Reference on EC 3.4.24.83 - anthrax lethal factor endopeptidase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vitale, G.; Bernardi, L.; Napolitani, G.; Mock, M.; Montecucco, C.
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor
Biochem. J.
352
739-745
2000
Bacillus anthracis
Duesbery, N.S.; Webb, C.P.; Leppla, S.H.; Gordon, V.M.; Klimpel, K.R.; Copeland, T.D.; Ahn, N.G.; Oskarsson, M.K.; Fukasawa, K.; Paull, K.D.; Vande Woude, G.F.
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
Science
280
734-737
1998
Bacillus anthracis
Pannifer, A.D.; Wong, T.Y.; Schwarzenbacher, R.; Renatus, M.; Petosa, C.; Bienkowska, J.; Lacy, D.B.; Collier, R.J.; Park, S.; Leppla, S.H.; Hanna, P.; Liddington, R.C.
Crystal structure of the anthrax lethal factor
Nature
414
229-233
2001
Bacillus anthracis
Tonello, F.; Ascenzi, P.; Montecucco, C.
The metalloproteolytic activity of the anthrax lethal factor is substrate-inhibited
J. Biol. Chem.
278
40075-40078
2003
Bacillus anthracis
Pellizzari, R.; Guidi-Rontani, C.; Vitale, G.; Mock, M.; Montecucco, C.
Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha
FEBS Lett.
462
199-204
1999
Bacillus anthracis
Rossetto, O.; de Bernard, M.; Pellizzari, R.; Vitale, G.; Caccin, P.; Schiavo, G.; Montecucco, C.
Bacterial toxins with intracellular protease activity
Clin. Chim. Acta
291
189-199
2000
Bacillus anthracis
Glomski, I.J.; Fritz, J.H.; Keppler, S.J.; Balloy, V.; Chignard, M.; Mock, M.; Goossens, P.L.
Murine splenocytes produce inflammatory cytokines in MyD88-dependent response to Bacillus anthracis spores
cell. Microbiol.
9
502-513
2007
Bacillus anthracis
Gubbins, M.J.; Berry, J.D.; Corbett, C.R.; Mogridge, J.; Yuan, X.Y.; Schmidt, L.; Nicolas, B.; Kabani, A.; Tsang, R.S.
Production and characterization of neutralizing monoclonal antibodies that recognize an epitope in domain 2 of Bacillus anthracis protective antigen
FEMS Immunol. Med. Microbiol.
47
436-443
2006
Bacillus anthracis
Bergman, N.H.; Passalacqua, K.D.; Gaspard, R.; Shetron-Rama, L.M.; Quackenbush, J.; Hanna, P.C.
Murine macrophage transcriptional responses to Bacillus anthracis infection and intoxication
Infect. Immun.
73
1069-1080
2005
Bacillus anthracis
Comer, J.E.; Galindo, C.L.; Chopra, A.K.; Peterson, J.W.
GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis
Infect. Immun.
73
1879-1885
2005
Bacillus anthracis
Koya, V.; Moayeri, M.; Leppla, S.H.; Daniell, H.
Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge
Infect. Immun.
73
8266-8274
2005
Bacillus anthracis
Xu, L.; Frucht, D.M.
Bacillus anthracis: A multi-faceted role for anthrax lethal toxin in thwarting host immune defenses
Int. J. Biochem. Cell Biol.
39
20-24
2007
Bacillus anthracis
Baillie, L.W.J.
Past, imminent and future human medical countermeasures for anthrax
J. Appl. Microbiol.
101
594-606
2006
Bacillus anthracis
Cui, X.; Li, Y.; Li, X.; Haley, M.; Moayeri, M.; Fitz, Y.; Leppla, S.H.; Eichacker, P.Q.
Sublethal doses of Bacillus anthracis lethal toxin inhibit inflammation with lipopolysaccharide and Escherichia coli challenge but have opposite effects on survival
J. Infect. Dis.
193
829-840
2006
Bacillus anthracis
Gujraty, K.; Sadacharan, S.; Frost, M.; Poon, V.; kane, R.S.; Mogridge, J.
Functional characterization of peptide-based anthrax toxin inhibitors
Mol. Pharmacol.
2
367-372
2005
Bacillus anthracis
-
Boyden, E.D.; Dietrich, W.F.
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
Nat. Genet.
