates the expression of MMP-13 in human osteoarthritis chondrocytes.
MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression.
miR-195 contributes to human osteoarthritis via targeting PTHrP.
MK801 regulates the expression of key osteoarthritis factors in osteoarthritis synovial fibroblasts through complement C5.
MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts.
MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis.
MMP13 and TIMP1 are functional markers for two different potential modes of action by mesenchymal stem/stromal cells when treating osteoarthritis.
MMP13 is a critical target gene during the progression of osteoarthritis.
Moderate joint loading reduces degenerative actions of matrix metalloproteinases in the articular cartilage of mouse ulnae.
Molecular changes indicative of cartilage degeneration and osteoarthritis development in patients with anterior cruciate ligament injury.
Molecular modelling studies of quinazolinone derivatives as MMP-13 inhibitors by QSAR, molecular docking and molecular dynamics simulations techniques.
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
New Hope for the Treatment of Osteoarthritis Through Selective Inhibition of MMP-13.
New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis.
NF-?B Phosphorylation Inhibition Prevents Articular Cartilage Degradation in Osteoarthritis Rats via 2-Aminoquinoline.
Non-Zinc-Binding Inhibitors of MMP-13: GRID-Based Approaches to Rationalize the Binding Process.
Notch Signaling Regulates MMP-13 Expression via Runx2 in Chondrocytes.
Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants.
Optimization of matrix metalloproteinase fluorogenic probes for osteoarthritis imaging.
Oral administration of N-acetyl cysteine prevents osteoarthritis development and progression in a rat model.
Osteoarthritic lesions: involvement of three different collagenases.
Osteoarthritis patients with high haemoglobin A1c have increased Toll-like receptor 4 and matrix metalloprotease-13 expression in the synovium.
Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol.
Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway: a new model of osteoarthritis.
Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis.
Osthole ameliorates cartilage degradation by downregulation of NF-?B and HIF-2? pathways in an osteoarthritis murine model.
Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis.
Oxidative stress-induced apoptosis and matrix loss of chondrocytes is inhibited by eicosapentaenoic acid.
Phenyl N-tert-butylnitrone down-regulates interleukin-1 beta-stimulated matrix metalloproteinase-13 gene expression in human chondrocytes: suppression of c-Jun NH2-terminal kinase, p38-mitogen-activated protein kinase and activating protein-1.
Phosphorylation of osteopontin in osteoarthritis degenerative cartilage and its effect on matrix metalloprotease 13.
Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs.
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice.
Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13.
Potent inhibitors precise to S1' loop of MMP-13, a crucial target for osteoarthritis.
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Proline-Serine-Threonine Phosphatase-Interacting Protein 2 Alleviates Diabetes Mellitus-Osteoarthritis in Rats through Attenuating Synovial Inflammation and Cartilage Injury.
Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGF?-dependent manner and limits osteoarthritis in mice.
Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes.
Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13.
Protein expression of MMP-13, uPA, and PAI-1 in pseudocapsular and interface tissue around implants of loose artificial hip joints and in osteoarthritis.
Proteolysis of the collagen fibril in osteoarthritis.
Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes.
Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats.
Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Recent Research Advances in Selective Matrix Metalloproteinase-13 Inhibitors as Anti-Osteoarthritis Agents.
Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).
Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage.
Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes.
Rice Porridge Containing Welsh Onion Root Water Extract Alleviates Osteoarthritis-Related Pain Behaviors, Glucose Levels, and Bone Metabolism in Osteoarthritis-Induced Ovariectomized Rats.
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.
Salubrinal reduces expression and activity of MMP13 in chondrocytes.
Salvia miltiorrhiza-asarum ointment combined with Chinese medical massage alleviates symptoms of osteoarthritis in a rat model through the Notch1/ matrix metalloproteinase-13 signaling pathway.
Selective MMP-13 inhibitors: promising agents for the therapy of Osteoarthritis.
Serum and knee synovial fluid matrix metalloproteinase-13 and tumor necrosis factor-alpha levels in patients with late-stage osteoarthritis.
Serum and knee synovial fluid matrixmetalloproteinase-13 and tumor necrosis factor-alpha levels in patients with late stage osteoarthritis.
