Reference on EC 3.4.24.B11 - ADAMTS1 endopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (P97857), Rattus norvegicus (Q9WUQ1)
Sandy, J.D.; Westling, J.; Kenagy, R.D.; Iruela-Arispe, M.L.; Verscharen, C.; Rodriguez-Mazaneque, J.C.; Zimmermann, D.R.; Lemire, J.M.; Fischer, J.W.; Wight, T.N.; Clowes, A.W.
Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4
J. Biol. Chem.
276
13372-13378
2001
Homo sapiens
Iruela-Arispe, M.L.; Carpizo, D.; Luque, A.
ADAMTS1: a matrix metalloprotease with angioinhibitory properties
Ann. N. Y. Acad. Sci.
995
183-190
2003
Homo sapiens
Rodriguez-Manzaneque, J.C.; Westling, J.; Thai, S.N.; Luque, A.; Knauper, V.; Murphy, G.; Sandy, J.D.; Iruela-Arispe, M.L.
ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors
Biochem. Biophys. Res. Commun.
293
501-508
2002
Homo sapiens
Vankemmelbeke, M.N.; Jones, G.C.; Fowles, C.; Ilic, M.Z.; Handley, C.J.; Day, A.J.; Knight, C.G.; Mort, J.S.; Buttle, D.J.
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters
Eur. J. Biochem.
270
2394-2403
2003
Homo sapiens (Q9UHI8)
Kuno, K.; Okada, Y.; Kawashima, H.; Nakamura, H.; Miyasaka, M.; Ohno, H.; Matsushima, K.
ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan
FEBS Lett.
478
241-245
2000
Mus musculus
Tang, B.L.
ADAMTS: a novel family of extracellular matrix proteases
Int. J. Biochem. Cell Biol.
33
33-44
2001
Mus musculus, Homo sapiens (Q9UHI8)
Kuno, K.; Terashima, Y.; Matsushima, K.
ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix
J. Biol. Chem.
274
18821-18826
1999
Mus musculus
Vazquez, F.; Hastings, G.; Ortega, M.A.; Lane, T.F.; Oikemus, S.; Lombardo, M.; Iruela-Arispe, M.L.
METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity
J. Biol. Chem.
274
23349-23357
1999
Homo sapiens (Q9UHI8), Homo sapiens
Rodriguez-Manzaneque, J.C.; Milchanowski, A.B.; Dufour, E.K.; Leduc, R.; Iruela-Arispe, M.L.
Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms
J. Biol. Chem.
275
33471-33479
2000
Homo sapiens
Luque, A.; Carpizo, D.R.; Iruela-Arispe, M.L.
ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165
J. Biol. Chem.
278
23656-23665
2003
Homo sapiens
Kaushal, G.P.; Shah, S.V.
The new kids on the block: ADAMTSs, potentially multifunctional metalloproteinases of the ADAM family
J. Clin. Invest.
105
1335-1337
2000
Mus musculus
Guenther, W.; Skaftnesmo, K.O.; Arnold, H.; Bjerkvig, R.; Terzis, A.J.
Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development
Acta Histochem.
107
121-131
2005
Rattus norvegicus
Kuno, K.; Bannai, K.; Hakozaki, M.; Matsushima, K.; Hirose, K.
The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential
Biochem. Biophys. Res. Commun.
319
1327-1333
2004
Mus musculus
Mittaz, L.; Russell, D.L.; Wilson, T.; Brasted, M.; Tkalcevic, J.; Salamonsen, L.A.; Hertzog, P.J.; Pritchard, M.A.
Adamts-1 is essential for the development and function of the urogenital system
Biol. Reprod.
70
1096-1105
2004
Mus musculus
Cross, A.K.; Haddock, G.; Stock, C.J.; Allan, S.; Surr, J.; Bunning, R.A.; Buttle, D.J.; Woodroofe, M.N.
ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes
Brain Res.
1088
19-30
2006
Rattus norvegicus
Suga, A.; Hikasa, H.; Taira, M.
Xenopus ADAMTS1 negatively modulates FGF signaling independent of its metalloprotease activity
Dev. Biol.
295
26-39
2006
Xenopus laevis
Krampert, M.; Kuenzle, S.; Thai, S.N.; Lee, N.; Iruela-Arispe, M.L.; Werner, S.
ADAMTS1 proteinase is up-regulated in wounded skin and regulates migration of fibroblasts and endothelial cells
J. Biol. Chem.
280
23844-23852
2005
Mus musculus
Lee, N.V.; Rodriguez-Manzaneque, J.C.; Thai, S.N.; Twal, W.O.; Luque, A.; Lyons, K.M.; Argraves, W.S.; Iruela-Arispe, M.L.
Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1
J. Biol. Chem.
280
34796-34804
2005
Homo sapiens (Q9UHI8)
Torres-Collado, A.X.; Kisiel, W.; Iruela-Arispe, M.L.; Rodriguez-Manzaneque, J.C.
ADAMTS1 interacts with, cleaves, and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2
J. Biol. Chem.
281
17827-17837
2006
Homo sapiens
Shozu, M.; Minami, N.; Yokoyama, H.; Inoue, M.; Kurihara, H.; Matsushima, K.; Kuno, K.
ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary
J. Mol. Endocrinol.
35
343-355
2005
Mus musculus
Lind, T.; Birch, M.A.; McKie, N.
Purification of an insect derived recombinant human ADAMTS-1 reveals novel gelatin (type I collagen) degrading activities
Mol. Cell. Biochem.
281
95-102
2006
Homo sapiens (Q9UHI8)
Liu, Y.J.; Xu, Y.; Yu, Q.
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively
Oncogene
25
2452-2467
2006
Mus musculus (P97857)
Cross, N.A.; Chandrasekharan, S.; Jokonya, N.; Fowles, A.; Hamdy, F.C.; Buttle, D.J.; Eaton, C.L.
The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican
Prostate
63
269-275
2005
Homo sapiens
Basile, D.P.; Fredrich, K.; Chelladurai, B.; Leonard, E.C.; Parrish, A.R.
Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor
Am. J. Physiol. Renal Physiol.
294
F928-F936
2008
Rattus norvegicus
Rehn, A.P.; Birch, M.A.; Karlstroem, E.; Wendel, M.; Lind, T.
ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing
Bone
41
231-238
2007
Homo sapiens
Lind, G.E.; Kleivi, K.; Meling, G.I.; Teixeira, M.R.; Thiis-Evensen, E.; Rognum, T.O.; Lothe, R.A.
ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis
Cell. Oncol.
28
259-272
2006
Homo sapiens
Brown, H.M.; Dunning, K.R.; Robker, R.L.; Pritchard, M.; Russell, D.L.
Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis
Dev. Biol.
300
699-709
2006
Mus musculus
Stankunas, K.; Hang, C.T.; Tsun, Z.Y.; Chen, H.; Lee, N.V.; Wu, J.I.; Shang, C.; Bayle, J.H.; Shou, W.; Iruela-Arispe, M.L.; Chang, C.P.
Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis
Dev. Cell
14
298-311
2008
Mus musculus
Lee, N.V.; Sato, M.; Annis, D.S.; Loo, J.A.; Wu, L.; Mosher, D.F.; Iruela-Arispe, M.L.
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2
EMBO J.
25
5270-5283
2006
Homo sapiens
Kalinski, T.; Krueger, S.; Sel, S.; Werner, K.; Roepke, M.; Roessner, A.
ADAMTS1 is regulated by interleukin-1beta, not by hypoxia, in chondrosarcoma
Hum. Pathol.
38
86-94
2007
Homo sapiens
Gerhardt, S.; Hassall, G.; Hawtin, P.; McCall, E.; Flavell, L.; Minshull, C.; Hargreaves, D.; Ting, A.; Pauptit, R.A.; Parker, A.E.; Abbott, W.M.
Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains
J. Mol. Biol.
373
891-902
2007
Homo sapiens (Q9UHI8)
Canals, F.; Colome, N.; Ferrer, C.; Plaza-Calonge, M.d.e.l.C.; Rodriguez-Manzaneque, J.C.
Identification of substrates of the extracellular protease ADAMTS1 by DIGE proteomic analysis
Proteomics
6 Suppl 1
S28-S35
2006
Homo sapiens
Sabatine, M.S.; Ploughman, L.; Simonsen, K.L.; Iakoubova, O.A.; Kirchgessner, T.G.; Ranade, K.; Tsuchihashi, Z.; Zerba, K.E.; Long, D.U.; Tong, C.H.; Packard, C.J.; Pfeffer, M.A.; Devlin, J.J.; Shepherd, J.; Campos, H.; Sacks, F.M.; Braunwald, E.
Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy
Arterioscler. Thromb. Vasc. Biol.
28
562-567
2008
Homo sapiens (Q9UHI8), Homo sapiens
Rodriguez-Manzaneque, J.C.; Carpizo, D.; Plaza-Calonge, M.d.e.l..C.; Torres-Collado, A.X.; Thai, S.N.; Simons, M.; Horowitz, A.; Iruela-Arispe, M.L.
Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion
Int. J. Biochem. Cell Biol.
41
800-810
2009
Homo sapiens (Q9UHI8)
Hatipoglu, O.F.; Hirohata, S.; Cilek, M.Z.; Ogawa, H.; Miyoshi, T.; Obika, M.; Demircan, K.; Shinohata, R.; Kusachi, S.; Ninomiya, Y.
ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells
J. Biol. Chem.
284
16325-16333
2009
Homo sapiens
Diamantis, I.; Luethi, M.; Hoesli, M.; Reichen, J.
Cloning of the rat ADAMTS-1 gene and its down regulation in endothelial cells in cirrhotic rats
Liver
20
165-172
2000
Rattus norvegicus (Q9WUQ1)
Pockert, A.J.; Richardson, S.M.; Le Maitre, C.L.; Lyon, M.; Deakin, J.A.; Buttle, D.J.; Freemont, A.J.; Hoyland, J.A.
Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration
Arthritis Rheum.
60
482-491
2009
Homo sapiens (Q9UHI8)
Hamel, M.G.; Ajmo, J.M.; Leonardo, C.C.; Zuo, F.; Sandy, J.D.; Gottschall, P.E.
Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension
Exp. Neurol.
210
428-440
2008
Homo sapiens
Takizawa, M.; Yatabe, T.; Okada, A.; Chijiiwa, M.; Mochizuki, S.; Ghosh, P.; Okada, Y.
Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes
FEBS Lett.
582
2945-2949
2008
Homo sapiens
Demircan, K.; Gunduz, E.; Gunduz, M.; Beder, L.B.; Hirohata, S.; Nagatsuka, H.; Cengiz, B.; Cilek, M.Z.; Yamanaka, N.; Shimizu, K.; Ninomiya, Y.
Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer
Head Neck
10
793-801
2009
Homo sapiens
Hatipoglu, O.F.; Hirohata, S.; Yaykasli, K.O.; Cilek, M.Z.; Demircan, K.; Shinohata, R.; Yonezawa, T.; Oohashi, T.; Kusachi, S.; Ninomiya, Y.
The 3-untranslated region of ADAMTS1 regulates its mRNA stability
Acta Med. Okayama
63
79-85
2009
Homo sapiens
Brown, H.M.; Dunning, K.R.; Robker, R.L.; Boerboom, D.; Pritchard, M.A.; Lane, M.; Russell, D.L.
ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice
Biol. Reprod.
83
549-557
2010
Mus musculus
Curry, T.E.
ADAMTS1 and versican: partners in ovulation and fertilization
Biol. Reprod.
83
505-506
2010
Mus musculus
Gustavsson, H.; Tesan, T.; Jennbacken, K.; Kuno, K.; Damber, J.E.; Welen, K.
ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors
BMC Cancer
10
288
2010
Homo sapiens
Keightley, M.C.; Sales, K.J.; Jabbour, H.N.
PGF2alpha-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer
BMC Cancer
10
488
2010
Homo sapiens
Casal, C.; Torres-Collado, A.X.; Plaza-Calonge, M.d.e.l..C.; Martino-Echarri, E.; Ramon Y Cajal, S.; Rojo, F.; Griffioen, A.W.; Rodriguez-Manzaneque, J.C.
ADAMTS1 contributes to the acquisition of an endothelial-like phenotype in plastic tumor cells
Cancer Res.
70
4676-4686
2010
Homo sapiens
Lee, Y.J.; Koch, M.; Karl, D.; Torres-Collado, A.X.; Fernando, N.T.; Rothrock, C.; Kuruppu, D.; Ryeom, S.; Iruela-Arispe, M.L.; Yoon, S.S.
Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1
Cancer Res.
70
948-956
2010
Mus musculus
Guo, C.; Wang, Y.; Liang, H.; Zhang, J.
ADAMTS-1 contributes to the antifibrotic effect of captopril by accelerating the degradation of type I collagen in chronic viral myocarditis
Eur. J. Pharmacol.
629
104-110
2010
Mus musculus
Lu, X.; Wang, Q.; Hu, G.; Van Poznak, C.; Fleisher, M.; Reiss, M.; Massague, J.; Kang, Y.
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis
Genes Dev.
23
1882-1894
2009
Homo sapiens
Esselens, C.; Malapeira, J.; Colome, N.; Casal, C.; Rodriguez-Manzaneque, J.C.; Canals, F.; Arribas, J.
The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration
J. Biol. Chem.
285
2463-2473
2010
Homo sapiens (Q9UHI8)
Hohberg, M.; Knoechel, J.; Hoffmann, C.J.; Chlench, S.; Wunderlich, W.; Alter, A.; Maroski, J.; Vorderwuelbecke, B.J.; Silva-Azevedo, L.D.; Knudsen, R.; Lehmann, R.; Fiedorowicz, K.; Bongrazio, M.; Nitsche, B.; Hoepfner, M.; Styp-Rekowska, B.; Pries, A.R.; Zakrzewicz, A.
Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries
J. Cell. Physiol.
226
350-361
2011
Homo sapiens
Yung, Y.; Maman, E.; Konopnicki, S.; Cohen, B.; Brengauz, M.; Lojkin, I.; Dal Canto, M.; Fadini, R.; Dor, J.; Hourvitz, A.
ADAMTS-1: a new human ovulatory gene and a cumulus marker for fertilization capacity
Mol. Cell. Endocrinol.
328
104-108
2010
Homo sapiens (Q8NE26), Homo sapiens (Q9UHI8), Homo sapiens
Hu, L.; Jonsson, K.B.; Andersen, H.; Edenro, A.; Bohlooly-Y, M.; Melhus, H.; Lind, T.
Over-expression of Adamts1 in mice alters bone mineral density
J. Bone Miner. Metab.
30
304-311
2011
Mus musculus
Fu, Y.; Nagy, J.A.; Brown, L.F.; Shih, S.C.; Johnson, P.Y.; Chan, C.K.; Dvorak, H.F.; Wight, T.N.
Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis
J. Histochem. Cytochem.
59
463-473
2011
Mus musculus
Sayasith, K.; Lussier, J.; Sirois, J.
Molecular characterization and transcriptional regulation of a disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) in bovine preovulatory follicles
Endocrinology
154
2857-2869
2013
Bos taurus (A7MB07), Bos taurus
Inagaki, J.; Takahashi, K.; Ogawa, H.; Asano, K.; Faruk Hatipoglu, O.; Cilek, M.Z.; Obika, M.; Ohtsuki, T.; Hofmann, M.; Kusachi, S.; Ninomiya, Y.; Hirohata, S.
ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor
Exp. Cell Res.
323
263-275
2014
Homo sapiens (Q9UHI8), Homo sapiens
Hong-Brown, L.Q.; Brown, C.R.; Navaratnarajah, M.; Lang, C.H.
Adamts1 mediates ethanol-induced alterations in collagen and elastin via a FoxO1-sestrin3-AMPK signaling cascade in myocytes
J. Cell. Biochem.
116
91-101
2015
Mus musculus (P97857)
Toba, H.; de Castro Bras, L.E.; Baicu, C.F.; Zile, M.R.; Lindsey, M.L.; Bradshaw, A.D.
Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium
Am. J. Physiol. Endocrinol. Metab.
310
E1027-E1035
2016
Mus musculus (P97857)
Tola, E.N.; Koroglu, N.D.; Yalcin, S.E.; Oral, H.B.
The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females
Arch. Gynecol. Obstet.
297
487-493
2018
Homo sapiens (Q9UHI8)
Noriega-Guerra, H.; Cruz, M.C.; Ribeiro, P.R.L.; Strnadel, J.; Wang, H.; Klemke, R.L.; Jaeger, R.G.; Freitas, V.M.
ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma
Exp. Cell Res.
363
271-282
2018
Homo sapiens
Pehlivan, S.; Gurses, M.S.; Ural, M.N.; Akyol, S.; Eren, F.; Turkmen Inanir, N.; Gulec, M.A.; Eren, B.; Fedakar, R.; Demircan, K.; Akyol, O.
The Role of ADAMTS1 and versican in human myocardial infarction a postmortem study
Lab. Med.
47
205-212
2016
Homo sapiens (Q9UHI8), Homo sapiens
Du, H.; Shih, C.; Wosczyna, M.; Mueller, A.; Cho, J.; Aggarwal, A.; Rando, T.; Feldman, B.
Macrophage-released ADAMTS1 promotes muscle stem cell activation
Nat. Commun.
8
669
2017
Mus musculus (P97857)
Fernandez-Rodriguez, R.; Rodriguez-Baena, F.J.; Martino-Echarri, E.; Peris-Torres, C.; Del Carmen Plaza-Calonge, M.; Rodriguez-Manzaneque, J.C.
Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis
Oncotarget
7
34507-34519
2016
Mus musculus (P97857)
Silva, S.V.; Lima, M.A.; Cella, N.; Jaeger, R.G.; Freitas, V.M.
ADAMTS-1 is found in the nuclei of normal and tumoral breast cells
PLoS ONE
11
e0165061
2016
Homo sapiens (Q9UHI8)
Vorkapic, E.; Folkesson, M.; Magnell, K.; Bohlooly-Y, M.; Laenne, T.; Wagsaeter, D.
ADAMTS-1 in abdominal aortic aneurysm
PLoS ONE
12
e0178729
2017
Mus musculus (P97857), Homo sapiens (Q9UHI8)
Rodriguez-Baena, F.J.; Redondo-Garcia, S.; Peris-Torres, C.; Martino-Echarri, E.; Fernandez-Rodriguez, R.; Plaza-Calonge, M.D.C.; Anderson, P.; Rodriguez-Manzaneque, J.C.
ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response
Sci. Rep.
8
13103
2018
Mus musculus (P97857)
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