38
240-244
2006
Bacillus subtilis
Mendelson, I.; Gat, O.; Aloni-Grinstein, R.; Altboum, Z.; Inbar, I.; Kronman, C.; Bar-Haim, E.; Cohen, S.; Velan, B.; Shafferman, A.
Efficacious, nontoxigenic Bacillus anthracis spore vaccines based on strains expressing mutant variants of lethal toxin components
Vaccine
23
5688-5697
2005
Bacillus anthracis
Sloat, B.R.; Cui, Z.
Nasal immunozation with a dual antigen anthrax vaccine induced strong mucosal and systemic immune responses against toxins and bacilli
Vaccine
24
6405-6413
2006
Bacillus anthracis
Moayeri, M.; Robinson, T.M.; Leppla, S.H.; Karginov, V.A.
In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin
Antimicrob. Agents Chemother.
52
2239-2241
2008
Bacillus anthracis
Chvyrkova, I.; Zhang, X.C.; Terzyan, S.
Lethal factor of anthrax toxin binds monomeric form of protective antigen
Biochem. Biophys. Res. Commun.
360
690-695
2007
Bacillus anthracis (Q52NH3), Bacillus anthracis
Karginov, V.A.; Nestorovich, E.M.; Schmidtmann, F.; Robinson, T.M.; Yohannes, A.; Fahmi, N.E.; Bezrukov, S.M.; Hecht, S.M.
Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives
Bioorg. Med. Chem.
15
5424-5431
2007
Bacillus anthracis
Gaddis, B.D.; Avramova, L.V.; Chmielewski, J.
Inhibitors of anthrax lethal factor
Bioorg. Med. Chem. Lett.
17
4575-4578
2007
Bacillus anthracis
Muehlbauer, S.M.; Evering, T.H.; Bonuccelli, G.; Squires, R.C.; Ashton, A.W.; Porcelli, S.A.; Lisanti, M.P.; Brojatsch, J.
Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis
Cell Cycle
6
758-766
2007
Bacillus anthracis
Wickliffe, K.E.; Leppla, S.H.; Moayeri, M.
Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome
Cell. Microbiol.
10
332-343
2008
Bacillus anthracis
Rossi Paccani, S.; Tonello, F.; Patrussi, L.; Capitani, N.; Simonato, M.; Montecucco, C.; Baldari, C.T.
Anthrax toxins inhibit immune cell chemotaxis by perturbing chemokine receptor signalling
Cell. Microbiol.
9
924-929
2007
Bacillus anthracis
During, R.L.; Gibson, B.G.; Li, W.; Bishai, E.A.; Sidhu, G.S.; Landry, J.; Southwick, F.S.
Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation
EMBO J.
26
2240-2250
2007
Bacillus anthracis
Kuzmic, P.; Cregar, L.; Millis, S.Z.; Goldman, M.
Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides
FEBS J.
273
3054-3062
2006
Bacillus anthracis
Juris, S.J.; Melnyk, R.A.; Bolcome, R.E.; Chan, J.; Collier, R.J.
Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin
Infect. Immun.
75
5052-5058
2007
Bacillus anthracis
Liu, S.; Wang, H.; Currie, B.M.; Molinolo, A.; Leung, H.J.; Moayeri, M.; Basile, J.R.; Alfano, R.W.; Gutkind, J.S.; Frankel, A.E.; Bugge, T.H.; Leppla, S.H.
Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature
J. Biol. Chem.
283
529-540
2008
Bacillus anthracis
Chang, H.H.; Tsai, M.F.; Chung, C.P.; Chen, P.K.; Hu, H.I.; Kau, J.H.; Huang, H.H.; Lin, H.C.; Sun, D.S.
Single-step purification of recombinant anthrax lethal factor from periplasm of Escherichia coli
J. Biotechnol.
126
277-285
2006
Bacillus anthracis
Schepetkin, I.A.; Khlebnikov, A.I.; Kirpotina, L.N.; Quinn, M.T.
Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening
J. Med. Chem.
49
5232-5244
2006
Bacillus anthracis
Dalkas, G.A.; Papakyriakou, A.; Vlamis-Gardikas, A.; Spyroulias, G.A.
Low molecular weight inhibitors of the protease anthrax lethal factor
Mini Rev. Med. Chem.
8
290-306
2008
Bacillus anthracis
Alfano, R.W.; Leppla, S.H.; Liu, S.; Bugge, T.H.; Herlyn, M.; Smalley, K.S.; Bromberg-White, J.L.; Duesbery, N.S.; Frankel, A.E.
Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells
Mol. Cancer Ther.
7
1218-1226
2008
Bacillus anthracis
Guichard, A.; Park, J.M.; Cruz-Moreno, B.; Karin, M.; Bier, E.
Anthrax lethal factor and edema factor act on conserved targets in Drosophila
Proc. Natl. Acad. Sci. USA
103
3244-3249
2006
Bacillus anthracis
Bolcome, R.E.; Sullivan, S.E.; Zeller, R.; Barker, A.P.; Collier, R.J.; Chan, J.
Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature
Proc. Natl. Acad. Sci. USA
105
2439-2444
2008
Bacillus anthracis
Fink, S.L.; Bergsbaken, T.; Cookson, B.T.
Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
Proc. Natl. Acad. Sci. USA
105
4312-4317
2008
Bacillus anthracis
Barson, H.V.; Mollenkopf, H.; Kaufmann, S.H.; Rijpkema, S.
Anthrax lethal toxin suppresses chemokine production in human neutrophil NB-4 cells
Biochem. Biophys. Res. Commun.
374
288-293
2008
Bacillus anthracis
Tan, Y.K.; Kusuma, C.M.; St John, L.J.; Vu, H.A.; Alibek, K.; Wu, A.
Induction of autophagy by anthrax lethal toxin
Biochem. Biophys. Res. Commun.
379
293-297
2009
Bacillus anthracis
Jung, K.H.; Seo, G.M.; Yoon, J.W.; Park, K.S.; Kim, J.C.; Kim, S.J.; Oh, K.G.; Lee, J.H.; Chai, Y.G.
Protein expression pattern of murine macrophages treated with anthrax lethal toxin
Biochim. Biophys. Acta
1784
1501-1506
2008
Bacillus anthracis
Gaddis, B.D.; Rubert Perez, C.M.; Chmielewski, J.
Inhibitors of anthrax lethal factor based upon N-oleoyldopamine
Bioorg. Med. Chem. Lett.
18
2467-2470
2008
Bacillus anthracis
Reig, N.; Jiang, A.; Couture, R.; Sutterwala, F.S.; Ogura, Y.; Flavell, R.A.; Mellman, I.; van der Goot, F.G.
Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax lethal toxin
Cell. Microbiol.
10
1190-1207
2008
Bacillus anthracis
Wickliffe, K.E.; Leppla, S.H.; Moayeri, M.
Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway
Cell. Microbiol.
10
1352-1362
2008
Bacillus anthracis
Levin, T.C.; Wickliffe, K.E.; Leppla, S.H.; Moayeri, M.
Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin
Cell. Microbiol.
10
2434-2446
2008
Bacillus anthracis
Omland, K.S.; Brys, A.; Lansky, D.; Clement, K.; Lynn, F.; Lynn, F.
Interlaboratory comparison of results of an anthrax lethal toxin neutralization assay for assessment of functional antibodies in multiple species
Clin. Vaccine Immunol.
15
946-953
2008
Bacillus anthracis
Chou, P.J.; Newton, C.A.; Perkins, I.; Friedman, H.; Klein, T.W.
Suppression of dendritic cell activation by anthrax lethal toxin and edema toxin depends on multiple factors including cell source, stimulus used, and function tested
DNA Cell Biol.
27
637-648
2008
Bacillus anthracis
Shaw, C.A.; Starnbach, M.N.
Both CD4+ and CD8+ T cells respond to antigens fused to anthrax lethal toxin
Infect. Immun.
76
2603-2611
2008
Bacillus anthracis
Nour, A.M.; Yeung, Y.G.; Santambrogio, L.; Boyden, E.D.; Stanley, E.R.; Brojatsch, J.
Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages
Infect. Immun.
77
1262-1271
2009
Bacillus anthracis
deCathelineau, A.M.; Bokoch, G.M.
Inactivation of rho GTPases by statins attenuates anthrax lethal toxin activity
Infect. Immun.
77
348-359
2009
Bacillus anthracis
Kocer, S.S.; Matic, M.; Ingrassia, M.; Walker, S.G.; Roemer, E.; Licul, G.; Simon, S.R.
Effects of anthrax lethal toxin on human primary keratinocytes
J. Appl. Microbiol.
105
1756-1767
2008
Bacillus anthracis
Xu, L.; Fang, H.; Frucht, D.M.
Anthrax lethal toxin increases superoxide production in murine neutrophils via differential effects on MAPK signaling pathways
J. Immunol.
180
4139-4147
2008
Bacillus anthracis
Warfel, J.M.; DAgnillo, F.