Single vs. repeated matrix metalloproteinase-13 knockdown with intra-articular short interfering RNA administration in a murine osteoarthritis model.
Suppression of cartilage degeneration by intra-articular injection of heparan sulfate 6-O endosulfatase in a mouse osteoarthritis model.
Targeted inhibition of ?-catenin by miR-320 and decreased MMP-13 expression in suppressing chondrocyte collagen degradation.
The effect of different treatment time of millimeter wave on chondrocyte apoptosis, caspase-3, caspase-8, and MMP-13 expression in rabbit surgically induced model of knee osteoarthritis.
The effects of amphiregulin induced MMP-13 production in human osteoarthritis synovial fibroblast.
The Effects of Laser Moxibustion on Knee Osteoarthritis Pain in Rats.
The effects of low-intensity pulsed ultrasound and nanomagnet applications on the expressions of MMP-13 and MAPKs in rabbit knee osteoarthritis.
The Evaluation of the Effect of Herbal Extract on Osteoarthritis: In Vitro and In Vivo Study.
The Influence of Wharton Jelly Mesenchymal Stem Cell toward Matrix Metalloproteinase-13 and RELA Synoviocyte Gene Expression on Osteoarthritis.
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
The Involvement of Mutual Inhibition of ERK and mTOR in PLC?1-Mediated MMP-13 Expression in Human Osteoarthritis Chondrocytes.
The morphology and histology study on rabbit degenerated medial meniscus after posterior cruciate ligament rupture.
The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis.
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.
The relationship between abnormal Core binding factor-? expression in human cartilage and osteoarthritis.
Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis.
Transcriptional activation of human MMP-13 gene expression by c-Maf in osteoarthritic chondrocyte.
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors.
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.
Upregulated ank expression in osteoarthritis can promote both chondrocyte MMP-13 expression and calcification via chondrocyte extracellular PPi excess.
Virtual screening on MMP-13 led to discovering new inhibitors including a non-zinc binding and a micro molar one: a successful example of receptor selection according to cross-docking results for a flexible enzyme.
Yeast microcapsule-mediated oral delivery of IL-1? shRNA for post-traumatic osteoarthritis therapy.
Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium.
[Biochemical analysis of the synovial fluid of the shoulder joint in patients with and without rotator cuff tears]
[Changes of six serum biomarkers of rabbits with experimental osteoarthritis].
[Effect of acupotomy lysis on serum matrix metalloproteinase (MMP)-3 and MMP-13 contents in osteoarthritis rabbits]
[Effects of intra-articular injection of p38 mitogen-activated protein kinase inhibitor on matrix metalloproteinase in articular cartilage of a rat model of osteoarthritis]
[Hydrogen sulfide in cartilage and its inhibitory effect on matrix metalloproteinase 13 expression in chondrocytes induced by interlukin-1?].
[Protective effect of LR-90 on articular cartilage in rabbit model of osteoarthritis].
[Regulating effects of transforming growth factor beta on gene expression of matrix metalloproteinase 13 mRNA in human hyaline chondrocytes]
[Transplantation of adipose derived mesenchymal stem cells alleviated osteoarthritis induced with anterior cruciate ligament transection].
Osteoarthritis, Knee
Allogeneic adipose-derived stem cell transplantation on knee osteoarthritis rats and its effect on MMP-13 and DDR2.
Association of IL-6, IL-8, MMP-13 gene polymorphisms with knee osteoarthritis susceptibility in the Chinese Han population.
Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis.
Chondrocyte calcium-sensing receptor expression is up-regulated in early guinea pig knee osteoarthritis and modulates PTHrP, MMP-13, and TIMP-3 expression.
Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis.
Effect of low intensity pulsed ultrasound on expression of TIMP-2 in serum and expression of mmp-13 in articular cartilage of rabbits with knee osteoarthritis.
Effect of Low-Intensity Pulsed Ultrasound on MMP-13 and MAPKs Signaling Pathway in Rabbit Knee Osteoarthritis.
Lack of association between MMP13 (rs3819089), ADAM12 (rs3740199-rs1871054) and ADAMTS14 (rs4747096) genotypes and advanced-stage knee osteoarthritis.
Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis.
Matrix metalloproteinase-13, NF-?B p65 and interleukin-1? are associated with the severity of knee osteoarthritis.
