an isoform PPEP-1 knockout strain strain has no growth defect in vitro. The knockout strain demonstrates higher affinity for collagen type I with attenuated virulence in hamsters; enzyme destabilizes the fibronectin network produced by human fibroblast
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crystal structures of Zmp1 in its unbound and peptide-bound forms. The structure analysis reveals a fold similar to Bacillus anthracis lethal factor. The structure consists of an upper N-terminal domain and a lower helical C-terminal domain with respect to the active-site helix aalpha4, which harbors two of the three zinc-binding residues His142 and His146 and the catalytic base Glu143 in the typical metalloprotease motif (H142E143TAH146)