Anthrax lethal toxin enhances TNF-induced endothelial VCAM-1 expression via an IFN regulatory factor-1-dependent mechanism
J. Immunol.
180
7516-7524
2008
Bacillus anthracis
Alfano, R.W.; Leppla, S.H.; Liu, S.; Bugge, T.H.; Meininger, C.J.; Lairmore, T.C.; Mulne, A.F.; Davis, S.H.; Duesbery, N.S.; Frankel, A.E.
Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis
Mol. Cancer Res.
7
452-461
2009
Bacillus anthracis
Chapelsky, S.; Batty, S.; Frost, M.; Mogridge, J.
Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol
PLoS ONE
3
e1421
2008
Bacillus anthracis
Raymond, B.; Batsche, E.; Boutillon, F.; Wu, Y.Z.; Leduc, D.; Balloy, V.; Raoust, E.; Muchardt, C.; Goossens, P.L.; Touqui, L.
Anthrax lethal toxin impairs IL-8 expression in epithelial cells through inhibition of histone H3 modification
PLoS Pathog.
5
e1000359
2009
Bacillus anthracis
Ha, S.D.; Ham, B.; Mogridge, J.; Saftig, P.; Lin, S.; Kim, S.O.
Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm
J. Biol. Chem.
285
2120-2129
2010
Bacillus anthracis
Pentelute, B.L.; Barker, A.P.; Janowiak, B.E.; Kent, S.B.; Collier, R.J.
A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor
ACS Chem. Biol.
5
359-364
2010
Bacillus anthracis
Raymond, B.; Ravaux, L.; Memet, S.; Wu, Y.; Sturny-Leclere, A.; Leduc, D.; Denoyelle, C.; Goossens, P.L.; Paya, M.; Raymondjean, M.; Touqui, L.
Anthrax lethal toxin down-regulates type-IIA secreted phospholipase A(2) expression through MAPK/NF-kappaB inactivation
Biochem. Pharmacol.
79
1149-1155
2010
Bacillus anthracis
Ngai, S.; Batty, S.; Liao, K.C.; Mogridge, J.
An anthrax lethal factor mutant that is defective at causing pyroptosis retains proapoptotic activity
FEBS J.
277
119-127
2010
Bacillus anthracis
Kong, Y.; Guo, Q.; Yu, C.; Dong, D.; Zhao, J.; Cai, C.; Hou, L.; Song, X.; Fu, L.; Xu, J.; Chen, W.
Fusion protein of DELTA 27LFn and EFn has the potential as a novel anthrax toxin inhibitor
FEBS Lett.
583
1257-1260
2009
Bacillus anthracis
Zakharova, M.Y.; Kuznetsov, N.A.; Dubiley, S.A.; Kozyr, A.V.; Fedorova, O.S.; Chudakov, D.M.; Knorre, D.G.; Shemyakin, I.G.; Gabibov, A.G.; Kolesnikov, A.V.
Substrate recognition of anthrax lethal factor examined by combinatorial and pre-steady-state kinetic approaches
J. Biol. Chem.
284
17902-17913
2009
Bacillus anthracis
Chiu, T.L.; Solberg, J.; Patil, S.; Geders, T.W.; Zhang, X.; Rangarajan, S.; Francis, R.; Finzel, B.C.; Walters, M.A.; Hook, D.J.; Amin, E.A.
Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening
J. Chem. Inf. Model.
49
2726-2734
2009
Bacillus anthracis
Hu, H.; Leppla, S.H.
Anthrax toxin uptake by primary immune cells as determined with a lethal factor-beta-lactamase fusion protein
PLoS ONE
4
e7946
2009
Bacillus anthracis
Moayeri, M.; Crown, D.; Dorward, D.W.; Gardner, D.; Ward, J.M.; Li, Y.; Cui, X.; Eichacker, P.; Leppla, S.H.
The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS)
PLoS Pathog.
5
e1000456
2009
Bacillus anthracis
Abrami, L.; Kunz, B.; van der Goot, F.G.
Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake
Proc. Natl. Acad. Sci. USA
107
1420-1424
2010
Bacillus anthracis
Dalkas, G.A.; Papakyriakou, A.; Vlamis-Gardikas, A.; Spyroulias, G.A.
Insights into the anthrax lethal factor-substrate interaction and selectivity using docking and molecular dynamics simulations
Protein Sci.