Single vs. repeated matrix metalloproteinase-13 knockdown with intra-articular short interfering RNA administration in a murine osteoarthritis model.
The effect of different treatment time of millimeter wave on chondrocyte apoptosis, caspase-3, caspase-8, and MMP-13 expression in rabbit surgically induced model of knee osteoarthritis.
The effects of low-intensity pulsed ultrasound and nanomagnet applications on the expressions of MMP-13 and MAPKs in rabbit knee osteoarthritis.
[Effects of Short Thrust Needing plus Electroacupuncture Intervention on Cartilage Tissue in Rabbits with Knee Osteoarthritis].
[Roles of biochemical factors in lateral compartment wear from varus knee osteoarthritis].
Osteochondritis Dissecans
Osteochondritis Dissecans (OCD)-Derived Chondrocytes Display Increased Senescence, Oxidative Stress, Chaperone-Mediated Autophagy and, in Co-Culture with Adipose-Derived Stem Cells (ASCs), Enhanced Expression of MMP-13.
Osteochondrodysplasias
Expression of Genes Encoding Extracellular Matrix Macromolecules and Metalloproteinases in Avian Tibial Dyschondroplasia.
Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway: a new model of osteoarthritis.
Osteolysis
Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival.
Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface.
MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1.
Non-bone metastatic cancers promote osteocyte-induced bone destruction.
Osteocytes respond to particles of clinically-relevant conventional and cross-linked polyethylene and metal alloys by up-regulation of resorptive and inflammatory pathways.
PAI-1, a target gene of miR-143, regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma.
Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas.
Upregulated osterix promotes invasion and bone metastasis and predicts for a poor prognosis in breast cancer.
Osteomyelitis
The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population.
Osteophyte
Associations of serum citrate levels with knee structural changes and cartilage enzymes in patients with knee osteoarthritis.
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.
Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice.
Grape seed proanthocyanidin extract (GSPE) ameliorates monosodium iodoacetate-induced osteoarthritis.
Insulin-Like Growth Factor II (IGF-II) Inhibits IL-1?-Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis.
Molecular changes in Articular Cartilage and Subchondral Bone in the Rat Anterior Cruciate Ligament Transection and Meniscectomized Models of Osteoarthritis.
Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis.
Role of the C-C chemokine receptor-2 in a murine model of injury-induced osteoarthritis.
Suppression of murine osteoarthritis by 4-methylumbelliferone.
Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis.
Osteoporosis
Dynamic expression of matrix metalloproteinases 2, 9 and 13 in ovariectomy-induced osteoporosis rats.
Effects of dioxin and estrogen on collagenase-3 in UMR 106-01 osteosarcoma cells.
Estrogen receptor alpha regulates matrix metalloproteinase-13 promoter activity primarily through the AP-1 transcriptional regulatory site.
[Electroacupuncture Intervention Improves Cartilage Degeneration and Subchondral Bone Osteoporosis of Knee-joint Possibly by Adjusting OPG/RANK/RANKL Signaling in Ovariectomized Rats].
Osteosarcoma
AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.
Collagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalization.
Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of carcinoma cells following Snail-mediated epithelial-mesenchymal transition.
Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression.
Effects of dioxin and estrogen on collagenase-3 in UMR 106-01 osteosarcoma cells.
Expression of collagenase-3 (MMP-13) in c-fos-induced osteosarcomas and chondrosarcomas is restricted to a subset of cells of the osteo-/chondrogenic lineage.
Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones.
Interleukin-32 stimulates osteosarcoma cell invasion and motility via AKT pathway-mediated MMP-13 expression.
MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression.
MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression.
PAI-1, a target gene of miR-143, regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma.
Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1.
Propofol inhibits proliferation and invasion of osteosarcoma cells by regulation of microRNA-143 expression.
Protective effects of acetaminophen on Ibuprofen-induced gastric mucosal damage in rats with associated suppression of matrix metalloproteinase.
Regulation of the collagenase-3 receptor and its role in intracellular ligand processing in rat osteoblastic cells.
Shikonin inhibits invasiveness of osteosarcoma through MMP13 suppression.
TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells.
Triclosan Blocks Mmp 13 Expression in Hormone-Stimulated Osteoblasts.
Ovarian Neoplasms
Clinical relevance of matrix metalloproteinase-13 determined with a new highly specific and sensitive ELISA in ascitic fluid of advanced ovarian carcinoma patients.
ETS-1 regulates vascular endothelial growth factor-induced matrix metalloproteinase-9 and matrix metalloproteinase-13 expression in human ovarian carcinoma cell SKOV-3.
Hypoxia-Inducible Factor-1? (HIF-1?) Promotes Hypoxia-Induced Invasion and Metastasis in Ovarian Cancer by Targeting Matrix Metallopeptidase 13 (MMP13).
The prognostic values of matrix metalloproteinases in ovarian cancer.
[Association of functional polymorphisms on MMP-12 and MMP-13 gene promoter region with epithelial ovarian carcinoma.]
Overweight
Obesity affects the chondrocyte responsiveness to leptin in patients with osteoarthritis.
Pancreatic Neoplasms
Leptin signaling enhances cell invasion and promotes the metastasis of human pancreatic cancer via increasing MMP-13 production.
The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways.
Parkinson Disease
MMP13 Expression Is Increased Following Mutant ?-Synuclein Exposure and Promotes Inflammatory Responses in Microglia.
Patellar Dislocation
Changes in cartilage and subchondral bone in a growing rabbit experimental model of developmental trochlear dysplasia of the knee.
Pemphigoid, Bullous
Increased expression of matrix metalloproteinase-2, matrix metalloproteinase-9 and matrix metalloproteinase-13 in lesional skin of bullous pemphigoid.
Peri-Implantitis
Histochemical and immunohistochemical evaluation of gingival collagen and metalloproteinases in peri-implantitis.
MMP13, TIMP2 and TGFB3 Gene Polymorphisms in Brazilian Chronic Periodontitis and Periimplantitis Subjects.
Periapical Granuloma
Collagenase-3 (MMP-13) is expressed in periapical lesions: an immunohistochemical study.
Collagenase-3 expression in periapical lesions: an immunohistochemical study.
Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions.
Periapical Periodontitis
Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions.
Sirtuin 1 regulates matrix metalloproteinase-13 expression induced by Porphyromonas endodontalis lipopolysaccharide via targeting nuclear factor-?B in osteoblasts.
Periodontal Diseases
Differential regulation of MMP-13 expression in two models of experimentally induced periodontal disease in rats.
Fusobacterium nucleatum increases collagenase 3 production and migration of epithelial cells.
Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases.
Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity.
MKK3/6-p38 MAPK negatively regulates murine MMP-13 gene expression induced by IL-1beta and TNF-alpha in immortalized periodontal ligament fibroblasts.
Silencing matrix metalloproteinase-13 (Mmp-13) reduces inflammatory bone resorption associated with LPS-induced periodontal disease in vivo.
Triclosan Blocks Mmp 13 Expression in Hormone-Stimulated Osteoblasts.
[The significance of the expression of matrix metalloproteinases in the differential diagnosis of periodontal diseases].
Periodontal Pocket
Periodontal and endodontic infectious/inflammatory profile in primary periodontal lesions with secondary endodontic involvement after a calcium hydroxide-based intracanal medication.
Periodontitis
Association of Common Variants in MMPs with Periodontitis Risk.
Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue.
Effect of Subantimicrobial Dose Doxycycline Treatment on Gingival Crevicular Fluid Levels of MMP-9 and MMP-13 in Periodontitis Stage 2, Grade B in Subjects with Type 2 Diabetes Mellitus.
Evaluation of collagenase-3 matrix metalloproteinase-13 gene-associated polymorphisms 11A/12A and -77A/G and its associated alleles with and without periodontitis.
Expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy and diseased human gingiva.
Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression.
Matrix metalloproteinase-13 is highly expressed in destructive periodontal disease activity.
MMP-13 and TIMP-1 determinations in progressive chronic periodontitis.
Non-Surgical Periodontal Therapy Reduces Saliva Adipokines and Matrix Metalloproteinases Levels in Periodontitis.
Prioritization of Candidate Genes for Periodontitis Using Multiple Computational Tools.
Salivary MMP-13 gender differences in periodontitis: A cross-sectional study from Sweden.