18
1774-1785
2009
Bacillus anthracis
Kuklenyik, Z.; Boyer, A.E.; Lins, R.; Quinn, C.P.; Gallegos-Candela, M.; Woolfitt, A.; Pirkle, J.L.; Barr, J.R.
Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for endopeptidase activity-based quantification of anthrax lethal factor in serum
Anal. Chem.
83
1760-1765
2011
Bacillus anthracis
Li, F.; Terzyan, S.; Tang, J.
Subsite specificity of anthrax lethal factor and its implications for inhibitor development
Biochem. Biophys. Res. Commun.
407
400-405
2011
Bacillus anthracis
Saebel, C.E.; Carbone, R.; Dabous, J.R.; Lo, S.Y.; Siemann, S.
Preparation and characterization of cobalt-substituted anthrax lethal factor
Biochem. Biophys. Res. Commun.
416
106-110
2011
Bacillus anthracis
Dalkas, G.A.; Chasapis, C.T.; Gkazonis, P.V.; Bentrop, D.; Spyroulias, G.A.
Conformational dynamics of the anthrax lethal factor catalytic center
Biochemistry
49
10767-10769
2010
Bacillus anthracis (P15917)
Little, S.F.; Webster, W.M.; Fisher, D.E.
Monoclonal antibodies directed against protective antigen of Bacillus anthracis enhance lethal toxin activity in vivo
FEMS Immunol. Med. Microbiol.
62
11-22
2011
Bacillus anthracis, Bacillus anthracis BH450
Liu, T.; Milia, E.; Warburton, R.R.; Hill, N.S.; Gaestel, M.; Kayyali, U.S.
Anthrax lethal toxin disrupts the endothelial permeability barrier through blocking p38 signaling
J. Cell. Physiol.
227
1438-1445
2012
Bacillus anthracis
Thomas, J.; Epshtein, Y.; Chopra, A.; Ordog, B.; Ghassemi, M.; Christman, J.W.; Nattel, S.; Cook, J.L.; Levitan, I.
Anthrax lethal factor activates K+ channels to induce IL-1beta secretion in macrophages
J. Immunol.
186
5236-5243
2011
Bacillus anthracis
Vuyisich, M.; Sanders, C.; Graves, S.
Binding and cell intoxication studies of anthrax lethal toxin
Mol. Biol. Rep.
2012
1-7
2012
Bacillus anthracis
Guichard, A.; McGillivray, S.; Cruz-Moreno, B.; Van Sorge, N.; Nizet, V.; Bier, E.
Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst
Nature
467
854-858
2010
Bacillus anthracis
Rivera, J.; Cordero, R.; Nakouzi, A.; Frases, S.; Nicola, A.; Casadevall, A.
Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins
Proc. Natl. Acad. Sci. USA
107
19002-19007
2010
Bacillus anthracis, Bacillus anthracis 34F2
Bromberg-White, J.; Lee, C.S.; Duesbery, N.
Consequences and utility of the zinc-dependent metalloprotease activity of anthrax lethal toxin
Toxins
2
1038-1053
2010
Bacillus anthracis
Xie, T.; Auth, R.D.; Frucht, D.M.
The effects of anthrax lethal toxin on host barrier function
Toxins
3
591-607
2011
Bacillus anthracis
Maize, K.; Kurbanov, E.; De La Mora-Rey, T.; Geders, T.; Hwang, D.; Walters, M.; Johnson, R.; Amin, E.; Finzel, B.
Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding
Acta Crystallogr. Sect. D
70
2813-2822
2014
Bacillus anthracis (P15917)
Moayeri, M.; Crown, D.; Jiao, G.; Kim, S.; Johnson, A.; Leysath, C.; Leppla, S.
Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection
Antimicrob. Agents Chemother.
57
4139-4145
2013
Bacillus anthracis (P15917), Bacillus anthracis
Vourtsis, D.; Chasapis, C.; Pairas, G.; Bentrop, D.; Spyroulias, G.
NMR conformational properties of an Anthrax lethal factor domain studied by multiple amino acid-selective labeling
Biochem. Biophys. Res. Commun.
450
335-340
2014
Bacillus anthracis (P15917)
Montpellier, L.; Siemann, S.
Effect of pH on the catalytic function and zinc content of native and immobilized anthrax lethal factor
FEBS Lett.
587
317-321
2013
Bacillus anthracis (P15917)
Ouyang, W.; Torigoe, C.; Fang, H.; Xie, T.; Frucht, D.