Silencing matrix metalloproteinase-13 (Mmp-13) reduces inflammatory bone resorption associated with LPS-induced periodontal disease in vivo.
Temporal expression of metalloproteinase-8 and -13 and their relationships with extracellular matrix metalloproteinase inducer in the development of ligature-induced periodontitis in rats.
[Effects of Bushenguchiwan on expression of matrix metalloproteinase-13 in rats' periodontium].
[The significance of the expression of matrix metalloproteinases in the differential diagnosis of periodontal diseases].
Peripheral Nervous System Diseases
Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation.
Plasmacytoma
Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions.
Pneumonia
Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis.
Pathophysiological changes induced by Pseudomonas aeruginosa infection are involved in MMP-12 and MMP-13 upregulation in human carcinoma epithelial cells and a pneumonia mouse model.
Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor ?B Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model.
Pneumoperitoneum
Gas-related impact of pneumoperitoneum on systemic wound healing.
Impact of pressure and gas type on anastomotic wound healing in rats.
Improved abdominal wall wound healing by helium pneumoperitoneum.
Polyhydramnios
Amniotic fluid concentrations of collagenase-1 and collagenase-3 are increased in polyhydramnios.
Porcine Reproductive and Respiratory Syndrome
Matrix metalloproteinase-13 expression in response to double-stranded RNA in human chondrocytes.
Pre-Eclampsia
Altered Maternal Serum Matrix Metalloproteinases MMP-2, MMP-3, MMP-9, and MMP-13 in Severe Early- and Late-Onset Preeclampsia.
Matrix metalloproteinase multiplex screening identifies increased MMP-2 urine concentrations in women predicted to develop preeclampsia.
Premature Birth
Replens Prevents Preterm Birth by Decreasing Type I Interferon Strengthening the Cervical Epithelial Barrier.
Prostatic Hyperplasia
Co-expression of TLR-9 and MMP-13 is associated with the degree of tumour differentiation in prostate cancer.
Prostatic Intraepithelial Neoplasia
Co-expression of TLR-9 and MMP-13 is associated with the degree of tumour differentiation in prostate cancer.
Prostatic Neoplasms
Characterization of expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in prostate cancer cell lines.
Co-expression of TLR-9 and MMP-13 is associated with the degree of tumour differentiation in prostate cancer.
Collagenase-3 expression by tumor cells and gelatinase B expression by stromal fibroblast-like cells are associated with biochemical recurrence after radical prostatectomy in patients with prostate cancer.
CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion.
Expression and functional role of CCR9 in prostate cancer cell migration and invasion.
Melatonin impedes prostate cancer metastasis by suppressing MMP-13 expression.
MicroRNA-143 inhibits cell migration and invasion by targeting matrix metalloproteinase 13 in prostate cancer.
Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13.
Plasma levels of E-cadherin and MMP-13 in prostate cancer patients: correlation with PSA, testosterone and pathological parameters.
Regulation of matrix metalloproteinase 13 expression by androgen in prostate cancer.
Small leucine zipper protein promotes the metastasis of castration-resistant prostate cancer through transcriptional regulation of matrix metalloproteinase-13.
The Transcription Factor SPDEF Suppresses Prostate Tumor Metastasis.
Pseudomonas Infections
Matrix Metalloproteinase-13 as a Target for Suppressing Corneal Ulceration Caused by Pseudomonas aeruginosa Infection.
Pathophysiological changes induced by Pseudomonas aeruginosa infection are involved in MMP-12 and MMP-13 upregulation in human carcinoma epithelial cells and a pneumonia mouse model.
Psoriasis
Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis.
Differences in Osteoimmunological Biomarkers Predictive of Psoriatic Arthritis among a Large Italian Cohort of Psoriatic Patients.
Pterygium
Cyclosporine A Downregulates MMP-3 and MMP-13 Expression in Cultured Pterygium Fibroblasts.
Inhibition of Pterygium Fibroblast Migration and Outgrowth by Bevacizumab and Cyclosporine A Involves Down-Regulation of Matrix Metalloproteinases-3 and -13.
Pulmonary Disease, Chronic Obstructive
Evaluation of collagenase activity, matrix metalloproteinase-8, and matrix metalloproteinase-13 in horses with chronic obstructive pulmonary disease.
Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism.
Proteomic Analysis in Lung Tissue of Smokers and COPD Patients.
Targeting matrix metalloproteinase-13 in bronchial epithelial repair.
Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD.
Pulmonary Fibrosis
Clinical significance of serum levels of matrix metalloproteinase-13 in patients with systemic sclerosis.
Delayed resolution of bleomycin-induced pulmonary fibrosis in absence of MMP13 (collagenase 3).
Loss of matrix metalloproteinase-13 attenuates murine radiation-induced pulmonary fibrosis.
Low dose pirfenidone suppresses transforming growth factor beta-1 and tissue inhibitor of metalloproteinase-1, and protects rats from lung fibrosis induced by bleomycina.
Radicular Cyst
Collagenase-3 (MMP-13) is expressed in periapical lesions: an immunohistochemical study.
Collagenase-3 expression in periapical lesions: an immunohistochemical study.
Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions.
High matrix metalloproteinase activity is a hallmark of periapical granulomas.
receptor protein-tyrosine kinase deficiency
Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.
Relative Energy Deficiency in Sport
Effect of type II diabetes-induced osteoarthritis on articular cartilage aging in rats: A study in vivo and in vitro.
Retinal Detachment
Retinal MMP-12, MMP-13, TIMP-1, and TIMP-2 Expression in Murine Experimental Retinal Detachment.
Retinoblastoma
HOXB5 promotes retinoblastoma cell migration and invasion via ERK1/2 pathway-mediated MMPs production.
Rickets
Rickets manifestations in a child with metaphyseal anadysplasia, report of a spontaneously resolving case.
Sacroiliitis
Interleukin 6 is not a crucial regulator in an animal model of tumour necrosis factor-mediated bilateral sacroiliitis.
Sarcoma, Kaposi
MiR99a modulates MMP7 and MMP13 to regulate invasiveness of Kaposi's sarcoma.
[Let-7 miRNA silencing promotes Kaposi's sarcoma-associated herpesvirus lytic replication via activating mitogen-activated protein kinase kinase kinase kinase 4 and its downstream factors].
Sarcoma, Synovial
Novel p38 MAP kinase inhibitor R-130823 suppresses IL-6, IL-8 and MMP-13 production in spheroid culture of human synovial sarcoma cell line SW 982.
Schistosomiasis
Effective Amelioration of Liver Fibrosis Through Lentiviral Vector Carrying Toxoplasma gondii gra15II in Murine Model.
Scleroderma, Diffuse
Serum levels of matrix metalloproteinase-13 in patients with eosinophilic fasciitis.
Scleroderma, Localized
Clinical significance of serum matrix metalloproteinase-13 levels in patients with localized scleroderma.
Serum levels of matrix metalloproteinase-13 in patients with eosinophilic fasciitis.
Scleroderma, Systemic
Clinical significance of serum levels of matrix metalloproteinase-13 in patients with systemic sclerosis.
Serum levels of matrix metalloproteinase-13 in patients with eosinophilic fasciitis.
Sepsis
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF.
Role of plasma matrix-metalloproteases (MMPs) and their polymorphisms (SNPs) in sepsis development and outcome in ICU patients.
TNF? cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis.
Severe Combined Immunodeficiency
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Shoulder Dislocation
Factors Expressed in an Animal Model of Anteroinferior Glenohumeral Instability.
Silicosis
Expression and localization of TIMP-1, TIMP-2, MMP-13, MMP-2, and MMP-9 in early and advanced experimental lung silicosis.
Matrix metalloproteinases 2, 9, and 13, and tissue inhibitors of metalloproteinases 1 and 2 in experimental lung silicosis.
Skin Neoplasms
Expression of Matrix Metalloproteinase-13 and Ki-67 in Nonmelanoma Skin Cancer in Xeroderma Pigmentosum and Non-xeroderma Pigmentosum.
Skin Ulcer
Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts.
Spinal Stenosis
The increased expression of matrix metalloproteinases associated with elastin degradation and fibrosis of the ligamentum flavum in patients with lumbar spinal stenosis.
Spondylosis
[Effects of Chiropractics on Intervertebral Disk Extracell Matrix and Metabolic Enzymes in Rats with Cervical Spondylosis].
Squamous Cell Carcinoma of Head and Neck
Alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells.
Association between high collagenase-3 expression levels and poor prognosis in patients with head and neck cancer.
Association of polymorphisms in IL-8, MMP-1 and MMP-13 with the risk and prognosis of oral and oropharyngeal squamous cell carcinoma.
Correlation Between the Expression of Matrix Metalloproteinase-9, Matrix Metalloproteinase-13, Tissue Inhibitor of Metalloproteinases-1, p16 and Differentiation of Head and Neck Squamous Cell Carcinoma: A Prospective Observational Study.
CXCR4 promotes oral squamous cell carcinoma migration and invasion through inducing expression of MMP-9 and MMP-13 via the ERK signaling pathway.
Elevated expression of MMP-13 and TIMP-1 in head and neck squamous cell carcinomas may reflect increased tumor invasiveness.
Evaluation of Collagen in Leukoplakia, Oral Submucous Fibrosis and Oral Squamous Cell Carcinomas Using Polarizing Microscopy and Immunohistochemistry
Identification and analysis of genes associated with head and neck squamous cell carcinoma by integrated bioinformatics methods.
Increase of MMP-13 expression in multi-stage oral carcinogenesis and epigallocatechin-3-gallate suppress MMP-13 expression.
Overexpression of MMP13 is associated with clinical outcomes and poor prognosis in oral squamous cell carcinoma.
p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells.
Prognostic value of matrix metalloproteinases in oral squamous cell carcinoma.
Regulation of programmed-death ligand in the human head and neck squamous cell carcinoma microenvironment is mediated through matrix metalloproteinase-mediated proteolytic cleavage.
Role of matrix metalloproteinase 13 gene expression in the evaluation of radiation response in oral squamous cell carcinoma.
Serum and saliva collagenase-3 (MMP-13) in patients with oral lichen planus and oral squamous cell carcinoma.
The usefulness of new serum tumor markers in head and neck squamous cell carcinoma.
[Collagenase 3 mRNA expression in squamous epithelial carcinomas of the oropharynx]
Stomach Neoplasms
Correlation of COX-2 and MMP-13 expressions with gastric cancer and their effects on prognosis.
Expression analysis of matrix metalloproteinase-13 in human gastric cancer in the presence of Helicobacter Pylori infection.
Expression of collagenase-3 (matrix metalloproteinase-13) in human gastric cancer.
Inhibition of epidermal growth factor receptor signaling prohibits metastasis of gastric cancer via downregulation of MMP7 and MMP13.
Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways.
SIRT1 inhibits gastric cancer proliferation and metastasis via STAT3/MMP-13 signaling.
[Expression and clinical significance of collagenase-3 (MMP-13) in gastric cancer]
[Retraction] Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways.
Stomach Ulcer
Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing.
Stroke
A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke.
Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet reactivity.
Matrix metalloproteinase-13 is activated and is found in the nucleus of neural cells after cerebral ischemia.
Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice.
Plasma Matrix Metalloproteinases in Patients With Stroke During Intensive Rehabilitation Therapy.
Sunburn
Noninvasive Assessment of UV-induced Skin Damage: Comparison of Optical Measurements to Histology and MMP Expression.
Synovitis
Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators.
Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis.
Baicalin Inhibits Inflammatory Responses to Interleukin-1? Stimulation in Human Chondrocytes.
Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model.
Elevated expression of ICAM-1 in synovium is associated with early inflammatory response for cartilage degeneration in type 2 diabetes mellitus.
Interleukin-34 overexpression mediated through tumor necrosis factor-alpha reflects severity of synovitis in knee osteoarthritis.
The expression of collagenase 3 (MMP-13) mRNA in the synovial tissue is associated with histopathologic type II synovitis in rheumatoid arthritis.
Transcriptional Profiling of Synovium in a Porcine Model of Early Post-traumatic Osteoarthritis.
Synucleinopathies
MMP13 Expression Is Increased Following Mutant ?-Synuclein Exposure and Promotes Inflammatory Responses in Microglia.
t-plasminogen activator deficiency
Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity.
Temporomandibular Joint Disorders
Activation of ?-catenin signalling leads to temporomandibular joint defects.
Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients.