Anthrax lethal toxin inhibits translation of hypoxia-inducible factor 1alpha and causes decreased tolerance to hypoxic stress
J. Biol. Chem.
289
4180-4190
2014
Bacillus anthracis
Antonelli, A.; Zhang, Y.; Golub, L.; Johnson, F.; Simon, S.
Inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives
J. Enzyme Inhib. Med. Chem.
29
663-669
2014
Bacillus anthracis
Lo, S.; Sbel, C.; Webb, M.; Walsby, C.; Siemann, S.
High metal substitution tolerance of anthrax lethal factor and characterization of its active copper-substituted analogue
J. Inorg. Biochem.
140
12-22
2014
Bacillus anthracis (P15917)
Liao, H.; Liu, H.; Chen, W.; Ho, Y.
Structure-based pharmacophore modeling and virtual screening to identify novel inhibitors for anthrax lethal factor
Med. Chem. Res.
23
3725-3732
2014
Bacillus anthracis (P15917)
-
Sun, C.; Fang, H.; Xie, T.; Auth, R.; Patel, N.; Murray, P.; Snoy, P.; Frucht, D.
Anthrax lethal toxin disrupts intestinal barrier function and causes systemic infections with enteric bacteria
PLoS ONE
7
e33583
2012
Bacillus anthracis (P15917), Bacillus anthracis
Levinsohn, J.; Newman, Z.; Hellmich, K.; Fattah, R.; Getz, M.; Liu, S.; Sastalla, I.; Leppla, S.; Moayeri, M.
Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome
PLoS Pathog.
8
e1002638
2012
Bacillus anthracis (P15917)
Kassab, E.; Darwish, M.; Timsah, Z.; Liu, S.; Leppla, S.; Frankel, A.; Abi-Habib, R.
Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity
Transl. Oncol.
6
25-32
2013
Bacillus anthracis (P15917)
Lo, S.Y.; Saebel, C.E.; Mapletoft, J.P.J.; Siemann, S.
Influence of chemical denaturants on the activity, fold and zinc status of anthrax lethal factor
Biochem. Biophys. Rep.
1
68-77
2015
Bacillus anthracis (P15917)
Goldberg, A.B.; Turk, B.E.
Inhibitors of the metalloproteinase anthrax lethal factor
Curr. Top. Med. Chem.
16
2350-2358
2016
Bacillus anthracis (P15917), Bacillus anthracis
Maize, K.M.; Kurbanov, E.K.; Johnson, R.L.; Amin, E.A.; Finzel, B.C.
Ligand-induced expansion of the S1 site in the anthrax toxin lethal factor
FEBS Lett.
589
3836-3841
2015
Bacillus anthracis (P15917), Bacillus anthracis
Zhang, W.W.; Wang, X.; Xie, P.; Yuan, S.T.; Liu, Q.H.
Anthrax lethal toxin suppresses high glucose induced VEGF over secretion through a post-translational mechanism
Int. J. Ophthalmol.
8
453-458
2015
Bacillus anthracis (P15917)
Ma, P.; Cardenas, A.E.; Chaudhari, M.I.; Elber, R.; Rempe, S.B.
The impact of protonation on early translocation of anthrax lethal factor kinetics from molecular dynamics simulations and milestoning theory
J. Am. Chem. Soc.
139
14837-14840
2017
Bacillus anthracis (P15917)
Ouyang, W.; Guo, P.; Fang, H.; Frucht, D.M.
Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation
J. Biol. Chem.
292
17919-17927
2017
Bacillus anthracis (P15917), Bacillus anthracis
Goldberg, A.B.; Cho, E.; Miller, C.J.; Lou, H.J.; Turk, B.E.
Identification of a substrate-selective exosite within the metalloproteinase anthrax lethal factor
J. Biol. Chem.
292
814-825
2017
Bacillus anthracis (P15917), Bacillus anthracis
Krantz, B.
Anthrax lethal toxin co-complexes are stabilized by contacts between adjacent lethal factors
J. Gen. Physiol.
148
1966-1970
2016
Bacillus anthracis (P15917)
Young, C.J.; Richard, K.; Beruar, A.; Lo, S.Y.; Siemann, S.
An investigation of the pH dependence of copper-substituted anthrax lethal factor and its mechanistic implications
J. Inorg. Biochem.
182
1-8
2018
Bacillus anthracis (P15917)
html completed