Tendinopathy
Active expression of matrix metalloproteinase-13 mRNA in the granulation tissue of equine superficial digital flexor tendinitis.
Enhanced tendon restoration effects of anti-inflammatory, lactoferrin-immobilized, heparin-polymeric nanoparticles in an Achilles tendinitis rat model.
Erratum: Posterior tibial tendinopathy associated with matrix metalloproteinase 13 promoter genotype and haplotype.
Posterior tibial tendinopathy associated with matrix metalloproteinase 13 promoter genotype and haplotype.
Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy.
Tendon degeneration is not mediated by regulation of Toll-like receptors 2 and 4 in human tenocytes.
Tenosynovitis
Production of cytokines, vascular endothelial growth factor, matrix metalloproteinases, and tissue inhibitor of metalloproteinases 1 by tenosynovium demonstrates its potential for tendon destruction in rheumatoid arthritis.
Thrombosis
Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet reactivity.
Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis.
Matrix metalloproteinase-13 unlucky for the forming thrombus.
MMP-13 binds to platelet receptors ?IIb?3 and GPVI and impairs aggregation and thrombus formation.
Modified platelet deposition on matrix metalloproteinase 13 digested collagen I.
Thymoma
LIFR functions as a metastasis suppressor in hepatocellular carcinoma by negatively regulating phosphoinositide 3-kinase/AKT pathway.
Thyroid Cancer, Papillary
Expression of MMP-13 is associated with invasion and metastasis of papillary thyroid carcinoma.
Thyroid Carcinoma, Anaplastic
Integrated analysis of transcriptome data revealed MMP3 and MMP13 as critical genes in anaplastic thyroid cancer progression.
Thyroid Neoplasms
Relaxin enhances the collagenolytic activity and in vitro invasiveness by upregulating matrix metalloproteinases in human thyroid carcinoma cells.
Tuberculosis
Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis.
Tuberculosis, Spinal
miRNA-155 expression and role in pathogenesis in spinal tuberculosis-induced intervertebral disc destruction.
Ureteral Obstruction
Twist1 in Infiltrating Macrophages Attenuates Kidney Fibrosis via Matrix Metallopeptidase 13-Mediated Matrix Degradation.
Urinary Bladder Neoplasms
microRNA-125b inhibits cell migration and invasion by targeting matrix metallopeptidase 13 in bladder cancer.
PLD1 promotes tumor invasion by regulation of MMP-13 expression via NF-?B signaling in bladder cancer.
Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer.
SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1.
Significance of collagenase 3 (matrix metalloproteinase 13) in invasive bladder cancer: correlation with pathological parameters.
SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells.
Uterine Cervical Neoplasms
Down-expression of GOLM1 enhances the chemo-sensitivity of cervical cancer to methotrexate through modulation of the MMP13/EMT axis.
Integrated analysis of HPV-mediated immune alterations in cervical cancer.
Vaccinia
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
Varicose Ulcer
Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds.
Varicose Veins
Matrix Metalloproteinases in Vascular Disease - A Potential Therapeutic Target?
Metalloproteinase expression in venous aneurysms.
Varicose veins possess greater quantities of MMP-1 than normal veins and demonstrate regional variation in MMP-1 and MMP-13.
Vascular Diseases
RECK suppresses interleukin-17/TRAF3IP2-mediated MMP-13 activation and human aortic smooth muscle cell migration and proliferation.
Vascular System Injuries
Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet reactivity.
Role of the fibrinolytic and matrix metalloproteinase systems in arterial neointima formation after vascular injury.
Virus Diseases
Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism.
Matrix Metalloproteinase-13 in Atherosclerotic Plaque Is Increased by Influenza A Virus Infection.
Targeting matrix metalloproteinase-13 in bronchial epithelial repair.
Vitamin D Deficiency
Vitamin D Inhibits Activities of Metalloproteinase-9/-13 in Articular Cartilage In Vivo and In Vitro.
Wiskott-Aldrich Syndrome
Differentially up-regulated genes in proliferating porcine neonatal pancreas cells caused by epidermal growth factor.
Xeroderma Pigmentosum
Expression of Matrix Metalloproteinase-13 and Ki-67 in Nonmelanoma Skin Cancer in Xeroderma Pigmentosum and Non-xeroderma Pigmentosum.